RESUMEN
Our review summarizes the latest approaches regarding a new class of nanomaterials - carbon nanotubes (CNTs) -, which are promising candidates in different areas of nanomedicine. This paper discusses the main applications of CNTs in the repair of injured nerves and also as delivery systems for cancer therapy in difficult to reach anatomic sites. In terms of neurological applications, we focus on neural interface, neural stimulation, microelectrodes, and differentiation of stem cell into neural cells. Also, we highlight the in vitro and in vivo applications of CNTs-mediated cancer therapy and we will explain why CNTs are used for the treatment of difficult tumors.
Asunto(s)
Nanotubos de Carbono/química , Neoplasias/terapia , Enfermedades Neurodegenerativas/terapia , Estimulación Eléctrica , Humanos , MicroelectrodosRESUMEN
The problem of microorganisms attaching and proliferating on implants and medical devices surfaces is still attracting interest in developing research on different coatings based on antibacterial agents. The aim of this work is centered on modifying titanium (Ti) based implants surfaces through incorporation of a natural compound with antimicrobial effect, torularhodin (T), by means of a polypyrrole (PPy) film. This study tested the potential antimicrobial activity of the new coating against a range of standard bacterial strains: Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and Pseudomonas aeruginosa. The morphology, physical and electrochemical properties of the synthesized films were assessed by SEM, AFM, UV-Vis, FTIR and cyclic voltammetry. In addition, biocompatibility of this new coating was evaluated using L929 mouse fibroblast cells. The results showed that PPy-torularhodin composite film acts as a corrosion protective coating with antibacterial activity and it has no harmful effect on cell viability.
Asunto(s)
Antibacterianos/farmacología , Carotenoides/farmacología , Materiales Biocompatibles Revestidos/farmacología , Polímeros/farmacología , Pirroles/farmacología , Titanio/farmacología , Animales , Antibacterianos/química , Antibacterianos/toxicidad , Bacterias/efectos de los fármacos , Carotenoides/química , Carotenoides/toxicidad , Línea Celular , Supervivencia Celular/efectos de los fármacos , Materiales Biocompatibles Revestidos/química , Materiales Biocompatibles Revestidos/toxicidad , Ratones , Polímeros/química , Polímeros/toxicidad , Pirroles/química , Pirroles/toxicidad , Propiedades de Superficie , Titanio/química , Titanio/toxicidadRESUMEN
Here, we report the synthesis, characterization and the impact of magnetite nanoparticles functionalized with cytostatic drugs, epirubicin (Epi) and fludarabine (Flu) (Fe3O4@Epi, Fe3O4@Flu) prepared by chemical co-precipitation method on tumoral cells in vitro. The average diameter of the resulted particles was about 4 nm for both Fe3O4@Epi and for Fe3O4@Flu. These bioactive nanostructured materials proved to significantly enhance the antitumor effect of tested cytostatic drugs in vitro. The most significant result was obtained in the case of Epi, where the tested magnetite nanostructured material enhanced the cytotoxic effect of this drug with more than 50%.