RESUMEN
In this open, clinically based, weight modification program, we determined in six sedentary obese adults (five women; one male; age range 30-62 years) that the combination of a modified calorie diet plus PGX® meal replacement and PGX® supplementation resulted in a significant reduction in several cardiovascular risk factors over a 12-week time period. This included a significant improvement in lipids (-0.98 mmol/l LDL-C), reduction in average weight (-9.2 kg), mean reduction in fat (-4.1%) and an increase in fat-free mass (2.8%).
Asunto(s)
Composición Corporal/efectos de los fármacos , Restricción Calórica , Enfermedades Cardiovasculares/prevención & control , Fibras de la Dieta/uso terapéutico , Obesidad/dietoterapia , Pérdida de Peso/efectos de los fármacos , Programas de Reducción de Peso , Tejido Adiposo/efectos de los fármacos , Adulto , Alginatos/farmacología , Alginatos/uso terapéutico , Compartimentos de Líquidos Corporales/efectos de los fármacos , Enfermedades Cardiovasculares/etiología , LDL-Colesterol/sangre , Dieta Reductora , Fibras de la Dieta/farmacología , Suplementos Dietéticos , Femenino , Ácido Glucurónico/farmacología , Ácido Glucurónico/uso terapéutico , Ácidos Hexurónicos/farmacología , Ácidos Hexurónicos/uso terapéutico , Humanos , Masculino , Mananos/farmacología , Mananos/uso terapéutico , Persona de Mediana Edad , Obesidad/sangre , Polisacáridos Bacterianos/farmacología , Polisacáridos Bacterianos/uso terapéutico , Factores de Riesgo , Conducta SedentariaRESUMEN
Air drying (AD), freeze-drying (FD), and vacuum-microwave drying (VMD) were applied to fresh North American ginseng roots to evaluate the effect of different drying techniques on pore characteristics and the subsequent recovery of ginsenoside content. FD ginseng root produced the lowest reductions in both total moisture content and water activity (P < 0.05), with no differences noted between Ontario or British Columbia ginseng. Ginseng roots from Ontario and British Columbia sources were therefore pooled to conduct the root porosity and ginsenoside measurements. Among samples, FD ginseng obtained the highest total porosity followed by VMD and AD, respectively (P < 0.05). All dehydrated samples had a porous structure with sizes that ranged from 0.002 µm to 172 µm, dominated by macropores (>1.5 µm). Pore characteristics of dried ginseng root were shown to affect recovery of ginsenosides, with the general trend being an increase in total porosity resulting in an increase in total ginsenoside recovered. High performance liquid chromatography results obtained on specific ginsenosides showed that AD of ginseng root resulted in the lowest recovery of total ginsenosides, most notably, Rg1 and Rb1, followed by VMD and FD, respectively. There was no specific difference in total ginsenoside recovery from roots dried at increasing power of VMD.
