[Evaluation of seroconversion after vaccination of medical staff against HBV infection].

AIM: Carry out analysis of formation of immune response in vaccinated medical staff against viral hepatitis B, detect risk factors by lack of seroconversion after vaccination. MATERIALS AND METHODS: In medical staff (49 individuals) retrospective analysis of dynamics of antibody titers against HBsAg (aHBs) after vaccination in 1998-2011, data on objective status and main laboratory parameters based on medical documentation was carried out. RESULTS: Among vaccinated the lack of response (aHBs < 10 mIU/ml) was observed in 20.4%, weak response (aHBs > or = 10 mIU/ml, < 100 mIU/ml)--in 34.7% and full response (aHBs > or = 100 mIU/ml)--in 44.9% of staff. Age over 40 years, male gender, obesity and insulin-resistance were linked with ineffectiveness of vaccination. With aHBs < 100 mIU/ml titers the patients became seornegative within 3 years after the immunization. With aHBs > or = 100 mIU/ml titers the patients remained seropositive for 10 years. CONCLUSION: Age over 40 years, male gender, obesity and insulin-resistance are linked with lack of formation of seroconversion after vaccination against HBV infection. When immune response is weak early monitoring of HBV titers is necessary with the aim of timely execution of revaccination. When immune response is adequate, revaccination is possible in 10 years.

[Hormonal mechanisms of morphofunctional changes in the gastric mucosa in chronic gastritis]. / Gormonal'nye mekhanizmy morfofunktsional'nykh izmenenii slizistoi obolochki zheludka pri khronicheskom gastrite.

The authors gave morphometric assessment of the mucous membrane of the stomach (MMS), investigated the proliferative activity of its cells and the levels of cyclic nucleotides (cAMP and cGMP) in 60 patients with different types of chronic gastritis. A parallel study was made of the blood levels of cortisol, thyroxine, insulin, STH, and gastrin. 10 healthy persons were investigated for control. A decrease in MMS thickness, redistribution of the sizable lobes of the glandular epithelium and stroma in favor of the latter were shown in atrophic (but not superficial) gastritis. In patients with atrophic gastritis the proliferative activity of MMS cells was significantly raised, the blood levels of cortisol and gastrin were elevated, the level of thyroxine was lowered, and insulin and STH levels were normal. Marked MMS atrophy was accompanied by cAMP and cGMP insufficiency. The relationships between the morphofunctional status and the proliferative activity of MMS cells, on the one hand, and the activity of the hormonal-cyclase systems, on the other hand, were followed. The mechanisms of pathological regeneration of MMS cell elements was specified, and its importance in the morphogenesis of atrophic gastritis was confirmed.