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This paper uses volcanic eruptions on the Caribbean islands of Montserrat and Saint Vincent to explore the role that British colonial rule in the past and near past (1800-2000) has played in response to and recovery from hazardous events, and in turn, the influence that the nature of the hazards has on these responses. It shows that systemic vulnerabilities to natural hazards have been created by inadequate aid responses and longer-term chronic problems and demonstrates that hazard impacts are compounded by them. Vulnerabilities could be reduced by analysing integrated hazard impacts to generate mitigative measures across hazards and identify actions that more closely match timescales of political decision-making. Incorporating local knowledge and experience into risk analysis will enable the most effective use of aid resources, ahead of emergencies. Finally, coupling aid for long-term development with emergency response would improve outcomes and adaptation to longer-term vulnerabilities in immediate rebuilding and short-term recovery.
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Desastres , Erupciones Volcánicas , Región del Caribe , Humanos , Medición de Riesgo , Indias OccidentalesRESUMEN
Rhinovirus (RV) infections are linked to the development and exacerbation of allergic diseases including allergic asthma. IgE, another contributor to atopic disease pathogenesis, has been shown to regulate DC antiviral functions and influence T cell priming by monocytes. We previously demonstrated that IgE-mediated stimulation of monocytes alters multiple cellular functions including cytokine secretion, phagocytosis, and influenza-induced Th1 development. In this study, we investigate the effects of IgE-mediated stimulation on monocyte-driven, RV-induced T cell development utilizing primary human monocyte-T cell co-cultures. We demonstrate that IgE crosslinking of RV-exposed monocytes enhances monocyte-driven Th2 differentiation. This increase in RV-induced Th2 development was regulated by IgE-mediated inhibition of virus-induced type I IFN and induction of IL-10. These findings suggest an additional mechanism by which two clinically significant risk factors for allergic disease exacerbations-IgE-mediated stimulation and rhinovirus infection-may synergistically promote Th2 differentiation and allergic inflammation.
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Hipersensibilidad/inmunología , Inmunoglobulina E/metabolismo , Interleucina-10/metabolismo , Monocitos/inmunología , Infecciones por Picornaviridae/inmunología , Rhinovirus/inmunología , Células Th2/inmunología , Diferenciación Celular , Células Cultivadas , Técnicas de Cocultivo , Humanos , Hipersensibilidad/epidemiología , Interferón Tipo I/metabolismo , Activación de Linfocitos , Infecciones por Picornaviridae/epidemiología , Riesgo , Estados Unidos/epidemiologíaRESUMEN
Volcanic ash has the capacity to impact human health, livestock, crops and infrastructure, including international air traffic. For recent major eruptions, information on the volcanic ash plume has been combined with relatively coarse-resolution meteorological model output to provide simulations of regional ash dispersal, with reasonable success on the scale of hundreds of kilometres. However, to predict and mitigate these impacts locally, significant improvements in modelling capability are required. Here, we present results from a dynamic meteorological-ash-dispersion model configured with sufficient resolution to represent local topographic and convectively-forced flows. We focus on an archetypal volcanic setting, Soufrière, St Vincent, and use the exceptional historical records of the 1902 and 1979 eruptions to challenge our simulations. We find that the evolution and characteristics of ash deposition on St Vincent and nearby islands can be accurately simulated when the wind shear associated with the trade wind inversion and topographically-forced flows are represented. The wind shear plays a primary role and topographic flows a secondary role on ash distribution on local to regional scales. We propose a new explanation for the downwind ash deposition maxima, commonly observed in volcanic eruptions, as resulting from the detailed forcing of mesoscale meteorology on the ash plume.
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The â¼3.48 billion-year-old Dresser Formation, Pilbara Craton, Western Australia, is a key geological unit for the study of Earth's earliest life and the habitats it occupied. Here, we describe a new suite of spheroidal to lenticular microstructures that morphologically resemble some previously reported Archean microfossils. Correlative microscopy shows that these objects have a size distribution, wall ultrastructure, and chemistry that are incompatible with a microfossil origin and instead are interpreted as pyritized and silicified fragments of vesicular volcanic glass. Organic kerogenous material is associated with much of the altered volcanic glass; variable quantities of organic carbon line or fill the insides of some individual vesicles, while relatively large, tufted organic-rich laminae envelop multiple vesicles. The microstructures reported herein constitute a new type of abiogenic artifact (pseudo-fossil) that must be considered when evaluating potential signs of early life on Earth or elsewhere. In the sample studied here, where hundreds of these microstructures are present, the combined evidence permits a relatively straightforward interpretation as vesicular volcanic glass. However, reworked, isolated, and silicified microstructures of this type may prove particularly problematic in early or extraterrestrial life studies since they adsorb carbon onto their surfaces and are readily pyritized, mimicking a common preservation mechanism for bona fide microfossils. In those cases, nanoscale analysis of wall ultrastructure would be required to firmly exclude a biological origin. Key Words: Microfossils-Pseudo-fossils-Volcanic vesicles-Archean life-Pilbara Craton-Dresser Formation. Astrobiology 18, 539-555.
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Planeta Tierra , Sedimentos Geológicos , Evolución Biológica , Exobiología , Fósiles , Origen de la Vida , Erupciones Volcánicas , Australia OccidentalAsunto(s)
Resistencia a la Enfermedad/inmunología , Interacciones Huésped-Patógeno/inmunología , Inmunoglobulina E/inmunología , Gripe Humana/inmunología , Gripe Humana/virología , Monocitos/inmunología , Células TH1/citología , Células TH1/inmunología , Presentación de Antígeno/inmunología , Antígenos/inmunología , Biomarcadores , Diferenciación Celular/inmunología , Técnicas de Cocultivo , Humanos , Monocitos/metabolismo , Subgrupos de Linfocitos T , Células TH1/metabolismo , Células Th2/inmunología , Células Th2/metabolismoRESUMEN
The Ethiopian Rift Valley hosts the longest record of human co-existence with volcanoes on Earth, however, current understanding of the magnitude and timing of large explosive eruptions in this region is poor. Detailed records of volcanism are essential for interpreting the palaeoenvironments occupied by our hominin ancestors; and also for evaluating the volcanic hazards posed to the 10 million people currently living within this active rift zone. Here we use new geochronological evidence to suggest that a 200 km-long segment of rift experienced a major pulse of explosive volcanic activity between 320 and 170 ka. During this period, at least four distinct volcanic centres underwent large-volume (>10 km3) caldera-forming eruptions, and eruptive fluxes were elevated five times above the average eruption rate for the past 700 ka. We propose that such pulses of episodic silicic volcanism would have drastically remodelled landscapes and ecosystems occupied by early hominin populations.
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BACKGROUND: IgE cross-linking triggers many cellular processes that drive allergic disease. While the role of IgE in mediating allergic responses is best described on basophils and mast cells, expression of the high-affinity IgE receptor on other innate immune cells, including monocytes, suggests that it may affect the function of these cells in allergic environments. OBJECTIVE: To determine the effect of IgE cross-linking on the function of human monocytes. METHODS: Monocytes purified from healthy donor blood samples were cultured for 4 to 96 hours with media alone, a cross-linking anti-IgE antibody or control IgG. Surface CD14 and CD64 expression and secreted cytokine concentrations were determined. Monocyte function was determined by assessing (1) phagocytosis of Escherichia coli or apoptotic HEp2 cells and (2) killing of intracellular E coli. Select experiments were performed on monocytes obtained from participants with elevated versus normal serum IgE concentrations. RESULTS: IgE cross-linking on monocytes increased CD14 expression and induced secretion of TNF-α, IL-6, and autoregulatory IL-10. These effects were greatest in individuals with elevated serum IgE concentrations. In contrast, IgE cross-linking reduced CD64 expression and significantly impaired phagocytic function without disrupting the capacity of monocytes to kill bacteria. CONCLUSIONS: IgE cross-linking drives monocyte proinflammatory processes and autoregulatory IL-10 in a serum IgE-dependent manner. In contrast, monocyte phagocytic function is critically impaired by IgE cross-linking. Our findings suggest that IgE cross-linking on monocytes may contribute to allergic disease by both enhancing detrimental inflammatory responses and concomitantly crippling phagocytosis, a primary mechanism used by these cells to resolve inflammation.
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Inmunoglobulina E/inmunología , Monocitos/inmunología , Fagocitosis/inmunología , Adolescente , Adulto , Antígenos de Superficie/inmunología , Basófilos/inmunología , Basófilos/fisiología , Células Cultivadas , Escherichia coli/inmunología , Escherichia coli/fisiología , Femenino , Humanos , Inflamación/inmunología , Inflamación/fisiopatología , Interleucina-10/inmunología , Interleucina-6/inmunología , Receptores de Lipopolisacáridos/inmunología , Masculino , Receptores de IgE/inmunología , Receptores de IgG/inmunología , Factor de Necrosis Tumoral alfa/inmunología , Adulto JovenRESUMEN
As continental rift zones mature the tectonic and volcanic processes associated with crustal extension become confined to narrow magmatic rift zones, reminiscent of oceanic spreading ridges. The formation of these rift zones and the development of ocean-ridge type topography is a significant milestone in rift evolution as it signifies the localization of crustal extension and rift-related volcanism. Here we show that lavas, which erupted since ~200 ka along part of the on-land Red Sea rift system in Afar, Ethiopia, have a consistent age-progression from the rift axis outwards, indicating that axial dyke intrusion has been the primary mechanism of segment growth and that focused magmatic accretion and extension in the crust have remained stable here over this period. Our results suggest that as this rift segment has formed, in thinned and intruded continental crust, the time-averaged surface opening rate has closely approximated the total extension rate between Africa and Arabia.
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Tree cores (Pinus nigra ssp. laricio) and leaves (Castanea sativa) from the flanks of Mount Etna, Sicily were analysed by ICP-MS to investigate whether volcanogenic cations within plant material provide an archive of a volcano's temporal and spatial depositional influence. There is significant compositional variability both within and between trees, but no systematic dendrochemical correlation with periods of effusive, explosive or increased degassing activity. Dendrochemistry does not provide a record of persistent but fluctuating volcanic activity. Foliar levels of bioaccumulated cations correspond to modelled plume transport patterns, and map short-term volcanic fumigation. Around the flanks of the volcano foliar variation is greater for volatile cations (Cs, Cd, Pb) than for lithophilic cations (Ba, Sr), consistent with trace-metal supply from volcanic aerosol during quiescent periods.