The impact of threat of shock-induced anxiety on alerting, orienting, and executive function in women: an ERP study.

The present study used a combination of the Threat-of-Shock paradigm and the Attention Network Test (ANT) to investigate how induced anxiety affects alerting, orienting, and executive control and whether individual differences in threat sensitivity moderate these effects. Forty-two female subjects completed the ANT task in alternation under shock-threat and no-shock ("safe") conditions while event-related potentials (ERPs) were recorded. The results showed that anxiety induced by the threat of shock had a significant impact on alerting and executive control functions at the neural level. Specifically, alerting-related N1 and stimulus-preceding negativity (SPN) differences between double cue and no cue conditions were greater in the threat versus safe state, suggesting that the induced anxiety promoted the early perception of cues and preparation for the target. Moreover, executive control-related P3 and sustained potential (SP) differences between incongruent and congruent trials were greater in the threat versus safe state, indicating that the induced anxiety might improve the attentional allocation efficiency and stimulate subjects to recruit more cognitive resources to resolve conflicts. However, orienting-related ERPs were not affected by the threat of shock, but the threat of shock promoted the processing efficiency of spatial-cue at the behavioral level. Analysis of individual differences revealed that trait anxiety moderated the attentional allocation efficiency when performing executive control related tasks in the threat versus safe state. Our findings demonstrate the adaptive significance of the threat of shock-induced anxiety in that being in an anxious state can enhance individuals' alerting, orienting, and executive functions.

Preventing prefrontal dysfunction by tDCS modulates stress-induced creativity impairment in women: an fNIRS study.

Stress is a major external factor threatening creative activity. The study explored whether left-lateralized activation in the dorsolateral prefrontal cortex manipulated through transcranial direct current stimulation could alleviate stress-induced impairment in creativity. Functional near-infrared spectroscopy was used to explore the underlying neural mechanisms. Ninety female participants were randomly assigned to three groups that received stress induction with sham stimulation, stress induction with true stimulation (anode over the left and cathode over the right dorsolateral prefrontal cortex), and control manipulation with sham stimulation, respectively. Participants underwent the stress or control task after the transcranial direct current stimulation manipulation, and then completed the Alternative Uses Task to measure creativity. Behavioral results showed that transcranial direct current stimulation reduced stress responses in heart rate and anxiety. The functional near-infrared spectroscopy results revealed that transcranial direct current stimulation alleviated dysfunction of the prefrontal cortex under stress, as evidenced by higher activation of the dorsolateral prefrontal cortex and frontopolar cortex, as well as stronger inter-hemispheric and intra-hemispheric functional connectivity within the prefrontal cortex. Further analysis demonstrated that the cortical regulatory effect prevented creativity impairment induced by stress. The findings validated the hemispheric asymmetry hypothesis regarding stress and highlighted the potential for brain stimulation to alleviate stress-related mental disorders and enhance creativity.

The Association between 5-Hydroxytryptamine Receptor 1B rs13212041 Polymorphism and Trait Anxiety in Chinese Han College Subjects.

Trait anxiety is a vulnerable personality factor for anxiety and depression. High levels of trait anxiety confer an elevated risk for the development of anxiety and other psychiatric disorders. There is evidence that 5-hydroxytryptamine receptor 1B (5-HT1B) gene polymorphisms play an important role in emotional disorders. Genotyping for four single-nucleotide polymorphisms (SNP) (rs11568817, rs130058, rs6297, and rs13212041) was conducted for 388 high trait anxious (HTA) individuals and 463 low traitanxious (LTA) individuals in Chinese Han college subjects. The results showed that the frequencies of the C-allele and TC + CC genotype of rs13212041 in the LTA individuals were higher than that in the HTA individuals (p = 0.025 and p = 0.014, respectively). Both the C-allele and TC + CC genotype were associated with trait anxiety decreasing (OR = 0.771 and OR = 0.71, respectively). Furthermore, different gene model analysis also showed that the C allele was a protective factor for trait anxiety in Chinese Han college subjects. These findings suggest that 5-HT1B rs13212014 may play a role in trait anxiety among China Han college subjects. The rs13212014 polymorphism may be involved in decreasing the risk of trait anxiety. These results also provide a novel insight into the molecular mechanism underlying trait anxiety.

Trait anxiety modulates the temporal dynamics of Stroop task switching: An ERP study.

The current study aimed to find neural evidence that trait anxiety interferes with one's shifting function processing efficiency. Twenty-five high trait-anxiety (HTA) and twenty-five low trait-anxiety (LTA) participants were instructed to complete a cue-based Stroop task-switching assessment of shifting function. No group difference in behavioral performance was shown, though event-related potential (ERP) results in the cue-locked period showed that only the LTA group had a general switch benefit in contingent negative variation (CNV) amplitude, indicating the LTA group exerted less task preparation effort. In the subsequent target-locked period, compared to the LTA group, the local switch cost of target-P3 was higher in the HTA group in incompatible trials, suggesting inefficient attentional resource allocation in the HTA group in incompatible trials. These ERP findings indicated that the HTA group ultimately achieved comparable behavioral performance with the LTA group at the expense of using more compensatory strategies at the neural level.

Spatiotemporal Dynamics of Affective and Semantic Valence Among Women.

As an important dimension of emotional assessment, valence can refer to affective valence reflecting an emotional response, or semantic valence reflecting knowledge about the nature of a stimulus. A previous study has used repeated exposure to separate these two similar cognitive processes. Here, for the first time, we compared the spatiotemporal dynamics of the affective and semantic modes of valence by combining event-related potentials with repeated exposure. Forty-seven female participants were assigned to the feeling-focused and semantic-focused groups and thereafter repeatedly viewed the pictures selected for the study. Self-report behavioral results showed that post-test scores were significantly lower than pre-test scores in the feeling-focused group, while the differences between the two tests were not significant in the semantic-focused group. At the neural level, N2 amplitudes decreased and early late positive potential amplitudes increased in both groups, suggesting that the participants perceived the repeated pictures more fluently and retrieved the traces of the stimulus spontaneously regardless of the valence they judged. However, the late positive potential amplitudes in anterior areas and the activity of the middle frontal gyrus were attenuated in the feeling-focused group; however, this component in posterior areas and the activity of the precentral gyrus were increased in the semantic-focused group. Therefore, the processes of affective and semantic valence are similar in the early stages of image perception and retrieval, while in the later stage of valence judgment, these processes show different brain activation patterns. The results provide electrophysiological evidence for the differences in psychological processes when judging the two modes of valence.

Task Difficulty Regulates How Conscious and Unconscious Monetary Rewards Boost the Performance of Working Memory: An Event-Related Potential Study.

The performance of working memory can be improved by the corresponding high-value vs. low-value rewards consciously or unconsciously. However, whether conscious and unconscious monetary rewards boosting the performance of working memory is regulated by the difficulty level of working memory task is unknown. In this study, a novel paradigm that consists of a reward-priming procedure and N-back task with differing levels of difficulty was designed to inspect this complex process. In particular, both high-value and low-value coins were presented consciously or unconsciously as the reward cues, followed by the N-back task, during which electroencephalogram signals were recorded. It was discovered that the high-value reward elicited larger event-related potential (ERP) component P3 along the parietal area (reflecting the working memory load) as compared to the low-value reward for the less difficult 1-back task, no matter whether the reward was unconsciously or consciously presented. In contrast, this is not the case for the more difficult 2-back task, in which the difference in P3 amplitude between the high-value and low-value rewards was not significant for the unconscious reward case, yet manifested significance for the conscious reward processing. Interestingly, the results of the behavioral analysis also exhibited very similar patterns as ERP patterns. Therefore, this study demonstrated that the difficulty level of a task can modulate the influence of unconscious reward on the performance of working memory.

Social exclusion modulates dual mechanisms of cognitive control: Evidence from ERPs.

Many studies have investigated how social exclusion influences cognitive control but reported inconsistent findings. Based on the dual mechanisms of control framework, this study investigated how social exclusion influences proactive and reactive modes of control (Experiment 1) and the underlying mechanisms (Experiment 2). The Cyberball game was used to manipulate social exclusion. Eighty-six female participants (about 40 for each experiment) performed cognitive control tasks while event-related potentials were recorded. In Experiment 1, an AX Continuous Performance Task (AX-CPT) was adopted to differentiate between proactive and reactive control. Results showed that social exclusion weakened proactive control but enhanced reactive control, as reflected by the weaker proactive control indicators (i.e., P3b and CNV), but strengthened reactive control indicators (accuracy and N2) in excluded individuals. More importantly, in Experiment 2, through varying in whether task cues were available before or after target onset in a cued-flanker task, we further manipulated the possibility of engaging proactive control, and found the weakened proactive control could be attributed to both impaired cognitive ability and lowered motivation to engage proactive control in excluded individuals. Together, these results provide insight on how social exclusion influences cognitive control and suggest promising implications for designing effective interventions to relieve the negative impact of social exclusion.

Regulation of negative emotions through positive reappraisal and distancing in high-trait-anxious women.

BACKGROUND: Positive reappraisal and distancing are two distinct cognitive reappraisal strategies for emotion regulation. Critically however, research examining the impact of elevated trait anxiety on cognitive reappraisal has often conflated these strategies. Thus, the present study investigated whether high-trait-anxious (HTA) women can effectively utilize positive reappraisal and distancing to regulate emotional responses to negative stimuli. METHODS: Twenty-six HTA women and twenty-seven low-trait-anxious (LTA) women were investigated in a self-generated reappraisal paradigm. Subjective measures of emotional regulation and event-related potentials (ERPs) were recorded while participants were instructed to passively view neutral or negative pictures, or to reinterpret negative pictures in a positive way (positive reappraisal) or a detached and unemotional way (distancing). RESULTS: HTA women, as compared to LTA women, reported smaller reductions in negative affect after positive reappraisal and smaller reductions in emotional arousal after distancing. Though ERP data did not reveal corresponding differences in the centro-parietal late positive potential during emotion regulation, data did reveal HTA women exhibited enhanced recruitment of cognitive control during positive reappraisal and greater preparatory processing before engaging in distancing. LIMITATIONS: Future research should examine the generalizability of the present results in clinical anxiety individuals, male sample and other reappraisal strategies. CONCLUSIONS: Overall, HTA women appeared to recruit more cortical resources, suggestive of compensatory mechanisms, to achieve a similar performance as LTA women when engaging in positive reappraisal and distancing strategies to regulate negative emotions. Therefore, the findings demonstrate that HTA women are characterized by the inefficient implementation of positive reappraisal and distancing strategies.

Psychometric Properties of the Effort-Reward Imbalance Questionnaire for Teachers (Teacher ERIQ).

The effort-reward imbalance (ERI) model is a theoretical model of a psychosocial work environment with adverse effects on health and well-being that focuses on a mismatch between high efforts spent and low rewards received at work. This study aimed to develop and psychometrically test an effort-reward imbalance questionnaire for teachers (Teacher ERIQ) based on the ERI model. The structure validity, reliability, and criterion validity of the new questionnaire's scores were evaluated in a sample of 475 Chinese teachers. The results of exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) showed that a structure of four factors of effort (workload, emotional demands, student-related issues, and social responsibility) and two factors of reward (emotional reward and material reward) in accordance with the ERI model had significant factor loadings and acceptable model fit. The Cronbach's Alpha coefficients of all dimensions' scores showed that the questionnaire scores had good reliability. Criterion validity was indicated by significant correlation coefficients of scores of most dimensions along with teachers' self-reported job burnout and non-reciprocal social relations, as well as the ANOVA results showing that the differences of the scores of the two criterion scales in different ERI ratio levels were significant. The results also showed that teacher's ERI level varied with demographic variables such as age, gender and school type. The Teacher ERIQ is a valid and reliable new measurement for assessing teachers' psychosocial work characteristics. It can be an important tool to provide new explanations of stress-related health risks among teachers and to guide the development of preventive measurements.

The impact of effort-reward imbalance on loneliness of the elderly: the multiple mediation effect of social support and control belief in social domain.

Objective: The empirical studies of loneliness have experienced unprecedented growth in the past decades. As such, there is now a growing body of research showing that loneliness is negatively related to physical and mental health. More recently, one of the most widely tested models of effort-reward imbalance (ERI) posits that the imbalance between high effort and low reward elicits strong negative emotions and sustained stress responses. Despite these developments, the mechanism between ERI and loneliness of the elderly remains unclear. In the current study, we explored how ERI influences loneliness via social support and control belief in social domain. Method: We selected a convenience sample aged 53-84 years old (N = 231) to complete a series of standard psychological assessments. Results: Multiple mediation analysis showed that (1) the positive effect of ERI on loneliness was partially mediated by social support (95% IC = -.001 to .078) and control belief in social domain (95% IC = .028 to .154), and (2) the chain mediating effect of both mediators was also significant (95% IC = .037 to .112). Discussion: The study suggests that ERI can influence loneliness through decreasing social support and subsequently reducing control belief in social domain.

Common and distinct brain responses to detecting top-down and bottom-up conflicts underlying numerical inductive reasoning.

Complex reasoning problems are commonly influenced by a combination of top-down and bottom-up conflicts; however, the common and distinct brain responses to the two types of conflicts have remained unclear. Participants were required to identify the hidden rules in a number series completion task, which included identity condition (e.g., 13, 13, 13), perceptual mismatch condition (bottom-up conflict, e.g., 13 13 +≡), and relational mismatch condition (top-down conflict, e.g., 13 13 14). The ERP results showed that (a) both the perceptual and relational mismatch conditions triggered greater P200, N200, P300, and late positive component than the identity condition, reflecting attention reallocation, perceptual template deviations, feelings of uncertainty, and working memory updating, respectively, and (b) smaller N400 and decreased late negative component were found in the relational mismatch condition in contrast to other conditions, which suggested that changing number values violated rule expectancy as top-down conflict. Therefore, multiple strategies were utilized to detect the conflicts underlying complex reasoning problems.

The creative thinking cognitive process influenced by acute stress in humans: an electroencephalography study.

This study examined the underlying neural mechanism of acute stress affecting creative thinking. Twenty-six male participants underwent the Alternative Uses Test before and after acute stress test (Montreal Imaging Stress Task). Compared to before stress, stressed participants responded with higher salivary cortisol and salivary alpha-amylase. The electroencephalogram results indicated a general decrease in upper-frequency alpha power after stress, compared with that of before stress. The decrease in upper-frequency alpha power observed in the first stage after exposure to stress was related to memory and attention. Additionally, stress also reduced the differences between individuals with different creative abilities. In summary, these findings indicated that acute stress impaired creative thinking and primarily affected the earlier phase of the process of creative cognition. This study provides some practical implications for educational practice and corporate innovation in that a more relaxed environment promotes creative output. Lay Summary Acute stress impaired creative thinking performance and mainly affects the earlier phase of the process of creative cognition. Additionally, stress seems to reduce the differences between individuals with different creative abilities.

Social exclusion weakens storage capacity and attentional filtering ability in visual working memory.

Social exclusion has been found to impair visual working memory (WM), while the underlying neural processes are currently unclear. Using two experiments, we tested whether the poor WM performance caused by exclusion was due to reduced storage capacity, impaired attentional filtering ability or both. The Cyberball game was used to manipulate social exclusion. Seventy-four female participants performed WM tasks while event-related potentials were recorded. In Experiment 1, participants were made to remember the orientations of red rectangles while ignoring salient green rectangles. Results showed that exclusion impaired the ability to filter out irrelevant items from WM, as reflected by the similar contralateral delay activity (CDA) amplitudes for one-target-one-distractor condition and two-targets condition, as well as the similar CDA amplitudes for two-targets-two-distractors condition and four-targets condition in excluded individuals. In Experiment 2, participants were asked to remember 1-5 colored squares. Results showed that exclusion reduced storage capacity, as the CDA amplitudes reached asymptote at loads of two items for exclusion group and at loads of three items for inclusion group. Together, these two experiments provided complementary evidence that WM deficits caused by social exclusion were due to reduced storage capacity and impaired attentional filtering ability.

Pleasure attainment or self-realization: the balance between two forms of well-beings are encoded in default mode network.

What is a good life and how it can be achieved is one of the fundamental issues. When considering a good life, there is a division between hedonic (pleasure attainment) and eudaimonic well-being (meaning pursuing and self-realization). However, an integrated approach that can compare the brain functional and structural differences of these two forms of well-being is lacking. Here, we investigated how the individual tendency to eudaimonic well-being relative to hedonic well-being, measured using eudaimonic and hedonic balance (EHB) index, is reflected in the functional and structural features of a key network of well-being-the default mode network (DMN). We found that EHB was positively correlated with functional connectivity of bilateral ventral medial prefrontal cortex within anterior DMN and bilateral precuneus within posterior DMN. Brain morphometric analysis showed that EHB was also positively correlated with gray matter volume in left precuneus. These results demonstrated that the relative dominance of one form of well-being to the other is reflected in the morphometric characteristics and intrinsic functions of DMN.

Electroencephalographic theta oscillatory dynamics reveal attentional bias to angry faces.

Although previous studies have reported the temporal neural dynamics (e.g., N2pc component) of threat-detection orientation for face-processing (e.g., the "anger superiority effect"), little is known about the neural oscillatory features of this phenomenon. Here, we extracted the event-related potentials and event-related oscillatory power dynamics from electroencephalographic data when participants performed a visual search task consisting of realistic angry, happy, and neutral facial expressions. We observed a shorter response time and a larger N2pc for angry faces than for happy faces, suggesting the existence of preferential processing for angry faces. Similarly, elevated theta synchronization was observed for angry faces compared to happy faces, while both angry and happy faces elicited heightened theta oscillatory activity on contralateral location of target face compared to ipsilateral location. Moreover, the theta oscillation difference negatively correlated with the amplitude of the N2pc difference. Our findings suggest that the occipital theta oscillation is engaged in the search advantage of angry facial expressions. Further, our results provide evidence that the theta oscillation may reflect the processing dynamics of threat-stimuli orientation in an ever-changing environment.

The temporal dynamics of detached versus positive reappraisal: An ERP study.

Detached reappraisal and positive reappraisal are regarded as two distinct types of cognitive reappraisal strategy, and the former is considered more disengaging than the latter. The conceptual framework of emotion regulation choice posits that strategies involving disengagement operate earlier and more efficiently than engagement strategies. Here, we compare for the first time the temporal dynamics of detached and positive reappraisal during the regulation and re-exposure phases thereof by measuring event-related potentials. During the regulation phase, pictures were viewed or regulated using detached or positive reappraisal. During the re-exposure phase, the same pictures were viewed again. Results showed that during regulation, central-parietal late positive potentials (LPPs) were greatly attenuated under both strategy types, with the regulation effect of detached reappraisal occurring earlier than that of positive reappraisal and resulting in a stronger attenuation of LPP amplitudes. Upon re-exposure, detached reappraisal exerted enduring effects on self-reported arousal and the central-parietal LPP, whereas positive reappraisal had an enduring effect only on pleasantness. These findings demonstrate the differential effects of detached and positive reappraisal on valence, arousal, and neural responses, and underline the striking differences in the temporal dynamics of these reappraisal strategies.

Enhanced conflict-driven cognitive control by emotional arousal, not by valence.

Emotion is widely agreed to have two dimensions, valence and arousal. Few studies have explored the effect of emotion on conflict adaptation by considering both of these, which could have dissociate influence. The present study aimed to fill the gap as to whether emotional valence and arousal would exert dissociable influence on conflict adaptation. In the experiments, we included positive, neutral, and negative conditions, with comparable arousal between positive and negative conditions. Both positive and negative conditions have higher arousal than neutral ones. In Experiment 1, by using a two-colour-word Flanker task, we found that conflict adaptation was enhanced in both positive and negative contexts compared to a neutral context. Furthermore, this effect still existed when controlling stimulus-response repetitions in Experiment 2, which used a four-colour-word Flanker task. The findings suggest emotional arousal enhances conflict adaptation, regardless of emotional valence. Thus, future studies should consider emotional arousal when studying the effect of emotion on conflict adaptation. Moreover, the unique role of the emotional context in conflict-driven cognitive control is emphasised.

The temporal dynamics underlying the comprehension of scientific metaphors and poetic metaphors.

The neural mechanisms underlying the processing of novel metaphors created from poetic contexts have been investigated in previous experiments. Considering the different attributes of metaphors, the current study compared the temporal dynamics for processing two kinds of novel metaphors with event-related potentials (ERPs): scientific metaphors and poetic metaphors. Amplitudes of the N400 (350-450ms) were similar for scientific metaphors and poetic metaphors. Within the LPC window (550-850ms), ERPs associated with these two kinds of novel metaphors were observed every 100ms in three successive subwindows. We found that due to a sustained late negativity overlapping in time and space with the LPC scientific metaphors seemingly elicited the least positive LPC throughout. More importantly, with the passage of time, the LPC waveforms for scientific metaphors diverged from those for poetic metaphors and conventional metaphors while LPC waveforms for poetic metaphors converged with those for conventional metaphors. The reported results indicate the possible different time courses for processing novel metaphors with different contextual structures and different functions. And the findings are compatible with recent brain imaging studies and complement them by adding such new dimensions as the temporal dynamics and the properties of novel metaphors.

Well-being and Anticipation for Future Positive Events: Evidences from an fMRI Study.

Anticipation for future confers great benefits to human well-being and mental health. However, previous work focus on how people's well-being correlate with brain activities during perception of emotional stimuli, rather than anticipation for the future events. Here, the current study investigated how well-being relates to neural circuitry underlying the anticipating process of future desired events. Using event-related functional magnetic resonance imaging, 40 participants were scanned while they were performing an emotion anticipation task, in which they were instructed to anticipate the positive or neutral events. The results showed that bilateral medial prefrontal cortex (MPFC) were activated during anticipation for positive events relative to neutral events, and the enhanced brain activation in MPFC was associated with higher level of well-being. The findings suggest a neural mechanism by which the anticipation process to future desired events correlates to human well-being, which provide a future-oriented view on the neural sources of well-being.