1.
Org Lett
; 13(9): 2318-21, 2011 May 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21452836
RESUMEN
JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation-transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furthermore, this versatile methodology allows for the synthesis of cyclopropyl and fluorinated analogs of the parent lead structure.