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1.
Clin Rheumatol ; 35(6): 1463-73, 2016 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-27041382

RESUMEN

The objective of the study is to find predictors of remission, radiographic progression (RP), and erosive disease in a cohort of patients with early onset rheumatoid arthritis (EORA) that followed a therapeutic protocol aiming at remission, in a real world tight-control setting. EORA patients were enrolled in a 3-year follow-up study. Clinical, biological, immunogenetic, and radiographical data were analyzed. Radiographs were scored according to Sharp-van der Heijde (SvdH) method. RP was defined by an increase of 3 units in 36 months. Remission was defined as DAS28 <2.6. A stepwise multiple logistic regression model was used to identify independent predictors of the three target outcomes. One hundred twenty-nine patients were included. Baseline disease activity was high. Significant overall improvement was observed, but only 33.3 % achieved remission. At 36 month, 50.4 % (65) of patients showed erosions. RP was observed in 62.7 % (81) of cases. Statistical analysis showed that baseline SvdH score was the only predictive factor associated with the three outcomes evaluated. Lower HAQ-DI and absence of autoantibodies were predictive of remission. Higher levels of ESR and presence of erosions at entry were predictive of RP. Independent baseline predictors of incident erosive disease were anti-CCP and RF positivity, symptom duration at baseline >3 months, and presence of HLA-DRB1 shared epitope. Radiographic damage at baseline was the main predictor of outcomes. Autoantibodies, HAQ and ESR at baseline, symptom duration before diagnosis, and HLA-DRB1 status had influence on clinical course and development of structural joint damage in Colombian RA patients.


Asunto(s)
Artritis Reumatoide/diagnóstico por imagen , Artritis Reumatoide/patología , Adulto , Antirreumáticos/administración & dosificación , Artritis Reumatoide/tratamiento farmacológico , Autoanticuerpos/sangre , Colombia , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Cadenas HLA-DRB1/genética , Humanos , Modelos Logísticos , Masculino , Metotrexato/administración & dosificación , Persona de Mediana Edad , Péptidos Cíclicos/inmunología , Estudios Prospectivos , Radiografía , Inducción de Remisión , Factor Reumatoide/inmunología , Índice de Severidad de la Enfermedad
2.
Rheumatol Int ; 32(2): 541-3, 2012 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21267573

RESUMEN

Relapsing polychondritis (RP) is an autoimmune disease characterized by inflammation and destruction of all type of body cartilage, and the cartilage trauma may be a trigger of the disease in a susceptible person. We describe the clinical and laboratory findings in a group of 18 patients with RP with (7 cases) or without (11 cases) anteceding cartilage trauma. The mean age was 41 years in the group with cartilage trauma and 55 years in the group without cartilage trauma. For both groups, female gender was predominant. All patients presented with auricular chondritis. Systemic manifestations and autoimmunity were more common in patients with anteceding trauma.


Asunto(s)
Enfermedades Autoinmunes/diagnóstico , Cartílago/inmunología , Cartílago/lesiones , Policondritis Recurrente/diagnóstico , Heridas y Lesiones/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Enfermedades Autoinmunes/epidemiología , Cartílago/patología , Comorbilidad/tendencias , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Policondritis Recurrente/epidemiología , Policondritis Recurrente/inmunología , Estudios Retrospectivos , Heridas y Lesiones/epidemiología , Heridas y Lesiones/inmunología
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