RESUMEN
BACKGROUND: Perioperative hypothermia is defined as a core temperature below 36 °C. The literature shows that perioperative hypothermia is a frequent but potentially preventable complication of the surgical process. The risk of experiencing perioperative hypothermia is inherent for all anesthetized patients, independent of the type of surgery. Unless preventative measures are taken, perioperative hypothermia occurs in 50 to 70 % of all surgical patients. In Germany and Austria the guideline "Preventing inadvertent perioperative hypothermia" has been published. In Wolfsburg we started already in 2012 with a standard operating procedure to prevent perioperative hypothermia in all surgical patients. In two clinical departments we established an additional prewarming-protocol starting prior to induction of anaesthesia on the normal ward on the day of surgery. MATERIAL AND METHODS: For a period of 6 months we analyzed all temperature data of patients having undergone surgery, beginning before the start of general anaesthesia until the end of the operation. RESULTS: In total 3228 patients were enrolled into the study. Prewarming was performed in 1329 patients. In 1902 patients active warming was limited to the intraoperative period. The total rate of hypothermia in all patients was 32.6 %, whereas the rate of hypothermia at the end of the operation was 19.3 %. In the group of patients without prewarming the overall rate was 39.1 vs. 25 % at the end of the operation. In the groups of patients with prewarming the total rates of hypothermia were 25.2 and 24.7 % overall and 14.4 and 12.5 % at the end of the operation. In multifactorial regression it could be shown that patients without prewarming had a 1.8-fold increased risk of perioperative hypothermia compared to patients with intraoperative warming only. CONCLUSION: We conclude that temperature management is a challenge in the clinical situation, and that it is difficult to achieve rates of hypothermia close to zero. The addition of prewarming was very effective in improving the results in our patients.
Asunto(s)
Hipotermia/prevención & control , Complicaciones Intraoperatorias/prevención & control , Atención Perioperativa/métodos , Adulto , Anestesia General/métodos , Temperatura Corporal , Regulación de la Temperatura Corporal , Femenino , Humanos , Hipotermia/epidemiología , Complicaciones Intraoperatorias/epidemiología , Masculino , Persona de Mediana Edad , Monitoreo Intraoperatorio , Recalentamiento/métodosRESUMEN
An efficient HPTLC--UV/FTIR coupling procedure is presented for the separation and rapid identification of flurazepam hydrochloride and its related substances in bulk powder and capsules. An optimized mobile phase was developed for the separation on specialized plates for HPTLC--FTIR in situ measurement containing a proportion of 50% magnesium tungstate. The proposed procedure shows several advantages to the related compound test of the pharmacopoeia, e.g. baseline separation of the known impurities and detection of the substances as peaks in the UV, Gram-Schmidt or window chromatograms. Furthermore, unambiguous identification is obtained by postrun extraction of the DRIFT spectra and comparison with reference spectra in the library. Quantification of the related compounds was carried out densitometrically. This method shows that the current resurgence of interest in modern instrumental TLC is rightful based on the flexibility and efficiency of this analytical method.