RESUMEN
Cerebral venous thrombosis (CVT) is a rare complication during pregnancy or the puerperium. Our aim was to identify thrombotic risk profiles that predispose to maternal CVT.The study comprised 151 individuals. All participants had a thrombotic workup that included the following: genetic markers: factor V Leiden G1691A and G20210A prothrombin mutations, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms; protein assays: protein C, protein S and antithrombin; other tests: blood typing and screening for hyperhomocysteinemia. Maternal CVT has been associated with factor V Leiden, the prothrombin G20210A mutation, protein C deficiency and hyperhomocysteinemia. We also speculate that non-O blood groups and preeclampsia could be independent risk factors for CVT.
Asunto(s)
Hiperhomocisteinemia/genética , Trombosis Intracraneal/genética , Polimorfismo de Nucleótido Simple , Complicaciones Hematológicas del Embarazo/genética , Protrombina/genética , Trombosis de la Vena/genética , Adulto , Antitrombina III/metabolismo , Biomarcadores/sangre , Análisis Mutacional de ADN , Factor V/genética , Femenino , Humanos , Hiperhomocisteinemia/complicaciones , Hiperhomocisteinemia/patología , Trombosis Intracraneal/complicaciones , Trombosis Intracraneal/patología , Metilenotetrahidrofolato Reductasa (NADPH2)/genética , Embarazo , Complicaciones Hematológicas del Embarazo/patología , Proteína C/metabolismo , Proteína S/metabolismo , Factores de Riesgo , Trombosis de la Vena/complicaciones , Trombosis de la Vena/patologíaRESUMEN
Our aim was to assess thrombophilic risk factors and the non-O blood group as contributors to the development of venous thromboembolism during pregnancy and the postpartum period. A total of 199 women underwent blood typing and an extensive thombophilia screening. Factor V Leiden, FII G20210A, protein C deficiency and non-O blood group were significantly associated with venous thromboembolism during pregnancy and postpartum period. A known thrombophilic factor may have consequences for future pregnancies and could have implications for clinical practice. For this reason, women with a history of thromboembolism should be screened for thrombophilia. The non-O blood group could also have an important influence, especially when concomitant with another prothrombotic risk factor mainly pregnancy and thrombophilia.
Asunto(s)
Antígenos de Grupos Sanguíneos/sangre , Complicaciones Hematológicas del Embarazo/sangre , Tromboembolia Venosa/sangre , Adulto , Estudios de Casos y Controles , Estudios de Cohortes , Femenino , Genotipo , Humanos , Persona de Mediana Edad , Embarazo , Factores de Riesgo , Adulto JovenRESUMEN
Our aim in this study was to investigate the association between elevated homocysteine levels and the two MTHFR polymorphisms, C677T and A1298C, with several pregnancy complications such as recurrent pregnancy loss, preeclampsia, placental abruption and intrauterine growth retardation. In 203 women with different placental vasculopathies, we determined the MTHFR C677T and the A1298C prevalence and their relative association to elevated homocysteine levels. The mean plasma homocysteine level was significantly higher in the pathologic groups when compared with the control group. We identified the carriage of the MTHFR A1298C polymorphism as a significant risk factor for vascular-related pregnancy complications. Women with MTHFR A1298C polymorphism or elevated homocysteine levels have an increased risk of placental vasculopathies. The MTHFR A1298C mutation also had a positive impact on elevated homocysteine levels. The lack of association between the MTHFR C677T polymorphism and pregnancy morbidities needs further studies.
Asunto(s)
Hiperhomocisteinemia/genética , Metilenotetrahidrofolato Reductasa (NADPH2)/genética , Placenta/irrigación sanguínea , Polimorfismo de Nucleótido Simple , Enfermedades Vasculares/genética , Estudios de Casos y Controles , Femenino , Humanos , Hiperhomocisteinemia/epidemiología , Embarazo , Complicaciones del Embarazo/epidemiología , Complicaciones del Embarazo/etiología , Complicaciones del Embarazo/genética , Prevalencia , Enfermedades Vasculares/epidemiologíaRESUMEN
AIMS: Our objectives were to assess inherited thrombophilia and non-O blood group for the risk of gestational vascular complications among the Tunisian population. METHODS: This study comprised 203 test subjects with adverse pregnancy outcomes including recurrent pregnancy loss, intra-uterine growth retardation, pre-eclampsia and placental abruption. Each subgroup was matched with 100 controls and analyzed separately. All patients were evaluated for factor V Leiden, factor II G20210A mutations and for non-O blood group. Protein S, protein C and antithrombin levels were determined and deficiencies noted. RESULTS: The factor V Leiden mutation, non-O blood group and protein C deficiency had the highest incidences among patients both as a whole and in the 4 subgroups. The factor II G20210A mutation, protein S and antithrombin deficiencies were not statistically significant risk factors. CONCLUSION: Our results provide evidence for a significant association between the factor V mutation and placental abruption. Furthermore, we found that this and the non-O blood group independently increased the risk for intra-uterine growth retardation in our population.