[Sexual development of boys with hypospadias].

The article presents the results of a clinical evaluation of 39 boys with hypospadias aged 10-15 years. The examination included clinical assessment of pubertal development, and Doppler ultrasound scan of the gonads, transrectal ultrasound of the prostate in adolescents over 14 years, the definition of serum levels of gonadotropins, sex steroids and inhibin B. Puberty in boys with hypospadias is characterized by later appearance of pubarhe, microphallus, lack of testicular blood flow, and hypotrophy of the prostate. Statistically significant difference in sexual development of boys with penile and scrotal hypospadias was detected. On the basis of the hormonal examination, a violation of function of Sertoli cells in 43% of boys with the penile hypospadias and in 68% with scrotal hypospadias was identified. Leydig cell dysfunction was not found.

[Congenital disorders of gonadal differentiation: clinico-morphological variants and surgical treatment].

The article presents the results of examination and surgical treatment of 25 patients with congenital disorders of gonadal differentiation. Survey plan included an assessment of the external genitalia, karyotyping and molecular analysis of Y-chromosome, determination of serum gonadotropins and testosterone levels, visualization of the gonads using ultrasound and laparoscopy methods, and intraoperative morphological examination of the material. Based on the results of a comprehensive survey, mixed testicular dysgenesis was identified in 25% of patients, complete testicular dysgenesis--in 16%, partial gonadal dysgenesis--in 44%, ovotesticular violation of sexualization--in 16% of patients. Clinical, macroscopic and morphological characteristics of each of these options are defined. The choice of sexual identity and tactics of surgical treatment are explained.

[The effectiveness of transcranial treatment using the AMO-ATOS-E apparatus for the correction of the reproductive system disorders in adolescent girls].

A combination of transcranial therapy and transcranial electrostimulation based on the use of the AMO-ATOS-E apparatus was applied to elucidate the hormonal status and to study lipid and carbohydrate metabolism in 84 girls of pubertal age. The correction of menstrual cycles in these patients brought about its normalization in 86.3% of the cases with the simultaneous reduction of their body weight by 9.26 +/- 4.28 kg during 3 months.