RESUMEN
The effect of local treatment of nose of lepromatous type of patients with different formulations of rifampicin nasal drops/sprays was investigated in a large number of patients. The preparations were either sprayed or instilled into the nostrils after flushing the nostrils with normal saline at 37 degrees C. It was observed that 10 mg/ml of rifampicin was effective in reducing the BI and MI to zero in nose in seven days in majority of the patients. No untoward effect was seen in any of the patients. It is suggested that nasal sprays/drops may be able to prevent the transmission of hanseniasis, as nose is recognised to be an important portal of exit of M. leprae. Further when rifampicin drops/sprays are used as soon as the diagnosis is made, the nasal deformity may be prevented. It is believed that local treatment along with systemic therapy would go a long way in controlling the transmission of hanseniasis.
Asunto(s)
Lepra Lepromatosa/prevención & control , Mycobacterium leprae/efectos de los fármacos , Nariz/microbiología , Rifampin/uso terapéutico , Administración Intranasal , Humanos , Rifampin/administración & dosificaciónRESUMEN
O efeito do tratamento local do nariz de paciente do tipo lepromatoso com diferentes formulaçöes de rifampicina em gotas ou "sprays" nasais, foi investigado em um grande número de pacientes. As preparaçöes foram ou aspergidas ou instiladas dentro das narinas depois de sua limpeza por jato com soluçäo salina normal a 37-C. Observou-se que 10 mg/ml de rifampicina eram eficazes na reduçäo do BI e do MI a zero no nariz em sete dias na maioria dos pacientes. Näo foi visto efeito desagradável em qualquer dos paciente. Sugere-se que "sprays"/gotas nasais possam prevenir a transmissäo da hanseníase, uma vez que o nariz é reconhecido ser uma importante porta de saida de M. leprae. Além disso a deformidade nasal pde ser prevenida quando a rifampicina "sprays"/gotas é usada täo logo o diagnóstico é feito. Acredita-se que o tratamento local juntamente com a terapia sistêmica contribuiriam muito no controle da transmissäo da hanseníase
Asunto(s)
Humanos , Lepra Lepromatosa/prevención & control , Deformidades Adquiridas Nasales/tratamiento farmacológico , Rifampin/uso terapéutico , Administración Intranasal , Mycobacterium leprae/efectos de los fármacos , Nariz/patología , Rifampin/administración & dosificaciónRESUMEN
Nose forms an important site at which the M. leprae in lepromatous leprosy (LL) patients lodge and multiply. Nose forms an important reservoir for M. leprae, from where they may be transmitted to healthy contacts. Inspite of realizing the above fact, nose does not normally receive due importance during the chemotherapy of leprosy. LL patients, after regular treatment with dapsone or rifampin for about 20 wks and 3 wks respectively are normally considered non-infectious. From the present investigation it is clear that local treatment of the ones with a bactericidal agent should perhaps be necessary during chemotherapy of LL patients to make them non-infectious and to control the transmission of the disease.
Asunto(s)
Lepra/transmisión , Mycobacterium leprae/aislamiento & purificación , Nariz/microbiología , Clofazimina/uso terapéutico , Dapsona/uso terapéutico , Quimioterapia Combinada , Humanos , Lepra/tratamiento farmacológico , Lepra/microbiología , Rifampin/uso terapéuticoAsunto(s)
Lepra/complicaciones , Rinitis/terapia , Yoga , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Masculino , Medicina Tradicional , Persona de Mediana Edad , Rinitis/etiologíaRESUMEN
The technique 'Jala Neti' as described in yoga is a general hygienic procedure to cleanse the nostrils effectively with a normal saline. The above mentioned technique was tried in three leprosy centres namely Jammikunt, Huzurabad and Warangal in Andhra Pradesh, India and was found to be acceptable to patients of leprosy. The technique has been found to be superior to the conventional method recommended to cleanse the nostrils in leprosy patients.