Mixed subtype of congenital mesoblastic nephroma with poor evolution: a case report and literature review / Nefroma mesoblástico congênito subtipo misto com má evolução: relato de caso e revisão da literatura

Abstract A male child born at 27 weeks, weighting 1305 g and presenting with a right-sided abdominal tumor. Computed tomography scan demonstrated the presence of a solid mass compressing the right kidney. Puncture biopsy revealed congenital mesoblastic nephroma. The patient underwent total right nephroureterectomy, and died on the second day after surgery.

Resumo Criança do gênero masculino, nascida com 27 semanas e 1.305 g de peso, apresentando tumor abdominal à direita. Tomografia computadorizada revelou formação sólida comprometendo o rim direito. Foi realizada biópsia por punção, cujo diagnóstico foi nefroma mesoblástico congênito. O paciente foi submetido a nefroureterectomia total direita, falecendo no segundo dia de pós-operatório.

Mixed subtype of congenital mesoblastic nephroma with poor evolution: a case report and literature review.

A male child born at 27 weeks, weighting 1305 g and presenting with a right-sided abdominal tumor. Computed tomography scan demonstrated the presence of a solid mass compressing the right kidney. Puncture biopsy revealed congenital mesoblastic nephroma. The patient underwent total right nephroureterectomy, and died on the second day after surgery.

Criança do gênero masculino, nascida com 27 semanas e 1.305 g de peso, apresentando tumor abdominal à direita. Tomografia computadorizada revelou formação sólida comprometendo o rim direito. Foi realizada biópsia por punção, cujo diagnóstico foi nefroma mesoblástico congênito. O paciente foi submetido a nefroureterectomia total direita, falecendo no segundo dia de pós-operatório.

Trends in prostate cancer incidence and mortality in a mid-sized Northeastern Brazilian city.

OBJECTIVE: International data have reported prostate cancer as the most frequent among men, and the third highest in mortality. A rise in incidence has been observed in the course of recent decades, probably influenced by early detection, mainly in asymptomatic men, through regular screening with prostate-specific antigen (PSA) testing. The purpose of this study was to contribute to information on trends in prostate cancer incidence and mortality using population-based data. METHODS: This was an exploratory ecological study of time trends, aiming at describing changes in prostate cancer incidence and mortality in Aracaju, Sergipe, Brazil, from 1996 to 2006. Rates were calculated from data of the Registro de Câncer de Base Populacional de Aracaju. Trends were calculated using the Joinpoint Regression Program. RESULTS: For the study period, 1,490 incident cases and 334 deaths were included. Incident cases were more common after 50 years of age, and deaths after 55 years. Age-standardized incidence rates of 46.6 and 50.0/100,000 were observed in the early years of the series, and then progressively increased, with rates higher than 100.0/100,000 in later years. For mortality, age-standardized rates varied from 21.6 and 16.6/100,000 to 24.1 and 28.9/100,000 in later years. Joinpoint analysis identified one joinpoint for the incidence series, resulting in two trends, the first with annual percent change of 34% and the second with 5.8%; for the mortality series no joinpoint was identified, and the annual percent change was 2.1%. CONCLUSION: There was a sharp increase in incidence rates during the study period, probably due to screening. Mortality rates had a small upward trend, and did not show major changes during the study period.

Trends in prostate cancer incidence and mortality in a mid-sized Northeastern Brazilian city / Tendências temporais de incidência e mortalidade por câncer de próstata em uma cidade de médio porte do nordeste brasileiro

OBJECTIVE: International data have reported prostate cancer as the most frequent among men, and the third highest in mortality. A rise in incidence has been observed in the course of recent decades, probably influenced by early detection, mainly in asymptomatic men, through regular screening with prostate-specific antigen (PSA) testing. The purpose of this study was to contribute to information on trends in prostate cancer incidence and mortality using population-based data. METHODS: This was an exploratory ecological study of time trends, aiming at describing changes in prostate cancer incidence and mortality in Aracaju, Sergipe, Brazil, from 1996 to 2006. Rates were calculated from data of the Registro de Câncer de Base Populacional de Aracaju. Trends were calculated using the Joinpoint Regression Program. RESULTS: For the study period, 1,490 incident cases and 334 deaths were included. Incident cases were more common after 50 years of age, and deaths after 55 years. Age-standardized incidence rates of 46.6 and 50.0/100,000 were observed in the early years of the series, and then progressively increased, with rates higher than 100.0/100,000 in later years. For mortality, age-standardized rates varied from 21.6 and 16.6/100,000 to 24.1 and 28.9/100,000 in later years. Joinpoint analysis identified one joinpoint for the incidence series, resulting in two trends, the first with annual percent change of 34% and the second with 5.8%; for the mortality series no joinpoint was identified, and the annual percent change was 2.1%. CONCLUSION: There was a sharp increase in incidence rates during the study period, probably due to screening. Mortality rates had a small upward trend, and did not show major changes during the study period.

OBJETIVO: Dados internacionais apontaram o câncer de próstata como o mais incidente e o terceiro em mortalidade entre os homens. O aumento da incidência tem sido observado nas últimas décadas, provavelmente por causa da detecção precoce, principalmente em homens assintomáticos, através do rastreamento regular com dosagem do antígeno prostático específico (PSA). O objetivo do estudo foi contribuir com as informações sobre as tendências de incidência e mortalidade por câncer de próstata a partir de extratos populacionais. MÉTODOS: Tratou-se de um estudo ecológico exploratório de tendências temporais, visando descrever as mudanças de incidência e mortalidade por câncer de próstata em Aracaju, SE, Brasil, no período de 1996 a 2006. As taxas foram calculadas a partir dos dados do Registro de Câncer de Base Populacional de Aracaju e as tendências temporais foram determinadas pelo Joinpoint Regression Program. RESULTADOS: No período do estudo, 1490 casos incidentes e 334 mortes foram incluídos. Os casos incidentes foram mais frequentes a partir de 50 anos de idade e as mortes a partir de 55 anos. Taxas padronizadas de incidência de 46,6 e 50,0/100.000 foram observadas nos primeiros anos da série, e um aumento progressivo acima de 100,0/100.000 foi observado nos últimos anos. Para a mortalidade, as taxas padronizadas variaram de 21,6 e 16,6/100.000 para 24,1 e 28,9/100.000. A análise do Joinpoint identificou duas tendências para a incidência, a primeira com percentual de mudança de 34,0% e a segunda com percentual de 5,8%; para a mortalidade, a análise resultou em uma tendência com percentual de 2,1%. CONCLUSÃO: Houve um grande aumento nas taxas de incidência, provavelmente devida ao rastreamento, durante o período de estudo. A mortalidade, entretanto, mesmo com uma pequena tendência de aumento, não apresentou grandes mudanças no tempo estudado.

Time trends in breast cancer incidence and mortality in a mid-sized northeastern Brazilian city.

BACKGROUND: Breast cancer incidence within an area is usually proportional to the area's income level. High-income areas have shown the highest incidence rates and since 2003, negative trends. As for mortality, rates are often higher in low-income regions. The purpose of this study was to analyze trends in incidence and mortality in a capital city of a northeastern Brazilian state with an intermediate human development index. METHODS: Incidence data from the Population-Based Cancer Registry of Aracaju and mortality data from the Official State Database for the period 1996-2006 were used. Incidence and mortality crude and age-standardized rates were calculated. Time trends were obtained using the Joinpoint Regression Model. RESULTS: For the period studied, invasive breast cancer age-standardized incidence rates increased annually with an annual percentage change (APC) of 2.9 (95% CI: 1.2-4.6). Significant increasing trends were observed in groups aged 45-54 years (APC: 3.9, 95% CI: 1.4 to 6.6), and 55-64 years (APC: 5.6, 95% CI: 1.8 to 9.6). Age-standardized mortality rates did not show an increasing trend (APC: 3.0, (95% CI: -2.8 to9.1), except for the group aged 55-64 years (APC: 11.3, 95% CI: 1.1 to 22.4). CONCLUSIONS: In the study community, breast cancer showed increasing incidence among women in the peri- and postmenopausal periods. However, mortality did not present increasing overall trends, except for among the group aged 55-64 years. For better outcomes, screening policies should focus on the peri- and postmenopausal periods of women's lives to diagnose disease.