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Naturwissenschaften ; 99(10): 843-52, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22955371

RESUMEN

Natural sources for novel insecticide molecules hold promise in view of their eco-friendly nature, selectivity, and mammalian safety. Recent progress in understanding the biology of insect olfaction and taste offers new strategies for developing selective pest control agents. We have isolated two natural insecticidal molecules from edible roots of Decalepis hamiltonii named Decalesides I and II, which are novel trisaccharides, highly toxic to household insect pests and stored-product insects. We have experimentally shown that insecticidal activity requires contact with tarsi on the legs but is not toxic orally. The insecticidal activity of molecules is lost by hydrolysis, and various sugars modify toxic response, showing that the insecticidal activity is via gustatory sites on the tarsi. Selective toxicity to insects by virtue of their gustatory site of action and the mammalian safety of the new insecticides is inherent in their chemical structure with 1-4 or 1-1 α linkage that is easily hydrolyzed by digestive enzymes of mammals. Decalesides represent a new chemical class of natural insecticides with a unique mode of action targeting tarsal chemosensory/gustatory system of insects.


Asunto(s)
Apocynaceae/química , Insectos , Insecticidas , Animales , Carbohidratos/química , Insecticidas/química , Insecticidas/aislamiento & purificación , Insecticidas/toxicidad , Dosificación Letal Mediana , Ratones , Raíces de Plantas/química , Factores de Tiempo , Pruebas de Toxicidad
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