RESUMEN
BACKGROUND: Prediabetes is increasing worldwide. Previous studies have demonstrated the potential of ß-glucan derived from oat or barley to lower blood glucose, body weight, and plasma lipid levels. These findings offer a potentially attractive strategy for reducing the risk of diabetes in prediabetic individuals. However, the effects of ß-glucan from Tremella fuciformis on glucose metabolism and anthropometric measurements in humans have yet to be studied. We hypothesized that ß-glucan from Tremella fuciformis may improve metabolic parameters in subjects with prediabetes. This study aimed to investigate the effects of a once-daily beverage containing Tremella fuciformis (snow mushroom) on anthropometric measurements, metabolic biomarkers, and insulin sensitivity in overweight/obese subjects with prediabetes. METHODS: In this double-blind RCT, 56 participants were randomly assigned to receive either a Tremella fuciformis beverage or placebo daily for 12 weeks. All parameters were assessed at baseline and after the intervention. RESULTS: After 12 weeks, participants in the intervention group exhibited significant improvements in glycated hemoglobin A1c (HbA1C; 6.03 ± 0.26% at baseline vs. 5.96 ± 0.25% at 12 weeks, p = 0.047, Cohen's d = 0.39) and waist circumference (95.2 ± 12.51 cm at baseline vs. 93.46 ± 11.48 cm at 12 weeks, p = 0.022, Cohen's d = 0.45). There were no adverse events reported. CONCLUSION: This exploratory study demonstrated that Tremella fuciformis beverage consumption may improve HbA1C and waist circumference in overweight/obese prediabetic individuals. Further research, including larger-scale RCTs and mechanistic studies, is needed to confirm these findings and optimize the therapeutic potential of Tremella fuciformis derivatives in managing prediabetes and preventing type 2 diabetes. TRIAL REGISTRATION: Registered in Thai Clinical Trials Registry (14/07/2021, TCTR20210714004).
RESUMEN
BACKGROUND: Athyreotic patients require a daily levothyroxine (LT4) doses of 1.6-1.8 mcg/kg of actual body weight (BW) to achieve normal thyroid stimulating hormone (TSH) levels. Lean body mass (LBM) calculation may be a more accurate determination of LT4 dose in obese patients. Previous studies were mainly investigated in Caucasians and LBM is markedly different between various ethnic groups. We aim to identify the optimal dose of LT4 replacement therapy in hypothyroid Thai patients including obese subjects. METHODS: We retrospectively reviewed the medical records of Thai adults with hypothyroidism at the thyroid clinic. Patients had been received LT4 (Brand: Euthyrox) at a stable dose ≥ 75 mcg/day for at least 1 year. Patients with thyroid cancer, pregnant, and lactating women were excluded. LBM was calculated by the Hume formula. RESULTS: Two hundred patients (80% females) with a mean age of 48.6 ± 14.8 years and a body mass index (BMI) of 24.5 ± 4.6 kg/m2 were included. Daily LT4 dose/kg of actual BW according to BMI 18.5-24.9, 25-29.9, and ≥ 30 kg/m2 were 1.67 ± 0.27, 1.51 ± 0.28 and 1.39 ± 0.34 mcg/kg, respectively. In contrast, LT4 dose/kg of LBM were 2.31 ± 0.39, 2.35 ± 0.45 and 2.36 ± 0.51 mcg/kg, respectively. CONCLUSIONS: LBM is considered a better indicator for calculating an appropriate LT4 replacement dose than actual BW in hypothyroid obese Thai patients. The recommended daily dose of LT4 is 2.3 mcg/kg of LBM that could be applied for all ranges of BMI.
