Asunto(s)
Dermatitis Atópica , Hipopigmentación , Vitíligo , Femenino , Humanos , Vitíligo/etiología , Dermatitis Atópica/etiologíaRESUMEN
OBJECTIVES: Malignant acral melanoma (AM) is relatively infrequent in white patients. Molecular investigations have returned variable results regarding the mutational pattern. We sought to describe the mutation profile and clinicopathologic features of AM. METHODS: We investigated BRAF, KIT, and NRAS mutational status in a series of 31 AM samples from white patients. RESULTS: Nodular melanoma was the most common histopathologic subtype (48.4%), followed by acral lentiginous melanoma (25.8%) and superficial spreading melanoma (25.8%). BRAF, KIT, and NRAS mutational rates were 12.9%, 17.2%, and 30.0%, respectively. We observed significant associations between KIT mutational status and a thinner Breslow thickness compared with wild-type (WT) status (P = .002), NRAS mutation status and younger age compared with WT. In patients presenting at least one mutation, triple-WT patients presented metastases most frequently. CONCLUSIONS: Although these data represent preliminary results, better knowledge of tumor biology and prognosis of AM can support the clinical approach and follow-up.
Asunto(s)
GTP Fosfohidrolasas/genética , Melanoma/genética , Proteínas de la Membrana/genética , Proteínas Proto-Oncogénicas B-raf/genética , Proteínas Proto-Oncogénicas c-kit/genética , Neoplasias Cutáneas/genética , Adulto , Anciano , Anciano de 80 o más Años , Análisis Mutacional de ADN , Femenino , Humanos , Masculino , Melanoma/patología , Persona de Mediana Edad , Mutación , Pronóstico , Neoplasias Cutáneas/patología , Población BlancaAsunto(s)
Alopecia/diagnóstico por imagen , Cabello/diagnóstico por imagen , Isquemia/diagnóstico por imagen , Presión/efectos adversos , Cuero Cabelludo/irrigación sanguínea , Adolescente , Adulto , Anciano , Alopecia/etiología , Niño , Preescolar , Dermoscopía , Femenino , Humanos , Lactante , Recién Nacido , Isquemia/etiología , Persona de Mediana Edad , Cuero Cabelludo/diagnóstico por imagen , Adulto JovenRESUMEN
A 69-year-old woman with invasive ductal breast cancer (BC) presented multiple asymptomatic alopecic areas of the scalp. Trichoscopy revealed peripheral black dots (BDs) and an atypical vascular pattern. Histopathology confirmed the diagnosis of BC metastases. Cutaneous and scalp metastases are a possible sign of advanced and widespread BC, and the diagnosis may be challenging. The trichoscopy of scalp metastases has never been described. BDs and an atypical vascular pattern in our case were a diagnostic clue.
Asunto(s)
Anticuerpos Monoclonales Humanizados/efectos adversos , Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico , Neoplasias Pulmonares/tratamiento farmacológico , Psoriasis/inducido químicamente , Anomalías Múltiples/diagnóstico , Anciano , Carcinoma de Pulmón de Células no Pequeñas/patología , Enfermedad de Darier/diagnóstico , Dermoscopía , Diagnóstico Diferencial , Cejas/anomalías , Humanos , Neoplasias Pulmonares/patología , Masculino , Estadificación de Neoplasias , Psoriasis/diagnóstico por imagenAsunto(s)
Antineoplásicos/uso terapéutico , Imidazoles/uso terapéutico , Melanoma/secundario , Oximas/uso terapéutico , Piridonas/uso terapéutico , Pirimidinonas/uso terapéutico , Neoplasias Cutáneas/patología , Síndrome de Sweet/etiología , Femenino , Humanos , Melanoma/tratamiento farmacológico , Persona de Mediana Edad , Neoplasias Cutáneas/tratamiento farmacológico , Síndrome de Sweet/patologíaAsunto(s)
Factores Inmunológicos/administración & dosificación , Pénfigo/tratamiento farmacológico , Rituximab/administración & dosificación , Esquema de Medicación , Femenino , Humanos , Factores Inmunológicos/efectos adversos , Masculino , Persona de Mediana Edad , Pénfigo/diagnóstico , Pénfigo/inmunología , Datos Preliminares , Recurrencia , Inducción de Remisión , Rituximab/efectos adversos , Factores de Tiempo , Resultado del TratamientoRESUMEN
A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest. The nodule was surgically removed, and hematoxylin and eosin stains of the specimen showed an asymmetrical, nonpigmented lesion with architectural and structural impairment, round cells with clear, whitish, foamy cytoplasm, multiple dermal mitoses and nuclear pleomorphism. Our first hypothesis was sebaceous carcinoma, a rare malignant neoplasm derived from epithelial cells showing sebaceous differentiation. A further histopathologic examination showed the presence of pigment in a few areas of the neoplasm. On immunohistochemical study, neoplastic cells were negative for wide-spectrum cytokeratin and diffusely positive for S-100, MART-1, and HMB-45 proteins. Our final diagnosis was nodular malignant melanoma (MM) with balloon epithelioid cells, a "bizarre" presentation of MM in vertical growth phase, mimicking metastatic and primary neoplasms of different lineage derivations.
RESUMEN
Nevus comedonicus is a rare, benign hamartoma of the pilosebaceous unit that may be isolated or part of the nevus comedonicus syndrome. Although rare in children, complication by hidradenitis suppurativa-like lesions has been described. We present a report of a 9-year-old girl in whom surgical excision was curative, with a review of the relevant literature.
Asunto(s)
Hamartoma/complicaciones , Hidradenitis Supurativa/etiología , Nevo/complicaciones , Antibacterianos/uso terapéutico , Niño , Femenino , Hamartoma/diagnóstico , Hidradenitis Supurativa/tratamiento farmacológico , Humanos , Nevo/congénitoRESUMEN
BACKGROUND: Narrowband-ultraviolet B (NB-UVB) is widely used for the treatment of several dermatological diseases. A cutaneous carcinogenic effect has been hypothesized, but not proved. METHODS: We retrospectively reviewed the data of patients treated with NB-UVB between January 1998 and December 2013 at the Dermatology Unit of our University Hospital, to evaluate the cutaneous carcinogenic risk of NB-UVB. RESULTS: In all, 375 patients were included, each receiving a mean follow-up of 6.9 years. Vitiligo and psoriasis were the most common diseases. In total, 19 non-melanoma skin cancers (NMSCs) were diagnosed in eight patients, after a mean latency of 5.2 years after the first radiation. No malignant melanoma (MM) was observed. The incidence rates of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) were 620.2/100 Ì000 p/y and 116.3/100 Ì000 p/y. NMSCs were more frequent in patients affected by psoriasis (P = .0232), with older age at the first radiation (mean = 68.8 years, P = .0001). CONCLUSION: Despite the small number of patients and limited follow-up, our data suggest that NB-UVB may trigger cutaneous carcinogenesis, mainly in patients at risk for NMSCs, increasing their personal risk for single and multiple neoplasms, usually superficial BCCs. MM risk does not seem to be enhanced.