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1.
Med Sante Trop ; 28(3): 302-306, 2018 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-30270836

RESUMEN

AIM: To determine the factors associated with the death of patients infected with human immunodeficiency virus (HIV) while hospitalized in the hepato-gastroenterology department of the Lomé University Hospital, Togo. PATIENTS AND METHOD: A retrospective cross-sectional study reviewed records covering a 10-year period from this department. It included all patients aged 15 years and older who were positive for HIV infection. RESULTS: The study included 432 HIV+ patients, including 201 men and 231 women (sex ratio: 0.87). Their median age was 41 years (interquartile range: 35 to 48.2 years). The death rate was 15.3 %, and differed significantly between men (19.4%) and women (11.7%) (P = 0.0262). The probability of death increased significantly with age assessed in quartiles (P = 0.0472). Impaired general status, jaundice, and abdominal distension were associated with a high risk of death (P = 0.0017). Conditions unrelated to HIV that were associated with a high risk of death were hepatocellular carcinoma, cirrhosis, and toxic hepatitis (P < 0.0001). Anemia and CD4 count were not associated with death. CONCLUSION: Death was associated with social and demographic (male sex and age) and clinical (altered general status, jaundice, cirrhosis, hepatocellular carcinoma and toxic hepatitis) factors.


Asunto(s)
Infecciones por VIH/mortalidad , Adulto , Causas de Muerte , Estudios Transversales , Femenino , Gastroenterología , Infecciones por VIH/terapia , Departamentos de Hospitales , Mortalidad Hospitalaria , Hospitalización , Hospitales de Enseñanza , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Togo
2.
Med Sante Trop ; 28(2): 193-196, 2018 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-29997079

RESUMEN

PURPOSE: To determine the epidemiological and diagnostic aspects of hepatobiliary diseases in people with HIV infection at the Lomé University Hospital. METHODS AND PATIENTS: This 5-year retrospective descriptive and analytic study included all people with HIV infection aged 15 years and older of either sex admitted with a hepatobiliary disease. RESULTS: Among all patients admitted for hepatobiliary diseases, people with HIV infection accounted for 2%. They were predominantly women. Our patients' mean age was 43.03±10.3 years. The principal reasons for consultation were asthenia (95.2%), jaundice (93.7%), and abdominal pain (80.9%). The main clinical symptoms were by deterioration of general status (84.1%) and pain of the right hypochondrium (66.7%); 63.5%were classified at WHO disease stage III or IV for HIV infection and disease. All our patients were positive for HIV1; and 86.5% had a CD4 count < 350 cells/mm3. We noted HVB/HIV coinfection in 39.6% and HVC/HIV coinfection in 19%. Cirrhosis had been diagnosed in 44.4%, hepatocellular carcinoma in 12.6%, and toxic or drug-induced hepatitis in 46%, while 8% had acute acalculous cholecystitis. No case of alcoholic steatohepatitis or AIDS cholangiopathy was noted. CONCLUSION: Hepatobiliary diseases are infrequent and varied among people with HIV infection; the most common are toxic hepatitis, cirrhosis, and hepatocellular carcinoma, and they do not differ according to CD4 counts.


Asunto(s)
Enfermedades de las Vías Biliares/diagnóstico , Enfermedades de las Vías Biliares/epidemiología , Hepatopatías/diagnóstico , Hepatopatías/epidemiología , Adulto , Anciano , Enfermedades de las Vías Biliares/etiología , Femenino , Infecciones por VIH/complicaciones , Hospitales Universitarios , Humanos , Hepatopatías/etiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Togo , Salud Urbana , Adulto Joven
3.
Med Sante Trop ; 27(4): 435-438, 2017 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-29313514

RESUMEN

To analyze the indications for upper gastrointestinal endoscopy (UGIE) and determine the frequency of the pathological findings observed in rural areas of Africa. This retrospective study includes 9 series of 5-day visits to perform these examinations. Patients were informed of the presence of the endoscopy team by a bulletin on a rural radio station and by general practitioners at the Kara University Hospital. Patients were recruited from the hospital clinics and from the general population of the Kara region. The study includes all UGIE reports from August, 2007, through September, 2014; these contain the indications for the procedure, the patients' sex and age, and the examination report. The study included 252 reports for 133 women and 119 men with a mean age of 42.44 years (range: 20 to 102 years). The most frequent indications were dyspeptic syndrome (79.76%) and diffuse abdominal pain (11.11%). In all, we observed 139 gastroduodenal lesions among the patients with dyspepsia, principally bile reflux (23.02%), gastroduodenal inflammatory lesions (18.71%) and gastroduodenal ulcers (17.99%). The most commonly observed lesions for diffuse abdominal pain were again, bile reflux (30.77%), followed by gastritis, esophageal mycoses, and tumors. This work made it possible to identify the various pathological lesions of the UGI tract seen on endoscopies in a rural hospital in Togo.


Asunto(s)
Endoscopía Gastrointestinal/estadística & datos numéricos , Enfermedades Gastrointestinales/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Hospitales Rurales , Hospitales Universitarios , Humanos , Masculino , Persona de Mediana Edad , Togo/epidemiología , Adulto Joven
4.
Med Sante Trop ; 26(4): 382-385, 2016 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-27934616

RESUMEN

To evaluate the hepatic and obstetric complications in pregnant women with cirrhosis. We report the cases of four pregnant women with cirrhosis treated in the gastroenterology and obstetrics-gynecology departments of the Lome Campus University Teaching Hospital between 2013 and 2015. The women's mean age was 32 years. Three were in the first trimester of pregnancy. Almost all had signs of advanced cirrhosis, including ascites (50%), lower-limb edema (75%), and jaundice (25%). All (100%) had liver failure and anemia. Cirrhosis was due to hepatitis virus B infection for 3 women. All had singleton pregnancies. Two mothers died; fetal outcome included one fetal loss and one stillbirth. This study shows the high risk associated with the combination of pregnancy and cirrhosis. Prognosis is poor for both mother and fetus.


Asunto(s)
Cirrosis Hepática , Complicaciones del Embarazo , Adulto , Femenino , Hospitales Universitarios , Humanos , Cirrosis Hepática/diagnóstico , Embarazo , Complicaciones del Embarazo/diagnóstico , Togo , Universidades
5.
Med Sante Trop ; 25(3): 319-22, 2015.
Artículo en Francés | MEDLINE | ID: mdl-26446744

RESUMEN

GOAL: To evaluate the knowledge abouthepatitis B virus (HBV) infection of patientsconsulting in the hepatogastroenterology department. MATERIALS/METHODS: This prospective, descriptive, and analytic study took place over a two-month period among outpatients in this department of the Lome Campus University Hospital. RESULTS: The study included 276 patients, predominantly male. Participants' mean age was 36.7 years (range: 17 to 75 years). In all, 190 patients (around 68.8%) confirmed that they had heard of this disease at least once, mainly via the media or the hospital. Twenty patients (10.5%) mentioned as the main means of infection sexual intercourse, body fluids (blood), and maternalfetal transmission. Overall, 28 participants reported having been vaccinated against HBV. Of those who had ever heard of this disease, only 58 (30.5%) knew that it exists in an acute form and 69 patients (36.3%) about its chronic form. Thirty (15.8%) patients knew that cirrhosis and liver cancer are its main complications, and 68 (35.8%) were unaware that HBV treatment is available in Togo. CONCLUSION: This study revealed that participants had a poor level of knowledge about HBV.


Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Virus de la Hepatitis B , Hepatitis B , Pacientes Ambulatorios , Adolescente , Adulto , Anciano , Femenino , Hospitales Universitarios , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Togo , Adulto Joven
6.
Med Sante Trop ; 25(3): 323-6, 2015.
Artículo en Francés | MEDLINE | ID: mdl-26446745

RESUMEN

PURPOSES: To study the epidemiological, clinical, and laboratory aspects of pancreatic pancreatic cancer in Togo, as well as its management. PATIENTS AND METHOD: This retrospective, descriptive study includes patients diagnosed with such cancers over an 8-year period based on features observed on imaging (ultrasound and computed tomography). RESULTS: During the study period, 30 patients, accounting for 0.68% of all admissions, were diagnosed with pancreatic cancer. Their average age was 55.6 years. The M/F sex ratio was 1.72. Weight loss was the most frequent clinical sign, found in 93%. Epigastric pain was reported by 60%. Laboratory results included cholestasis in 97%, hyperglycemia in 47%, hyperlipasemia in 17%, hyperamylasuria in 13%, and hyperamylasemia in 10%. Assays showed elevated Ca19-9 in 23% of patients and elevated ACE in 7%. Abdominal ultrasound showed a poorly defined heterogeneous mass that deformed the contours of the pancreas, with the tumor in the head of the pancreas in 96% of patients. Abdominal CT showed a pancreatic tumor of variable size with hepatic metastases and dilatation of the pancreatic duct in 11 cases. Management involved mainly administration of step 2 or 3 analgesics. The average duration of hospitalization was 12.4 days and death occurred before discharge in 87% of the cases. CONCLUSION: The incidence of pancreatic cancer seems to be rising in Togo. Its prognosis is very poor. Early detection is essential to reduce mortality.


Asunto(s)
Neoplasias Pancreáticas , Femenino , Gastroenterología , Departamentos de Hospitales , Hospitalización , Hospitales de Enseñanza , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/epidemiología , Neoplasias Pancreáticas/terapia , Estudios Retrospectivos , Togo
7.
Med Sante Trop ; 25(3): 312-5, 2015.
Artículo en Francés | MEDLINE | ID: mdl-26039374

RESUMEN

OBJECTIVE: To describe the different gastrointestinal manifestations encountered in adult patients with HIV infection in a gastroenterology department in Togo. PATIENTS AND METHODS: This one-year (2011) prospective, descriptive study included all adult HIV-positive patients admitted to our department. Patients not known to be HIV-positive before admission were tested after informed consent. RESULTS: 82 (8.4% of departmental admissions) HIV-positive patients participated in the study. Their mean age was 38.78 years ± 9 years, and they were mainly women (sex-ratio = 0.82). The reasons for consultation were mainly asthenia (39%), weight loss (35.4%), and vomiting (34.1%). Their histories included tuberculosis (4%), jaundice (4%), and herpes zoster (2%). Nearly all (91%) had CD4 counts below 350 cells/L, and most (80%) were treated with antiretroviral agents (ARV) before admission. Most patients were also chronic alcoholics (72%) and took traditional herbal treatments (55%). General symptoms included deterioration of the general condition (77%) and conjunctival pallor (48%). Physical signs included ascites (32%) and hepatomegaly (29%). All patients were positive for HIV-1; 30% were co-infected with HBV and 1.2% with HCV. The main diagnoses were hepatobiliary diseases (46%), including cirrhosis (24.4%), acute toxic hepatitis (12%), and hepatocellular carcinoma (6.1%). Of the latter, one also had lung metastases. Esophageal diseases included candidal esophagitis (24%), and the gastric diseases, two gastric ulcers (2%) and one case of gastric cancer. The primary disease of the colon and small bowel was acute gastroenteritis (38%). Peritoneal conditions were all tuberculosis (7%), and pancreatic involvement was acute pancreatitis (2%).


Asunto(s)
Enfermedades Gastrointestinales/etiología , Infecciones por VIH/complicaciones , Adulto , Estudios Transversales , Femenino , Enfermedades Gastrointestinales/epidemiología , Humanos , Masculino , Estudios Prospectivos , Togo
8.
Transfus Clin Biol ; 22(1): 17-21, 2015 Mar.
Artículo en Francés | MEDLINE | ID: mdl-25595821

RESUMEN

OBJECTIVE: To evaluate transfusion practice in the hepatogastroenterology department of the Campus Teaching Hospital of Lomé. METHODOLOGY: This is a respective, descriptive and analytical study conducted from January 1 to December 31, 2013 on cases of in-patients' observation in the department. The cases of in-patients of more than 15 years old, having benefited from a blood transfusion were included. FINDINGS: During the study period, 849 patients were admitted; 136 were transfused, or blood transfusion rate of 16.02%. The average age of patients was of 48.25 years with extremes of 15 and 90 years. The most transfused rhesus blood group was O positive (36.76%). Red blood cell was the most frequently used blood product (94.12%). The transfusion was performed in 58.82% of cases as a matter of emergency. Gastrointestinal bleeding were the main indications (55.88%). The average pre-transfusion hemoglobinemia was 6.51 g/dL±1.67. The average post-transfusion hemoglobinemia was 8.95 g/dL±1.75. Liver disease (cirrhosis and hepatocellular carcinoma) were the main diagnosis associated with blood transfusion (44.85%). The quantity of blood to be transfused was not calculated in 100% of cases. In 11.03% of cases, the compatibility test has not been done in the laboratory. Incidents during blood transfusion were noted in 5 cases. CONCLUSION: Blood transfusion is frequent in the department. There is a good observance of blood transfusion safety regulations. However, its practice remains to be improved.


Asunto(s)
Transfusión Sanguínea/estadística & datos numéricos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Gastroenterología , Departamentos de Hospitales , Hospitales de Enseñanza , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Togo , Adulto Joven
10.
Med Sante Trop ; 24(4): 432-4, 2014.
Artículo en Francés | MEDLINE | ID: mdl-25466421

RESUMEN

GOAL: To describe the epidemiological, clinical, and endoscopic aspects of attempted suicides treated in the gastroenterology department of Lome Campus Teaching Hospital. METHODS: This retrospective study examined data collected over a 5-year period for patients admitted for attempted suicide by consumption of toxic substances (for example, caustics, medications, and insecticides) and who had an upper gastrointestinal endoscopy. Caustic lesions are described according to Di Costanzo's classification. RESULTS: Of 3075 admissions in the department during the study period, 35 (1.14%) were admitted for attempted suicide. Only 21 of these cases (60%) met our inclusion criteria. The patients' mean age was 25.86 years old, and 71% were female. These attempted suicides were most frequent among high school and college students (52%). The ingested substances were mostly caustic in nature (13 cases). Twenty patients (95%) were admitted less than 12 hours after the suicide attempt. The dominant symptoms at the department were abdominal pain and throat inflammation. Ten patients had an upper gastrointestinal endoscopy within 24 hours after the attempt. In the case of caustic ingestion, severe lesions (IIb, III) represented 53% of the cases. An esophageal stricture was noticed on the patient admitted 45 days after a suicide attempt by ingestion of a caustic substance. CONCLUSION: The frequency of attempted suicides is underestimated here because most patients are admitted to the internal medicine or psychiatric departments. Caustic substances were the main substances used and caused severe lesions.


Asunto(s)
Endoscopía Gastrointestinal , Intoxicación/diagnóstico , Intento de Suicidio , Adulto , Femenino , Hospitales de Enseñanza , Humanos , Masculino , Intoxicación/epidemiología , Estudios Retrospectivos , Intento de Suicidio/estadística & datos numéricos , Togo
11.
Med Sante Trop ; 24(3): 279-82, 2014.
Artículo en Francés | MEDLINE | ID: mdl-25151988

RESUMEN

Few studies have examined ultrasound imaging of abdominal manifestations of HIV-AIDS, although these rank second only to its pleuropulmonary manifestations. Thus, this study sought to determine the features of abdominal ultrasound in HIV infection. This prospective, descriptive and analytical study took place in the radiology department of the University Hospital Campus Lomé and covered the three-year period of 2009-2011. It included all patients older than 15 years with positive HIV serology. During the study period, 566 patients met the inclusion criteria. Ultrasound examination showed the liver appeared normal in 153 patients (27.0%), but homogeneously hyperechoic and thus suggestive of hepatic steatosis in 107 (18.9%). The bile duct was dilatated in 12 patients or 2.1%. An anomaly in the corticomedullary differentiation in normal-sized kidneys was noted in 28.1% (159 patients). Diffuse homogeneous hypertrophy of the pancreas was found in 3 patients (0.53%). Splenomegaly was noted in 387 patients (68.4%); the echopattern of the spleen was diffusely micronodular in 6 patients (1.1%). Deep adenopathies were found in 29 patients (5.1%) and ascites in 46 patients (8.1%). Abdominal ultrasound is a medical imaging technique available in developing countries, less expensive than others, which can be considered an alternative to computed tomography (CT) in the countries of sub-Saharan Africa for the exploration of the abdominal manifestations of HIV.


Asunto(s)
Enfermedades del Sistema Digestivo/diagnóstico por imagen , Infecciones por VIH/complicaciones , Páncreas/patología , Esplenomegalia/diagnóstico por imagen , Adolescente , Adulto , Femenino , Humanos , Hipertrofia , Hallazgos Incidentales , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Togo , Ultrasonografía , Adulto Joven
12.
Med Sante Trop ; 24(2): 208-13, 2014.
Artículo en Francés | MEDLINE | ID: mdl-24919209

RESUMEN

OBJECTIVE: To evaluate by a reliable method the protein-energy nutritional status of adults hospitalized in the hepatology and gastroenterology department of the Lomé Campus University Hospital. METHODS: This cross-sectional prospective study conducted from March 1 to September 15, 2012, included 103 inpatients aged at least 16 years. The variables evaluated were: triceps skinfold thickness (TST), mid-arm muscle circumference (MAMC), serum albumin, CRP, and orosomucoid. The Child-Pugh classification was used to evaluate the clinical severity of liver disease. RESULTS: Within this population of patients with cirrhosis, 40 were alcohol-dependent (39.0%) and 85 had anorexia (82.5%); 49 were in group B of the Child-Pugh classification, and 37 in group C. We found a non-significant (p = 0.324) difference in TST measurement between the three Child-Pugh groups: A (8.4 ± 4.5); B (6.1 ± 3.7); and C (6.4 ± 7.2). The prevalence of protein-energy malnutrition ranged from 52.0% to 82.5%, when evaluated by MAMC or TST. Our results confirm the need to pay additional attention to the protein-energy nutritional status of inpatients in this department, by adding reliable tools, such as the TST and MAMC, to the biochemistry analysis to characterize undernutrition.


Asunto(s)
Brazo/anatomía & histología , Desnutrición Proteico-Calórica/epidemiología , Grosor de los Pliegues Cutáneos , Pesos y Medidas Corporales , Estudios Transversales , Gastroenterología , Departamentos de Hospitales , Hospitalización , Hospitales Universitarios , Humanos , Cirrosis Hepática/complicaciones , Persona de Mediana Edad , Estado Nutricional , Prevalencia , Estudios Prospectivos , Desnutrición Proteico-Calórica/etiología , Togo
13.
Med Sante Trop ; 23(3): 300-3, 2013.
Artículo en Francés | MEDLINE | ID: mdl-24104189

RESUMEN

OBJECTIVE: To assess the knowledge, the attitudes, and the practices of hospital nursing staff in relation to the infectious risks of the hepatitis B and C viruses. METHODS: Cross-sectional descriptive survey conducted at the Lome Campus Teaching Hospital among the nursing staff present during at least one of the 2 consecutive workdays of the survey. RESULTS: The total nursing staff included 190 people, 115 (60.5%) of whom participated in the investigation. Slightly more than three-fifths were men (61.7%). Their mean age was 37.9 ± 10.7 years. The contaminated materials encountered most often were blood (94.8%), needle-drawn fluids (77.4%), and biopsy samples (53.9%). Staff most often did not comply with protective measures: 75.5% did not use gloves regularly and 46.0% did not use bibs. More than one third of the nursing staff (34.8%) had had such a needle-stick or related accident, but only 8.8% had reported them: 74.2% because of the potential administrative difficulties and 25.8% because of ignorance (25.8%). Staff knowledge about the means of transmission of these viruses was good (98.3%). The vaccination coverage rate of the nurses questioned was 51.3%. CONCLUSION: Training and awareness campaigns about the occupational risks of HBV and HCV remain necessary.


Asunto(s)
Competencia Clínica , Hepatitis B/transmisión , Hepatitis C/transmisión , Hospitales de Enseñanza , Control de Infecciones , Transmisión de Enfermedad Infecciosa de Paciente a Profesional/prevención & control , Adulto , Estudios Transversales , Femenino , Vacunas contra Hepatitis B , Hospitales Universitarios , Humanos , Masculino , Personal de Enfermería en Hospital , Pautas de la Práctica en Enfermería/estadística & datos numéricos , Togo
14.
Arch Pediatr ; 20(3): 274-7, 2013 Mar.
Artículo en Francés | MEDLINE | ID: mdl-23380033

RESUMEN

Chylous ascites is rare in children. We report on a case of chylous ascites in an 1-month-old infant in Togo. The infant had been appropriately vaccinated, had normal growth and psychomotor development, and he was living in a rural area. He had fever that had started 3 months earlier and persisted despite various treatments with antimalarials and antibiotics. Then progressively abdominal pain with abdominal distension developed, while lactescent ascites was discovered after puncture. The patient was referred to the Lomé teaching hospital for advanced management. Intradermic reaction to tuberculin (IRD) was positive (16 mm). Chylous ascites liquid analysis revealed apparently lymphocytic pleocytosis. Culture on special milieu allowed isolation of Mycobacterium tuberculosis. The clinical course was favorable with antituberculosis treatment. Peritoneal tuberculosis should be suspected in endemic areas in the case of a persistent fever with abdominal bloating and effusion, whatever the patient's age and the nature of ascites liquid.


Asunto(s)
Ascitis Quilosa/etiología , Peritonitis Tuberculosa/complicaciones , Humanos , Lactante , Peritonitis Tuberculosa/diagnóstico
15.
Med Trop (Mars) ; 71(1): 71-3, 2011 Feb.
Artículo en Francés | MEDLINE | ID: mdl-21585097

RESUMEN

The purpose of this study was to describe digestive tract emergencies observed in adult HIV-infected patients at the Campus Teaching Hospital in Lomé, Togo. The files of patients admitted in emergency to the Gastroenterology Department of the Lomé Campus Teaching Hospital from January 2005 to December 2009 were retrospectively reviewed. All patients over the age of 15 years with positive HIV serology were included in the study group. Out of a total of 842 files reviewed, 70 involved patients who were positive for HIV (8.31%). Mean patient age was 38 years and the sex ratio was 0.89. The most frequent reasons for admission were weight lost (75.7%), diarrhea (45.7%), and vomiting (41.4%). The main clinical signs were deterioration of general state (78.6%), conjunctive paleness (54.3%), fever (50%), and dehydration (17.1%). Digestive tract manifestations included thrush (37.1%), abdominal pain (21.4%) and ascites (18.6%). The most frequent diagnoses were infectious diarrhea (47.14%), digestive candidiasis (40%), and peritoneal tuberculosis (18.6%). The death rate during emergency treatment was 18.6%. These results demonstrate the high frequency and severity of digestive tract complications in HIV patients and underline the need for early management.


Asunto(s)
Enfermedades Gastrointestinales/virología , Infecciones por VIH/complicaciones , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Adulto , Anciano , Urgencias Médicas , Femenino , Gastroenterología , Departamentos de Hospitales , Hospitales Universitarios , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Togo , Adulto Joven
16.
Med Trop (Mars) ; 71(6): 625-6, 2011 Dec.
Artículo en Francés | MEDLINE | ID: mdl-22393636

RESUMEN

The purpose of this prospective study is to describe a series of adult HIV-infected patients treated for peritoneal tuberculosis over a 36-month period in Lome, Togo. A total of 32 cases were included. Mean patient age was 38 years (range, 20 to 69). The M/F sex ratio was 0.52. Ascites with fever was observed in all cases. Ascitic fluid was exsudative in 10.6% of cases and lymphocytic in 93.7%. Peritoneal tuberculosis was isolated in 27 patients, associated with pleural involvement in 15.6 % of cases, hematological in 75% and hepatic in 21.9%. Patients responded poorly to therapy and prognosis was unfavorable with a mortality rate of 12.5%. HIV infection substantially alters the epidemiological, clinical and therapeutic profile of peritoneal tuberculosis.


Asunto(s)
Infecciones por VIH/epidemiología , VIH-1 , Peritonitis Tuberculosa/epidemiología , Infecciones Oportunistas Relacionadas con el SIDA/complicaciones , Infecciones Oportunistas Relacionadas con el SIDA/epidemiología , Adulto , Anciano , Ciudades , Estudios de Cohortes , Femenino , Infecciones por VIH/complicaciones , VIH-1/fisiología , Humanos , Masculino , Persona de Mediana Edad , Peritonitis Tuberculosa/etiología , Togo/epidemiología , Adulto Joven
17.
Med Trop (Mars) ; 70(3): 311-2, 2010 Jun.
Artículo en Francés | MEDLINE | ID: mdl-20734610

RESUMEN

This prospective study was conducted over a 12-month period on patients who underwent upper digestive endoscopy for hematemesis in the medical intensive care unit (ICU) of the Tokoin University Hospital Center in Lomé, Togo. A total of 44 patients with a mean age of 44 years were included. The sex-ratio was 2.61. Risk factors included use of non-steroid anti-inflammatory (NSAI) in 16 patients (36.4%) and alcohol abuse in 13 (29.6%). At the time of admission to the ICU, 21 patients (47.7%) were in hemodynamic shock and 11 (25%) presented signs of portal hypertension. The underlying etiology was peptic ulcer in 18 cases (40.9%) including 13 cases of duodenal ulcer and 5 cases of stomach ulcer, rupture of esophageal varicosities in 8 (18.2%), gastric tumor in 6 (13.6%), Mallory Weiss syndrome in 5 (11.4%), gastritis in 4 (9,1%), and esophagitis in 3 (6.8%) due to peptic inflammation in 2 and mycotic infection in 1. The mortality rate was 45.5%. The main causes of hematemesis were peptic ulcer and rupture of esophageal varicosities. The death rate was high due to inadequate care facilities.


Asunto(s)
Hematemesis/etiología , Hematemesis/mortalidad , Unidades de Cuidados Intensivos/estadística & datos numéricos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Candidiasis/complicaciones , Úlcera Duodenal/complicaciones , Várices Esofágicas y Gástricas/complicaciones , Esofagitis/complicaciones , Esofagitis/microbiología , Femenino , Gastritis/complicaciones , Gastritis/microbiología , Hematemesis/diagnóstico , Hematemesis/terapia , Humanos , Masculino , Síndrome de Mallory-Weiss/complicaciones , Persona de Mediana Edad , Úlcera Péptica/complicaciones , Estudios Prospectivos , Factores de Riesgo , Neoplasias Gástricas/complicaciones , Úlcera Gástrica/complicaciones , Tasa de Supervivencia , Togo/epidemiología
18.
Med Trop (Mars) ; 70(1): 43-8, 2010 Feb.
Artículo en Francés | MEDLINE | ID: mdl-20337114

RESUMEN

PURPOSE: To evaluate the efficacy of Widal-Felix serodiagnostic testing in Togo. METHOD: This study using a cohort of 200 patients recruited at hospitals in Lome and Atakpame from November 2005 to April 2006 was designed to compare the sensitivity and specificity of the routinely used technique (plate agglutination) and reference technique (tube agglutination). RESULTS: Findings showed that the prevalence of typhoid fever was 1.5% while that of paratyphoid fever was nil. The hardest-hit age group was young people between 11 to 20 years. Men were two times more likely than women to be infected (sex-ratio, 0.5). The most useful symptoms for discriminating patients seropositive for Salmonella typhi from other serological profiles were abdominal pain (p<0.034) and diarrhea (p<0.008). The thick-drop malaria test was positive in all 3 patients (100%) with proven typhoid fever in comparison with 3.9% of the 154 patients with negative Widal-Felix serodiagnostic tests and 26.2% of the 42 patients with intermediate serological profiles. The sensitivity and specificity of the plate technique were 60.0% and 98.06% respectively. The sensitivity and specificity of laboratory analysis were 60.0% and 91.08% respectively. CONCLUSION: The gap between the specificity of the routine plate technique and laboratory analysis underscores the difficulty of performing and interpreting the Widal-Felix serodiagnostic test. The low sensitivity and specificity of the Widal-Felix serodiagnostic test also cast doubt on systematic use for diagnosis in patients presenting fever and on initiation of antibiotic treatment based on agglutination of a single antigen. To improve the specificity of the Widal-Felix serodiagnostic test, we recommend standardization of interpretation criteria and use of tube agglutination. We also see the need for development of another reproducible immunologic test for the diagnosis of typhoid and paratyphoid infections.


Asunto(s)
Pruebas de Aglutinación , Fiebre Tifoidea/diagnóstico , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Sensibilidad y Especificidad , Togo , Adulto Joven
19.
Med Trop (Mars) ; 69(1): 48-50, 2009 Feb.
Artículo en Francés | MEDLINE | ID: mdl-19499733

RESUMEN

The purpose of this report was to describe the profile of esogastroduodenal disease diagnosed by upper digestive tract endoscopy (UDTE) in a rural area of Togo. This prospective study combines data collected during two two-week screening campaigns carried out in the Kara region. Patients were informed of the presence of the endoscopy team by means of a bulletin on a rural radio station. All male and female patients 15 years or older were included. A total of 220 UDTE procedure reports were recorded and analyzed including 107 men and 113 women with a mean age of 37.7 years (range: 15-84 years). Disease was detected in 72 procedures mainly in the 21 to 41 year age group (47.2 %) with a higher proportion of men than women: 38% versus 27% respectively. The most frequent indications for UDTE were epigastralgia (47.7 %) including 39% of procedures leading to the discovery of disease and diffuse abdominal pain (21.8 %). The procedure was carried out for follow-up purposes in 19.1% of cases. The most common lesions were peptic ulcer (34.2%), inflammatory disease including esophagitis, gastritis, and bulboduodenitis (32.4%), gastroduodenal bile reflux (9.3%), pylorobulbar stenosis (5.5%), tumoral disease (3.7%), and esophageal varicosities (3.7%). This study based on UDTE diagnostic procedures provided insight into the profile of esogastroduodenal disease in rural Africa. These screening campaigns required special organization using appropriate equipment and personnel.


Asunto(s)
Endoscopía Gastrointestinal , Enfermedades Gastrointestinales/diagnóstico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Enfermedades Gastrointestinales/epidemiología , Humanos , Masculino , Tamizaje Masivo , Persona de Mediana Edad , Estudios Prospectivos , Población Rural , Togo/epidemiología , Adulto Joven
20.
Mali Med ; 24(3): 40-2, 2009.
Artículo en Francés | MEDLINE | ID: mdl-20093214

RESUMEN

PURPOSE: To count the aetiology of proctorrhagia in Lomé. METHODS: It is a retrospective study, over 12 years (1st January 1995-31 December 2006), realised from the reports of the coloscopy . It included the patients of the two sexes, old of more than 15 years, having presented a proctorrhagia explored by ano-rectoscopy and coloscopy. RESULTS: The proctorrhagia represent 38.72% of the indications of the coloscopy. The patients from 24 to 45 years were reached (52.94%). A male prevalence was found (sex-ratio: 2.4). Among the aetiology found, the haemorrhoids more frequent (23.53%), were followed by the non specific colitis (16.47%), the ulcero- haemorrhage rectocolitis (15.29%), the colon diverticulosis (10.58%), the amoebic colitis (9.4%) and colorectal cancer (5.88%). The hemorroid were associated with a non specific colitis (1 case), a ulcero-hemorrhagic rectocolitis (1 case), an amoebic colitis (1 case) and diverticulose colic (1 case). In 12 cases (14.12%), no aetiology was found. CONCLUSION: The haemorrhoids represent the most frequent aetiology of the proctorrhagia in Lomé; however their discovery in ano-rectoscopy should not exempt realisation of a complete coloscopy in the search of other causes.


Asunto(s)
Población Negra , Hemorragia Gastrointestinal/etiología , Enfermedades del Recto/etiología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Tiempo , Togo , Adulto Joven
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