1.
Nat Prod Commun
; 9(5): 633-6, 2014 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25026706
RESUMEN
A highly diastereoselective total synthesis of (+)-pseudohygroline (1) starting from D-proline is described using Wittig olefination and MacMillan-alpha-hydroxylation as key reactions. (+)-Pseudohygroline is an important molecule in alkaloid chemistry as it was prepared as part of the first chemical proof of the absolute stereochemistry of biosynthetically important (+)-hygroline (2) and (+)-hygrine (3).