A Subjective Assessment of Chemotherapy Drug-Induced Taste and Smell Alteration in Non-head and Neck Cancer Patients: A Questionnaire-Based Cross-Sectional Study.

OBJECTIVE: This study aimed to evaluate alterations in taste and smell perceptions among non-head and neck cancer patients receiving chemotherapy, aiming to identify factors influencing these changes. METHODS: A cohort of 70 non-head and neck cancer patients undergoing one to four cycles or more than four cycles, over a six-month period, from oncology outpatient clinics was recruited. Participants completed structured taste and smell questionnaires with assistance from interviewers. Demographic data, recurrence history, chemotherapy cycles, drug regimens, and taste and smell perceptions were analyzed using descriptive statistics and chi-square tests. RESULTS: The mean age of participants was 46.5 years, with a predominance of females (81.4%) and breast cancer cases (42.9%). Taste changes were more prevalent (62.9%) than smell changes (32.9%) post chemotherapy, particularly among those on combination drug regimens. Salty taste alterations were the most common (30.0%), followed by sweet taste (22.9%) and sour/bitter tastes (14.3%). Moreover, 38.57% of patients reported experiencing dysgeusia, while 30% noted the occurrence of parosmia post chemotherapy. CONCLUSION: Chemotherapy-induced alterations in taste and smell significantly impact the quality of life and nutritional status of cancer patients. Despite often being overlooked, these changes warrant increased attention in oncological practice to inform treatment decisions and enhance symptom management, particularly in palliative care settings. Further research is needed to explore the implications of chemosensory alterations on patient outcomes and treatment strategies.

Assessment of Mesiobuccal Canals in Endodontically Treated Teeth in Indore Population by Cone Beam Computed Tomography: A Cross-Sectional Study.

BACKGROUND: Owing to the complicated anatomical nature of maxillary molars, untreated root canals may directly affect the outcome of root canal therapy. Therefore, cone beam computed tomography (CBCT) scan is an important tool in the evaluation of root canal systems, particularly for the detection of the second mesiobuccal (MB2) canal in maxillary molars. AIMS AND OBJECTIVES: The current study was undertaken to detect and evaluate filled/unfilled MB2 canals in endodontically treated, asymptomatic maxillary molars, and its correlation with periapical pathology by utilizing cone beam computed tomography (CBCT). MATERIAL AND METHOD: A retrospective study of 80 CBCTs of patients underwent scanning for various treatment modalities, with asymptomatic endodontically treated permanent maxillary first molars selected. Data collection occurred between January and June 2023. CBCT machine used was KODAK 9000 (Rochester, NY: Carestream Health) (Complementary Metal Oxide Semiconductor {CMOS} sensor, continuous mode and 12-28 sec scan time, 90-500 µm voxel size, and 5x3.5 cm field of view {FOV}). The axial images at mid-root level were used to assess the presence of the MB2 canal. RESULT: The study included 39 (48.8%) right maxillary first molars and 41 (51.3%) left maxillary first molars. Overall, in 62 (77.5%) maxillary first molars, MB2 was missed by the practicing dentist, and in 13 (16.3%) maxillary first molars MB2 canal was not present. Of all the maxillary first molars with MB2 canal (n=67), 53 (79.1%) canals had a periapical infection, five (7.5%) showed widening of periodontal ligament space whereas nine (13.4%) had no abnormality. CONCLUSION: MB2 canals were present in the majority of cases and most of the unfilled MB2 canals showed evidence of periapical radiolucencies and showed a direct impact on the prognosis.

Influence of Windowing and Evaluation of Metal Artifact Reduction Algorithm on Five Different Restorative Materials by Using Different Cone Beam Computed Tomography (CBCT) Scanners: A CBCT Study.

OBJECTIVES: To assess the influence of windowing, and to evaluate, and compare the effect of the metal artifact reduction (MAR) and non-metal artifact reduction (non-MAR) algorithms on different high-density restorative dental materials using different cone beam computed tomography (CBCT) devices. MATERIAL AND METHOD: Height and diameter of all cylindrical shape metals including amalgam, cobalt-chromium, composite, gutta-percha, and titanium were measured using a digital caliper device. Polymethylmethacrylate block and arch phantom with a cylindrical-shaped perforation containing five different metals were submitted to tomographic acquisition with six different cone beam computed tomographic devices in small fields of view with their MAR enabled and disabled. Windowing was done using ITK-SNAP software (3.8.2) which was used as a contrast medial tool for window level and window width. The data was analyzed for probability distribution using the Kolmogorov-Smirnov test, where a p-value of <0.05 indicated that the data were not normally distributed. The comparison of length and width was done using the Wilcoxon sign rank test. Comparison of categorical variables was done using the Chi-square test where a p-value of <0.05 was considered statistically significant. RESULTS: Length and width of all these metals measured using MAR and non-MAR CBCT were found to be statistically non-significant (p-value of >0.05). MAR algorithm significantly reduces metals artifact produced by high-density restorative materials (p-value of <0.05). CONCLUSION: Amalgam and cobalt-chromium produced more artifacts while composite and gutta-percha did not produce enough artifacts to be reduced by the MAR algorithm. Large window width and high window level would be beneficial to reduce the metal artifact.

Impact Strength of Various Types of Acrylic Resin: An In Vitro Study.

AIM: The aim of this study is to evaluate and compare the impact strength of conventional acrylic resin, high-impact acrylic resin, high-impact acrylic resin reinforced with silver nanoparticles, and high-impact acrylic resin reinforced with a zirconium oxide powder. MATERIALS AND METHODS: A total of 60 samples were prepared of dimensions 60 mm length × 7 mm width × 4 mm thickness to test impact strength. Machined stainless steel dies of the same dimension were used to form molds for the fabrication of these samples. Of 60 samples, 15 samples were prepared each from conventional acrylic resin (Group A1), high-impact acrylic resin (Group A2), acrylic resin reinforced with silver nanoparticles (Group A3), and acrylic resin reinforced with zirconium oxide powder (Group A4). Izod-Charpy pendulum impact testing machine was used. RESULTS: The impact strength of group A1 was in the range of 2.83-3.30 kJ/m2 (M = 3.12 kJ/m2, SD = 0.16), group A2 was in range of 5.10-5.78 kJ/m2 (M = 5.51 kJ/m2, SD = 0.18), group A3 was in range 3.18-3.56 kJ/m2 (M = 3.37 kJ/m2, SD = 0.11), and group A4 was in range 7.18-7.78 kJ/m2 (M = 7.5 kJ/m2, SD = 0.18). Statistical analysis using one-way ANOVA and t-test revealed significant differences (p < 0.001). CONCLUSION: High-impact acrylic resin reinforced with zirconium oxide powder has the highest impact strength. CLINICAL SIGNIFICANCE: This research sheds light on the usefulness of novel filler materials in clinical prosthodontics.

Evaluation of efficacy of artificial intelligence in orthopantomogram in detecting and classifying radiolucent lesions.

Aim and Objective: The objective of our study was to build a convolutional neural network (CNN) model and detection and classification of benign and malignant radiolucent lesions in orthopantomogram (OPG) by implementing CNN. Method: Two basic CNN models were implemented on Anaconda with Python 3 on 64-bit, CNN-I for detection of radiolucency and CNN-II for classification of radiolucency into benign and malignant lesions. One hundred fifty eight OPG with radiolucency and 115 OPG without radiolucency was used for training and validation of CNN models. Data augmentation was performed for the training and validation dataset. The evaluation of the performance of both CNN by new data consisting (60 OPG images) 30 benign and 30 malignant lesions. Statistical Analysis: Performed using SPSS (Statistical package for social science) 20.0 version. The descriptive statistics was performed. The Cohen kappa correlation coefficient was used for assessment of reliability of the diagnostic methods. P < .05 was considered statistically significant. Determination of sensitivity, specificity, positive and negative predictive value was also performed. Result: CNN-I showing sensitivity for detection of the benign lesion is 76.6% and sensitivity for the malignant lesion is 63.3% with overall sensitivity is 70%. CNN-II showing sensitivity for classification of the benign lesion is 70% and for classification of the malignant lesion is 63.3% with overall classification sensitivity is 66.6%. The kappa correlation coefficient value for diagnosis made by CNN-II is 0.333 and P < .05. Conclusion: Both CNN showed statistically significant and satisfactory results in detecting and classifying radiolucency in OPG.

Facial Nerve Palsy as Complication in COVID-19 Associated Mucormycosis: A Case Series.

Mucormycosis is an opportunistic fungal infection indicating a high mortality rate. Among six varieties of involved sites, rhino cerebral mucormycosis (RCM) is not the most uncommon. During the COVID-19 pandemic, with the increase, in predisposing conditions incidence rate of mucormycosis progressed. For aggressive treatment, an early diagnosis can be armored to reduce morbidity and mortality. Clinically RCM poses non-specific symptoms and signs delaying diagnosis. This is associated with orbital cellulitis and sinusitis, one-sided headache behind the eye, diplopia, blurring of visions, nasal congestion, rhinorrhea, epistaxis, nasal hypoesthesia, facial pain and numbness, and a history of black nasal discharge. Not commonly the complications of cranial nerve involvement have been reported. In the present case series, three presentations of facial nerve palsy in COVID-19 associated with mucormycosis are added to the literature database.

Impact of COVID-19 Lockdown on Oral Oncology-related Outpatient Volume at Indian Dental Institutions.

AIM AND OBJECTIVE: This study aimed to evaluate the impact of the lockdown on oral oncology-related out-patient volume at Indian dental institutions. MATERIALS AND METHODS: The total number of newly diagnosed cases of oral submucous fibrosis, oral leukoplakia, oral lichen planus, and oral cancers, recorded at two dental institutional settings before lockdown (January-March 2020) and after lockdown (June-August 2020), were included retrospectively and compared. RESULTS: The study included a total of 797 cases at both institutions. At Institution-I, a total of 312 cases were recorded before the lockdown, and 63 cases were recorded after the lockdown. At Institution-II, a total of 311 cases were reported before lockdown, and 111 cases were recorded after lockdown. Comparisons between the pre-lockdown and post-lockdown data yielded a significant change in the proportions of oral sub-mucous fibrosis, oral leukoplakia, oral lichen planus, and oral cancers at both institutions (Chi-square test; p < 0.001). Following the lockdown, a substantial reduction was observed in the proportion of oral submucous fibrosis (OSMF) cases at both institutions, and the proportion of oral cancers increased at both institutions. There was a significant difference between the proportions of cases reported before lockdown at both institutions (p < 0.001). However, after-lockdown, no such differences were noted (p = 0.69); the absence of significance could most likely be due to the low sample size or low-power during the post-lockdown period. CONCLUSION: The oral potentially malignant disorders (OPMD) and oral cancer (OC) patient volumes reduced substantially following lockdown. During the post-lockdown period, the proportion of oral cancers increased, whereas the proportion of OSMF cases decreased. Results indicate that OPMD and oral cancer patients were impacted differently by the lockdown. CLINICAL SIGNIFICANCE: This study provides insight into the impact of lockdown and highlights the importance of reestablishing oral oncology-related patient care. A vital discussion is also provided on useful compensatory strategies that may reduce delays during the ongoing crisis. How to cite this article: Panta P, Reddy P, Misra SR, et al. Impact of COVID-19 Lockdown on Oral Oncology-related Outpatient Volume at Indian Dental Institutions. J Contemp Dent Pract 2021;22(5):501-505.

Assessment of knowledge and anxiety levels due to COVID-19 pandemic among health care professionals and general population in Indore City: A cross sectional study.

BACKGROUND: COVID 19 pandemic has led to economic downturn worldwide, and it has negatively affected mental health of the health workers as well as the general population. The pandemic has created psychological impact in the minds of people that even after recovery from critical illness assessment of anxiety symptoms is necessary. OBJECTIVE: This study was undertaken to assess the knowledge and anxiety levels among health care workers and non-medico/ general population of Indore, Madhya Pradesh. METHODS: A descriptive, cross sectional study was conducted among 247 participants comprising of medical and dental professionals , paramedical staff and non medico/ general population of Indore city, India. The questionnaire was divided into three sections, the first section comprised questions pertaining to socio demographic characteristics, second section comprised ten questions pertaining to awareness and attitude towards preventive measures whereas the third section assessed anxiety levels by use of 21 item Depression, Anxiety , Stress Scale ( DASS-21). RESULTS: Participants of medical profession (50.2%) outnumbered other participants; significant difference (p=0.001) was reported among dental professionals on answering minimum physical distance to be maintained. Anxiety scores were found to be low (92.7%) and statistically significant association was seen between age of participants and anxiety levels (p=0.021). CONCLUSION: Participants in the present study reported good knowledge regarding COVID-19 pandemic. Anxiety scores among the participants were found to be low.