RESUMEN
Surfactants are the most common inactive ingredients used in topical drug products. Surfactants in topical products play many functional roles such as emulsifiers, permeation enhancers, and solubilizers. This study was aimed to evaluate the influence of incremental change in the concentration of a surfactant (tween 80) on the quality attributes and performance of semisolid topical products. Four creams were prepared using metronidazole as a model drug using the same manufacturing protocol and similar composition except for the concentration of tween 80, which was increased by 5% w/w across SF1 to SF4. The quality attributes like globule size, pH, drying rate, and in-vitro permeation profile were characterized. The critical quality attributes did not differ significantly across the products. However, there was a significant difference in the permeation profile of the products. The permeation flux (Jmax) varied from SF1 to SF4 (51.25 ± 35.29 to 307.98 ± 138.89 ng/cm2/h, respectively). The reason for the difference in the performance of products despite having consistent quality attributes was investigated. One of the major reasons was found to be the difference in the time course of degree of saturation of drug during the evaporative metamorphosis. This study confirms that the time course of degree of saturation is one of the important quality attributes of the topical product that could influence bioavailability and performance of topical products.
Asunto(s)
Surfactantes Pulmonares , Tensoactivos , Emulsionantes , PolisorbatosRESUMEN
Vaccines are considered the most economical and effective preventive measure against most deadly infectious diseases. Vaccines help protect around three million lives every year, but hundreds of thousands of lives are lost due to the instability of vaccines. This review discusses the various types of instability observed, while manufacturing, storing, and distributing vaccines. It describes the specific stability problems associated with each type of vaccine. This review also discusses the various measures adopted to overcome these instability problems. Vaccines are classified based on their components, and this review discusses how these preventive measures relate to each type of vaccine. This review also includes certain case studies that illustrate various approaches to improve vaccine stability. Last, this review provides insight on prospective methods for developing more stable vaccines.
Asunto(s)
Vacunas/química , Estabilidad de Medicamentos , HumanosRESUMEN
Biological products such as protein-based biopharmaceuticals are playing an important role in the healthcare and pharmaceutical industry. The interaction between biological products and packaging materials has become the focus of many studies since it can reduce the effectiveness of biological products. These interactions are heavily influenced by the surface properties and physicochemical nature of the therapeutic agents and the packaging materials. Therefore, it is critical to understand the interactions between packaging materials and biological products in order to design biocompatible packaging materials and develop approaches to minimize adverse interactions. We describe the interactions that occur when using several common packaging materials, including glass and polymer. We discuss the interaction between these materials and biological products such as blood, blood derivatives, recombinant proteins, monoclonal antibodies, and gene therapeutics. We also summarize approaches for overcoming these interactions. Understanding the interactions between biological materials and packaging materials is critical for the development of novel packaging materials that improve the safety of pharmaceutical products.
Asunto(s)
Productos Biológicos/química , Embalaje de Productos , Industria Farmacéutica , Vidrio/química , Polímeros/químicaRESUMEN
The present study aimed to develop a continuous single-step manufacturing platform to prepare a porous, low-density, and floating multi-particulate system (mini-tablet, 4 mm size). This process involves injecting inert, non-toxic pressurized CO2gas (P-CO2) in zone 4 of a 16-mm hot-melt extruder (HME) to continuously generate pores throughout the carrier matrix. Unlike conventional methods for preparing floating drug delivery systems, additional chemical excipients and additives are not needed in this approach to create minute openings on the surface of the matrices. The buoyancy efficiency of the prepared floating system (injection of P-CO2) in terms of lag time (0 s) significantly improved (P < 0.05), compared to the formulation prepared by adding the excipient sodium bicarbonate (lag time 120 s). The main advantages of this novel manufacturing technique include: (i) no additional chemical excipients need to be incorporated in the formulation, (ii) few manufacturing steps are required, (iii) high buoyancy efficiency is attained, and (iv) the extrudate is free of toxic solvent residues. Floating mini-tablets containing acetaminophen (APAP) as a model drug within the matrix-forming carrier (Eudragit® RL PO) have been successfully processed via this combined technique (P-CO2/HME). Desired controlled release profile of APAP from the polymer Eudragit® RL PO is attained in the optimized formulation, which remains buoyant on the surface of gastric fluids prior to gastric emptying time (average each 4 h).
Asunto(s)
Líquidos Corporales/química , Composición de Medicamentos/métodos , Sistemas de Liberación de Medicamentos/métodos , Acetaminofén/administración & dosificación , Acetaminofén/química , Analgésicos no Narcóticos/administración & dosificación , Analgésicos no Narcóticos/química , Dióxido de Carbono , Portadores de Fármacos , Vaciamiento Gástrico , Ácidos Polimetacrílicos , Porosidad , Bicarbonato de Sodio , Estómago , ComprimidosRESUMEN
The purpose of this study was to prepare a temperature-sensitive gel containing silver nanoparticles and to investigate its anti-bacterial properties in vitro. The aqueous gel was prepared using Pluronic F127 (18-22%) and Pluronic F68 (3-9%) in a cold method to obtain a proper gelation temperature at 37 degrees C. Viscoelastic properties of the system were measured by rheological measurements and the physicochemical properties were evaluated by MJ-22 Dial-reflex metaloscope and Zetasizer Nano ZS90. The in vitro antimicrobial activity was evaluated by a disk diffusion test, minimum inhibitory concentration, and minimum bactericidal concentration. A temperature-sensitive gel containing silver nanoparticles with 20 wt% F127 and 6 wt% F68 had suitable fluidity at 25 degrees C and was semi-solid at 37 degrees C. Silver nanoparticle size averaged 78.0 nm. The gel optimized formulation achieved a suitable viscosity. The MIC and MBC of the gel ranged from 1.0 to 2.0 mg/L against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The activity of the gel against these three species was significantly enhanced (p<0.05) compared to 400 mg/L Asimi standard. This optimized silver nanoparticle dosage form demonstrated a high potential for further development for the clinical treatment of bacterial vaginosis.
Asunto(s)
Antibacterianos/administración & dosificación , Antibacterianos/farmacología , Plata/administración & dosificación , Plata/farmacología , Antibacterianos/química , Bacterias/efectos de los fármacos , Bacterias/crecimiento & desarrollo , Pruebas Antimicrobianas de Difusión por Disco , Composición de Medicamentos , Geles , Concentración de Iones de Hidrógeno , Nanopartículas , Poloxámero , Reología , Plata/química , Tensoactivos , Temperatura , ViscosidadRESUMEN
A class of thermosensitive biodegradable multiblock copolymers with acid-labile acetal linkages were synthesized from Pluronic triblock copolymers (Pluronic P85 and P104) and di-(ethylene glycol) divinyl ether. The novel polymers were engineered to form thermogels at body temperature and degrade in an acidic environment. The Pluronic-based acid-labile polymers were characterized using nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry. In vitro biocompatibility of the synthesized polymers was evaluated using calorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The polymers showed reverse thermogelling behavior in water around body temperature. The sol-gel transition temperatures of the polymers synthesized from Pluronic P85 and P104 were lowered from 70.3 to 30 degrees C and from 68.5 to 26.9 degrees C, respectively, when the synthesized polymers were compared with corresponding Pluronic block copolymers at a concentration of 25wt.%. The hydrophobic dye solubilization confirmed the formation of polymeric micelles in the aqueous solution. The sizes of the multiblock copolymers increased on a rise in temperature, indicating that thermal gelation was mediated by micellar aggregation. The thermally driven hydrogels showed preferential polymer degradation at acidic pH. At pH 5.0 and 6.5, the release of 40kDa fluorescein isothiocyanate-dextran (FITC-dextran) from the thermally formed hydrogels was completed within 2 and 9 days, respectively. However, FITC-dextran was continuously released up to 30 days at neutral pH. The mechanism of FITC-dextran release at pH 5.0 was mainly an acid-catalyzed degradation, whereas both diffusion and pH-dependent degradation resulted in FITC-dextran release at pH 6.5. The novel polymers hold great potential as a pH-sensitive controlled drug delivery system owing to their interesting phase transition behavior and biocompatibility.
Asunto(s)
Sistemas de Liberación de Medicamentos , Concentración de Iones de Hidrógeno , Polímeros/química , Calorimetría , Luz , Micelas , Dispersión de Radiación , TemperaturaRESUMEN
Drug efflux by intestinal P-glycoprotein (P-gp) is recognized as a significant biochemical barrier affecting oral absorption for a number of drugs apart from the cytochrome P450 3A enzyme. Various conflicting reports have been published regarding the effects of grapefruit juice (GFJ) on P-gp mediated drug efflux, in which GFJ has been shown to have no effect, as an inhibitor effect or activation of the enzyme. Therefore the present study's objective was to provide clarification of previous findings, adopting a two-way approach, involving both single dose and multiple dosage regimens. Diltiazem (DTZ) 15 mg/kg was administered concomitantly with 5 ml/kg of GFJ to one group (n = 6) of male Wistar rats and another group (n = 6) of animals were provided distilled water with DTZ (the control). A third group of rats was administered GFJ orally for six days and on seventh day GFJ and DTZ were administered concomitantly. The Cmax and AUC of DTZ were decreased significantly in the presence of multiple dose treatment of GFJ. These data were also decreased in presence of simultaneous treatment of single dose GFJ. In vitro metabolism studies and gut sac experiments were conducted in order to understand the mechanism involved. In the liver S9 fraction prepared from the rats treated with multiple doses of GFJ, DTZ metabolism was significantly increased compared to the control. Furthermore, the amount of drug transported from the duodenum was reduced in GFJ treated rats compared to that of the control (1581.0 +/- 7.8 nM vs 1084.81 +/- 6.1 nM, respectively). Grapefruit juice was also reported to inhibit the organic anion transporting polypeptide (OATP), an influx transporter thus reducing the blood levels of OATP substrates which was evident from the in vitro studies. The amount of drug transported from the duodenum was reduced in the presence of pravastatin, a specific OATP inhibitor (1581.0 +/- 7.8 nM to 1265.0 +/- 5.5 nM). Oral single dose exposure to GFJ showed no effect on P-gp, whereas multiple dose administration of GFJ resulted in increased levels of P-gp expression and decreased levels of OATP, thus showing a varied effect on intestinal absorption, and therefore overcoming the inhibition of DTZ metabolism in rats.
Asunto(s)
Bebidas , Bloqueadores de los Canales de Calcio/farmacocinética , Citrus paradisi/química , Diltiazem/farmacocinética , Animales , Bloqueadores de los Canales de Calcio/administración & dosificación , Bloqueadores de los Canales de Calcio/metabolismo , Cromatografía Líquida de Alta Presión , Citocromo P-450 CYP3A/metabolismo , Diltiazem/administración & dosificación , Diltiazem/metabolismo , Interacciones Farmacológicas , Duodeno/metabolismo , Felodipino/administración & dosificación , Felodipino/farmacocinética , Técnicas In Vitro , Absorción Intestinal , Hígado/metabolismo , Masculino , Preparaciones Farmacéuticas/metabolismo , Ratas , Ratas Wistar , Fracciones Subcelulares/metabolismoRESUMEN
The compatibility of promethazine hydrochloride (PMZ) with various tableting excipients has been investigated by isothermal stress testing (IST) and differential scanning calorimetry (DSC). DSC thermograms of PMZ and each of the excipients investigated were compared with their corresponding physical mixtures (1:1) for evaluation. Furthermore, Fourier transform infrared spectroscopy (FTIR) data was used to corroborate the results of DSC and IST. A preliminary sustained release tablet formulation of the drug, prepared using compatible excipients, was stored under accelerated storage conditions (40 degrees C/75% RH) and analyzed for stability, drug release and bioadhesion characteristics for up to 3 months. Based on DSC results alone, drug-excipient interactions were observed with Pearlitol SD200, lactose monohydrate and zinc stearate. Chromatographic analysis of the stressed binary mixture (stored at 55 degrees C for 3 weeks) containing PMZ-lactose monohydrate showed brown discoloration indicating potential interaction. However, stressed physical mixtures of PMZ-Pearlitol SD200 and PMZ-zinc stearate indicated compatibility as opposed to the thermal analysis. The tablet formulation was found to be very stable after 3 months of storage at accelerated stability conditions. Also, the release profiles and bioadhesive properties were found to be unaltered. Thus, both thermal and non-thermal methods were utilized to successfully evaluate the compatibility of excipients with PMZ and the tablet formulation was found to be stable.
Asunto(s)
Antialérgicos/administración & dosificación , Antialérgicos/química , Prometazina/administración & dosificación , Prometazina/química , Adhesividad , Rastreo Diferencial de Calorimetría , Química Farmacéutica , Preparaciones de Acción Retardada , Incompatibilidad de Medicamentos , Excipientes , Cinética , Solubilidad , Espectroscopía Infrarroja por Transformada de Fourier , ComprimidosRESUMEN
A simple and rapid stability-indicating HPLC method was developed for determination of promethazine hydrochloride (PMZ) in hot-melt extruded (HME) films and sustained release tablets. Chromatographic separation was achieved on a 150 mm x 4.6 mm i.d., 3 microm particle size, C8 (2) column with acetonitrile-25mM phosphate buffer (pH 7.0), 50:50 (v/v) as mobile phase at a flow rate of 1 mL min(-1). Quantitation was achieved with UV detection at 249 nm based on peak area. The method was validated in terms of linearity, precision, accuracy, robustness specificity, limits of detection and quantitation according to ICH guidelines. Specificity was validated by subjecting the drug to acid, base, oxidative, reductive and dry heat degradations. None of the degradation products obtained by forced degradation interfered with the PMZ peak. The method was successfully applied for assessing the stability of the drug in the HME films and sustained release tablet formulations. In addition, uniformity of PMZ content in HME films was also determined using the method developed. Excipients present in either of the dosage forms analyzed did not interfere with the analysis indicating the specificity of the method. Due to its simplicity and accuracy, the method is suitable for application to various dosage forms.
Asunto(s)
Antagonistas de los Receptores Histamínicos H1/análisis , Prometazina/análisis , Cromatografía Líquida de Alta Presión , Formas de Dosificación , Calor , Concentración de Iones de Hidrógeno , Hidrólisis , Oxidación-Reducción , Estándares de Referencia , Reproducibilidad de los Resultados , Solubilidad , Espectrofotometría UltravioletaRESUMEN
The objective of this study was to investigate the influence of tartaric acid (TTA) on the bioadhesive, moisture sorption, and mechanical properties of hot-melt-extruded (HME) hydroxypropyl cellulose (HPC) films containing polymer additives. Two Klucel EF and LF batches (HPC, MW: 80000 and 95000, respectively) containing the model antifungal drug ketoconazole (one batch of each MW with and without TTA 4%) were prepared into films by HME using a Killion extruder (Model KLB-100). The bioadhesive properties of the HPC films, with and without TTA, were investigated ex vivo on the human nails. The parameters measured were work of adhesion and peak adhesion force (PAF). A statistically significant increase in both the area under the curve (AUC) and PAF was seen for the HME films containing TTA than those without TTA. Moisture content of hot-melt extruded HPC films was determined using thermogravimetric analysis (TGA). TGA data collected at the two-week interval (25 degrees C/60% RH), measured higher moisture content for the TTA-containing films than those without TTA. Tensile strength and percent elongation were determined utilizing a TA.XT2i Texture Analyzer(R) equipped with a 50-kg load cell, TA-96 grips, and Texture Expert software. TTA functioned as an effective plasticizer, increasing percent elongation and decreasing tensile strength of the HPC films. TTA could potentially be a candidate for transnail applications in film devices prepared by hot-melt extrusion technology.
Asunto(s)
Celulosa/análogos & derivados , Uñas , Tartratos/química , Adhesivos Tisulares/química , Agua/química , Antifúngicos/química , Fenómenos Biomecánicos , Celulosa/química , Humanos , Técnicas In Vitro , Cetoconazol/química , Ensayo de Materiales , Peso Molecular , Tecnología Farmacéutica , TermogravimetríaRESUMEN
The objective of this investigation is to study the influence of chlorpheniramine maleate (CPM) on the chemical and physical-mechanical properties of hydroxypropylcellulose (HPC) hot-melt extruded films without the use of a traditional plasticizer HPC films containing CPM in concentrations of 1, 5, and 10 wt% were prepared by hot-melt extrusion utilizing a Randcastle Microtruder (Model #RCP-0750) with a 6-in. flex-film die. The physical-mechanical properties including tensile strength and percent elongation were determined on an Instron according to the ASTM standards. Glass transition temperatures and thermal analysis of the extruded films were determined utilizing a DSC 2920 Modulated DSC and Thermal Analyst 2000 software. The crystalline properties of the drug, polymer, and extruded films were studied via wide angle X-ray diffraction (XRD) using a Philips Vertical Scanning Diffractometer (Type 42273, Philips Electronic Instrument, Mount Vernon, NY). Gel permeation chromatography was used to study the stability of the polymer matrix as a function of different concentrations of CPM and processing conditions. CPM functioned as an effective plasticizer, increasing percent elongation and decreasing tensile strength in a concentration dependent manner All three concentrations of extruded films exhibited a 10- to 12-fold decrease in tensile strength in contrast to a fourfold increase in percent elongation when testing was performed perpendicular to flow vs. in the direction of flow. The drug was also shown by XRD and DSC data to be in solution in the HPC matrix within the films up to the 10% level. In addition, CPM functioned as a processing aid in the extrusion of hot-melt films, stabilizing the weight-average molecular weight of HPC and allowing for film processing at lower temperatures. CPM could potentially be a candidate antihistamine for transdermal or transmucosal applications in film devices prepared by hot-melt extrusion technology.
Asunto(s)
Celulosa/química , Clorfeniramina/química , Administración Tópica , Rastreo Diferencial de Calorimetría , Celulosa/análogos & derivados , Cromatografía en Gel , Antagonistas de los Receptores Histamínicos H1/química , Resistencia a la Tracción , Difracción de Rayos X/métodosRESUMEN
The objective of this study was to investigate the in vivo bioadhesive properties of hydroxypropylcellulose (HPC) films containing seven polymer additives on the epidermis of 12 human subjects, including two ethnic sub-groups. HPC films containing polyethylene glycol (PEG 3350) alone, Vitamin E TPGS (TPGS) 5%, sodium starch glycolate 5%, Eudragit E-100 5%, carbomer 974P and 971P 5%, and polycarbophil 5%, all with and without plasticizer, were prepared by hot-melt extrusion utilizing a Randcastle Microtruder (Model #RCP-0750). Bioadhesion testing was performed using a Chatillon digital force gauge DFGS50 attached to a Chatillon TCD-200 motorized test stand to determine force of adhesion (FA), elongation at adhesive failure (EAF), and modulus of adhesion (MA) for the 12 films tested. In vivo, the TPGS-incorporated film exhibited a two-fold increase in FA when compared to the control film containing the PEG 3350 5%. The carbomer 971P and polycarbophil containing films were determined to have the highest FA and EAF, and the lowest MA of all films tested. The film containing carbomer 971P had a higher FA than the film containing 974P. In addition, films in one ethnic sub-group exhibited higher FA and EAF than the other. Force--deflection profiles obtained from these experiments indicate that the force of adhesion, elongation at adhesive failure and modulus of adhesion are a function of the polymer additive in the HPC extruded films. The incorporation of carbomer 971P and a polycarbophil into HPC films increased bioadhesion significantly when compared to the film containing HPC and PEG 3350. Differences in FA and EAF were discovered between two ethnic sub-groups tested.
Asunto(s)
Adhesivos/farmacología , Celulosa/análogos & derivados , Celulosa/farmacología , Femenino , Humanos , MasculinoRESUMEN
Films containing hydroxypropylcellulose (HPC) and polyethylene oxide (PEO) were prepared using a Randcastle extruder (Model 750) with and without Vitamin E TPGS (TPGS, D-alpha-tocopheryl polyethylene glycol 1000 succinate) as an additive. Conventional plasticizers including polyethylene glycol 400 (PEG 400), triethyl citrate (TEC), and acetyltributyl citrate (ATBC) were also incorporated into films containing a 50:50 blend of HPC and PEO. The physical-mechanical properties including tensile strength (TS) and percent elongation (%E) were determined on an Instron according to the ASTM standards. Glass transition temperatures (T(g)) of the extruded films were determined utilizing a DSC 2920 Modulated differential scanning calorimeter and THERMAL ANALYST 2000 software. Gel permeation chromatography was used to study the stability of the polymer films under the processing conditions. The addition of 1, 3, and 5% Vitamin E TPGS, respectively, decreased the glass transition temperature of the extruded films containing either a 50:50 or 80:20 ratio of HPC to PEO in an almost linear fashion. In addition, the presence of 3% Vitamin E TPGS lowered the T(g) over 11 degrees C when compared with the HPC/PEO 50:50 blend film without TPGS, thus functioning as a plasticizer. The tensile strength decreased with increasing concentrations of TPGS, and the %E increased over 3-fold when compared with the HPC/PEO film that contained no additives. The film containing 3% Vitamin E TPGS had a similar tensile strength to that of the films containing 3% PEG 400, and a 3-fold increase in percent elongation when compared with the films containing 3% TEC and 3% ATBC. In addition, the Vitamin E TPGS facilitated the processing of the HPC/PEO films by decreasing the barrel pressure, drive amps, and torque of the extruder equipment.
Asunto(s)
Celulosa/análogos & derivados , Sistemas de Liberación de Medicamentos/métodos , Polietilenglicoles/química , Vitamina E/análogos & derivados , Administración Cutánea , Celulosa/administración & dosificación , Celulosa/química , Polietilenglicoles/administración & dosificación , Temperatura , Resistencia a la Tracción , Vitamina E/administración & dosificación , Vitamina E/químicaRESUMEN
The objective of this study was to investigate the moisture absorption, physical-mechanical and bioadhesive properties of hot-melt extruded hydroxypropylcellulose (HPC) films containing polymer additives. These additives included polyethylene glycol (PEG) 5%, polycarbophil 5%, carbomer 5%, Eudragit E-100 5%, and sodium starch glycolate (SSG) 5%. Relative humidity (RH) and temperature parameters of the films studied included 25 degree C at 0, 50, 80 and 100% RH, and 40 degrees C at 0 and 100% RH, stored for 2 weeks. Tensile strength and percent elongation were determined on an Instron according to the ASTM standards. The bioadhesive properties of the HPC/PEG 3350 5% film and the polycarbophil 5% containing films, with and without PEG, were investigated in vivo on the human epidermis. Although all films studied exhibited an increase in percent water content as the percent RH increased, the SSG containing film exhibited an almost three-fold increase in percent water content compared to that of the HPC/PEG film. The temperature storage condition of 40 degrees C/100% RH (versus 25 degrees C/100% RH) increased the percent water content of the SSG containing film. Percent elongation was highest for films containing polycarbophil 5% (without PEG). In addition, the HPC film containing polycarbophil 5% exhibited a greater force of adhesion and elongation at adhesive failure in vivo, and a lower modulus of adhesion when compared to the HPC/PEG film. A novel approach to determine bioadhesion of films to the human epidermis is presented.
Asunto(s)
Materiales Biocompatibles/química , Celulosa/análogos & derivados , Epidermis/fisiología , Fenómenos Fisiológicos de la Piel , Resinas Acrílicas/química , Adhesividad , Celulosa/química , Calor , Humanos , Polietilenglicoles/química , Ácidos Polimetacrílicos/química , Análisis de Regresión , Almidón/análogos & derivados , Almidón/químicaRESUMEN
The objective of this study was to investigate the effect of co-grinding the model drug, triamcinolone acetonide (TAA), with a polymeric surfactant on the in vitro performance of a model pMDI suspension system. The physicochemical properties of TAA after co-grinding with the surfactant, Pluronic F77, were determined by laser light diffraction, helium pycnometry and equilibrium solubility measurements. TAA-surfactant interaction was investigated by differential scanning calorimetry and Fourier transform infrared spectroscopy (FTIR). The suspension characteristics of pMDI formulations prepared with co-ground TAA and surfactant were investigated by determining their in situ sedimentation, rheological profiles and vapor pressure. The performance characteristics of the pMDI formulations were determined by cascade impaction and dose delivery through-the-valve (DDV) measurements. It was found that the presence of Pluronic F77 decreased the solubility of TAA in the propellant medium. Co-grinding TAA particles with Pluronic F77 influenced the particle size distribution, sedimentation and flocculation characteristics of the pMDI suspension formulation. The addition of Pluronic F77 decreased the viscosity of the pMDI formulation. Formulating the suspension pMDI system with co-ground TAA and Pluronic F77 decreased the mass median aerodynamic diameter (MMAD) of the emitted aerosol and increased the percent respirable fraction (%RF). The co-ground TAA and Pluronic F77 pMDI suspension formulation exhibited greater physical stability which was due to the influence of the co-grinding technique on the physicochemical properties of the TAA particle surface and the propellant dispersion medium. The changes induced by co-grinding with Pluronic F77 improved the performance characteristics of a pMDI suspension formulation by stabilizing the suspension and influencing the flocculation characteristics. Co-grinding is a process which may be useful when developing new pMDI systems containing HFA propellants.
Asunto(s)
Antiinflamatorios/administración & dosificación , Antiinflamatorios/química , Química Farmacéutica/métodos , Excipientes/química , Nebulizadores y Vaporizadores , Poloxámero/química , Tensoactivos/química , Triamcinolona Acetonida/administración & dosificación , Triamcinolona Acetonida/química , Administración por Inhalación , Aerosoles , Excipientes/administración & dosificación , Tamaño de la Partícula , Poloxámero/administración & dosificación , Reología , Solubilidad , Tensoactivos/administración & dosificación , Suspensiones , VolatilizaciónRESUMEN
Hydroxypropylcellulose (HPC) films containing drugs or hydrophilic or hydrophobic plasticizers were prepared by a hot melt extrusion process. Polyethylene glycol 8000 (PEG 8000) 2%, triethyl citrate (TEC) 2%, acetyltributyl citrate (ATBC) 2%, and polyethylene glycol 400 (PEG 400) 1% were the plasticizing agents studied. In addition, either hydrocortisone (HC) 1% or chlorpheniramine maleate (CPM) 1% was incorporated into the films as a model drug. The physical-mechanical properties of the films that were investigated included tensile strength (TS), percentage elongation (%E), and Young's modulus (YM). Differential scanning calorimetry (DSC) was utilized to determine glass transition temperatures (Tg's). These parameters were studied as a function of time and temperature. The glass transition temperatures initially decreased with the inclusion of the drugs and plasticizers. However, after 6 months aging, films containing PEG 400 and HC showed a marked increase in Tg. The films containing PEG 400 showed physical-mechanical instability in all parameters studied. All extruded films exhibited a marked decrease in TS in contrast to a large increase in %E when testing was performed perpendicular to flow versus in the direction of flow. In addition, a consistent film of HPC in the absence of drugs or plasticizers could not be extruded due to the excessive stress on the equipment. Although the theoretical percentage of CPM on aging remained fairly constant over the processing temperature ranges in this study, the HC levels remaining in the extruded films during storage were a function of time and temperature.