Nanocomposite fibrous scaffold mediated mandible reconstruction and dental rehabilitation: An experimental study in pig model.

Mandible reconstruction and dental rehabilitation after trauma or tumor resection represent a serious challenge for maxillofacial surgeons. This study aimed to investigate the bone formation potential of nanocomposite fibrous scaffold (silica-nanohydroxyapatite-gelatin reinforced with poly L-lactic acid yarns - CSF) for delayed Titanium (Ti) implantation, which was compared to autograft (AG) taken from the iliac crest. The grafts were placed in critical-sized mandibular defects in an adult pig model for 6 months followed by dental implant placement for another 3 months. There was complete union and vascularised lamellar bone formation within 6 months. Moreover, the biological processes associated with angiogenesis, bone maturation and remodelling were seen in CSF, which was comparable to AG. Later, when Ti dental implant was placed on newly formed bone, CSF group demonstrated better osseointegration. In short, nanocomposite fibrous scaffold promoted quality bone formation in mandible defect that leads to successful osseointegration, suggesting as a potential candidate for implant-based rehabilitation in clinics in future.

Multifunctional graphene oxide loaded nanofibrous membrane for removal of dyes and coliform from water.

In this study, we fabricated a trifunctional polyurethane (PU)/graphene oxide (GO) electrospun membrane for adsorption of organic dyes such as methylene blue (MB) and rhodamine B (RB). Moreover, the prepared membrane showed antifouling property and inhibition against bacteria. The GO modified PU nanofiber shows a maximum adsorption capacity of 109.88  mg/g and 77.15 mg/g towards MB and RB respectively. Theoretical studies confirmed that the dye adsorption is followed pseudo-second-order kinetics and the Langmuir adsorption isotherm. The superhydrophilic PU/10GO membrane exhibits high water flux of 17,706 lm-2hr-1. This membrane also exhibits good antifouling property for separating oil-in-water emulsions with 99.99% separation efficiency. The Mechanism of antifouling was investigated using Hermia model. The results showed that PU/GO membranes also have antibacterial activity against Gram-negative and Gram-positive bacterias. Thus a superhydrophilic nanofibrous antifouling membrane that can reject both organic dye molecule and bacteria from contaminated water is developed using simple electrospinning technique.