RESUMEN
A biomonitoring system is proposed, which involves measurement of environmental genetoxicants, determination of mutagenic accumulation in biological substrates of human beings and the severity of genetic abnormalities in their somatic cells. The toxicogenetical monitoring system includes the assessment of the examinees mental status. The results of application of the system are given by using as an example two Yaroslavl (machine-building and oil-processing) plants.
Asunto(s)
Carcinógenos/efectos adversos , Monitoreo del Ambiente/métodos , Mutagénesis/efectos de los fármacos , Mutágenos/efectos adversos , Neoplasias Experimentales/inducido químicamente , Exposición Profesional/efectos adversos , Adulto , Animales , Carcinógenos/análisis , ADN de Neoplasias/efectos de los fármacos , ADN de Neoplasias/genética , Humanos , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Persona de Mediana Edad , Mutágenos/análisis , Neoplasias Experimentales/genética , Neoplasias Experimentales/metabolismo , Estudios RetrospectivosRESUMEN
The paper presents the monitoring results of the genetic and mental status of workers from 2 plants of Yaroslavl. The groups of the examinees were formed in terms of unhealthy working conditions and residence in clean or polluted areas of the city. The individuals working under harmful and living under unfavourable environmental conditions were found to be more commonly acute or chronically stressed or fatigable than the control workers. Those under stress were shown to be more responsive to environmental genetic toxic agents. Whether psychological training may be used to form groups at high genetic risk is discussed.