RESUMEN
El trastorno esquizoafectivo se define por la presentación de síntomas psicóticos y clínica afectiva, aun cuando se considera una entidad nosológica controvertida, con dificultad para consensuar definiciones o criterios diagnósticos. Dadas las dificultades conceptuales, ha sido un reto el estudio de medidas terapéuticas eficaces y su publicación en la literatura científica, extrapolándose generalmente las recomendaciones clínicas de aquellas generadas para poblaciones mixtas con esquizofrenia o trastorno bipolar. El presente estudio intentó buscar y resumir de forma sistemática la evidencia publicada hasta la fecha sobre el uso de clozapina en pacientes con trastorno esquizoafectivo. Se identificaron siete estudios en total, heterogéneos en cuanto a diseño y metodología, siendo las muestras siempre mezclas de pacientes con esquizofrenia o trastorno bipolar. Se resumió la evidencia en una tabla y se realizó un resumen narrativo sobre los hallazgos, sugiriendo que la clozapina podría ser un tratamiento eficaz para los síntomas tanto afectivos como psicóticos, indistintamente de una fase aguda o de mantenimiento. (AU)
Schizoaffective disorder is defined by the appearance of positive psychotic symptomatology as well as affective features, even when it is considered a controversial nosologic entity, proving difficult to accord on its definition or diagnostic criteria. Due to these conceptual differences, it has been a challenge to study effective therapeutic measures and, consequently, the availability of data in the current literature, resulting in the extrapolation of clinical guidelines and recommendations initially established for patients with schizophrenia or bipolar disorder. The current study aimed to systematically search and summarize the published evidence to date about the use of clozapine in patients with schizoaffective disorder. Seven studies were identified, that are heterogeneous on their designs and methodology, including samples of patients mixed with bipolar or schizophrenic disorders. The evidence was summarized both in a table and a narrative fashion, suggesting that clozapine may be an effective treatment for both psychotic and affective symptoms, indistinctively of an acute or maintenance phase. (AU)
Asunto(s)
Humanos , Trastorno Bipolar/tratamiento farmacológico , Trastorno Bipolar/terapia , Clozapina/efectos adversos , Esquizofrenia , Resultado del Tratamiento , Trastornos Psicóticos/tratamiento farmacológico , Trastornos Psicóticos/terapiaRESUMEN
Schizoaffective disorder is defined by the appearance of positive psychotic symptomatology as well as affective features, even when it is considered a controversial nosologic entity, proving difficult to accord on its definition or diagnostic criteria. Due to these conceptual differences, it has been a challenge to study effective therapeutic measures and, consequently, the availability of data in the current literature, resulting in the extrapolation of clinical guidelines and recommendations initially established for patients with schizophrenia or bipolar disorder. The current study aimed to systematically search and summarize the published evidence to date about the use of clozapine in patients with schizoaffective disorder. Seven studies were identified, that are heterogeneous on their designs and methodology, including samples of patients mixed with bipolar or schizophrenic disorders. The evidence was summarized both in a table and a narrative fashion, suggesting that clozapine may be an effective treatment for both psychotic and affective symptoms, indistinctively of an acute or maintenance phase.
