Rhinovirus infection and co-infection in children with severe acute respiratory infection during the COVID-19 pandemic period.

Rhinovirus causes respiratory tract infections in children and is found in co-infections. The objective of this research was to study the clinical profile of rhinovirus infection and co-infection in children with severe acute respiratory infection (SARI) during the COVID-19 pandemic period. We included 606 children ranging in age from 0.1 to 144 months of age from March 2020 to December 2021, hospitalized in the Pediatric Intensive Care Unit (PICU). The samples were collected by secretion from the nasopharynx region. A total of 259 children were tested positive for viral infection, 153 (59.07%) of them had a single rhinovirus infection and, 56 (36.6%) were aged between 60.1 and 144 months. Nine types of co-infections were identified and were found coinfection with three or more viruses (22/104, 21.15%). Observing the seasonality, the number of cases was similar between 2020 (49.53%) and 2021 (51.47%). Patients with a single infection (86.88%) and coinfection (67.30%) were more likely to have coughed. Patients with co-infection required the use of O2 for longer than those with a single rhinovirus infection. Hemogram results obtained from individuals with a single infection had higher levels of urea when compared to patients with co-infection with and other respiratory viruses. Multiple correspondence analyses indicated different clinical symptoms and comorbidities in patients with co-infection compared to those with single infection. The results found that the rhinovirus was much prevalent virus during the pandemic period and was found in co-infection with other virus types, what is important to diagnostic for the correct treatment of patients.

Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic.

The main pathogens of severe respiratory infection in children are respiratory viruses, and the current molecular technology allows for a rapid and simultaneous detection of a wide spectrum of these viral pathogens, facilitating the diagnosis and evaluation of viral coinfection. METHODS: This study was conducted between March 2020 and December 2021. All children admitted to the ICU with a diagnosis of SARI and who were tested by polymerase chain reaction on nasopharyngeal swabs for SARS-CoV-2 and other common respiratory viral pathogens were included in the study. RESULTS: The result of the viral panel identified 446 children, with one infected with a single virus and 160 co-infected with two or more viruses. This study employed descriptive analyses, where a total of twenty-two coinfections among SARI-causing viruses were identified. Thus, the five most frequent coinfections that were selected for the study are: hRV/SARS-CoV-2 (17.91%), hRV/RSV (14.18%), RSV/SARS-CoV-2 (12.69%), hRV/BoV (10.45%), and hRV/AdV (8.21%). The most significant age group was 38.1%, representing patients aged between 24 and 59 months (61 individuals). Patients older than 59 months represented a total of 27.5%, comprising forty-four patients. The use of oxygen therapy was statistically significant in coinfections with Bocavirus, other CoVs, Metapneumovirus, and RSV. Coinfections with SARS-CoV-2 and the other different coinfections presented a similar time of use of oxygen therapy with a value of (p > 0.05). In the year 2020, hRV/BoV was more frequent in relation to other types of coinfections, representing a total of 35.1%. The year 2021 presented a divergent profile, with hRV/SARS-CoV-2 coinfection being the most frequent (30.8%), followed by hRV/RSV (28.2%). Additionally, 25.6% and 15.4% represented coinfections between RSV/SARS-CoV-2 and hRV/AdV, respectively. We saw that two of the patients coinfected with hRV/SARS-CoV-2 died, representing 9.52% of all deaths in the study. In addition, both hRV/hBoV and hRV/RSV had death records for each case, representing 8.33% and 6.67% of all deaths, respectively. CONCLUSION: Coinfections with respiratory viruses, such as RSV and hBoV, can increase the severity of the disease in children with SARI who are admitted to the ICU, and children infected with SARS-CoV-2 have their clinical condition worsened when they have comorbidities.

Acometimento do sistema musculoesquelético por queimaduras de terceiro grau em pacientes ambulatoriais: Série de casos / Musculoskeletal system involvement by third degree burns in ambulatory patients: Case series

OBJETIVO: Descrever acometimentos no sistema musculoesquelético de pessoas com sequela de queimadura de terceiro grau quanto à amplitude de movimento, flexibilidade e força muscular, cujo acompanhamento fisioterapêutico foi realizado em regime ambulatorial. MÉTODO: Série de casos com sete sujeitos avaliados no Laboratório do Movimento ­ Dr. Cláudio A. Borges utilizando o goniômetro para mensuração da amplitude de movimento de membros superiores e inferiores, teste de Thomas modificado e teste de Sentar e Alcançar para flexibilidade de retofemoral e isquiotibiais, dinamômetros Jamar® e Lafayette® para quantificar a força de preensão manual e de membros inferiores, respectivamente. RESULTADOS: O principal agente causador das queimaduras foi o álcool líquido e todos os casos apresentaram déficit de amplitude de movimento e força muscular em membros inferiores maior em relação aos membros superiores, bem como, redução da flexibilidade de retofemoral e isquiotibiais e redução da força de preensão manual e de membros inferiores, quando observados os valores de normalidade descritos na literatura. CONCLUSÕES: As queimaduras de terceiro grau causam perdas nas características teciduais da pele e do músculo que culminam em déficits no sistema musculoesquelético e podem causar dependência de cuidados devido à presença de alterações físicas.

OBJECTIVE: To describe affections of the musculoskeletal system in people with after-effects from third degree burns sequelae regarding to range of motion, flexibility and muscular strength, whose physiotherapeutic follow-up was performed in outpatient regimen. METHODS: Case series with seven subjects evaluated in the Laboratory of Movement - Dr. Cláudio A. Borges using the goniometer for measuring upper and lower limb range of motion, modified Thomas test, and Sit and Reach test for flexibility of rectus femoris and hamstrings, Jamar® dynamometer and Lafayette® to quantify manual and lower limb grip strength, respectively. RESULTS: The primary agent for the burns was liquid alcohol and all cases presented a deficit of range of motion and muscle strength in the lower limbs larger than the upper limbs, as well, reduction of rectus femoris and hamstrings' flexibility and reduction of manual gripping strength and lower limbs, when the normality values described in the literature were observed. CONCLUSIONS: Third degree burns cause loss of the tissue and muscles' characteristics, which culminates in deficits in the musculoskeletal system and can cause dependence on care due to the presence of physical changes.

Lesão inalatória confirmada por broncoscopia nos pacientes admitidos em uma UTI de queimados / Inhalation injury confirmed by bronchoscopy in patients admitted to a burns ICU

OBJETIVO: Verificar a incidência de lesão inalatória confirmada por broncoscopia em pacientes com queimaduras faciais e/ou histórico de exposição a fumaça em uma Unidade de Terapia Intensiva para Queimados. MÉTODO: Estudo transversal retrospectivo baseado em coleta de prontuários de pacientes internados entre agosto de 2015 e maio de 2020. Na análise estatística realizou-se a caracterização dos dados categóricos e contínuos, teste exato de Fisher, teste de Shapiro-Wilk e teste de Kruskal-Wallis sendo avaliados no software STATA® 14 com nível de significância de 5%. RESULTADOS: 82 pacientes com lesão inalatória foram classificados em grupos de nenhuma lesão/leve, moderada e grave, com incidência de 19,2 casos de lesão inalatória a cada 100 internações na unidade de terapia intensiva de queimados e tempo médio de internação de 35,6 dias; destes, 27 faleceram. Os pacientes com lesão grave ficaram por menor tempo em ventilação mecânica. CONCLUSÕES: A avaliação por broncoscopia no atendimento inicial imediato ou em até 24h da admissão do paciente com queimadura facial pode ser adotada para otimizar o diagnóstico e realizar a classificação da lesão inalatória aprimorando a visualização do prognóstico, o atendimento e tratamento a estes pacientes.

OBJECTIVE: To verify the incidence of inhalation injury confirmed by bronchoscopy in patients with facial burns and/or a history of exposure to smoke in a Burns Intensive Care Unit. METHODS: Retrospective cross-sectional study based on the collection of medical records of patients hospitalized between August 2015 and May 2020. In the statistical analysis the categorical and continuous data were characterized, Fisher's exact test, Shapiro-Wilk test, and Kruskal-Wallis test were evaluated in STATA® 14 software with a 5% significance level. RESULTS: 82 patients with inhalation injury were classified into groups of no/mild, moderate and severe injuries, with an incidence of 19.2 cases of inhalation injury for every 100 admissions in the intensive care unit for burns patients with an average length of stay of 35.6 days; of these 27 died. Patients with severe injuries were on mechanical ventilation for a shorter time. CONCLUSIONS: The bronchoscopy evaluation in the immediate initial care or within 24 hours of admission of patients with facial burns can be adopted to optimize the diagnosis and perform the classification of the inhalation injury improving the visualization of the prognosis, care and treatment of these patients.