[The cerebral sodium uretric peptide (see text symbol) patients with chronic cardiac insufficiency under decreased and preserved ejection fraction].

The concentration of cerebral sodium uretic peptide was analyzed in patients with chronic cardiac insufficiency and in healthy volunteers. The study established that concentration of cerebral sodium uretic peptide was higher in patients with chronic cardiac insufficiency as compared control group and reflected severity of pathologic process. In patients with decreased ejection fraction the levels cerebral sodium uretic peptide were higher as compared with patients with preserved ejection fraction. According data of the present study the existing threshold of concentration of cerebral sodium uretic peptide has a lower diagnostic sensitivity to exclude chronic cardiac insufficiency (100 pg).

[Psychiatric disturbances in patients with acute myocardial infarction and other critical states in conditions of department of reanimation and intensive therapy].

In this review we present in short data of domestic and foreign studies on somatogenic delirium in patients with acute myocardial infarction and with other critical states. The review also contains definitions of basic conceptions, contemporary approaches to diagnosis and management of this complication.

[Determination of free fatty-acid carrier protein by enzyme immunoassay and non-instrumental method in acute coronary syndrome].

The purpose of the investigation was to study changes in and relationships with the clinical and echocardiographic parameters in the serum level of cardiac fatty-acid carrier protein (cFACP) with acute myocardial infarction (MI), as well as the efficiency of non-instrumental determination of the content of cFACP, by using the test systems "CardioFACP" in the diagnosis of acute MI. The investigation showed the high diagnostic value of cFACP as the earliest marker of acute MI during both its enzyme immunoassay and non-instrumental determination. The sensitivity of the test system "CardioFACP" was found to be greater than that of the troponin test within the first hours of acute MI. The findings support the specific features of the kinetics of cFACP and its sensitivity in detecting cardiomyocyte lesions, on the one hand, and determine perspectives for its use to diagnose MI and reocclusions of the infarction-related coronary artery after reperfusion therapy, on the other.

[Cardiomyoplasty with autological mononuclear cells of the bone marrow in patients with acute myocardial infarction].

AIM: To study efficacy and safety of transplantation of bone marrow autologous mononuclear cells (BMAMC) in patients with acute myocardial infarction; to examine BMAMC distribution in the human body after intracoronary introduction. MATERIAL AND METHODS: The open controlled trial investigated 26 AMI patients (16 entered the study group and 10 were controls). Cell cardiomyoplasty with BMAMC was performed by intracoronary injection of the cells after stenting the coronary artery supplying blood to the infarction zone on AMI day 7-21. BMAMC were isolated by gradient centrifugation. Distribution of mononuclear cells was studied with radionuclear indication of the cells 99m-Tc-HMPAO. All the patients were examined with Tl-199 perfusion scintigraphy of the heart 2 weeks and 6 months after the treatment, echocardiography, 24-h ECG monitoring, 6-min walk test. RESULTS: All the patients were followed up for 6 months. Two patients (one in each group) developed recurrent myocardial infarction 3 months after the first. Radionuclide investigations revealed fixation of labelled mononuclear cells in the heart both in initial hours after the treatment and 24 hours after it. As shown by myocardial scintigraphy, intracoronary administration of the cells with short-term arterial occlusion was followed by much greater number of labeled cells. By follow-up month 6, in the study group, left ventricular ejection fraction increased more: 12.7 +/- 3.2% versus 10.4 +/- 2.5% in the control group (p = 0.09); moreover, a stable defect of myocardial perfusion reduced more (by 29 +/- 24% against 20 +/- 18%, respectively, p = 0.1). Malignant arrhythmia, complications during and after bone marrow aspiration, intracoronary administration of cell suspension were not registered. CONCLUSION: Intracoronary administration of BMAMC in AMI patients is safe and provides their transfer and fixation in the myocardium. BMAMC transplantation has a positive effect on recovery of perfusion and contractile function of left ventricular myocardium in AMI patients.

[Clinical experience of the use of autologous mononuclear bone marrow cells in patients with ischemic heart disease and dilated cardiomyopathy].

Between March 2003 and February 2005 cell therapy with mononuclear bone marrow cells (MBMC) was used in 38 and 4 patients with ischemic heart disease and dilated cardiomyopathy, respectively. Intracardiac administration of MBMC (87+/-12 millions) was carried out during coronary artery bypass surgery and/or left ventricular aneurysm resection (n=25) or in cardiac catheterization laboratory (n=17). For verification of cells fixation they were labeled with "Ceretec" 99mTc-HMPAO. Accumulation of labeled cells after 24 hours was 1.6+/-0.001%. After 6 months parameters of intracardiac hemodynamics and transitory myocardial perfusion defects improved significantly in all patients with ischemic heart disease.

[The effects of intracoronary infusion of bone marrow mononuclears on myocardial contractility].

The effects of intracoronary infusion of bone marrow mononuclears (BMM) on myocardial contractility after myocardial infarction (MI) was studied in 16 post-infarction patients. The intracoronary infusion of autologic BMM during the subacute period of MI did not have a significant effect on myocardial contractility, the functional class of chronic heart failure, physical tolerance, and quality of life evaluated three and six months after the transplantation. Intracoronary BMM transplantation did not provoke ventricular tachycardia or ventricular fibrillation. BMM transplantation into an infarcted myocardium did not exacerbate coronary heart disease in post-infarction patients.

[Regeneration of myocardium]. / Regeneratsiia miokarda.

It has been systematized modern data on the myocardial regeneration and the regulation of cardiac cell proliferation in mammals and man. It has been performed an analysis published works which indicate that cardiomyocyte division and DNA synthesis in myocardial cells increase in many times during different pathological conditions. It has been generalized and analyzed results of experimental and clinical researches on the participation of stem cells in the regeneration of the heart. It has been present literature data on the telomeres and telomerase in cardiomyocytes.