DiabeText, a mobile health intervention to support medication taking and healthy lifestyle in adults with type 2 diabetes: Study protocol for a randomized controlled trial.

AIM: To evaluate the effectiveness of DiabeText, a low-intensity, multifaceted, mobile health (mHealth) intervention to support medication taking and lifestyle change targeted to people with type 2 diabetes (T2D). DESIGN: Phase III, 12-months, two-arm (1:1 allocation ratio), randomized parallel-group trial. METHODS: We will recruit 740 adults with glycated hemoglobin (A1c) >8% (>64 mmol/mol) and with at least one prescription of a non-insulin antidiabetic drug. They will be allocated to a control (usual care) group or an intervention (DiabeText messaging intervention) group. The primary outcome measure will be A1c at 12 months follow-up. Secondary outcomes will include medication possession ratio and behavioral and psychological outcomes. DISCUSSION: Recent trials suggest that digital health interventions can effectively support diabetes self-management improving T2D control and reducing important T2D complications. In Spain this type of interventions is understudied. IMPACT: This trial will strengthen the evidence base of the impact of mHealth interventions to support diabetes self-management. If effective, DiabeText may offer a low-cost and highly scalable strategy to improve health at the population level in a sustainable way. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT05006872; Official Title: Supporting People with Type 2 Diabetes in Effective Use of their Medicine Through a System Comprising Mobile Health Technology Integrated with Clinical Care.

Non-adherence to non-insulin glucose-lowering drugs: Prevalence, predictors and impact on glycemic control and insulin initiation. A longitudinal cohort study in a large primary care database in Spain.

BACKGROUND: A better understanding of patient non-adherence to type 2 diabetes medication is needed to design effective interventions to address this issue. OBJECTIVES: (1) To estimate the prevalence of non-adherence to diabetes medication; (2) to examine its impact on glycemic control and insulin initiation; (3) to develop and validate a prediction model of non-adherence. METHODS: We conducted a longitudinal cohort study based on data from electronic health records. We included adult patients registered within the Health Service of the Balearic Islands (Spain) starting a new prescription of a non-insulin glucose-lowering drug between January 2016 and December 2018. We calculated non-adherence at 12 months follow-up, defined as medication possession ratio (MPR) ≤ 80%. We fitted multivariable regression models to examine the association between non-adherence and glycemic control and insulin initiation and identified predictors of non-adherence. RESULTS: Of 18,119 patients identified, after 12 months follow-up, 5,740 (31.68%) were non-adherent. Compared with non-adherent, adherent patients presented lower HbA1c levels (mean difference = -0.32%; 95%CI = -0.38%; -0.27%) and were less likely to initiate insulin (aOR = 0.77; 95%CI = 0.63; 0.94). A predictive model explained 22.3% of the variation and presented a satisfactory performance (AUC = 0.721; Brier score = 0.177). The most important predictors of non-adherence were: non-Spanish nationality, currently working, low adherence to previous drugs, taking biguanides, smoker and absence of hypertension. CONCLUSION: Around one-third of the patients do not adhere to their non-insulin glucose-lowering drugs. More research is needed to optimise the performance of the predicting model before considering its implementation in routine clinical practice.

[Evolution of the outpatient antibiotic prescription between 2012 and 2018. Characteristics of the ABPresclín platform created for the analysis of antibiotic prescription in the health service of the Balearic Islands.] / Evolución de la prescripción antibiótica ambulatoria entre 2012 y 2018. Características de la plataforma ABPresclín creada para el análisis de prescripción antibiótica en el Servicio de Salud de las Islas Baleares.

OBJECTIVE: One of the fist lines of action of the National Plan against Antibiotic Resistance (PRAN) is to monitor the use of antibiotics as a fundamental basis for the fight against resistance. In order to know the antibiotic prescription habits, we pretended to describe the outpatient prescription of systemic antibiotics in the Balearic Islands through exploitation of ABPresclín database. METHODS: It was an ecological descriptive study of the electronic outpatient prescriptions of systemic antibiotics of the Health Service of the Balearic Islands from 2012 to 2018. Combining the prescription with population information data by year and geographical area, prescription rates were obtained per 1,000 person, distributed by professional, health centres, geographical areas: distribution per patient characteristics, type of antibiotics and associated diagnoses. RESULTS: 3,517,101 prescriptions are analyzed with an average prescription period (TPp) per 1,000 person-years of 472.1. A quarter of the population received at least one prescription of antibiotics. TPp was higher in over 80 years (899.0) and in women (553.4). 68.9% of the prescription was made in primary care (AP) and 17.9% in out-of-hours settings. TPp in AP was 333.1, varying from 192.3 to 527.0, according to basic health areas. The TPp of the most commonly used antibiotics was: amoxicillin/clavulanic (143), amoxicillin (95.9), azithromycin (54.5), fosfomycin (41.5) and ciprofloxacin (29.7). The main associated diagnoses were: lower respiratory infections (16.5%), urinary infections (15%), non-infectious (15%), tonsillitis (14.3%) and upper respiratory infections (13%). CONCLUSIONS: Balearic Islands have a relatively low antibiotic prescription rate with a marked variability between prescribers. Amoxicillin/clavulanic was the most prescribed antibiotic, with an increase in azithromycin. Respiratory infections were the main reason for prescription. ABPresclín is useful to promote better use of antibiotics.

OBJETIVO: Una de las líneas de actuación del Plan Nacional frente a la Resistencia a los Antibióticos (PRAN) es la vigilancia del uso de los antibióticos como pilar fundamental en la lucha frente a la resistencia. Con la finalidad de conocer los hábitos de prescripción de antibióticos, este trabajo pretendió describir la prescripción ambulatoria de antibióticos sistémicos en Baleares mediante la explotación de la base de datos ABPresclín. METODOS: Se elaboró un diseño descriptivo ecológico de la prescripción ambulatoria de antibióticos sistémicos en el Servicio de Salud de las Islas Baleares, entre 2012 y 2018. Se realizó un análisis descriptivo de la prescripción antibiótica que, si se refería a un denominador poblacional por año o periodo, permitía obtener tasas de prescripciones por cada 1.000 personas, distribuidas por profesional, por cupo o por áreas geográficas (zonas básicas de salud y áreas), o bien según las características del paciente, el tipo de antibióticos y los diagnósticos asociados. RESULTADOS: Se analizaron 3.517.101 prescripciones, con una tasa de prescripción del período (TPp) por cada 1.000 personas-año de 472,1. Una cuarta parte de la población recibió al menos una prescripción de antibióticos. La TPp fue mayor en >80 años (899) y en mujeres (553,4). El 68,9% de la prescripción se realizó en consulta de atención primaria (AP) y el 17,9% en urgencias extrahospitalarias. La TPp en AP fue de 333,1, variando entre 192,3 y 527, según las zonas básicas de salud. La TPp de los antibióticos más utilizados fue: amoxicilina/clavulánico, 143; amoxicilina, 95,9; azitromicina, 54,5; fosfomicina, 41,5; y ciprofloxacino, 29,7. Se asociaron principalmente los diagnósticos de infecciones respiratorias de vías bajas (16,5%), infecciones urinarias (15%), no infecciosos (15%), amigdalitis (14,3%) e infecciones respiratorias de vías altas (13%). CONCLUSIONES: Baleares presenta una tasa de prescripción de antibióticos relativamente baja, con una marcada variabilidad. Amoxicilina/clavulánico es el antibiótico más prescrito, con incremento de la azitromicina. Las infecciones respiratorias son el principal motivo de prescripción. ABPresclín resulta útil para promover un mejor uso de antibióticos.

Evolución de la prescripción antibiótica ambulatoria entre 2012 y 2018. características de la plataforma abpresclín creada para el análisis de prescripción antibiótica en el servicio de salud de las Islas Baleares / Evolution of the outpatient antibiotic prescription between 2012 and 2018. Characteristics of the ABPresclín platform created for the analysis of antibiotic prescription in the health service of the Balearic Islands

OBJETIVO: Una de las líneas de actuación del Plan Nacional frente a la Resistencia a los Antibióticos (PRAN) es la vigilancia del uso de los antibióticos como pilar fundamental en la lucha frente a la resistencia. Con la finalidad de conocer los hábitos de prescripción de antibióticos, este trabajo pretendió describir la prescripción ambulatoria de antibióticos sistémicos en Baleares mediante la explotación de la base de datos ABPresclín. MÉTODOS: Se elaboró un diseño descriptivo ecológico de la prescripción ambulatoria de antibióticos sistémicos en el Servicio de Salud de las Islas Baleares, entre 2012 y 2018. Se realizó un análisis descriptivo de la prescripción antibiótica que, si se refería a un denominador poblacional por año o periodo, permitía obtener tasas de prescripciones por cada 1.000 personas, distribuidas por profesional, por cupo o por áreas geográficas (zonas básicas de salud y áreas), o bien según las características del paciente, el tipo de antibióticos y los diagnósticos asociados. RESULTADOS: Se analizaron 3.517.101 prescripciones, con una tasa de prescripción del período (TPp) por cada 1.000 personas-año de 472,1. Una cuarta parte de la población recibió al menos una prescripción de antibióticos. La TPp fue mayor en >80 años (899) y en mujeres (553,4). El 68,9% de la prescripción se realizó en consulta de atención primaria (AP) y el 17,9% en urgencias extrahospitalarias. La TPp en AP fue de 333,1, variando entre 192,3 y 527, según las zonas básicas de salud. La TPp de los antibióticos más utilizados fue: amoxicilina/clavulánico, 143; amoxicilina, 95,9; azitromicina, 54,5; fosfomicina, 41,5; y ciprofloxacino, 29,7. Se asociaron principalmente los diagnósticos de infecciones respiratorias de vías bajas (16,5%), infecciones urinarias (15%), no infecciosos (15%), amigdalitis (14,3%) e infecciones respiratorias de vías altas (13%). CONCLUSIONES: Baleares presenta una tasa de prescripción de antibióticos relativamente baja, con una marcada variabilidad. Amoxicilina/clavulánico es el antibiótico más prescrito, con incremento de la azitromicina. Las infecciones respiratorias son el principal motivo de prescripción. ABPresclín resulta útil para promover un mejor uso de antibióticos

OBJECTIVE: One of the fist lines of action of the National Plan against Antibiotic Resistance (PRAN) is to monitor the use of antibiotics as a fundamental basis for the fight against resistance. In order to know the antibiotic prescription habits, we pretended to describe the outpatient prescription of systemic antibiotics in the Balearic Islands through exploitation of ABPresclín database. METHODS: It was an ecological descriptive study of the electronic outpatient prescriptions of systemic antibiotics of the Health Service of the Balearic Islands from 2012 to 2018. Combining the prescription with population information data by year and geographical area, prescription rates were obtained per 1,000 person, distributed by professional, health centres, geographical areas: distribution per patient characteristics, type of antibiotics and associated diagnoses. RESULTS: 3,517,101 prescriptions are analyzed with an average prescription period (TPp) per 1,000 person-years of 472.1. A quarter of the population received at least one prescription of antibiotics. TPp was higher in over 80 years (899.0) and in women (553.4). 68.9% of the prescription was made in primary care (AP) and 17.9% in out-of-hours settings. TPp in AP was 333.1, varying from 192.3 to 527.0, according to basic health areas. The TPp of the most commonly used antibiotics was: amoxicillin/clavulanic (143), amoxicillin (95.9), azithromycin (54.5), fosfomycin (41.5) and ciprofloxacin (29.7). The main associated diagnoses were: lower respiratory infections (16.5%), urinary infections (15%), non-infectious (15%), tonsillitis (14.3%) and upper respiratory infections (13%). CONCLUSIONS: Balearic Islands have a relatively low antibiotic prescription rate with a marked variability between prescribers. Amoxicillin/clavulanic was the most prescribed antibiotic, with an increase in azithromycin. Respiratory infections were the main reason for prescription. ABPresclín is useful to promote better use of antibiotics

Habitos de alimentación y actividad física en un instituto de Educación Secundaria secundaria de Baleares / Dietary habits and physical activity in a secondary school in the balearic islands

Objetivo Evaluar los cambios en los hábitos de alimentación y actividad física así como la prevalencia de obesidad y sobrepeso que se han producido en una cohorte de alumnos entre 1° y 4° de secundaria tras una intervención no estructurada de educación para la salud. Método Estudio descriptivo longitudinal. Se recogieron variables antropométricas y de hábitos de alimentación, ocio y actividad física a los alumnos de 1° de ESO (n=61) y se midieron de nuevo cuando cursaban 4° de ESO. Se realizo un analisis apareado de los datos mediante el test Mc Nemar-Bowker. Durante el periodo de estudio se realizaron sesiones educativas sobre alimentación saludable y actividad física. Resultados La prevalencia de sobrepeso ha mejorado significativamente (de 14,8% a 3,7%) y se ha incrementado el nivel de actividad física. No se han detectado cambios en la calidad del desayuno ni en la calidad de la dieta mediterránea. Conclusiones Algunos de los aspectos estudiados han mejorado sin poderse atribuir esa mejora a las sesiones educativas realizadas. Conocer y analizar los hábitos de vida saludable de los adolescentes permitirá planificar intervenciones realistas, adaptadas al entorno concreto, estructuradas y continuadas en el tiempo, que aborden las áreas de conocimientos, habilidades y emociones y que vayan dirigidas no sólo a los jóvenes sino también a sus familias, al entorno interno del centro educativo y a la coordinación de los recursos comunitarios que permita un abordaje coordinado (AU)

Objective To evaluate the changes in dietary habits and physical activity, as well as the prevalence of obesity and overweight that have occurred in a cohort of 1st and 4th year secondary school pupils after non-structured health education activities. Method A descriptive, longitudinal study, in which anthropometric variables, dietary habits, leisure and physical activity were collected in the 1st year secondary school pupils (n=61), and they were measured again when they were in the 4th year. The differences between the two school years were analysed using the Mc Nemar-Bowker Test. During the period of the study educational sessions were given on healthy eating and physical activity. Results The prevalence of overweight decreased significantly (from 14.8% to 3.7%) and the level of physical activity has increased. No statistical differences were detected in the quality of breakfast or in the quality of the Mediterranean diet. Conclusions Some of the aspects studied have improved without being able to attribute this improvement to the educational sessions given. To determine and analyse the healthy living habits of adolescents would enable us to plan realistic interventions, adapted to the particular environment. They should be structured and continuous over time and approach areas of knowledge, skills and emotions, and directed, not only at the young people, but also their families, the internal environment of the educational centre. There should be coordination of community resources in order to make a coordinated approach (AU)

[Dietary habits and physical activity in a secondary school in the Balearic islands]. / Habitos de alimentación y actividad física en un instituto de Educación Secundaria secundaria de Baleares.

OBJECTIVE: To evaluate the changes in dietary habits and physical activity, as well as the prevalence of obesity and overweight that have occurred in a cohort of 1st and 4th year secondary school pupils after non-structured health education activities. METHOD: A descriptive, longitudinal study, in which anthropometric variables, dietary habits, leisure and physical activity were collected in the 1st year secondary school pupils (n=61), and they were measured again when they were in the 4th year. The differences between the two school years were analysed using the Mc Nemar-Bowker Test. During the period of the study educational sessions were given on healthy eating and physical activity. RESULTS: The prevalence of overweight decreased significantly (from 14.8% to 3.7%) and the level of physical activity has increased. No statistical differences were detected in the quality of breakfast or in the quality of the Mediterranean diet. CONCLUSIONS: Some of the aspects studied have improved without being able to attribute this improvement to the educational sessions given. To determine and analyse the healthy living habits of adolescents would enable us to plan realistic interventions, adapted to the particular environment. They should be structured and continuous over time and approach areas of knowledge, skills and emotions, and directed, not only at the young people, but also their families, the internal environment of the educational centre. There should be coordination of community resources in order to make a coordinated approach.

[Estimating the coverage of systematic vaccinations among the Balearic Island infant population]. / Estimación de la cobertura de las vacunaciones sistemáticas en la población infantil de las Islas Baleares.

BACKGROUND: In order for vaccination programs to be carried out properly, it is essential for the vaccination coverage to be known. On the Balearic Islands, the reported coverage was much less than for the rest of Spain. The objective of this study is that of estimating the coverage of the vaccinations included on the recommended schedule up to 18 months of age (4 doses of oral polio, tetanus and diphtheria; 3 doses of whooping cough; 1 dose of measles, rubella and mumps). METHODS: A descriptive, cross-sectional study of the population base. The ideal-time frequency distribution estimators and the corresponding confidence intervals were calculated at 95% (CI95%) for a sample of the resident two-year-old (born in 1995) Balearic Island population selected by means of a single-stage conglomerate random sampling based on census sections. The National Public Health System and National Health Institute vaccination records were reviewed, the data from the vaccination document having been requested from the families and the clinical record from the private pediatricians by telephone. RESULTS: The sample included 606 children, it having been possible to obtain full information on 532 children. Full information was obtained on 377 cases (62%) from the public health sector records. The least degree of coverage was found for the diphtheria vaccine, 518 children having been fully vaccinated, 96.8% (CI95% = 94.8-98.1), the highest degree of coverage having been found for the whooping cough vaccine, 537 children, 98.9% (CI95% = 97.5-99.5). CONCLUSIONS: Good vaccination coverage was found to exist on the Balearic Islands, being similar to what has been being estimated for Spain as a whole. The objective included within the Polio Eradication Plan is accomplished, very little information being gathered from the public sector.

Estimación de la cobertura de las vacunaciones sistemáticas en la población infantil de las Islas Baleares / Estimating the coverage of systematic vaccinations among the Balearic Island infant population

Fundamentos: Para un buen desarrollo de los programas de vacunación es primordial conocer la cobertura de vacunación. En las Islas Baleares la cobertura notificada era muy inferior a la del resto de España. El objetivo de este trabajo es la estimación de la cobertura de las vacunas incluidas en el calendario recomendado hasta los 18 meses de edad (4 dosis de polio oral, tétanos y difteria; 3 de tosferina; 1 de sarampión, rubeola y parotiditis).Métodos: Estudio descriptivo, transversal, de base poblacional. Se calcularon los estimadores puntuales de distribución de frecuencias y los intervalos de confianza al 95 per cent (IC95 per cent) correspondientes, sobre una muestra de la población residente en Baleares de dos años de edad (nacida en 1995), seleccionada por muestreo aleatorio por conglomerados en una sola etapa a partir de las secciones censales. Se consultan los registros de vacunas de Sanidad y de los centros de salud del Insalud, se pide telefónicamente a las familias los datos del documento de vacunación y a los pediatras privados los de la historia clínica. Resultados: La muestra incluía 606 niños. Pudo obtenerse la información completa de 532. Se consiguió la información completa de 377 casos (62 per cent) a partir de los registros del sector público. La cobertura más baja fue la de la vacuna antidiftérica, 518 niños complentamente vacunados, el 96,8 per cent (IC95 per cent = 94,8 - 98,1) y la más alta la de la vacuna antipertussis, 537 niños, el 98,9 per cent (IC95 per cent = 97,5 - 99,5).Conclusiones: En las Islas Baleares existe una buena cobertura de la vacunación, similar a lo que se viene estimando en España en su totalidad. Se cumple el objetivo incluido en el Plan de Erradicación de la Polio. La información recogida desde el sector público es escasa (AU)