RESUMEN
The formulation of a specific algaecide can greatly influence the bioavailability, uptake, and consequent control of the targeted alga. In this research, three copper-based algaecide formulations were evaluated in terms of copper sorption to a specific problematic alga and amount of copper required to achieve control. The objectives of this study were (1) to compare the masses of copper required to achieve control of Lyngbya wollei using the algaecide formulations Algimycin-PWF, Clearigate, and copper sulfate pentahydrate in laboratory toxicity experiments; (2) to relate the responses of L. wollei to the masses of copper adsorbed and absorbed (i.e., dose) as well as the concentrations of copper in the exposure water; and (3) to discern the relation between the mass of copper required to achieve control of a certain mass of L. wollei among different algaecide formulations. The critical burden of copper (i.e., threshold algaecide concentration that must be absorbed or adsorbed to achieve control) for L. wollei averaged 3.3 and 1.9 mg Cu/g algae for Algimycin-PWF and Clearigate, respectively, in experiments with a series of aqueous copper concentrations, water volumes, and masses of algae. With reasonable exposures in these experiments, control was not achieved with single applications of copper sulfate despite copper sorption >13 mg Cu/g algae in one experiment. Factors governing the critical burden of copper required for control of problematic cyanobacteria include algaecide formulation and concentration, volume of water, and mass of algae. By measuring the critical burden of copper from an algaecide formulation necessary to achieve control of the targeted algae, selection of an effective product and treatment rate can be calculated at a given field site.
Asunto(s)
Sulfato de Cobre/toxicidad , Cobre/toxicidad , Cianobacterias/efectos de los fármacos , Desinfectantes/toxicidad , Etanolaminas/toxicidad , Compuestos Organometálicos/toxicidad , Cobre/metabolismo , Sulfato de Cobre/metabolismo , Cianobacterias/metabolismo , Desinfectantes/metabolismo , Etanolaminas/metabolismo , Eutrofización/efectos de los fármacos , Floraciones de Algas Nocivas , Compuestos Organometálicos/metabolismoRESUMEN
Chlorpyrifos (an insecticide) and chlorothalonil (a fungicide) are transported in stormwater runoff and can be lethal to receiving aquatic system biota. This study determined removal rates of chlorpyrifos and chlorothalonil in simulated stormwater runoff treated in constructed wetland mesocosms. Using sentinel species, Ceriodaphnia dubia and Pimephales promelas, observed declines in toxicity of the simulated runoff after treatment were 98 and 100%, respectively. First order removal rates were 0.039/h for chlorpyrifos and 0.295/h for chlorothalonil in these experiments. Constructed wetland mesocosms were effective for decreasing concentrations of chlorpyrifos and chlorothalonil in simulated stormwater runoff, and decreasing P. promelas and C. dubia mortality resulting from these exposures. The results from this study indicate that constructed wetlands could be part of an efficient mitigation strategy for stormwater runoff containing these pesticides.
Asunto(s)
Contaminación Ambiental , Plaguicidas/toxicidad , Contaminantes Químicos del Agua/toxicidad , Purificación del Agua , Animales , Cloropirifos/toxicidad , Daphnia , Descontaminación/métodos , Fungicidas Industriales/toxicidad , Insecticidas/toxicidad , Nitrilos/toxicidad , Movimientos del AguaRESUMEN
Chlorothalonil is a commonly used fungicide in rural and urban environments and can be incidentally introduced into aquatic systems through rainfall runoff or direct overspray and drift from aerial applications. Few studies have been published regarding risks to aquatic organisms exposed to chlorothalonil, so this study was performed to provide a first-order risk characterization for receiving system biota. Definitive laboratory toxicity tests were conducted with aqueous solutions of chlorothalonil and sentinel aquatic organisms (Ceriodaphnia dubia Richard and Pimephales promelas Rafinesque). P. promelas was more sensitive (7-day potency=6.1% mortality/mug/L) than C. dubia (7-day potency=0.94% mortality/mug/L) to chlorothalonil exposures. All mortality of P. promelas and C. dubia resulting from these chlorothalonil exposures occurred within the first 96h and no sublethal effects (i.e., growth or reproduction) were detected under these experimental conditions following 7-day exposures.
Asunto(s)
Cladóceros , Cyprinidae , Fungicidas Industriales/toxicidad , Nitrilos/toxicidad , Contaminantes Químicos del Agua/toxicidad , Animales , Dosificación Letal Mediana , Medición de RiesgoRESUMEN
This study was done to characterize responses of Ceriodaphnia dubia Richard and Pimephales promelas Rafinesque exposed to aqueous solutions of chlorothalonil (tetrachloroisophthalonitrile) and chlorpyrifos (O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate). Chlorothalonil (a fungicide) and chlorpyrifos (an insecticide) are intensely used in agricultural, silvicultural, and urban settings. These pesticides may enter aquatic systems through several pathways including rainfall runoff. C. dubia and P. promelas have been used to monitor surface waters and discern the effects of pesticides that contaminate those waters. Modified static renewal exposures (7 or 10 days) with individual solutions of chlorothalonil and chlorpyrifos were used to obtain mortality data for C. dubia and P. promelas, from which potency curves were derived, as well as sublethal effects data (reproduction or growth). In these experiments P. promelas was more sensitive to chlorothalonil, and C. dubia was more sensitive to chlorpyrifos. Lower and upper thresholds (i.e., LC(0) and LC(100)) for 7-day P. promelas exposures to chlorothalonil were 14.4 and 30.8 microg/L, respectively, in contrast to the lower and upper threshold values, 103 and 210 microg/L, respectively, for C. dubia. Ten-day exposures of C. dubia to chlorpyrifos resulted in lower and upper threshold values of 0.05 and 0.09 microg/L, whereas 10-day exposures of P. promelas to chlorpyrifos yielded threshold values of 26 and 274 microg/L. The results of this study illustrated differences in species' sensitivities to chlorothalonil and chlorpyrifos as well as differences in the duration of the exposure necessary to illustrate effects that might be elicited from pesticide exposures.
Asunto(s)
Cloropirifos/toxicidad , Cladóceros , Cyprinidae , Fungicidas Industriales/toxicidad , Insecticidas/toxicidad , Nitrilos/toxicidad , Contaminantes Químicos del Agua/toxicidad , Agricultura , Animales , Agricultura Forestal , Dosificación Letal Mediana , Factores de TiempoRESUMEN
Laboratory studies of algicide toxicity to algal species provide information to improve the efficacy and efficiency of copper-containing algicides in actual field situations. The objectives of this study were (1) to measure the influence of copper form, initial concentration, and duration of exposure on the response of Raphidocelis subcapitata, a planktonic freshwater green alga; (2) to determine the contact time required for these copper-containing algicides (Clearigate, Cutrine-Plus, and copper sulfate) and the target species to obtain control; (3) to measure the critical burden of the three algicides required to obtain control of R. subcapitata; (4) to measure the residence time of the copper applied as the algicides in the water column of three waters having different water characteristics ( i.e., alkalinity, hardness, pH, and conductivity); and (5) to contrast exposures of copper (as algicides) required to control algae and the lower thresholds causing adverse effects on sensitive nontarget animal species. Algal control (EC(100)) was accomplished at 55.8, 117.5, and 187.5 microg Cu/L for CuSO(4), Cutrine-Plus and Clearigate with a contact time of 3 days in all cases. The critical burdens of copper (concentration sorbed by the algae) were 4.2, 7.3, and 7.9 microg Cu/mg algae (dry weight) for CuSO(4), Cutrine-Plus, and Clearigate, respectively. Because algicide toxicity generally decreases as cell density increases, the density of cells in algal blooms may hamper algicide effectiveness even at maximum label application rates. Determinations of critical burdens for algicides and target algal species provide necessary information to forecast the performance of algicide applications in field situations. The margin of safety ( i.e., the difference between the concentration where control of algae was obtained and the lower threshold concentration causing adverse effects on nontarget species) was greatest for Cutrine-Plus. However, the margins of safety are minimal (< 0, 12.5, and 82.5 microg Cu/L for Ceriodaphnia dubia exposed to CuSO(4), Clearigate, and Cutrine-Plus, respectively) when they are applied according to their labels.
Asunto(s)
Amino Alcoholes/toxicidad , Antídotos/toxicidad , Chlorophyta , Sulfato de Cobre/toxicidad , Cobre/química , Etanolamina/toxicidad , Herbicidas/toxicidad , Compuestos Organometálicos/toxicidad , Contaminantes Químicos del Agua/toxicidad , Cobre/toxicidad , Etanolaminas , Eutrofización , Dosificación Letal Mediana , Control de Plagas , Dinámica Poblacional , Agua/químicaRESUMEN
Constructed wetlands have been proposed as a potential best management practice (BMP) to mitigate effects of pesticide-associated agricultural runoff. Wetland mesocosms (14 m x 59-73 m) were amended with chlorpyrifos to simulate a storm runoff event at concentrations of 73, 147 and 733 microg/l. Water, sediment and plant samples collected weekly for 12 weeks indicated that chlorpyrifos rapidly sorbed to sediment and plant material, with approximately 47-65% of measured chlorpyrifos mass retained within the first 30-36 m of wetland mesocosms. Of the measured mass, approximately 55% and 25% were retained by sediments and plants, respectively. A field-scale evaluation of a constructed wetland's mitigation capability was performed in the Lourens River watershed of Cape Town, South Africa. Results indicate that the wetland was able to retain and considerably decrease the concentration (and hence toxicity) of chlorpyrifos and suspended sediment entering the receiving waterbody (Lourens River). This research provides fundamental answers concerning constructed wetland capabilities that are necessary for constructing field-scale systems within agricultural watersheds.
Asunto(s)
Cloropirifos/análisis , Ecosistema , Insecticidas/análisis , Modelos Teóricos , Movimientos del Agua , Agricultura , Disponibilidad Biológica , Monitoreo del Ambiente , Sedimentos Geológicos/química , Plantas/química , Contaminación del Agua/prevención & controlRESUMEN
BACKGROUND: The unique pharmacological properties of buprenorphine may make it a useful maintenance therapy for opiate addiction. This meta-analysis considers the effectiveness of buprenorphine relative to methadone. METHODS: A systematic literature search identified five randomized clinical trials comparing buprenorphine to methadone. Data from these trials were obtained. Retention in treatment was analyzed with a Cox proportional hazards regression. Urinalyses for opiates were studied with analysis of variance and a common method of handling missing values. A meta-analysis was used to combine these results. RESULTS: Subjects who received 8-12 mg/day buprenorphine had 1.26 times the relative risk of discontinuing treatment (95% confidence interval 1.01-1.57) and 8.3% more positive urinalyses (95% confidence interval 2.7-14%) than subjects receiving 50-80 mg/day methadone. Buprenophrine was more effective than 20-35 mg/day methadone. There was substantial variation in outcomes in the different trials. CONCLUSIONS: The variation between trials may be due to differences in dose levels, patient exclusion criteria and provision of psychosocial treatment. The difference in the effectiveness of buprenorphine and methadone may be statistically significant, but the differences are small compared to the wide variance in outcomes achieved in different methadone treatment programs. Further research is needed to determine if buprenorphine treatment is more effective than methadone in particular settings or in particular subgroups of patients.
Asunto(s)
Buprenorfina/uso terapéutico , Metadona/uso terapéutico , Narcóticos/uso terapéutico , Trastornos Relacionados con Opioides/rehabilitación , Análisis de Varianza , Humanos , Narcóticos/orina , Trastornos Relacionados con Opioides/orina , Cooperación del Paciente , Pacientes Desistentes del Tratamiento/estadística & datos numéricos , Modelos de Riesgos Proporcionales , Resultado del TratamientoRESUMEN
The vascular macrophyte Typha latifolia Linnaeus (common cattail) may be a sentinel for evaluating potential phytotoxicity to rooted aquatic macrophytes in aquatic systems. To further evaluate the potential utility of this species, T. latifolia seed germination, shoot growth, and root elongation were measured in 7-day aqueous exposures using mean measured aqueous copper concentrations of 10.0, 23, 41, 62, 174, and 402 microg Cu/L, which were > or = 62% of nominal concentrations. Seed germination and seedling shoot growth were not significantly affected by any of these copper concentrations as compared to controls. Mean measured no-observed-effect-concentration (NOEC) and lowest-observed-effect-concentration (LOEC) for root elongation were 18.6 microg Cu/L and 35.0 microg Cu/L, respectively. Seven-day sediment tests were conducted by amending uncontaminated sediments with copper sulfate to mean measured concentrations of 7.9, 17.1, 21.0, 51.2, 89.5, and 173.5 mg Cu/kg, which were > or = 84% of nominal concentrations. Seed germination was not significantly different from controls. Mean measured NOEC and LOEC values for seedling shoot growth were 89.5 mg Cu/kg and 173.5 mg Cu/kg, respectively, and mean measured NOEC and LOEC values for root growth were 14.0 mg Cu/kg and 19.7 mg Cu/kg, respectively. These results demonstrate that T. latifolia early seedling growth can be utilized for assessing aqueous and sediment toxicity of copper.
Asunto(s)
Sulfato de Cobre/farmacología , Germinación/efectos de los fármacos , Poaceae/crecimiento & desarrollo , Semillas/crecimiento & desarrollo , Poaceae/efectos de los fármacos , Semillas/efectos de los fármacos , Contaminantes del Suelo/análisis , Contaminantes Químicos del Agua/análisisRESUMEN
In designing aquatic herbicides containing copper, an important goal is to maximize efficacy for target species while minimizing risks for nontarget species. To have a margin of safety for nontarget species, the concentration, duration of exposure (i.e., uptake), and form (i.e., species) of copper used for herbicidal properties should not elicit adverse effects on populations of nontarget species. To determine the potential for risk or adverse effects (conversely the margin of safety), data regarding the comparative toxicity of copper-containing herbicides are crucial. A series of comparative toxicity experiments was conducted, including baseline estimates of toxicity (LC50s, LOECs), sensitive species relationships (thresholds and exposure-response slopes), and bioavailability of toxic concentrations and forms of copper 7 days after initial herbicide application. Aqueous 48-h toxicity experiments were performed to contrast responses of Daphnia magna Strauss, Hyalella azteca Saussure, Chironomus tentans Fabricius, and Pimephales promelas Rafinesque to copper herbicides: Clearigate(R), Cutrine(R)-Plus, and copper sulfate. D. magna was the most sensitive aquatic animal tested for all three herbicides; 48-h LC50s for organisms exposed to Clearigate, Cutrine-Plus, and copper sulfate were 29.4, 11.3, and 18. 9 microg Cu/L, respectively. In terms of potency (calculated from the linearized portion of the exposure-response curves, which included 50% mortality), D. magna was the most sensitive animal tested. Organisms exposed to Clearigate, Cutrine-Plus, and copper sulfate had exposure-response slopes of 2.55, 8.61, and 5.07% mortality/microg Cu/L, respectively. Bioavailability of Clearigate and Cutrine-Plus was determined by comparing survival data (LC50s) of test organisms exposed to herbicide concentrations during the first and last 48-h of a 7-day exposure period. Even in these relatively simplified water-only exposures, a transformation of copper to less bioavailable species over time was observed with a 100-200% decrease in toxicity (i.e., an increase in 48-h LC50s) for all four test animals. This series of laboratory experiments provides a worst-case scenario for determining the risk associated with the manufacturer's recommended application rates of Clearigate (100-1,000 microg Cu/L), Cutrine-Plus (200-1,000 microg Cu/L), and copper sulfate (100-500 microg Cu/L) in natural waters for four nontarget freshwater animals.
Asunto(s)
Chironomidae/efectos de los fármacos , Cobre , Cyprinidae , Daphnia/efectos de los fármacos , Herbicidas/farmacocinética , Herbicidas/toxicidad , Amino Alcoholes/farmacocinética , Amino Alcoholes/toxicidad , Animales , Disponibilidad Biológica , Chironomidae/metabolismo , Sulfato de Cobre/farmacocinética , Sulfato de Cobre/toxicidad , Cyprinidae/metabolismo , Daphnia/metabolismo , Relación Dosis-Respuesta a Droga , Etanolamina/farmacocinética , Etanolamina/toxicidad , Etanolaminas , Agua Dulce , Dosificación Letal Mediana , Compuestos Organometálicos/farmacocinética , Compuestos Organometálicos/toxicidadRESUMEN
OBJECTIVE: This study describes differences between public and private substance abuse treatment programs. METHOD: Data from the National Drug and Alcoholism Treatment Unit Survey (NDATUS) were analyzed with regression models that evaluated the association between ownership and program characteristics. RESULTS: Programs operated by state and local government and nonprofit agencies had more staff, but federal and for-profit programs employed more psychologists and medical doctors. We found that, in most treatment settings, for-profit programs were smaller and more likely to specialize in providing treatment in a single setting. Methadone maintenance programs were larger when operated under for-profit ownership, however. For-profit programs received more funding from private insurance and client fees. CONCLUSIONS: We found substantial differences between public and private programs, but this division was not strictly dichotomous. Federal programs differed from public programs operated by state and local governments. Programs operated by nonprofit agencies had characteristics that placed them between private for-profit and public programs. State and local agencies are contracting with private managed behavioral health care organizations to provide sub stance abuse treatment and other mental health care. The characteristics of for-profit programs may represent the future direction of substance abuse treatment.
Asunto(s)
Servicios de Salud Mental/economía , Sector Privado/economía , Sector Público/economía , Centros de Tratamiento de Abuso de Sustancias/economía , Humanos , Seguro de Salud/economía , Análisis Multivariante , Trastornos Relacionados con Sustancias/rehabilitación , Estados UnidosRESUMEN
This study evaluated the effectiveness of constructed wetlands for tertiary treatment of a petroleum refinery effluent. Specific performance objectives were to decrease 5-day biochemical oxygen demand (BOD(5)) and ammonia by at least 50% and to reduce toxicity associated with this effluent. Two bench-scale wetlands (replicates) were constructed in a greenhouse to provide tertiary treatment of effluent samples shipped from the refinery to the study site. Integrated wetland features included Typha latifolia Linnaeus planted in low organic (0.2%), sandy sediment, 48-h nominal hydraulic retention time, and 15-cm overlying water depth. Targeted constituents and aqueous toxicity were monitored in wetland inflows and outflows for 3 months. Following a 2 to 3-week stabilization period, effective and consistent removal of BOD(5) and ammonia (as NH(3)-N) from the effluent was observed. Average BOD(5) removal was 80%, while NH(3)-N decreased by an average of 95%. Survival of Pimephales promelas Rafinesque and Ceriodaphnia dubia Richard (7-day, static, renewal exposures) increased by more than 50% and 20%, respectively. Reproduction of C. dubia increased from zero in undiluted wetland inflow to 50% of controls in undiluted wetland outflow. This study demonstrated the potential for constructed wetlands to decrease BOD(5), ammonia, and toxicity in this refinery effluent.
Asunto(s)
Residuos Industriales , Oxígeno/metabolismo , Petróleo , Plantas/efectos de los fármacos , Amoníaco/química , Relación Dosis-Respuesta a Droga , Factores de TiempoRESUMEN
Atrazine was amended into constructed wetlands (59-73x14x0.3 m) for the purpose of monitoring transport and fate of the pesticide to obtain information necessary to provide future design parameters for constructed wetlands mitigation of agricultural runoff. Following pesticide amendment, a simulated storm and runoff event equal to three volume additions was imposed on each wetland. Targeted atrazine concentrations were 0 microg/l (unamended control), 73 microg/l, and 147 microg/l. Water, sediment, and plant samples were collected weekly for 35 days from transects longitudinally distributed throughout each wetland and were analyzed for atrazine using gas chromatography. Between 17 and 42% of measured atrazine mass was within the first 30-36 m of wetlands. Atrazine was below detection limits (0.05 microg/kg) in all sediment and plant samples collected throughout the duration of this study. Aqueous half lives ranged from 16 to 48 days. According to these data, conservative buffer travel distances of 100-280 m would be necessary for effective runoff mitigation.
RESUMEN
Effects of a homologous series of three primarily linear alcohol ethoxylate surfactants were studied in laboratory flow-through 28-day early-life-stage tests with fathead minnow (Pimephales promelas Rafinesque). Surfactants were a C(9-11), C(12-13), and C(14-15) with an average of 6, 6.5, and 7 ethylene oxide units per mole of alcohol, respectively. Average measured surfactant recoveries were 103%, 81%, and 79% of nominal concentrations for the C(9-11) EO 6, C(12-13) EO 6.5, and C(14-15) EO 7 studies, respectively. Embryo survival at 48 h was not adversely affected at any of the concentrations tested. Impaired hatching and deformed fry were observed only in the C(12-13) EO 6.5 study. The 28-day LC50 values were 4.87, 2.39, and 1.02 mg/L for the C(9-11) EO 6, C(12-13) EO 6.5, and C(14-15) EO 7 surfactants, respectively. The corresponding NOECs for survival were 1.01, 1.76, and 0.74 mg/L. Posthatch fry growth was more sensitive than survival for the C(12-13) EO 6.5 and C(14-15) EO 7 surfactants. Survival of posthatch fry decreased with increasing surfactant alkyl chain length. Twenty-eight-day laboratory data were compared to 96-h laboratory, 10-day laboratory and 30-day stream mesocosm data for fathead minnow previously determined for these surfactants. Survival endpoints from the different exposures were comparable and only varied within a factor of two. Similarity of results suggests that it is possible to effectively use 96-h, 10-day, or 28-day laboratory data to predict environmental effects concentrations of these surfactants for fish. http://link.springer-ny. com/link/service/journals/00244/bibs/37n4p536.html++ +HEA
Asunto(s)
Cyprinidae , Óxido de Etileno/toxicidad , Tensoactivos/toxicidad , Alcoholes/toxicidad , Animales , Cyprinidae/embriología , Embrión no Mamífero/efectos de los fármacos , Óxido de Etileno/análogos & derivados , Concentración de Iones de Hidrógeno , Relación Estructura-Actividad , Temperatura , Pruebas de Toxicidad/métodosRESUMEN
Two microcosm-scale wetlands (570-liter containers) were integratively designed and constructed to investigate transfers and transformations of zinc associated with an aqueous matrix, and to provide future design parameters for pilot-scale constructed wetlands. The fundamental design of these wetland microcosms was based on biogeochemical principles regulating fate and transformations of zinc (pH, redox, etc.). Each wetland consisted of a 45-cm hydrosoil depth inundated with 25 cm of water, and planted with Scirpus californicus. Zinc ( approximately 2 mg/liter) as ZnCl2 was amended to each wetland for 62 days. Individual wetland hydraulic retention times (HRT) were approximately 24 h. Total recoverable zinc was measured daily in microcosm inflow and outflows, and zinc concentrations in hydrosoil and S. californicus tissue were measured pre- and post-treatment. Ceriodaphnia dubia and Pimephales promelas7-day aqueous toxicity tests were performed on wetland inflows and outflows, and Hyalella azteca whole sediment toxicity tests (10-day) were performed pre- and post-treatment. Approximately 75% of total recoverable zinc was transferred from the water column. Toxicity decreased from inflow to outflow based on 7-day C. dubia tests, and survival of H. azteca in hydrosoil was >80%. Data illustrate the ability of integratively designed wetlands to transfer and sequester zinc from the water column while concomitantly decreasing associated toxicity.
Asunto(s)
Ecosistema , Plantas/metabolismo , Eliminación de Residuos Líquidos/métodos , Contaminantes Químicos del Agua/metabolismo , Purificación del Agua/métodos , Zinc/metabolismo , Animales , Biotransformación , Chironomidae/efectos de los fármacos , Crustáceos/efectos de los fármacos , Oxidación-Reducción , Suelo/análisis , Tasa de Supervivencia , Pruebas de Toxicidad , Eliminación de Residuos Líquidos/instrumentación , Contaminantes Químicos del Agua/toxicidad , Purificación del Agua/instrumentación , Zinc/toxicidadRESUMEN
BACKGROUND: The Department of Veterans Affairs is adopting the Decision Support System (DSS), computer software and databases which include a cost-accounting system which determines the cost of health care products and patient encounters. OBJECTIVES: A system for providing cost data for cost-effectiveness analysis should be provide valid, detailed, and comprehensive data that can be aggregated. METHODS: The design of DSS is described and compared with those criteria. Utilization data from DSS was compared with other VA utilization data. Aggregate DSS cost data from 35 medical centers was compared with relative resource weights developed for the Medicare program. RESULTS: Data on hospital stays at 3 facilities found that 3.7% of the stays in DSS were not in the VA discharge database, whereas 7.6% of the stays in the discharge data were not in DSS. DSS reported between 68.8% and 97.1% of the outpatient encounters reported by six facilities in the ambulatory care data base. Relative weights for each Diagnosis Related Group based on DSS data from 35 VA facilities correlated with Medicare weights (correlation coefficient of .853). CONCLUSIONS: DSS will be useful for research if certain problems are overcome. It is difficult to distinguish long-term from acute hospital care. VA does not have a complete database of all inpatient procedures, so DSS has not assigned them a specific cost. The authority to access encounter-level DSS data needs to be centralized. Researchers can provide the feedback needed to improve DSS cost estimates. A comprehensive encounter-level extract would facilitate use of DSS for research.
Asunto(s)
Análisis Costo-Beneficio/métodos , Sistemas de Apoyo a Decisiones Administrativas , Investigación sobre Servicios de Salud/métodos , Hospitales de Veteranos/economía , United States Department of Veterans Affairs/economía , Costos de la Atención en Salud/estadística & datos numéricos , Investigación sobre Servicios de Salud/economía , Costos de Hospital/estadística & datos numéricos , Humanos , Reproducibilidad de los Resultados , Estados UnidosRESUMEN
Sediments were collected from Steilacoom Lake, Pierce County, in Washington State, and amended with copper sulfate (nominal concentrations of 800, 1,000, 1,500, and 2,000 mg Cu/kg dry weight) to assess copper bioavailability to Hyalella azteca, Chironomus tentans, or Ceriodaphnia dubia. H. azteca survival and C. tentans survival and growth were not significantly affected, with 10-day no observed effects concentrations (NOEC) and lowest observed effects concentrations (LOEC) of 2,010 and >2,010 mg Cu/kg, respectively. C. dubia was the most sensitive organism tested with 10-day NOEC and LOECs for survival and reproduction of 906 and 1,469 mg Cu/kg, respectively. Sediment AVS concentrations were <0.15 micromol/g, while simultaneously extracted metal (SEM) concentrations were >/=5. 71 micromol Cu/g. Dissolved interstitial water concentrations ranged from below detection (0.010 mg/L) to 0.24 mg Cu/L, with interstitial water toxicity units as high as 3.4. Based on this study, effects to C. dubia may occur at bulk sediment concentrations >906 mg Cu/kg. Further, AVS and interstitial water concentrations are not accurate predictors of copper bioavailability in Steilacoom Lake.
Asunto(s)
Cobre/farmacocinética , Contaminantes Ambientales/farmacocinética , Animales , Disponibilidad Biológica , Chironomidae/metabolismo , Crustáceos/metabolismo , Daphnia/metabolismo , Sedimentos GeológicosRESUMEN
Responses of aquatic invertebrates to 30-day exposures to a nonionic linear alcohol ethoxylate (LAE) surfactant (C12-13AE-6.5) were evaluated in 10 outdoor stream mesocosms. Responses were measured as changes in invertebrate densities and invertebrate drift densities during a 14-day pretreatment period, a 30-day treatment period, and a 14-day posttreatment period relative to untreated control stream densities. Mean measured surfactant concentrations in duplicate streams were 0.32, 0.88, 1.99, and 5.15 mg LAE/liter, with two streams serving as untreated controls. Statistically significant effects were observed on simulid, copepod, and cladoceran population densities during the treatment period. Based on these effects, the no-observed-effect concentration (NOEC) for invertebrate densities was <0.32 mg LAE/liter and the lowest-observed-effect concentration (LOEC) was 0.32 mg LAE/liter. No statistically significant differences due to treatment were detected in drifting invertebrates; however, a trend was observed with increased numbers of invertebrates drifting in the streams treated with 5.15 mg LAE/liter as compared with controls.
Asunto(s)
Alcoholes/efectos adversos , Ecosistema , Glicoles de Etileno/efectos adversos , Agua Dulce/química , Invertebrados/efectos de los fármacos , Contaminantes Químicos del Agua/efectos adversos , Análisis de Varianza , AnimalesRESUMEN
The effects of exposure duration, test organism, and test endpoint on the toxicity of cadmium to a variety of freshwater species were evaluated. Toxicity of cadmium was assessed by monitoring the survival and reproduction of Ceriodaphnia dubia Richard; the survival of Daphnia magna Straus; and the survival and growth of Hyalella azteca Saussure, Chironomus tentans Fabricius, and Pimephales promelas Rafinesque. Organisms were exposed in static systems for 48 h, 96 h, 7 d, 10 d, and 14 d to determine acute and chronic toxicity. Relative sensitivities of test organisms exposed to aqueous cadmium varied with test duration and test endpoint. In general, H. azteca was the most sensitive organism tested, followed in decreasing sensitivity by P. promelas, C. dubia, D. magna, and C. tentans. Mortality of C. dubia and D. magna was consistent up to 7 d, after which little additional mortality occurred. Effects of test duration on cadmium toxicity were most pronounced for H. azteca and C. tentans, with mortality and growth becoming increasingly sensitive with increasing test duration.
Asunto(s)
Cadmio/toxicidad , Chironomidae/efectos de los fármacos , Crustáceos/efectos de los fármacos , Peces , Agua Dulce/química , Contaminantes Químicos del Agua/toxicidad , Animales , Pruebas de ToxicidadRESUMEN
Sediments that represented a wide range of characteristics were amended with silver compounds to observe partitioning and bioavailability. In laboratory studies, silver partitioning to particulates, sediment pore water, and overlying water was measured and bioavailability of silver was determined using Hyalella azteca in 10-day sediment toxicity tests. Three silver compounds were used as sources of silver for this study: silver nitrate, silver chloride, and silver thiosulfate complex. Sediment amendment procedures were adjusted as necessary depending on the characteristics of the individual compounds. Several sediment characteristics such as organic carbon, pH, redox, and acid volatile sulfides regulated silver partitioning and bioavailability. Bioavailability of silver was correlated with the overlying water concentration of silver. Ten-day LC50 values ranged from 1.62 to 379.7 mg Ag/kg for H. azteca exposed to sediments amended with AgNO3. In laboratory experiments, silver chloride and silver thiosulfate were orders of magnitude less toxic and bioavailable than silver nitrate, with 10-day LC50 values greater than the highest concentrations of AgCl and silver thiosulfate complex amended to sediments (2560 and 1125 mg Ag/kg, respectively.