Low rCBV values in glioblastoma tumor progression under chemoradiotherapy.

PURPOSE: After standard treatment for glioblastoma, perfusion MRI remains challenging for differentiating tumor progression from post-treatment changes. Our objectives were (1) to correlate rCBV values at diagnosis and at first tumor progression and (2) to analyze the relationship of rCBV values at tumor recurrence with enhancing volume, localization of tumor progression, and time elapsed since the end of radiotherapy in tumor recurrence. METHODS: Inclusion criteria were (1) age > 18 years, (2) histologically confirmed glioblastoma treated with STUPP regimen, and (3) tumor progression according to RANO criteria > 12 weeks after radiotherapy. Co-registration of segmented enhancing tumor VOIs with dynamic susceptibility contrast perfusion MRI was performed using Olea Sphere software. For tumor recurrence, we correlated rCBV values with enhancing tumor volume, with recurrence localization, and with time elapsed from the end of radiotherapy to progression. Analyses were performed with SPSS software. RESULTS: Sixty-four patients with glioblastoma were included in the study. Changes in rCBV values between diagnosis and first tumor progression were significant (p < 0.001), with a mean and median decreases of 32% and 46%, respectively. Mean rCBV values were also different (p < 0.01) when tumors progressed distally (radiation field rCBV values of 1.679 versus 3.409 distally). However, changes and, therefore, low rCBV values after radiotherapy in tumor recurrence were independent of time. CONCLUSION: Chemoradiation alters tumor perfusion and rCBV values may be decreased in the setting of tumor progression. Changes in rCBV values with respect to diagnosis, with low rCBV in tumor progression, are independent of time but related to the site of recurrence.

A solar evaporator fabricated from corncob waste for the desalination of seawater and removal of oil/herbicides from contaminated water.

Corncob (CC) based solar evaporators were employed to desalinize seawater brought from the Vallarta coast in Mexico. The pure CC produced an evaporation-rate and evaporation-efficiency of 0.63 kg m-2 h-1 and 38.4%, respectively, under natural solar light. Later, the CC was coated with carbonized CC (CCCE evaporator) or was coated with graphene (CCGE evaporator). Those evaporators were used for the desalination of seawater and obtained higher evaporation rates of 1.59-1.67 kg m-2 h-1, and higher evaporation efficiencies of 92-94% (under natural solar light). The desalination experiments were repeated under artificial solar light and the evaporation-rates/evaporation-efficiencies slightly decreased to 1.43-1.52 kg m-2 h-1/88-92%. The surface analysis of the evaporators by FTIR, XPS and Raman revealed that the CCGE evaporator had on its surface a lower content of defects and a higher amount of OH groups than the CCCE evaporator. Therefore, the CCGE evaporator had higher evaporation-rates/evaporation-efficiencies in comparison with the CCCE evaporator. Furthermore, we purified water contaminated with three different herbicides (fomesafen, 2-6 dichlorobenzamide and 4-chlorophenol at 30 ppm) by evaporation and using natural solar light. Interestingly, the CCCE and CCGE evaporators also removed the herbicides by physical adsorption with efficiencies of 12-22.5%. Moreover, the CCGE evaporator removed vegetable oil from contaminated water by adsorption and its maximum adsorption capacity was 1.72 g/g. Overall, our results demonstrated that the corncob-based evaporators studied here are a low-cost alternative to obtain clean water under natural solar light and this one was more effective for the desalination of seawater than the artificial sunlight (Xe lamp).

Development of a visible-light-active-NiTiO3 coating for the efficient removal of the persistent herbicide 2,6-dichlorobenzamide (BAM) from drinking water.

In the present research work, the photocatalytic evaluation of NiTiO3 nanoparticles immobilized on glass plates by the spin-coating procedure was carried out in the degradation of the recalcitrant herbicide 2,6-dichlorobenzamide (BAM). The concentrations of Ni employed to synthesize NiTiO3 nanoparticles were 1 wt% (1TESNi) and 2 wt% (2TESNi). The stability of coatings was evaluated by several washings and thermal treatments, which were verified by UV-vis analyses. The morphology of the coatings was studied by scanning electron microscopy (SEM-EDS). The coatings displayed thickness values of 1.35 and 2.56 µm for TiO2 and 1TESNi, respectively. The crystalline phases of the coatings were analyzed by X-ray diffraction (XRD), confirming the presence of NiTiO3 and other phases related to TiO2. The bandgap of 1TESNi, compared with the bare TiO2, was reduced from 2.96 to 2.40 eV as a consequence of Ni addition. The TiO2, 1TESNi and 2TESNi coatings were evaluated in the photodegradation of BAM using visible-light for 240 min. The highest effectiveness was displayed by the 1TESNi coating, obtaining degradation of 92.56% after 240 min. Also, the photocatalytic efficiency of the 1TESNi coating was only reduced 1.99% after 3 reuse cycles in the BAM degradation. The scavenger tests revealed that the main oxidizing species involved in the reaction were the •OH- and •O2- radicals. The 1TESNi coating showed the highest photocatalytic efficiency because of its absorption in the visible-light region, valuable surface area and electronic charge separation. Thus, these advantageous features guarantee that NiTiO3 coatings are an efficient method for degrading recalcitrant herbicides from drinking water using a practical way to recover and reuse photocatalysts.

Novel polypropylene-TiO2:Bi spherical floater for the efficient photocatalytic degradation of the recalcitrant 2,4,6-TCP herbicide.

In this work, spherical photocatalytic floaters were fabricated by depositing TiO2:Bi (TBi) particles on polypropylene (PP) spheres (recycled from beer cans). These particles were deposited on the sphere (TBi-sphere) by the spray coating technique and evaluated their performance for the photocatalytic degradation of 2,4,6-trichlorophenol (2,4,6-TCP) herbicide. SEM images demonstrated that the BTi powders consisted in conglomerated grains with sizes of 20-80 nm and the analysis by X-ray diffraction confirmed the presence of rutile and anatase phases in the BTi. The photocatalytic experiments showed that the TBi and TBi-sphere produced maximum degradation of 90 and 97% for 2,4,6-TCP, respectively, after 4 h under UV-Vis light. The photocatalytic powders/composites were reused 3 times and the loss of degradation efficiency was 3 and 16% for the TBi powder and TBi-sphere, respectively. This means that the TBi-sphere is more stable for the continuous degradation of the 2,4,6-TCP contaminant. The TiO2:Bi powder was compared with the commercial TiO2 (P25) and found that the TiO2:Bi powder had higher light absorption (≈42%) and higher surface area (≈105%) than the P25. Therefore, the degradation percentage for the 2,4,6-TCP was 52% higher in the sample doped with Bi. Also, scavenger experiments were carried out and found that the main oxidizing agents produced for the degradation of 2,4,6-TCP were •OH- radicals and •O2- anions. Other species such as h+ were also produced at lower amount. Hence, our results demonstrated that spherical/floatable photocatalytic composites are a viable option to remove herbicide residuals from the water, which is of interest in water-treatment-plants.

An eco-friendly and sustainable support of agave-fibers functionalized with graphene/TiO2:SnO2 for the photocatalytic degradation of the 2,4-D herbicide from the drinking water.

In this research, we evaluated the photocatalytic performance of biodegradable composites for the removal of the 2,4-Dichlorophenoxyacetic acid (2,4-D) herbicide. The composite was composed by agave fibers (AgF), graphene-microplates (GM) and titanium dioxide TiO2/SnO2 (TSn) nanoparticles (NPs) and was named TSn + AgF/GM. Both, the TSn NPs and the GM were deposited on the AgF using the Dip-coating method. According to the analysis by X-Ray Diffraction (XRD), the crystalline phase for the TiO2 and SnO2 was anatase and tetragonal-rutile, respectively. The Scanning Electron Microscopy (SEM) images demonstrated that the AgF were completely saturated by the GM (which had average dimensions of 15 µm × 22 µm) and by conglomerations of TSn NPs with average size of 642 nm. The TSn NPs and the TSn + AgF/GM composite were evaluated for the photocatalytic degradation of the 2,4-D herbicide under ultraviolet-visible (UV-Vis) light and found a maximum degradation of 98.4 and 93.7% (after 4 h) for the TSn NPs and the TSn + AgF/GM composite, respectively. Reuse cycles were also performed and the degradation percentage decreased by 13.1% and by 7.8% (after 3 cycles of reuse) when the TSn NPs and the TSn + AgF/GM composite are employed, respectively. Scavenger experiments were also carried out and found that the oxidizing agents are mainly produced in the order of: •OH>•O2- > h+; then, the main oxidizing agents generated during the photocatalytic reaction were the hydroxyl radicals. Thus, the photocatalytic system studied in this work for the degradation of 2,4-D could pave the way for the development of new eco-friendly/floatable photocatalysts, which can be applied in wastewater-treatment plants.

A sustainable and green chlorophyll/TiO2:W composite supported on recycled plastic bottle caps for the complete removal of Rhodamine B contaminant from drinking water.

This investigation reports the photocatalytic performance of the tungsten doped titania (TiO2:W or TW) with and without coating of chlorophyll (Chl) for the removal of the RhB dye from the drinking water. These particles were also supported on recycled plastic bottle caps (Bcap) to form other photocatalytic composites (TW/Bcap and TW + Chl/Bcap). The SEM images demonstrated that the TW particles without Chl had irregular shapes and sizes of 0.8-12 µm. The TW particles coated by the Chl presented shapes of quasi-rounded grains and smaller particle sizes of 0.8-1.8 µm. The photocatalytyic experiments showed that the photocatalyst powders containing Chl removed completely the RhB dye from the water after 2h under UV-VIS light, while the photocatalyst without Chl removed a maximum of 95% of the RhB. Interestingly, the TW/Bcap and TW + Chl/Bcap composites removed 94-100% of the RhB after 2h. Those ones removed such dye by photocatalysis and by physical adsorption at the same time (as confirmed by the absorbance and FTIR measurements), therefore, the removal of RhB was still very high. Scavenger experiments were also achieved and found that the •OH radicals are the main oxidizing species generated by the photocatalysts with and without Chl. The •O2- radicals and holes (h+) were the secondary oxidizing species. The presence of the chlorophyll on the photocatalyst increased in general the light absorption and the photocurrent. Overall, our work demonstrated that making composites with recycled plastic bottle caps is a feasible alternative to remove dyes from contaminated drinking water with high efficiency and low cost.

Photocatalytic materials immobilized on recycled supports and their role in the degradation of water contaminants: A timely review.

Global concern about environmental pollution has increased in recent times due to the cumulative harmful impact on the human health occasioned by the diverse toxic substances released into the environment. Water reduced availability for human consumption and its pollution have been paid so much attention due to their relevance in agricultural and industrial activities. In this context, the advanced oxidation processes for removing contaminants from water, more specifically photocatalytic processes, have displayed their usefulness due to features such as easy application, low-cost, harmless effects and sustainable decontamination efficiency. This timely review is centered on worldwide studies, where efforts aimed at employing recycled materials as supports for purification applications such as the removal of different contaminants (dyes, pharmaceutical contaminants, and heavy metals) dissolved in aqueous environments have been reported. Materials like polyethylene terephthalic (PET), polystyrene (PS), disposal textile fabrics, newspapers, aluminum soda cans, rubber, waste electronic and electric components and used batteries have been employed either as supports for immobilizing catalysts or as photocatalysts. The present work offers a discussion of the ways through which photocatalytic composites have been immobilized or produced, employed characterization techniques, removal efficiencies achieved during photocatalytic degradation and possible degradation mechanism of pollutants; not only the highlights of all these studies are discussed, but also paths for future research works that could help improve the reported results are suggested. These new practical tools stand as novel sustainable strategies for the removal of emerging contaminants reusing waste flexible materials.

Efficient solar removal of acetaminophen contaminant from water using flexible graphene composites functionalized with Ni@TiO2:W nanoparticles.

This work presents the morphological, structural and photocatalytic properties of flexible graphene composites decorated with Ni@TiO2:W nanoparticles (TiNiW NPs) with an average size of 27 ± 2 nm. The TiNiW NPs were immobilized on the surface of a flexible graphene composite using a PVA-based slurry-paste (FG/TiNiW composite). The SEM study showed that the TiNiW NPs remained exposed on the surface of the FG/TiNiW composite, which benefited its photocatalytic activity. The photocatalytic performance for the degradation of acetaminophen (ACT) was evaluated using both the TiNiW powders and the FG/TiNiW composite, obtaining maximum degradation efficiencies of 100 and 86%, respectively, after 3 h under natural solar irradiation. The degradation of ACT was caused mainly by the reactive oxygen species such as OH radicals and h+, which was confirmed by scavenger experiments. Photoluminescence, XPS and absorbance experiments revealed that oxygen vacancy defects were created by i) doping the TiNiW NPs with W and by ii) introducing graphene into the composites. These defects enhanced the absorbance of light in the range of 400-800 nm, which in turn, promoted the photocatalytic degradation of ACT. Moreover, the reuse experiments confirmed that both the TiNiW NPs and FG/TiNiW composite were very stable for the degradation of ACT, since degradation efficiencies >82% were obtained after 4 reuse cycles for both photocatalysts. The experimental findings of this work demonstrate that the flexible TiO2/graphene composites are a feasible option for the removal of pharmaceutical contaminants from water using natural solar irradiation.

Layered double hydroxides and related hybrid materials for removal of pharmaceutical pollutants from water.

Pharmaceuticals and their by-products are recalcitrant contaminants in water. Moreover, the high consumption of these drugs has many detrimental effects on body waters and ecosystems. In this timely review, the advances in molecular engineering of layered double hydroxides (LDH) that have been used for the removal of pharmaceutical pollutants are discussed. The approach starts from the strategies to obtain homogeneous synthesis of LDH that allow the doping and/or surface functionalization of different metals and oxides, producing heterojunction systems as well as composites with carbon and silica-based materials with high surface area. Adsorption is considered as a traditional removal of pharmaceutical pollutants, so the kinetic and mechanism of this phenomenon are analyzed based on pH, temperature, ionic strength, in order to obtain new insights for the formation of multifunctional LDH. Advanced oxidation methodologies, mainly heterogeneous photocatalysis and Fenton-like processes, stand out as the more efficient even to obtain the mineralization of the drugs. The LDH have the advantage of structural memory that favors regeneration processes. The reconstruction of calcined LDH can be used to improve drug removal, through a combination of adsorption capacity/catalytic activity. A meticulous analysis of the persistence, toxicity and bioaccumulation of the most common pharmaceuticals has allowed us to highlight the ability of the LDH to remove recalcitrant drugs at relatively low concentrations (ppm, ppb), in contrast to other mixed oxide nanostructures and homogeneous oxidation processes. In this sense, the mechanism of drug removal by LDH is discussed based on the importance of the use of composites, scavenger agents, Fenton and electro-Fenton processes, membranes, thin films and coatings, among others. In addition, the ecotoxicity of LDH is also reviewed to indicate that these layered structures can exhibit biocompatibility or high toxicity depending on the adsorbed drug and ions/metals that compose them. Undoubtedly, the LDH have a unique flexible structure with adsorption capacity and catalytic activity, facts that explain the important reasons for their extensive use in the environmental remediation of pharmaceutical pollutants from water.

Cerium-doped ß-Ni(OH)2 hexagon nanosheets: an effective photocatalyst for the degradation of the emerging water pollutant, naproxen.

Nickel hydroxide ß-Ni(OH)2 hexagonal nanosheets were synthetized via a hydrothermal exfoliation process. The practical microwave-assisted hydrothermal method facilitated obtaining layered nickel 3D nanoplates with cerium functionalization in 5 h. The as-produced nanostructures were characterized by XRD, XPS, FESEM, FTIR, PL, UV-vis, and BET techniques. The hydroxilated structures are nano-thick hexagonal plates with sides 28 nm in length and an average thickness of 5 nm. UV and PL irradiation was used to study the photoactive properties in the degradation of a pharmaceutical emerging pollutant, naproxen. UV-vis spectroscopy and high-performance liquid chromatography monitoring indicated that the Ni(OH)2-Ce nanostructures are an effective photocatalyst for naproxen degradation, including 40% mineralization of this highly recalcitrant drug. The photocatalyst showed stability for two consecutive cycles, preserving its photoactive and structural characteristics. Ce3+-doped nanoplates and surface functionalized Ce4+ act as charge separators and scavenging agents for the enhanced photodegradation of naproxen.

SEOM clinical guideline of diagnosis and management of low-grade glioma (2017)

Diffuse infiltrating low-grade gliomas include oligodendrogliomas and astrocytomas, and account for about 5% of all primary brain tumors. Treatment strategies for these low-grade gliomas in adults have recently changed. The 2016 World Health Organization (WHO) classification has updated the definition of these tumors to include their molecular characterization, including the presence of isocitrate dehydrogenase (IDH) mutation and 1p/19p codeletion. In this new classification, the histologic subtype of grade II-mixed oligoastrocytoma has also been eliminated. The precise optimal management of patients with low-grade glioma after resection remains to be determined. The risk-benefit ratio of adjuvant treatment must be weighed for each individual (AU)

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SEOM clinical guideline of diagnosis and management of low-grade glioma (2017).

Diffuse infiltrating low-grade gliomas include oligodendrogliomas and astrocytomas, and account for about 5% of all primary brain tumors. Treatment strategies for these low-grade gliomas in adults have recently changed. The 2016 World Health Organization (WHO) classification has updated the definition of these tumors to include their molecular characterization, including the presence of isocitrate dehydrogenase (IDH) mutation and 1p/19p codeletion. In this new classification, the histologic subtype of grade II-mixed oligoastrocytoma has also been eliminated. The precise optimal management of patients with low-grade glioma after resection remains to be determined. The risk-benefit ratio of adjuvant treatment must be weighed for each individual.

Correction to: SEOM clinical guideline of diagnosis and management of low-grade glioma (2017).

The original version of this article unfortunately contained a mistake. Figure 3 was incorrect.

Photo-assisted inactivation of Escherichia coli bacteria by silver functionalized titanate nanotubes, Ag/H2Ti2O5·H2O.

One-dimensional titanate nanotubes (H2Ti2O5·H2O) functionalized with silver nanoparticles (AgNPs) exhibited unique properties for the effective inactivation of the Gram-negative Escherichia coli within 45 minutes under irradiation using a 65 W halogen lamp. The pathway of the photo-assisted catalytic inactivation was examined by SEM and TEM using a reproducible biological protocol for sample preparations. The membrane integrity of the bacteria was damaged due to the oxidative stress caused by the reactive oxygen species, the bacteriostatic effect of the highly-dispersed-surface AgNPs (∼5 nm) and the sharp nanotube penetration that induced the cell death.

Antifungal Nanocomposites Inspired by Titanate Nanotubes for Complete Inactivation of Botrytis cinerea Isolated from Tomato Infection.

Antifungal silver nanocomposites inspired by titanate nanotubes (AgTNTs) were successfully evaluated for the effective inactivation of the phytopathogenic fungus Botrytis cinerea within 20 min. One-dimensional H2Ti3O7 nanotubes functionalized with silver nanoparticles (AgNPs) exhibit unique surface and antifungal properties for the photoinactivation of B. cinerea. Nanostructured titanates were synthesized by the eco-friendly, practical, microwave-induced, hydrothermal method followed by a highly monodispersive AgNP UV-photodeposition. Protonated nanotubes of ∼11 nm in diameter and four-layers displayed high surface areas, 300 m2/g, with a size functionalization of 5 nm for the AgNPs. UV-vis DRS and XPS allowed the characterization and/or quantification of surface reactive species and cytotoxic silver species such as Ag°, Ag+. The effective biocidal properties of the nanocomposites were confirmed by using the well-known Gram-negative bacteria Escherichia coli, and then proceeding to the effective inactivation of the phytopathogenic fungus under visible light. The photoassisted inactivation mechanism was examined by HAADF-STEM, HRTEM, and FESEM electronic microscopies. A plasmalemma invagination due to oxidative stress caused by reactive oxygen, silver cytotoxicity species, and AgTNT sharp morphology damage expands the conidia to induce the cell death. The impact of the eco-friendly inactivation is significant because of the ease with which it is carried out and the possibility of being performed in situ with plants like tomato and grapes, which are ranked among the most valuable agricultural products worldwide.

Facile Synthesis of Decahedral Particles of Anatase TiO2 with Exposed {001} Facets.

This paper reports a facile synthesis of decahedral particles of anatase TiO2 dominated by {101} and {001} faces. The decahedral particles has been enhanced by means a microwave-assisted hydrothermal method using TiF4 as a titanium precursor and HF as capping agent to promote oriented growth and formation of {001} faces in only 4 h. The prepared samples were characterized by scanning electron microscopy, high resolution of transmission electron microscopy and X-ray diffraction. The morphology of anatase TiO2 particles is consisted of near-perfect-truncated-bipyramid-shape. Reaction time is a key factor to obtain truncated-bipyramid-shaped particles with sharp and well-defined edges. Reaction times longer than 4 h induce irregular particles. Decahedral anatase TiO2 particles are truncated bypiramid crystals which have eight {101} and two {001} facets at top/bottom surfaces. The average size of decahedral anatase TiO2 particles are -250 nm for the samples obtained without applying the microwave irradiation and -350 nm for reaction 4 h.

Photoconversion of 4-nitrophenol in the presence of hydrazine with AgNPs-TiO2 nanoparticles prepared by the sol-gel method.

The photocatalytic properties of functionalized TiO2 with silver nanoparticles (AgNPs) for the conversion of 4-nitrophenol to 4-aminophenol in the presence of hydrazine were investigated. The TiO2 semiconductor synthesized by the sol-gel method was functionalized with AgNPs at different loadings, and their structural and optical properties were characterized by several techniques. The functionalized TiO2 with 1.5wt% AgNPs presented the highest photocatalytic activity for the conversion of 4-nitrophenol with appropriate hydrazine concentrations (0.5M). The photoefficiency enhancement under UV light irradiation was attributed to the electron transfer from the TiO2 semiconductor surface to the adsorbed acceptor reactant (4-nitrophenol) through the deposited AgNPs.

A prognostic model based on preoperative MRI predicts overall survival in patients with diffuse gliomas.

BACKGROUND AND PURPOSE: Diffuse gliomas are classified as grades II-IV on the basis of histologic features, with prognosis determined mainly by clinical factors and histologic grade supported by molecular markers. Our aim was to evaluate, in patients with diffuse gliomas, the relationship of relative CBV and ADC values to overall survival. In addition, we also propose a prognostic model based on preoperative MR imaging findings that predicts survival independent of histopathology. MATERIALS AND METHODS: We conducted a retrospective analysis of the preoperative diffusion and perfusion MR imaging in 126 histologically confirmed diffuse gliomas. Median relative CBV and ADC values were selected for quantitative analysis. Survival univariate analysis was made by constructing survival curves by using the Kaplan-Meier method and comparing subgroups by log-rank probability tests. A Cox regression model was made for multivariate analysis. RESULTS: The study included 126 diffuse gliomas (median follow-up of 14.5 months). ADC and relative CBV values had a significant influence on overall survival. Median overall survival for patients with ADC < 0.799 × 10(-3) mm(2)/s was <1 year. Multivariate analysis revealed that patient age, relative CBV, and ADC values were associated with survival independent of pathology. The preoperative model provides greater ability to predict survival than that obtained by histologic grade alone. CONCLUSIONS: ADC values had a better correlation with overall survival than relative CBV values. A preoperative prognostic model based on patient age, relative CBV, and ADC values predicted overall survival of patients with diffuse gliomas independent of pathology. This preoperative model provides a more accurate predictor of survival than histologic grade alone.

Understanding the adsorptive and photoactivity properties of Ag-graphene oxide nanocomposites.

Nanocomposites of graphene oxide (GO) and silver nanoparticles (AgNPs) were synthetized using a practical photochemical silver functionalization. Their photocatalytic activities were evaluated with two dyes, Rhodamine B and Indigo Carmine, under visible-light irradiation. The prepared nanocomposites were characterized by HRTEM, FESEM, XRD, Raman, FTIR and UV-vis absorption spectroscopy. These nanocomposites present new defect domains of sp(3) type in combination with several graphitic functional groups that act as nucleation sites for anchoring AgNPs, while the sp(2)-sp(3) edge defects domains of GO generate the photoactivity. Furthermore, their photocatalytic performances are governed by their large adsorption capacity, and strong interaction with dye chromophores. A comprehensive photocatalytic way underlying the importance of adsorption is suggested to explain the low visible-light responsive photoactivity of the AgNPs-GO nanocomposites and the possible binding-site saturation. Then, the usage of H2SO4 allows the production of ionic species and helps to confirm the strong adsorption of both dyes. The ability to synthesize AgNPs-GO nanocomposites with extensive adsorptive capacity is certainly of interest for the efficient removal of hazardous materials.

Green tide deactivation with layered-structure cuboids of Ag/CaTiO3 under UV light.

In this work, an alternative to deactivate noxious green tide Tetraselmis suecica in the short-term is proposed by employing Perovskite-like cube-shaped, crystalline CaTiO3 semiconductors functionalized with atomic silver nanoparticles. CaTiO3 was prepared by a microwave-assisted hydrothermal method and then Ag(0)NPs (1 wt% of CaTiO3), were added by the photoreduction method. The XRD results show that crystalline CaTiO3 has an orthorhombic unit cell with a Perovskite-like structure. Images obtained by FESEM and HRTEM microscopies show well-faceted CaTiO3 rectangular prismatic morphology functionalizated with silver nanoparticles ≈ 13.5 nm. XPS and EDS-FESEM has confirmed the composition of CaTiO3 and silver occurring mainly as reduced metal. The UV inactivation of noxious T. suecica with Ag/CaTiO3 nanocomposites formed on bare materials results in complete deactivation of the algae in 12 min. The direct contact between harmful algae and Ag/CaTiO3 nanocomposite is necessary to deactivate the algae and inhibits algae viability.