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Respir Physiol Neurobiol ; 229: 34-42, 2016 07 15.
Artículo en Inglés | MEDLINE | ID: mdl-27102012

RESUMEN

Mixtures of anhydrous ethyl alcohol and gasoline substituted for pure gasoline as a fuel in many Brazilian vehicles. Consequently, the concentrations of volatile organic compounds (VOCs) such as ketones, other organic compounds, and particularly aldehydes increased in many Brazilian cities. The current study aims to investigate whether formaldehyde, acetaldehyde, or mixtures of both impair lung function, morphology, inflammatory and redox responses at environmentally relevant concentrations. For such purpose, C57BL/6 mice were exposed to either medical compressed air or to 4 different mixtures of formaldehyde and acetaldehyde. Eight hours later animals were anesthetized, paralyzed and lung mechanics and morphology, inflammatory cells and IL-1ß, KC, TNF-α, IL-6, CCL2, MCP-1 contents, superoxide dismutase and catalalase activities were determined. The extra pulmonary respiratory tract was also analyzed. No differences could be detected between any exposed and control groups. In conclusion, no morpho-functional alterations were detected in exposed mice in relation to the control group.


Asunto(s)
Acetaldehído/toxicidad , Contaminantes Atmosféricos/toxicidad , Formaldehído/toxicidad , Pulmón/efectos de los fármacos , Compuestos Orgánicos Volátiles/toxicidad , Contaminación del Aire , Animales , Fenómenos Biomecánicos , Femenino , Pulmón/patología , Pulmón/fisiopatología , Mediciones del Volumen Pulmonar , Masculino , Ratones Endogámicos C57BL , Modelos Animales , Mucosa Nasal/efectos de los fármacos , Mucosa Nasal/metabolismo , Mucosa Nasal/patología , Estrés Oxidativo/efectos de los fármacos , Estrés Oxidativo/fisiología , Presión , Ventilación Pulmonar , Factores de Tiempo
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