Salivary Fluoride Bioavailability after Brushing with Brazilian Red Propolis Dentifrice: A Clinical Study.

INTRODUCTION: Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products. OBJECTIVE: This study aimed to evaluate the availability of fluoride in saliva samples after using a dentifrice incorporated with Brazilian red propolis (BRP, INPI Patent no. BR1020170110974) and to compare it to a conventional fluoridated dentifrice in healthy participants. METHODS: This study was conducted implementing a double-blind, randomized, controlled, and crossover design. Saliva samples of participants were collected at the following time points: 0 at baseline and 5, 15, 30, 45, and 60 minutes after brushing with each dentifrice. Salivary fluoride concentrations showed no statistically significant difference when comparing the two treatments (p > 0.05). All available fluoride concentrations in saliva decreased after one hour, with no significant difference between BRP and conventional fluoridated dentifrice treatment samples (p > 0.05). RESULTS: The results showed that there was no difference between the analyzed fluoride concentrations 1 hour after brushing with the different dentifrices. CONCLUSIONS: The results of this study suggest that the propolis incorporated in the dentifrice did not interfere with the kinetics and bioavailability of the fluoride ion in saliva samples, enabling its integration with the pharmaceutical formula and thereby promoting its anti-inflammatory and antimicrobial benefits without compromising the anticaries activity of the formulation.

Camellia sinensis in Dentistry: Technological Prospection and Scientific Evidence.

PURPOSE: This study aimed to evaluate reports of patents for oral care formulations, based on Camellia sinensis (C. sinensis), deposited and granted in intellectual property banks. METHODS: A survey was conducted through collection, treatment, and analysis of extracted information from patent reports selected. The documentary research was conducted in January 2021 on formulations with C. sinensis for dental applications, including since the first patent deposits until the current time. The risk of bias of clinical trials with these formulations was analyzed to verify the scientific evidence. The data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products. RESULTS: Data and information from 20 selected patents were extracted. The United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO) were the banks with the largest number of patents for products/formulations with C. sinensis for oral care applications with 7 (35%) and 6 (30%) patent registrations, respectively. Other banks did not provide patents related to the search. Patents of compositions were the largest with 14 filings, and the remainder of formulations are represented specially by mouthwashes and toothpastes. As for clinical application, 18 patents were filed as products with antimicrobial and antibiofilm action, while 2 patents are directed to the treatment of xerostomia. In general, the aspects of the studies of clinical efficacy pointed to a low risk of bias. CONCLUSION: The study pointed out a small number of products protected by patents for Camellia sinensis for oral care indication, highlighting mainly mouthwash compositions and formulations. In the methodological parameters of clinical trials carried out with the formulations, the majority pointed out a low risk of bias.

Antimicrobial Efficacy of Propolis-Containing Varnish in Children: A Randomized and Double-Blind Clinical Trial.

Dental caries is a sugar-dependent condition common in childhood, which causes microbiological imbalance in dental biofilm. The present study evaluated the antimicrobial efficacy of a 2.5% Brazilian Red Propolis (BRP) dental varnish to prevent caries in children. Seventy-five children with high caries risk, aged between 36 and 71 months and with no caries, were assigned to three groups to receive varnish treatment containing 2.5% BRP, 1% chlorhexidine, or 5% fluoride. The varnish was applied to the occlusal surfaces of the deciduous second molars on the first day of treatment (D1), after 90 days (D90), and 180 days of the start of treatment (D180). Saliva was collected to assess S. mutans before each varnish application and 180 days at the end of treatment (D360). Values were expressed in log10 (CFU/mL). Statistics were performed by applying repeated measures of variance analysis, Tukey's multiple comparisons test, and paired t-test. In the first dilution (1 : 10), there was microbial load reduction at the following periods: BRP in D0-D90 (p < 0.05) and D0-D180 (p < 0.01); fluoride in D0-D90 (p < 0.001); and chlorhexidine in D0-D180 (p < 0.05). In the second dilution (1 : 100), there was microbial load reduction in the groups at the following periods: BRP in D0-D90 (p < 0.05) and D0-D180 (p < 0.01); fluoride in D0-D180 (p < 0.05), and chlorhexidine in D0-180 (p < 0.01) and D0-360 (p < 0.05). The 2.5% BRP dental varnish was effective in decreasing S. mutans colonies in saliva when used within 90 days.

Clinical and Antimicrobial Evaluation of Copaifera langsdorffii Desf. Dental Varnish in Children: A Clinical Study.

BACKGROUND: The objective of this study was to evaluate the clinical and microbiological efficacies of (C. langsdorffii) dental varnish in children at high risk of dental caries.. METHODS: This is a longitudinal, randomized, controlled clinical trial. Ninety high-risk caries-free children (ICDAS II = 0) were recruited and randomly divided into three groups: C. langsdorffii, chlorhexidine, or fluoride. The varnishes were applied on the second deciduous molars for three times: baseline (D0), after 90 days (D90), and after 180 days (D180). Saliva was collected on D0, D90, D180, and D360 to evaluate S. mutans reduction. Statistics were carried out by ANOVA, Tukey's test, and the paired t-test. RESULTS: Copaiba varnish demonstrated significant S. mutans reduction: D360 versus D0 (p < 0.0001), D180 versus D0 (p < 0.001), D360 versus D90 (p < 0.001), D180 versus D90 (p < 0.001), and D360 versus D180 (p < 0.05). Chlorhexidine varnish significantly reduced S. mutans at D180 versus D0 (p < 0.05). Fluoride reduced at D180 versus D0 (p < 0.001). CONCLUSIONS: Three annual applications of this varnish showed substantial antimicrobial activity against S. mutans and caries prevention for up to 12 months.

Clinical and Microbiological Evaluation of Brazilian Red Propolis Containing-Dentifrice in Orthodontic Patients: A Randomized Clinical Trial.

AIM: To evaluate the efficacy of dentifrice containing brazilian red propolis (BRP) in adolescents under orthodontic treatment. Materials and Methods. This is a randomized, double-blind, clinical trial. A total of 92 participants free from caries were randomized into 2 groups; the first received fluoride dentifrice, and the second received fluoride dentifrice incorporated with BRP. The gingival bleeding index (GBI) was recorded, and saliva was collected on the baseline (D0) and after 28 days (D28) for microbiological analysis. Data from GBI and Colony Forming Units (CFU) (log10) were expressed as mean and standard deviation. RESULTS: The two groups reduced GBI significantly, with no difference in the intergroup analysis. In the intragroup analysis, it was observed that G2 (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (S. mutans bacteria, it was observed that only G2 had a statistically significant reduction (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (. CONCLUSIONS: Dentifrice containing BRP demonstrated better clinical and microbiological activity. Future studies are needed to better identify effects to establish the use of dentifrice containing propolis in biofilm control.

Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo.

INTRODUCTION: Dental caries is the most prevalent disease in humans and its incidence is particularly high during childhood. The use of medicinal plants is a common practice in Brazil. OBJECTIVE: To evaluate the optimal antimicrobial concentration of Copaifera langsdorffii (copaiba) oil-resin, in the form of dental varnish, against Streptococcus mutans (S. mutans) in children. METHODS: Twenty-four children, caries-free, aged until 6 years old, were selected to participate in this study. The varnish was applied to the occlusal surfaces of all deciduous molars. The antimicrobial activity was analyzed in saliva, whose collection was conducted in two phases: before applying the copaiba varnish and after use to verify the instantaneous effectiveness of Copaifera langsdorffii dental varnish in the reduction of S. mutans. The microbiological analysis was repeated twice, establishing dilutions of 1:10 mL and 1:100 mL. RESULTS: Comparisons between different times within the same dilution were carried out by repeated measures analysis of variance (ANOVA) associated with Tukey's multiple comparisons test. Comparisons of conditions prior to and after treatment were performed using the t test for paired samples and it indicated that the 1% formulation promoted a more significant decrease in the number of S. mutans colonies (p = 0,0026). CONCLUSION: Copaiba oil-resin, in the form of dental varnish, has antimicrobial activity against S. mutans in all the concentrations studied. Further studies to identify the long-term activity and anticaries effect of this varnish are required to establish its use in caries prevention.

O uso do plasma rico em plaquetas para correção de defeitos ósseos maxilares em Implantodontia / Use of platelet-rich-plasma for correction of maxillary bone defects in Implantology

O sucesso da reabilitação com implantes dentários está associado diretamente à quantidade e qualidade do tecido ósseo presente, favorecendo ou não o tratamento. A atrofia óssea dos maxilares, principalmente quando localizada nos rebordos alveolares, dificulta ou impede a reabilitação do aparelho estomatognático com o uso de implantes osseointegráveis. Na Odontologia, o plasma rico em plaquetas tem sido bastante estudado, sendo utilizado principalmente em cirurgias periodontais, cirurgias maxilofaciais e em pequenos enxertos ósseos em região alveolar para posterior colocação de implantes dentários. Diante disso, o objetivo do presente estudo foi realizar uma revisão de literatura sobre o plasma rico em plaquetas, abordando sua importância na Implantodontia, assim como sua obtenção e manipulação, características do material e indicações de aplicação. Muitos estudos demonstram as vantagens biológicas do plasma rico em plaquetas na reparação óssea em aplicações na clínica médica e odontológica. Esse biomaterial é uma alternativa viável, eficaz e de baixo custo relativo útil para acelerar os processos cicatriciais em tecidos moles e duros, podendo ser utilizado de forma isolada ou associado a outro biomaterial (AU).

The success of rehabilitation with dental implants is directly associated to the quantity and quality of bone tissue, favoring the treatment or not. The maxillary bone atrophy, especially when located in the alveolar ridges, obstructs or impedes the rehabilitation of the stomatognathic system with the use of dental implants. In Dentistry, the platelet-rich plasma has been studied extensively, being used especially in periodontal surgery, maxillofacial surgery, and small bone grafts in alveolar region for later placement of dental implants. Therefore, the aim of this study was to review the literature about the platelet-rich plasma, addressing its importance in Implantology, as well as obtaining and handling, characteristics of the material and directions for applying it. Many studies demonstrate the biological benefits of plateletrich plasma on bone healing in applications in medical and dental clinic. This biomaterial is a viable, effective and relatively low-cost useful alternative for speeding up the healing process in soft and hard tissues, and may be used alone or associated with another biomaterial (AU).

Parestesia do nervo alveolar inferior após exodontia de terceiros molares inferiores: da prevenção ao tratamento / Inferior alveolar nerve paresthesia post extraction of mandibular third molars: prevention to treatment

A cirurgia de remoção dos terceiros molares inclusos é uma situação cada vez mais frequente na prática clínica odontológica cirúrgica e, com isso, está relacionada a uma série de possíveis acidentes e complicações. Este trabalho objetivou realizar uma revisão de literatura sobre situações de parestesia do nervo alveolar inferior após a cirurgia de remoção de terceiros molares inferiores inclusos; estabelecer métodos preventivos para as lesões neurais e um protocolo de tratamento. Foram utilizados artigos científicos das bases de dados eletrônicos PUBMED, LILACS, Scielo e livros de cirurgia. Foram selecionados artigos publicados entre os anos de 2001 a 2015, com exclusão de artigos com publicação anterior ao ano de 2001. A parestesia é um distúrbio neurosensitivo local, de natureza temporária ou definitiva, decorrente de danos às fibras nervosas, sendo o nervo alveolar inferior o mais acometido em exodontia dos terceiros molares inferiores inclusos. O quadro de parestesia pode ser solucionado espontaneamente. Embora não haja um protocolo de tratamento das parestesias na Odontologia, diversas modalidades terapêuticas têm sido empregadas para tal. O correto planejamento e o emprego adequado da técnica ajudam a minimizar a ocorrência dessa complicação. Apesar de não haver um consenso no tratamento das lesões neurais, o protocolo mais aceito pela maioria dos autores inclui uso de complexos vitamínicos B (B1, B6 e B12) e laserterapia de baixa intensidade (AU).

The removal surgery of the third molars is an increasingly frequent situation in surgical dental clinical practice and, therefore, it is related to a number of possible accidents and complications. This study aimed to conduct a literature review of paresthesia situations of the inferior alveolar nerve after the removal surgery of unerupted third molars; establish preventive methods for the neural injuries and a treatment protocol. Scientific articles from electronic databases, such as PubMed, LILACS, Scielo, and surgery books were used. Articles published between the years 2001-2015, excluding articles with prior publication to 2001, were selected. Paresthesia is a local neurosensitive disorder of temporary or permanent nature, resulting from damage to the nerve fibers, and the inferior alveolar nerve is the most affected in extraction of unerupted third molars. The paresthesia frame can be solved spontaneously. Although there is not a treatment protocol of paresthesia in Dentistry, many therapeutic modalities have been used for that. The correct planning and the proper use of the technique help to minimize the occurrence of this complication. While there is no consensus in the treatment of the neural damage, the accepted protocol by most of the authors include taking vitamins B (B1, B6 and B12) and low intensity laser therapy (AU).

Condições de saúde física e mental dos idosos atendidos em urgência e emergência / Physical and mental health conditions of elderly patients assisted in an urgency and emergency service

Objetivo: descrever a situação de saúde física e mental dos idosos que sofreram acidentes e foram atendido sem um hospital de referência em urgência e emergência. Método: estudo quantitativo, descritivo, transversal, desenvolvido com 182 idosos. A coleta de dados ocorreu ao serem utilizados o Questionário BOAS e o software STATA® v.12. A análise dos dados consistiu no estudo descritivo e exploratório das características clínicas dos idosos de forma univariada. Foram utilizados os testes estatísticos Qui-Quadrado e Exato de Fischer para as variáveis nominais. Para as variáveis ordinais, o Teste Qui-Quadrado de Tendência Linear. Em todas as análises, adotou-se o nível de significância estatístico de 5% (α ≤ 0,05). Resultados: destacaram-se queda com fratura/traumatismo e doenças crônico-degenerativas (48,3%). Os idosos não tinham sentimento de solidão (84,7%); nem vontade de chorar (86,2%); sentiam que a vida valia a pena (96%); não tinham arrependimentos (87,4%); se sentiam felizes (92,7%) e que se sentiam satisfeitos com a vida (77,2%).Conclusão: as causas de acidentes estão relacionadas aos fatores individuais, diante da vida ativa e da falta de estrutura de residências e comunidades.

Avaliação de hábitos de higiene bucal e satisfação em usuários de prótese parcial removível / Assessment of mouth hygiene habits and the satisfaction of removable partial denture

A prótese parcial removível a grampo (PPRG) possibilita reabilitar áreas parcialmente edêntulas, restaurando a função mastigatória, estética e fonética. Apesar dos avanços da Odontologia observados nas últimas décadas, estudos indicam que a higiene bucal dos pacientes usuários de PPRG ainda é precária. Desse modo, o objetivo desse estudo foi verificar os hábitos de higienização das próteses e cavidade bucal, bem como o nível de satisfação dos pacientes usuários de PPRG atendidos na Universidade Federal do Ceará (UFC). Trata-se de um estudo descritivo, quantitativo onde foi aplicado um questionário a 31 pacientes usuários de PPRG. Os dados foram analisados através do teste qui-quadrado e expressos na forma de frequência absoluta e percentual considerando uma confiança de 95%. Da amostra, a maioria (77,4%) era do gênero feminino, com idade entre 40 a 60 anos, (64,5%) possuíam ensino médio completo e haviam recebido orientações de higiene após a instalação da prótese (96,8%). O método de higienização mais utilizado foi a escovação mecânica com dentifrício. Quanto à frequência de higienização, 71% responderam realizá-la 3 ou mais vezes ao dia. A cárie foi apontada como o principal fator etiológico das perdas dentárias, apresentando uma diferença significativa em relação ao grau de satisfação dos pacientes com a prótese. Verificou-se que a maior parte dos indivíduos está muito satisfeita com o tratamento, embora ainda apresentem falhas na execução dos métodos de higiene bucal e da prótese.

Removable partial denture with clasps (RPDC) restores partially toothless areas, coupled to the chewing, aesthetic and phonetic functions. In spite of progress in dentistry during the last decades, several studies indicate that mouth hygiene of RPDC patients is rather low. Current analysis verifies the hygiene of dentures and mouth cavity and the satisfaction level of patients with RPDC attended by the dentistry school of the Universidade Federal do Ceará, Brazil. Methods: The descriptive and quantitative study comprised a questionnaire to 31 RPDC users. Data were analyzed by χ2 test and expressed in absolute frequency at 95% confidence level. Most subjects (77.4%) were female, aged between 40 and 60 years (64.5%), with complete college. They had received hygiene directions after the installation of the denture (96.8%). The hygiene method most employed was mechanical brushing with dentifrice, three or more times a day, for 71.0% of the interviewed. Caries was the main etiological factor in teeth loss with a significant difference related to the satisfaction degree of patients with the prosthesis. Most subjects were highly satisfied with the treatment even though there were flaws in the execution of mouth and denture hygiene.

Aplicação da técnica da muralha de silicona em paciente pediátrico û relato de caso / Application of the silicon guide technique in pediatric patient û case report

Para a reconstrução de dentes anteriores que sofreram fraturas ou restaurações envolvendo o ângulo incisal, a Dentística dispõe de um tratamento que oferece a cópia ideal da estrutura palatina, a técnica de restauração usando a muralha de silicona. Esta técnica permite recuperar a estética de forma rápida, conservadora e oferece uma grande vantagem para a Odontopediatria como a redução do tempo de cadeira do paciente infantil. O objetivo do presente trabalho foi relatar um caso em que foi aplicada a técnica da muralha de silicona em paciente pediátrico. Paciente CIG, gênero masculino, 8 anos de idade, apresentando fratura oblíqua das coroas dos dentes 11 e 21. Após procedimentos emergenciais, o paciente teve suas arcadas moldadas e posterior moldagem de gesso, reconstrução em cera, confecção da muralha e restauração dos dentes fraturados. O caso foi solucionado apenas com recursos de Dentística, técnica da muralha, utilização de ceroplastia e resinas compostas fotopolimerizáveis, alcançando-se um bom resultado estético. Portanto, conclui-se que a confecção da técnica da muralha de silicona para restauração direta em dentes anteriores traz vantagens no tempo gasto para realização do procedimento clínico, além de resultado satisfatório e estético.

For the reconstruction of fractured anterior teeth or restorations involving the incisal angle, the silicone guide technique offers an ideal copy of the palatal structure. This technique allows a fast and conservative aesthetics restoration, as well as reduces chair time, an important advantage at odontopediatric procedures. The aim of this study was to report a case in which the silicone guide technique was applied at the treatment of a pediatric patient. CIG, male patient 8 years old, presenting oblique fracture on crowns of teeth #11 #21. After emergency procedures, dental impressions from the patient were taken and a cast model was made, followed by the wax-up. Then silicone wall was manufactured and teeth were restored. The case was solved using just dentistry resources such as the guide technique, wax-up, and light cured composite resins and has achieved satisfactory results. Therefore, it was concluded that the silicone guide technique applied to direct restoration in anterior teeth has the advantage of reduced chair time obtaining satisfactory aesthetic results.

Associação entre o uso da chupeta e a diminuição do risco de morte súbita em bebês / Relation between the use of pacifier and the reduction of cot death

Objetiva-se nesse artigo realizar um levantamento na literatura sobre a associação entre o uso de chupetas na prevenção de morte súbita em crianças. Foi realizada uma revisão de literatura e escolhidos 34 artigos publicados entre os anos de 1978 e 2012 em bancos de dados como PubMed e Scielo, usando os descritores: "morte súbita", "chupetas" e "SIDS". À medida que a mortalidade infantil vem sendo reduzida devido às melhorias socioeconômicas, ambientais e na assistência médica, as mortes súbitas na infância (MSI) tendem a assumir papel relativamente mais importante. Concluiu-se que, de acordo com a literatura, o uso de chupeta por lactentes vem reduzindo consideravelmente a incidência de morte súbita dos mesmos (AU)

The aim of this study was to present a literature review about the use of pacifiers use in the prevention of sudden infant death. A search was conducted in PubMed and SciELO, for studies published between 1978 and 2012 using the key words: "sudden death", "pacifiers", and "SIDS". Thirty four studies were selected. As infant mortality has been reduced due to socioeconomics and environmental improvements, as well as to better medical care, there is a tendency to dedicate greater attention to the sudden infant death syndrome (SIDS). It was concluded that according to the literature the use of pacifiers may reduce considerably the incidence of sudden death of them (AU)

Application of BMP-2 for bone graft in Dentistry

Introduction:The global increase life expectancy and the resulting tooth loss has required searching for new rehabilitation alternatives in Dentistry. Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. Objective: To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. Material and methods: The following databases were searched: Pubmed, Bireme, Lilacs, and Scielo and 30 articles published between 1965 and 2013 were found using the following descriptors: "dental implants", "maxillary sinus", and "biocompatible materials". Results: Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. In recent years, morphogenetic protein has presented a large clinical use. Conclusion: Despite being a high-cost biomaterial, rhBMP-2 is a viable and very effective alternative for reconstruction of defects of the face.

Profile of temporomandibular disorder patients submitted to dental and physiotherapeutic treatment at a private clinic

Introduction: Temporomandibular disorder (TMD) is the term used in Dentistry to define the structural and disorder changes affect the physiology of the masticatory system composed of TMJ and related to musculoskeletal structures. Objective: To conduct a descriptive, transversal and documentary study aiming to determine the profile of 14 TMD patients undergoing simultaneous dental and physiotherapeutic treatment at a private practice of the city of Fortaleza-Ce. Material and methods: The following instruments for the collection of the data were employed: files registering the evaluation and evolution, findings of the radiographic examinations and forms. Data were statistically analyzed through SPSS software, version 10.0. Results: Most of the sample was composed by females aged 32 years (+/-10.60) in average, mainly complaining about chronic headache, masticatory myalgia , TMJ pain, cervicalgy, otalgia, among others. The complete sample presented, at least, one pathology associated to and/or concomitant to TMD. The radiographic findings showed TMJ alterations and tooth losses. Analgesics were the most used drugs. Conclusion: TMD is a complex syndrome, with many etiologies and symptoms, aggravating and perpetuating factors, requiring multiple and even more specialized therapeutic management attempting treatment success.