Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells.

Radiotherapy is hypothesized to have an immune-modulating effect on the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) to sensitize it to anti-PD-1 antibody (a-PD-1) treatment. We collected paired pre- and posttreatment specimens from a clinical trial evaluating combination treatment with GVAX vaccine, a-PD-1, and stereotactic body radiation (SBRT) following chemotherapy for locally advanced PDACs (LAPC). With resected PDACs following different neoadjuvant therapies as comparisons, effector cells in PDACs were found to skew toward a more exhausted status in LAPCs following chemotherapy. The combination of GVAX/a-PD-1/SBRT drives TME to favor antitumor immune response including increased densities of GZMB+CD8+ T cells, TH1, and TH17, which are associated with longer survival, however increases immunosuppressive M2-like tumor-associated macrophages (TAMs). Adding SBRT to GVAX/a-PD-1 shortens the distances from PD-1+CD8+ T cells to tumor cells and to PD-L1+ myeloid cells, which portends prolonged survival. These findings have guided the design of next radioimmunotherapy studies by targeting M2-like TAM in PDACs.

Investigating the gastrointestinal physiology of mature horses with and without a history of cribbing behavior in response to feeding a digestive support supplement.

Cribbing, a stereotypic oral behavior observed in horses, involves placing incisors on a fixed object, arching the neck, pulling against the object, and emitting an audible grunt. This behavior has been associated with gastrointestinal (GI) dysfunction and gastric ulceration. In this randomized crossover study, we investigated the impact of a GI support supplement (SPL) on the GI environment and physiology of four cribbing (CB) and four non-cribbing horses (NCB). Mature Quarter Horses, acclimated to individual stalls for 16 hours daily with paddock turnout in pairs for 8 hours per day, were randomly assigned to receive either the SPL or placebo for 21 days, followed by a 2-week washout period. Fecal and gastric samples were collected for pH determination and blood samples were analyzed for serum cortisol and gastrin levels. Endoscopic examinations assessed gastric ulcer severity, and cribbing frequency and bouts were recorded via video surveillance. Data were analyzed using a mixed-model ANOVA. Results showed no differences in fecal and gastric pH between cribbing statuses. However, an interaction between supplementation and cribbing status was observed for squamous mucosa ulcer scores (P=0.003). There were no differences in glandular mucosa ulcer scores, serum cortisol, serum gastrin, and crib-bite count between CB and NCB horses or between supplementation groups. Crib-bout duration did not differ with supplementation, but differences were found between periods (P<0.05) and hour ranges (P<0.001). Our findings suggest that the GI support supplement may not effectively address cribbing behavior or alter the GI environment in NCB or CB horses.

Spanking and executive functioning in US children: A longitudinal analysis on a matched sample.

BACKGROUND: Spanking has been linked to multiple maladaptive child outcomes. However, previous research linking spanking with children's executive function skills (EFs; inhibitory control, cognitive flexibility, and working memory) is limited by research designs that do not adequately address selection bias concerns, wherein the participant characteristics potentially differ between those who are spanked versus not spanked. OBJECTIVE: Using a representative sample of US children aged 5 to 6, this study strengthened the evidence for causal estimates on the link between spanking and subsequent EFs with a matched-group design. Low-frequency spanking and potential moderators (child gender, parent race/ethnicity, parental warmth) were tested to determine if they moderated the link between spanking and EFs. PARTICIPANTS: Data were drawn from the Early Childhood Longitudinal Study, Kindergarten Class of 2010-11 (Ns = 12,750-12,830). To mitigate selection bias, entropy-balanced matching was utilized to match spanked versus not-spanked groups, and lagged dependent variable regression analyses were conducted on the matched sample to predict EFs by spanking group status. RESULTS: After matching, spanking at age 5 was associated with lower inhibitory control and lower cognitive flexibility at age 6, but was not significantly predictive of later working memory. The association with inhibitory control was observed even for low frequency spanking. However, no evidence of moderation by child gender, parent race/ethnicity, and parental warmth was identified. CONCLUSIONS: This study provides evidence that spanking is associated with lower executive functioning in children, although the associations varied by different EF domains.

Stability of blood lead levels in children with low-level lead absorption.

Current child blood lead (Pb) screening guidelines assume that blood lead levels (BLLs) are relatively stable over time, and that only youngest children are vulnerable to the damaging effects of lower-range BLLs. This study aimed to test the stability of lower-range (≤ 10 µg/dL) child BLLs over time, and whether lower-range BLLs diminished with age among children aged 6 months to 16 years living in a lower-income neighborhood with a density of pre-1986 housing and legacy contamination. Age, sex, family income, age of residence, and/or residence proximity to point sources of Pb, were tested as potential additional factors. Capillary blood samples from 193 children were analyzed by inductively coupled plasma mass spectrometry (ICPMS). Multiple imputation was used to simulate missing data for 3 blood tests for each child. Integrated Growth Curve models with Test Wave as a random effect were used to test BLL variability over time. Among N = 193 children tested, at Time 1 testing, 8.7% had the BLLs ≥ 5 µg/dL (CDC "elevated" BLL reference value at the time of data collection) and 16.8% had BLLs ≥ 3.5 µg/dL (2021 CDC "elevated" BLL reference value). Modeling with time as a random effect showed that the variability of BLLs were attributable to changes within children. Moreover, time was not a significant predictor of child BLLs over 18 months. A sex by age interaction suggested that BLLs diminished with age only among males. Of the additional environmental factors tested, only proximity to a major source of industrial or vehicle exhaust pollution predicted child BLL variability, and was associated with a small, but significant BLL increase (0.22 µg/dL). These findings suggest that one or two BLL tests for only infants or toddlers are insufficient for identifying children with Pb poisoning.

Racial Identification as a Protective Factor for At-Risk Parenting in Black Parents: A Longitudinal, Multi-Method Investigation.

Although considerable literature focuses on risk factors predicting parents' likelihood to engage in maltreatment, relatively less work evaluates potentially protective parental resources, particularly culturally relevant qualities. The current investigation utilized a multi-method longitudinal study to examine parents' racial identification as a possible resource, hypothesizing that Black parents with stronger racial group identification would demonstrate lower at-risk parenting, operationalized as lower child abuse risk and less negative observed parenting. In a sample of 359 mothers and fathers (half self-identified Black, half non-Hispanic White), controlling for socioeconomic status, findings partially supported the hypothesis. Black parents' greater racial identification was associated with lower child abuse risk and less observed negative parenting, whereas the reverse was true for White parents. The potential limitations of current assessment approaches to gauge at-risk parenting in parents of color are discussed, as well as how racial identification could be considered in culturally informed prevention programming for at-risk parenting.

Social Information Processing Theory Indicators of Child Abuse Risk: Cultural Comparison of Mothers from Peru and the United States.

Much of the research conducted on social information processing (SIP) factors predictive of child abuse risk has been conducted in North America, raising questions about how applicable such models may be in other cultures. Based on the premise that the parents' child abuse risk is affected by both risk and protective factors, the current study considered how specific SIP socio-cognitive risk factors (acceptability of parent-child aggression as a discipline approach; empathic ability; frustration tolerance) as well as social support satisfaction as a resource related to child abuse risk by comparing a sample of mothers in Peru (n = 102) with a sample of mothers in the U.S. (n = 180). Using multi-group regression analyses, the current investigation identified that lower empathy was more salient for the abuse risk of U.S. mothers relative to the salience of lower frustration tolerance for Peruvian mothers. Although effects were observed for the approval of parent-aggression for the child abuse risk of both samples, such approval did not appear to be related to the Peruvian mothers' actual use of such tactics. When considered alongside the socio-cognitive risk factors, greater social support satisfaction did not significantly relate to child abuse risk for either sample. The findings are discussed in reference to future cross-cultural work that may need to better examine how factors may or may not be universal to craft more culturally informed child abuse prevention programs.

Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease.

We aimed to identify cardiopulmonary long-term effects after severe COVID-19 disease as well as predictors of Long-COVID in a prospective registry. A total of 150 consecutive, hospitalized patients (February 2020 and April 2021) were included six months post hospital discharge for a clinical follow-up. Among them, 49% experienced fatigue, 38% exertional dyspnea and 75% fulfilled criteria for Long-COVID. Echocardiography detected reduced global longitudinal strain (GLS) in 11% and diastolic dysfunction in 4%. Magnetic resonance imaging revealed traces of pericardial effusion in 18% and signs of former pericarditis or myocarditis in 4%. Pulmonary function was impaired in 11%. Chest computed tomography identified post-infectious residues in 22%. Whereas fatigue did not correlate with cardiopulmonary abnormalities, exertional dyspnea was associated with impaired pulmonary function (OR 3.6 [95% CI: 1.2-11], p = 0.026), reduced GLS (OR 5.2 [95% CI: 1.6-16.7], p = 0.003) and/or left ventricular diastolic dysfunction (OR 4.2 [95% CI: 1.03-17], p = 0.04). Predictors of Long-COVID included length of in-hospital stay (OR: 1.15 [95% CI: 1.05-1.26], p = 0.004), admission to intensive care unit (OR cannot be computed, p = 0.001) and higher NT-proBNP (OR: 1.5 [95% CI: 1.05-2.14], p = 0.026). Even 6 months after discharge, a majority fulfilled criteria for Long-COVID. While no associations between fatigue and cardiopulmonary abnormalities were found, exertional dyspnea correlated with impaired pulmonary function, reduced GLS and/or diastolic dysfunction.

An interdisciplinary team-based approach for significantly reducing lower-level lead poisoning in U.S. children.

Child lead poisoning damages central nervous system, immune, and renal function, and is the longest-standing public health epidemic in U.S. history. While primary prevention is the ultimate goal, secondary intervention is critical for curbing effects among children already exposed. Despite the lowering of child blood lead level (BLL) reference value in 2012 and again in 2021, few changes to secondary intervention approaches have been discussed. This study tested a novel interdisciplinary approach integrating ongoing child BLL-monitoring with education and home mitigation for families living in neighborhoods at high-risk of child lead exposure. In children ages 6 months to 16 years, most of whom had lowest range exposures, we predicted significantly reduced BLLs following intervention. Methods: Twenty-one families with 49 children, were offered enrollment when at least 1 child in the family was found to have a BLL > 2.5 µg/dL. Child BLLs, determined by ICPMS, were monitored at 4- to 6-month intervals. Education was tailored to family needs, reinforced through repeated parent engagement, and was followed by home testing reports with detailed case-specific information and recommendations for no-cost/low-cost mitigation. Results: Ninety percent of enrolled families complied with the mitigation program. In most cases, isolated, simple-to-mitigate lead hazard sources were found. Most prevalent were consumer products, found in 69% (11/16) of homes. Lead paint was identified in 56% (9/16) of homes. Generalized linear regression with Test Wave as a random effect showed that children's BLLs decreased significantly following the intervention despite fluctuations. Conclusion: Lower-level lead poisoning can be reduced through an interdisciplinary approach that combines ongoing child BLL monitoring; repeated, one-on-one parent prevention education; and identification and no-cost/low-cost mitigation of home lead hazards. Biannual child BLL monitoring is essential for detecting and responding to changes in child BLLs, particularly in neighborhoods deemed high-risk for child lead poisoning.

Psychosocial Resources Predicting Maternal and Paternal Positive Parenting and Lower Child Abuse Risk.

Young children have the highest victimization rates of physical abuse in their first year of life, making up nearly half of all child abuse-related fatalities. More effective prevention is needed to reduce child victimization, yet many risk reduction models rely on problematic inclusion criteria, only intervene after maltreatment has occurred, or focus only on mothers. More proactive prevention models that promote positive parenting practices early in the transition to parenthood could be key to reducing child maltreatment. The current study sought to assess how both mothers' and fathers' psychosocial resources (e.g., emotion regulation, coping, and social support) and empathy can predict positive parenting and predict lower child abuse risk across time in a cross-lagged model. Parenting and abuse risk were examined prenatally, through the transition into parenthood, until children were 4 years old. First time mothers and their partners were recruited in the third trimester of pregnancy and assessed again when children were 6 months, 18 months, and 4 years old. Separate path models for mothers and fathers analyzed whether psychosocial resources and empathy at earlier timepoints predicted their positive parenting and lower abuse risk by the time children were age 4. Findings demonstrated that mothers' earlier empathy predicted later positive parenting and earlier positive parenting predicted later empathy. Fathers' lower prenatal abuse risk predicted greater subsequent empathy. Both mothers' and fathers' psychosocial resources and empathy at earlier timepoints predicted later positive parenting. Parents' psychosocial resources can be integral assets in positive, effective parenting approaches both concurrently and longitudinally. Mothers' and fathers' resources are an important point of intervention prior to and during the transition into parenthood to support healthier families that would confer benefits to child functioning.

Applying Socio-Emotional Information Processing theory to explain child abuse risk: Emerging patterns from the COVID-19 pandemic.

BACKGROUND: The COVID-19 pandemic exerted profound effects on parents, which may translate into elevated child abuse risk. Prior literature demonstrates that Social Information Processing theory is a useful framework for understanding the cognitive processes that can contribute to parental abuse risk, but the model has not adequately integrated affective processes that may coincide with such cognitions. OBJECTIVE: Given parents experienced intense emotions during the pandemic, the current study sought to examine how socio-emotional processes might account for abuse risk during the pandemic (perceived pandemic-related increases in harsh parenting, reported physical and psychological aggression, and child abuse potential). PARTICIPANTS AND METHODS: Using two groups of mothers participating in online studies, the combined sample of 304 mothers reported on their abuse risk and cognitive and anger processes. RESULTS: Greater approval of physical discipline and weaker anger regulation abilities were directly or indirectly related to measures of abuse risk during the pandemic, with maternal justification to use parent-child aggression to ensure obedience consistently relating to all indicators of abuse risk during the pandemic. CONCLUSIONS: Socio-emotional processes that include anger appear particularly relevant during the heightened period of strain induced by the pandemic. By studying multiple factors simultaneously, the current findings can inform child abuse prevention efforts.

Child and parent factors predictive of mothers' and fathers' perceived family functioning.

Understanding family functioning, particularly the risk and protective factors that may contribute to adaptive versus maladaptive family processes, is critical to promote child and family well-being and resilience. Guided by family systems theory and the family stress model, this study longitudinally investigated parents' and toddlers' individual-level challenges and parental internal resources as potential predictors of subsequent perceived family functioning (i.e., general family functioning and family conflict), while accounting for earlier couple functioning. First-time mothers' and fathers' reports of psychological distress, perceived child behavior problems, intrapersonal resources (i.e., coping, emotion regulation, and empathy), and couple functioning (i.e., relationship satisfaction and intimate partner violence victimization) were assessed when their child was 18 months and 4 years of age. Using autoregressive path models, results suggested that greater maternal distress and paternal perceptions of toddler behavior problems predicted later reports of perceived family dysfunction, whereas parental intrapersonal resources predicted more adaptive perceived family functioning. Overall, findings indicate mutual or bidirectional influence within the family, consistent with the family systems principle of reciprocal causality. Clinical implications are discussed, including the need to bolster parents' existing strengths as well as providing prevention and early screening of depressive symptoms among parents. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial.

AIMS: The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction (HFpEF). To date, neither established heart failure therapies nor pulmonary vasodilators proved beneficial. This study investigated the efficacy of chronic treatment with the oral soluble guanylate cyclase stimulator riociguat in patients with PH-HFpEF. METHODS AND RESULTS: The phase IIb, randomized, double-blind, placebo-controlled, parallel-group, multicentre DYNAMIC trial assessed riociguat in PH-HFpEF. Patients were recruited at five hospitals across Austria and Germany. Key eligibility criteria were mean pulmonary artery pressure ≥25 mmHg, pulmonary arterial wedge pressure >15 mmHg, and left ventricular ejection fraction ≥50%. Patients were randomized to oral treatment with riociguat or placebo (1:1). Patients started at 0.5 mg three times daily (TID) and were up-titrated to 1.5 mg TID. The primary efficacy endpoint was change from baseline to week 26 in cardiac output (CO) at rest, measured by right heart catheterization. Primary efficacy analyses were performed on the full analysis set. Fifty-eight patients received riociguat and 56 patients placebo. After 26 weeks, CO increased by 0.37 ± 1.263 L/min in the riociguat group and decreased by -0.11 ± 0.921 L/min in the placebo group (least-squares mean difference: 0.54 L/min, 95% confidence interval 0.112, 0.971; P = 0.0142). Five patients dropped out due to riociguat-related adverse events but no riociguat-related serious adverse event or death occurred. CONCLUSION: The vasodilator riociguat improved haemodynamics in PH-HFpEF. Riociguat was safe in most patients but led to more dropouts as compared to placebo and did not change clinical symptoms within the study period.

Psychometric Evidence for Indirect Assessment of Child Abuse Risk in Child Welfare-Involved Mothers.

Most research on factors related to physical child abuse risk rely heavily on direct self-report measures, which is a methodological strategy susceptible to participant response distortions. Such methodological reliance obfuscates the interpretations rendered about the risk factors predictive of child abuse. Efforts to develop alternative indirect assessment approaches, such as analog tasks, show promise, although most of those studies have applied these methods to community samples rather than with child welfare-involved samples. The present study evaluated the psychometric evidence for four separate analog tasks that have not yet been considered with mothers identified for child maltreatment by child welfare services, also contrasted to a sociodemographically matched sample of mothers. The results indicate acceptable reliability for the analog tasks, with additional evidence of validity. However, the two groups of mothers did not substantively differ across measures, suggesting that identification for abuse through child protective services does not differentiate from those closely matched on critical sociodemographic characteristics. The promising preliminary results of these analog tasks in the current study suggest that indirect analog assessment approaches to estimate child abuse risk could be useful in efforts to minimize dependence on self-report methods.

Role of maternal emotion in child maltreatment risk during the COVID-19 pandemic.

Purpose: Preliminary research early in the COVID-19 pandemic suggested children appeared to be at increased risk for child maltreatment, particularly as parents struggled with mental health and economic strains. Such strains were likely to influence parental emotions about their children, affecting their parent-child interactions to contribute to elevated maltreatment risk. To identify the potential affective elements that may contribute to such increased maltreatment risk, the current study focused on whether maternal worry about children's behavior specifically as well as maternal anger were related to increased risk for neglect or physical or psychological aggression six months into the pandemic. Method: The racially diverse sample included 193 mothers who completed an online survey during the COVID-19 pandemic in late September-early October 2020. Results: Mothers' reported increases in neglect and physical and psychological aggression during the pandemic were significantly related with established measures of maltreatment risk. Furthermore, path models indicated that maternal anger and worry about children's behavior, as well as their interaction, were significantly related to indicators of physical aggression risk and neglect during the pandemic, but only maternal anger related to increased psychological aggression during the pandemic. Conclusions: Maternal worry and anger about children's behavior may have exacerbated risk for maltreatment under the stressful conditions of the COVID-19 pandemic. Findings suggest affective reactions of both parental worry and anger focused on child behavior warrants greater empirical attention and consideration in intervention efforts both during the pandemic and potentially post-pandemic.

Mediators between Positive and Negative Parenting and Child Depressive and Anxious Symptoms: Findings from a Diverse, At-Risk Sample.

BACKGROUND: Although children's depressive and anxious symptoms have been broadly construed as internalizing problems, the current study sought to identify factors that may differentially contribute to these two mental health problems in a high-risk sample. Prior research has not adequately tested both depressive versus anxious symptoms simultaneously, nor has it adequately considered the role of negative versus positive parenting simultaneously, thereby neglecting the potential overlap in both sets of constructs. Overlooking such potential statistical overlap obfuscates how factors may differentially contribute to either depressive versus anxious symptoms. Existing research has also focused on lower-risk community samples. METHOD: The present study investigated whether children's negative self-concept or maladaptive attributional style mediated the link between both negative and positive parenting in a racially diverse, at-risk sample of 65 primary school-age children recruited from mental health agencies. RESULTS: When tested together, more negative parenting, but not less positive parenting, retained direct effects on both depressive and anxious symptoms. Both negative self-concept and maladaptive attributional style fully mediated the association between less positive parenting and children's depressive symptoms, whereas positive self-concept, but not attributional style, mediated between less positive parenting and anxious symptoms. CONCLUSIONS: The current findings underscore potential differential intervention targets for these two internalizing problems and highlight the need for future research to consider both depressive and anxious symptoms, and related predictors, simultaneously to control for their shared variance.

Parenting style history in predicting harsh parenting and child abuse risk across the transition to parenthood: Role of gender.

BACKGROUND: Intergenerational transmission of abuse processes imply that individuals abused as children are more likely to abuse their own children when they become parents, with similar intergenerational patterns observed for parenting styles. OBJECTIVE: The present study addresses an important gap in the literature regarding the intergenerational cycle, investigating how perceived parenting style history predicts mothers' and fathers' child abuse risk across the transition to parenthood, with particular attention to the role of gender by comparing cross-gender and same-gender grandparent-parent dyads. PARTICIPANTS AND METHODS: The sample is drawn from a four-wave longitudinal study that enrolled 203 families beginning the final trimester of mothers' pregnancy until children were four years old. Parents responded to measures on parenting style history received from both their mothers and fathers as well as measures of their own child abuse risk, parent-child aggression, and personal parenting style. RESULTS: Mothers demonstrated more same-gender effects, whereas fathers demonstrated more cross-gender effects-both patterns supportive of a tendency to follow maternal influences when considering child abuse risk. With regards to behavior, both mothers' and fathers' reports of parent-children aggression were most influenced by perceived harsh parenting received from their fathers. CONCLUSIONS: Future development of parenting interventions could be more individualized to the participating parent's reported personal history of parenting style and gender.

Spotlight on Maternal Perceptions of Child Behavior: A Daily Diary Study with Child Welfare-Involved Mothers.

Research has documented a variety of factors-including stress, attributions, and anger-that may increase parents' risk for child maltreatment, but most of this research is based on low-risk, community samples of parents' perceptions about themselves and their children. Moreover, parents are usually asked to provide self-reports wherein they summarize their general impressions distal from actual parenting. The current study employed experience sampling methods with a high-risk sample. Mothers identified for child maltreatment reported on their stress and coping as well as their perceptions regarding children's misbehavior and good behavior using end-of-day surveys for up to four weeks. Only maternal reports of children's good behavior based on personality and mood were relatively stable; stress, coping, and reports on child misbehavior varied considerably across days, implying that contributors to daily fluctuations in these factors could represent intervention targets. Although maternal perceptions of misbehavior severity, anger, and negative attributions were interrelated, only anger about misbehavior related to maternal stress levels. Mothers who reported better coping perceived their child's behavior more favorably that day and were more likely to ascribe positive behavior to the child's mood and personality. Current findings highlight the importance of positive coping mechanisms in parental perceptions of children; such findings should be replicated to determine how to maximize parental resources that reduce child maltreatment risk.

Assessing Mothers' Automatic Affective and Discipline Reactions to Child Behavior in Relation to Child Abuse Risk: A Dual-Processing Investigation.

Given the scope and adverse clinical consequences of child abuse, assessment of salient etiological factors can lend critical insights needed for abuse prevention. Increasingly, dual-processing models have been applied to aggression, which postulate that parallel automatic and conscious processes can evoke aggressive behavior, implicating both affective and cognitive elements in both routes. Using two samples of mothers (n = 110 and n = 195), the current investigation considered evidence of the reliability and convergent, concurrent, and construct validity of the new Automatic Parent Emotion Analog Response task relevant to parent-child aggression, contrasted with a self-reported conscious processing measure. Findings provide evidence that affective reactions of both anger and worry relate to child abuse risk and inclination to respond aggressively, and demonstrate how mothers' automatic reactions relate to both perceived child misbehavior and child dangerous behavior. Current results lend psychometric support for automatic processing in parent-child aggression consistent with other dual-processing theories of aggression.

Factors Distinguishing Reciprocal Versus Nonreciprocal Intimate Partner Violence Across Time and Reporter.

Although intimate partner violence (IPV) is often conceptualized as occurring unilaterally, reciprocal or bidirectional violence is actually the most prevalent form of IPV. The current study assessed physical IPV experiences in couples and evaluated risk and protective factors that may be differentially associated with reciprocal and nonreciprocal IPV concurrently and over time. As part of a multi-wave longitudinal study, women and men reported on the frequency of their IPV perpetration and victimization three times across the transition to parenthood. Participants also reported on risk factors related to personal adjustment, psychosocial resources, attitudes toward gender role egalitarianism, and sociodemographic characteristics at each wave. Participants were classified into one of four IPV groups (reciprocal violence, male perpetrators only, female perpetrators only, and no violence) based on their self-report and based on a combined report, which incorporated both partners' reports of IPV for a maximum estimate of violence. Women and men were analyzed separately, as both can be perpetrators and/or victims of IPV. Cross-sectional analyses using self-reported IPV data indicated that IPV groups were most consistently distinguished by their levels of couple satisfaction, across gender; psychological distress also appeared to differentiate IPV groups, although somewhat less consistently. When combined reports of IPV were used, sociodemographic risk markers (i.e., age, income, and education) in addition to couple functioning were among the most robust factors differentiating IPV groups concurrently, across gender. In longitudinal analyses, sociodemographic vulnerabilities were again among the most consistent factors differentiating subsequent IPV groups over time. Several gender differences were also found, suggesting that different risk factors (e.g., women's social support and men's emotion regulation abilities) may need to be targeted in interventions to identify, prevent, and treat IPV among women and men.

Longitudinal Analysis of Short-term Changes in Relationship Conflict During COVID-19: A Risk and Resilience Perspective.

This study uses a risk and resilience framework to examine short-term self-reported changes in relationship conflict early in the COVID-19 pandemic (March and April 2020). Longitudinal data from U.S. adults in a romantic relationship (N = 291) were collected via three waves of an online survey. Participants self-reported anxiety, depression, increased alcohol use, and dyadic coping since the pandemic. Relationship conflict variables included whether the participant reported that they and their partner "had disagreements related to the Coronavirus," "had more disagreements than usual," "had more verbal fights than usual," and "had more physical fights than usual" in the past two weeks. Analyses controlled for sociodemographic characteristics as well as days spent in lockdown and employment change due to COVID-19. Results indicated that couples' disagreement and verbal fighting scores increased from Time 1 to Time 2, but disagreements related to COVID-19 and physical fighting did not. Couples with higher levels of dyadic coping reported fewer fights and disagreements on average. However, dyadic coping did not buffer participants from increases in relationship conflict. Increased alcohol use since the pandemic was positively associated with disagreements related to COVID-19, disagreement scores, and verbal fighting scores. More days spent in lockdown was associated with increases in disagreements related to COVID-19. The conditions created by COVID-19 may contribute to worsening relationship conflict, even among couples who start with high levels of dyadic coping. Depression and alcohol use may contribute to poorer relationship quality during the pandemic. There is need for enhanced intervention and mental health supports to mitigate the potential effects of the pandemic on couples' relationship functioning.