RESUMEN
Hen egg white lysozyme injected intracutaneously into mice inhibits the intradermal diffusion of India Ink. The effect of lysozyme persists in presence of hyaluronidase. Lysozyme injected i.p. into mice inhibits acetic acid (i.p.) induced leakage of Pontamine Sky Blue into the abdominal cavity. The data suggest that lysozyme might be tried for applications outside the microbiological field.
Asunto(s)
Permeabilidad Capilar/efectos de los fármacos , Carbono , Muramidasa/farmacología , Animales , Colorantes/metabolismo , Difusión , Clara de Huevo , Hialuronoglucosaminidasa/farmacología , Masculino , RatonesRESUMEN
A series of 3-O-derivatives of 1,2,5,6-di-O-isopropylidene-alpha-D-glucofuranose were prepared and tested for their pharmacological activity in comparison with tribenoside, a well known drug structurally related, and with other anti-inflammatory agents. Almost all the compounds had a very low toxicity and few of them showed a notable antiinflammatory and antipyretic activity and were able to clearly decrease the venous wall permeability.