Asunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Antiinflamatorios no Esteroideos/uso terapéutico , Anticolesterolemiantes/efectos adversos , Anticolesterolemiantes/uso terapéutico , Resina de Colestiramina/efectos adversos , Resina de Colestiramina/uso terapéutico , Inhibidores de la Ciclooxigenasa/efectos adversos , Inhibidores de la Ciclooxigenasa/uso terapéutico , Diclofenaco/efectos adversos , Diclofenaco/uso terapéutico , Osteoartritis/tratamiento farmacológico , Sulfonamidas/efectos adversos , Sulfonamidas/uso terapéutico , Antiinflamatorios no Esteroideos/farmacocinética , Anticolesterolemiantes/farmacocinética , Celecoxib , Resina de Colestiramina/farmacocinética , Inhibidores de la Ciclooxigenasa/farmacocinética , Diclofenaco/farmacocinética , Método Doble Ciego , Combinación de Medicamentos , Interacciones Farmacológicas , Quimioterapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Pirazoles , Sulfonamidas/farmacocinéticaRESUMEN
Electroencephalographic (EEG) activity associated with voluntary and spontaneous saccades were analyzed in 12 normal subjects to determine the influence of volition upon the presaccadic spike potentials (SPs). In addition, two different electrode configurations, of a temporal and a parietal derivation, and two different filter bandwidths were simultaneously analyzed to clarify issues regarding the structure, function, and origin of SPs. An off-line averaging of the pre- and postsaccadic EEG epochs showed distinct spike potentials associated with spontaneous saccades in both the temporal and the parietal locations. Subsequent statistical analyses indicated that the amplitude of the SPs associated with spontaneous saccades was not significantly different from the respective amplitude of SPs preceding voluntary saccades. Independent effects of filter bandwidth and electrode derivation are suggestive of a complex late presaccadic EEG activity.
