[Treatment of acute abscesses and gangrene of the lungs]. / Lechenie ostrykh abstsessov i gangren legkikh.

Complex treatment of acute abscesses and gangrene of the lungs, including intensive therapy and resuscitation, nonoperative treatment with the use of methods for releasing microcirculation from blocking, inhibition of proteolysis in the focus, differentiated correction of the functional activity of phagocytes in the focus of affection, etc., is conducive to reduction of the frequency of the development of a chronic process and drop of mortality.

[Procoagulant and proteolytic activities of leukocytes in the foci of acute abscesses and gangrene of the lungs]. / Prokoaguliantnaia i proteoliticheskaia aktivnost' leikotsitov v ochage porazheniia u bol'nykh ostrymi abstsessami i gangrenoi legkikh.

Essential role in development of acute purulent destruction of the lungs in attributed to proteinases of polimorphonuclear leukocytes. Poor localization of the destruction focus seems to result from low procoagulant activity of pulmonary macrophages. If the activity of purulent and destructive process stands high the ability of phagocytes to synthesize and release proteinases is realized fully. epsilon-Aminocaproic acid prohibits phagocytic proteolytic activity from growing under the influence of stimulators. Correction of defective leukocytic proteolysis and mononuclear activity can be done with prodigiozan, streptokinase and epsilon-aminocaproic acid.

[Plasmapheresis in combined treatment of severe forms of abscesses and gangrene of the lungs]. / Plazmaferez v kompleksnom lechenii tiazhelykh form abstsessov i gangren legkikh.

With an adjuvant course of plasmapheresis, a combined treatment of severe acute abscesses and gangrene of the lungs brought about a marked short-term clinical response in 48 out of 50 treated patients. The responders had their temperature returned to normal, amount of sputum significantly reduced. They recovered good appetite and gained weight. There was also attenuation of DIC syndrome and endotheliosis, improvement of cellular and humoral immunity. Upon the discharge 35 patients had complete or partial response, 10 patients developed a chronic process. Lethal outcomes reached 10%.

[Value of correcting microcirculatory disorders of inflammatory foci in the treatment of infection]. / Znachenie likvidatsii mikrotsirkuliatornykh narushenii v zone vospalite'lnogo ochaga pri lechenii sepsisa.

Experience in the treatment of 94 patients with sepsis is discussed. Studies showed that microcirculatory disorders occurring around the inflammatory focus are among the main causes of insufficient efficacy of antibiotic therapy. For correction of the microcirculatory changes, the authors suggest (in addition to vasodilators, inhibitors of proteases and heparin used earlier for this purpose) transfusion of chilled plasma which is a antithrombin-III donator. As the result of such treatment mortality reduced from 45.8 to 16.7%.