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The emergence of antimicrobial resistance in bacteria, especially in agents associated with urinary tract infections (UTIs), has initiated an exciting effort to develop biocompatible nanoparticles to confront their threat. Designing simple, cheap, biocompatible, and efficient nanomaterials as bactericidal agents seems to be a judicious response to this problem. Here, a solvothermal method was hired for the one-pot preparation of the cellulose gum (carboxymethyl cellulose, CMC) magnetic composite to prepare a cost-effective, efficient, and biocompatible support for the plant-based stabilization of the silver NPs. The green stabilization of the Ag NPs is performed using Euphorbia plant extract with high efficiency. Various characterization methods, including FT-IR, XRD, SEM, EDS, TEM, and VSM were used to study the composition and properties of Fe3O4@CMC/AgNPs. The composite shows well integrity and monodispersity with a mean diameter of <300 nm, indicating its potential for bio-related application. The CMC functionalities of the proposed material facilitated the stabilization of the Ag NPs, resulting in their monodispersity and enhanced performance. The manufactured composite was used as an antibacterial agent for the removal of UTIs agents, collected from 200 hospitalized patients with acute coronary syndrome, which showed promising results. This study showed that the concentration of the Ag NPs has a direct relationship with the antibacterial properties of the composite.
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Antibacterianos , Tecnología Química Verde , Nanopartículas del Metal , Plata , Plata/química , Plata/farmacología , Antibacterianos/farmacología , Antibacterianos/química , Nanopartículas del Metal/química , Materiales Biocompatibles/química , Materiales Biocompatibles/farmacología , Carboximetilcelulosa de Sodio/química , Extractos Vegetales/química , Extractos Vegetales/farmacología , Humanos , Pruebas de Sensibilidad Microbiana , Euphorbia/química , Infecciones Urinarias/tratamiento farmacológico , Infecciones Urinarias/microbiologíaRESUMEN
In metal-organic frameworks (MOFs), confined space as a chemical nanoreactor is as essential as coordinatively unsaturated metal site catalysis. The properties of MOFs can be adjusted through the incorporation of functional groups and open metal sites in frameworks that can modify the catalytic performance. In this regard, a set of defect-engineered MOFs, Ex-MOF-808(NH2, NO2, H) and Mix-MOF-808(NH2, NO2, H), were synthesized by ultrasonic-assisted linker exchange approach (Ex-MOFs) and solvothermal mixing ligand method (Mix-MOFs), respectively. Further, the relationship between the preparation method, structural properties, and catalytic efficiency of the prepared materials in the selective oxidation of methyl phenyl sulfide (MPS) has been investigated. By analyzing zeta potential, it was found that in the exchange method, the amount of defect and functional groups on the surface of MOFs are more than in the mixing method, which also affects the catalytic activity. In our contribution, mix-MOF-808(NO2) carrying nitro groups at their organic linkers, which has a well-dispersion of nitro groups at the framework exhibits selective conversion of MPS to sulfone (91 %). Furthermore, the performance of stable heterogeneous catalysts was investigated for three cycles, which demonstrated their great potential for advanced catalytic oxidation.
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In this work, a simple green synthesis method of the novel metal-organic framework (MOF) nanocomposite PCN-224/Au-NPs (Au-NPs = gold nanoparticles) is described. In this regard, initially, PCN-224 was synthesized. Afterward, in a single-step, one-pot procedure, under visible-light irradiation, Au-NPs were fabricated on PCN-224. The cytotoxicity effect of the synthesized PCN-224/Au-NPs nanocomposite was investigated in human colon cancer cells. Determination of the apoptosis induction was done by the Annexin- V/propidium iodide flow cytometry method. Besides, to ascertain the biocompatibility of the synthesized sample, the cytotoxicity of PCN-224/Au-NPs was evaluated on the human embryonic kidney (HEK)-293 cell line. The substantial anticancer activity with the biocompatibility of the structure, the green facile synthesis, and the MOF surface of the synthesized nanocomposite make it special for utilization in therapeutic applications.
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Neoplasias Colorrectales , Nanopartículas del Metal , Estructuras Metalorgánicas , Humanos , Oro/farmacología , Oro/química , Circonio/farmacología , Circonio/química , Estructuras Metalorgánicas/farmacología , Estructuras Metalorgánicas/química , Nanopartículas del Metal/uso terapéutico , Nanopartículas del Metal/química , Células HEK293 , Neoplasias Colorrectales/tratamiento farmacológicoRESUMEN
The objective of current research was to prepare a new biodegradable coating containing chitosan (Ch) and zataria multiflora essential oil (ZMEO) (free and Pickering emulsion (PEO) forms), in order to enhance the Salmo trutta shelf life. Our results showed, the mean of films thickness, mechanical properties (elastic modulus (EM) and tensile strength (TS) analysis) and WVP in different treatments were ranged from 0.103 ± 0.003 (for Ch) to 0.109 ± 0.003 (for Ch-PEO (2.5 %)) µm for thickness, from 3.2 ± 1.6 (for Ch) to 8.15 ± 2.3 (for Ch-EO) MPa for EM, from 1.3 ± 0.5 (for Ch-EO) to 1.6 ± 0.06 (for Ch) Mpa for TS and from 0.1 ± 0.02 (for Ch) to 0.8 ± 0.05 (for Ch-EO) (×10 - 11(g m/m2 s Pa) for WVP. In current research, the lowest and highest total viable counts (TVC) was related to Ch-PEO (1.7 log CFU/g) and control treatments (4.65 log CFU/g). The lowest and highest of pH was related to the Ch-PEO (6.45) and the control (7.1), the lowest and highest of PV (peroxide value) was related to Ch-PEO (0.34 meq/kg) and control treatment (1.37 meq/kg), the lowest and highest of TBARS (thiobarbituric acid reactive substances) was related to Ch-PEO (0.37 mg/kg) and control treatment (2.23 mg/kg) and also the lowest and highest of TVB-N (total volatile base nitrogen) was related to Ch-PEO (17.7 mg) and control (59 mg). Also, Ch-PEO showed the best sensory properties after sixteen days. Among all the treatments in all the tests, the best maintenance property was related to the Ch-PEO, therefore, chitosan coatings containing ZM Pickering emulsion should be considered as a potential active coating in the fish industry.
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Cancer monitoring plays a critical role in improving patient outcomes by providing early detection, personalized treatment options, and treatment response tracking. Carbon-based electrochemical biosensors have emerged in recent years as a revolutionary technology with the potential to revolutionize cancer monitoring. These sensors are useful for clinical applications because of their high sensitivity, selectivity, rapid response, and compatibility with miniaturized equipment. This review paper gives an in-depth look at the latest developments and the possibilities of carbon-based electrochemical sensors in cancer surveillance. The essential principles of carbon-based electrochemical sensors are discussed, including their structure, operating mechanisms, and critical qualities that make them suited for cancer surveillance. Furthermore, we investigate their applicability in detecting specific cancer biomarkers, evaluating therapy responses, and detecting cancer recurrence early. Additionally, a comparison of carbon-based electrochemical sensor performance measures, including sensitivity, selectivity, accuracy, and limit of detection, is presented in contrast to existing monitoring methods and upcoming technologies. Finally, we discuss prospective tactics, future initiatives, and commercialization opportunities for improving the capabilities of these sensors and integrating them into normal clinical practice. The review highlights the potential impact of carbon-based electrochemical sensors on cancer diagnosis, treatment, and patient outcomes, as well as the importance of ongoing research, collaboration, and validation studies to fully realize their potential in revolutionizing cancer monitoring.
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Técnicas Biosensibles , Neoplasias , Humanos , Carbono , Estudios Prospectivos , Técnicas Electroquímicas/métodos , Técnicas Biosensibles/métodos , Neoplasias/diagnósticoRESUMEN
Vanillin is a popular flavoring agent in many food products. Simple, fast, and reliable quantification of this compound is crucial for the food industry. In this work, we have developed a new electrochemical sensor for accurate detection of vanillin in various real samples. The composite electrode was made of sodium montmorillonite nanoclay (SMM) and gold nanoparticles modified ZIF-67 (Au@ZIF-67), in which SMM contributes to the large adsorption capacity of the analyte, ZIF-67 and SMM supply more sensing active sites, and gold nanoparticles provide high electrical conductivity. The sensing electrode was comprehensively characterized using Brunauer-Emmett-Teller, EDS, XRD, SEM, FTIR, and TEM, and its electrochemical behavior for determination of vanillin including the electrooxidation mechanism of vanillin and different parameters such as scan rate and pH value was investigated. The result revealed that a two electron-two proton process was involved in the electrooxidation of vanillin, which takes place more readily due to the lower potential on the surface of SMM/Au@ZIF-67/carbon paste electrode. The new composite electrode was also more sensitive to vanillin detection with an anodic peak current almost 2.6 times more than that of the bare electrode. A linear sensing concentration range was established between 1 and 1200 nM with a detection limit of 0. 3 nM and a limit of quantitation of 1 nM. For real samples, the sensor demonstrated excellent recovery rates and reliability that was comparable to the standard high-performance liquid chromatography method.
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Oro , Nanopartículas del Metal , Oro/química , Nanopartículas del Metal/química , Bentonita , Reproducibilidad de los Resultados , Técnicas Electroquímicas/métodos , ElectrodosRESUMEN
Metal-organic frameworks (MOFs) are attractive functional materials due to their high surface area, high porosity, and flexible compositions. However, the high precursor cost and complex synthetic processes hinder their large-scale applications. Herein, a novel green approach has been developed toward the synthesis of Cu-based MOF by a solvent-free mechano-synthesis method and utilizing consumed polyethylene terephthalate (PET)-derived benzenedicarboxylate (BDC) as the linker. The as-prepared CuBDC and aminated CuBDC (CuBDC-NH2) act as green catalysts for the reduction of deleterious 4-nitrophenol (4-NP) into the value-added 4-aminophenol (4-AP). Compared with CuBDC, CuBDC-NH2 shows increased adsorption capability and reduction efficiency. The mechanism and thermodynamic studies suggest that the adsorption of 4-NP on CuBDC-NH2 is an endothermic, spontaneous, favorable, and physical adsorption process. Furthermore, CuBDC-NH2 can expedite the reduction of 4-NP by participating in an adsorptive catalytic process. With the CuBDC-NH2 catalyst, the catalytic normalized kinetic rate of 4-NP was achieved 11.28 mol/min. mg, outperforming state-of-the-art catalysts, and a complete reduction occur in 5 min for a concentrated effluent (200-ppm 4-NP). The plastic waste-derived MOF-mediated catalytic valorization of organic pollutants demonstrated here opens an avenue for the green recycling/utilization of plastic waste, providing meaningful insights into the sustainable management of organic pollutants in wastewater.
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Contaminantes Ambientales , Tereftalatos Polietilenos , NitrofenolesRESUMEN
Here, we prepared UiO-66-NH2 and employed a post-synthesis modification method for its functionalization with a ß-cyclodextrin (ß-CD) organic compound. The resulting composite was employed as a support for the heterogenization of the Pd NPs. Various techniques, including FT-IR, XRD, SEM, TEM, EDS, and elemental mapping, were used to characterize UiO-66-NH2@ß-CD/PdNPs, indicating its successful preparation. Three C-C coupling reactions, including the Suzuki, Heck, and Sonogashira coupling reactions, were promoted using the produced catalyst. As a result of the PSM, the proposed catalyst displays improved catalytic performance. In addition, the suggested catalyst was highly recyclable up to 6 times.
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In this report, the novel UiO66NH2 based-MOF(Zr) catalytic system which further modified with nitrogen-rich organic ligand (5-aminotetrazole) using post synthetic modification (PSM) approach has been prepared here as an efficient catalyst to promote the A3-coupling preparation of propargyl amines in green aquatic media. This newly highly efficient catalyst was synthesized upon Zr-based MOF (UiO66NH2) which successfully functionalized with 2,4,6trichloro1,3,5triazine (TCT) and 5aminotetrazole, following through stabilization of gold metal (Au) nanopartilces. The addition of N-rich organic ligand through post-synthesis modification which can be assisted to stabilize the bister and stable gold nanoparticles caused to unique structure of the final composite in favor of the progress of the A3 coupling reaction. Also several strategies comprising XRD, FT-IR, SEM, BET, TEM, TGA, ICP, EDS and elemental mapping analyzes, were used to indicate the successful preparation of the UiO-66-NH2@ Cyanuric Chloride@ 5-amino tetrazole/Au-NPs. The results of productivity catalyst are accomplished in good to excellent yields for all sort of reactions under mild conditions which is a proof of superior activity heterogeneous catalyst containing Au-nanoparticles. In addition, the suggested catalyst represented excellent reusability with no remarkable loss in activity up 9 sequential runs.
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In this research, the one-step synthesis of novel porphyrin-based nanocomposites was performed easily using a photochemical under visible light illumination strategy. As a result, the focus of this research is on synthesizing and using decorated ZnTPP (zinc(II)tetrakis(4-phenyl)porphyrin) nanoparticles with Ag, Ag/AgCl/Cu, and Au/Ag/AgCl nanostructures as antibacterial agents. Initially, ZnTPP NPs were synthesized as a result of the self-assembly of ZnTPP. In the next step, in a visible-light irradiation photochemically process, the self-assembled ZnTPP nanoparticles were used to make ZnTPP/Ag NCs, ZnTPP/Ag/AgCl/Cu NCs, and ZnTPP/Au/Ag/AgCl NCs. A study on the antibacterial activity of nanocomposites was carried out for Escherichia coli, and Staphylococcus aureus as pathogen microorganisms by the plate count method, well diffusion tests, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) values determination. Thereafter, the reactive oxygen species (ROS) were determined by the flow cytometry method. All the antibacterial tests and the flow cytometry ROS measurements were carried out under LED light and in dark. The (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was applied to investigate the cytotoxicity of the ZnTPP/Ag/AgCl/Cu NCs, against Human foreskin fibroblast (HFF-1) normal cells. Due to the specific properties such as admissible photosensitizing properties of porphyrin, mild reaction conditions, high antibacterial properties in the presence of LED light, crystal structure, and green synthesis, these nanocomposites were recognized as kinds of antibacterial materials that are activated in visible light, got the potential for use in a broad range of medical applications, photodynamic therapy, and water treatment.
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Nanopartículas del Metal , Nanocompuestos , Humanos , Especies Reactivas de Oxígeno , Nanocompuestos/química , Fotosíntesis , Escherichia coli , Antibacterianos/farmacología , Antibacterianos/química , Nanopartículas del Metal/químicaRESUMEN
Pendimethalin (PND) is a herbicide that is regarded to be possibly carcinogenic to humans and toxic to the environment. Herein, we fabricated a highly sensitive DNA biosensor based on ZIF-8/Co/rGO/C3N4 nanohybrid modification of a screen-printed carbon electrode (SPCE) to monitor PND in real samples. The layer-by-layer fabrication pathway was conducted to construct ZIF-8/Co/rGO/C3N4/ds-DNA/SPCE biosensor. The physicochemical characterization techniques confirmed the successful synthesis of ZIF-8/Co/rGO/C3N4 hybrid nanocomposite, as well as the appropriate modification of the SPCE surface. The utilization of ZIF-8/Co/rGO/C3N4 nanohybrid as a modifier was analyzed using. The electrochemical impedance spectroscopy results showed that the modified SPCE exhibited significantly lowered charge transfer resistance due to the enhancement of its electrical conductivity and facilitation of the transfer of charged particles. The proposed biosensor successfully quantified PND in a wide concentration range of 0.01-35 µM, with a limit of detection (LOD) value of 8.0 nM. The PND monitoring capability of the fabricated biosensor in real samples including rice, wheat, tap, and river water samples was verified with a recovery range of 98.2-105.6%. Moreover, to predict the interaction sites of PND herbicide with DNA, the molecular docking study was performed between the PND molecule and two sequence DNA fragments and confirmed the experimental findings. This research sets the stage for developing highly sensitive DNA biosensors that will be used to monitor and quantify toxic herbicides in real samples by fusing the advantages of nanohybrid structures with crucial knowledge from a molecular docking investigation.
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Técnicas Biosensibles , Grafito , Herbicidas , Humanos , Carbono , Simulación del Acoplamiento Molecular , Técnicas Electroquímicas/métodos , ADN/química , Grafito/química , ElectrodosRESUMEN
Three nickel substituted Keggin-type polyoxometalates, α-[SiW9O37{Ni(H2O)}3]-10 (denoted as SiW9Ni3), was intercalated into Zn3Al based Layered Double Hydroxide (Zn3Al-LDH) by the selective ion-exchange technique. The as-synthesized nanocomposite, SiW9Ni3@Zn3Al, was used as heterogeneous nanoreactor to promote the synthesis of drug-like aminoimidazopyridine small molecule skeletons via the well-known Ugi-type Groebke-Blackburn-Bienaymé reaction (GBB 3-CRs) in the absence of any acid/additive and under mild and solvent-free conditions. A synergistic catalytic effect between SiW9Ni3 polyoxometalate and Zn3Al-LDH precursors is evidenced by a higher catalytic property of the SiW9Ni3@Zn3Al composite compared to the individual constituents separately. Lewis/Bronsted acidity of the SiW9Ni3 polyoxometalate and Zn3Al-LDH precursors appear to be essential for the catalytic performance of the composite. Furthermore, the catalytic performance of SiW9Ni3@Zn3Al was also tested in GBB 3-CRs synthesis of amino imidazothiazole under mild and solvent-free conditions.
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In this research a highly efficient and heterogeneous catalyst of ZSM-5@APTMS@(E)-4-((pyridin-2-ylimino)methyl) benzaldehyde@Cu-NPs was synthesized for upgrading the A3 coupling reaction for the synthesis of propargylamines under mild conditions. Rational tuning of the microenvironment of metallic NPs to improve efficiency and reusability in catalytic performances is of significance for scalable applications. Firstly, ZSM-5 was immobilized with APTMS (3-aminopropyltrimethoxysilane) and further modified with (E)-4-((pyridin-2-ylimino)methyl)benzaldehyde. Subsequently, the amine-activated zeolite@(E)-4-((pyridin-2-ylimino)methyl)benzaldehyde was applied to increase the stabilization of Cu metal nanoparticles. The catalyst was treated with hydrazine to reduce Cu(ii) to Cu(0), which led to active metal sites. The results of catalytic performance in comparison with different parts of catalysis indicate high efficiency due to the stabilization of copper nanoparticles onto the newly synthesized support of MOF modified with nitrogen aromatic groups. The addition of N-rich organic ligand through modification alters the electronic structure of the final composite in favor of the progress of the A3-coupling reaction. Moreover, the proposed catalyst showed no reduction in the catalytic performance up to four cycles, and a minor loss of efficiency occurs after the seventh cycle. In addition, the catalyst was effectively recycled up to 7 times without leaching of Cu-NPs.
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The biological approach for synthesizing nanoparticles (NPs) using plant extracts is an efficient alternative to conventional physicochemical methods. Galegine, isolated from Galega (Galega officinalis L.), has anti-diabetic properties. In the present study, silver nanoparticles (AgNPs) loaded onto urea-based periodic mesoporous organosilica (AgNPs/Ur-PMO) were bio-synthesized using G. officinalis leaf extract. The synthesized NPs were characterized and confirmed via analysis methods. Different concentrations of biosynthesized AgNPs/Ur-PMO nanoparticles (0, 1, 5, 10, and 20 mg L-1) were used as elicitors in cell suspension culture (CSC) of G. officinalis. The callus cells from hypocotyl explants were treated at their logarithmic growth phase (8th d) and were collected at time intervals of 24, 72, 120, and 168 h. The viability and growth of cells were reduced (by 17% and 35%, respectively) at higher concentrations and longer treatments of AgNPs/Ur-PMO; however, the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA) were increased (1.23 and 3.01 fold, respectively in comparison with the control average). The highest total phenolic (2.43 mg g-1 dry weight) and flavonoid (2.22 mg g-1 dry weight) contents were obtained 168 h after treatment with 10 mg L-1 AgNPs/Ur-PMO. An increasing tendency in the antioxidant enzyme activities was also observed in all the elicitor concentrations. Treatment with AgNPs/Ur-PMO (in particular 5 mg L-1 for 120 h) significantly enhanced the galegine content (up to 17.42 mg g-1) about 1.80 fold compared with the control. The results suggest that AgNPs/Ur-PMO can be used as an effective elicitor for enhancing galegine production in the CSC of G. officinalis. KEY POINTS: ⢠The green biosynthesis of AgNPs/Ur-PMO was done using G. officinalis leaf extract ⢠Its toxicity as an elicitor increased with increasing concentration and treatment time ⢠AgNPs/Ur-PMO significantly increased the antioxidant capacity and galegine content.
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Galega , Nanopartículas del Metal , Antioxidantes , Nanopartículas del Metal/química , Plata/química , Peróxido de Hidrógeno , Extractos Vegetales/químicaRESUMEN
p_Aminophenol, namely 4-aminophenol (4-AP), is an aromatic compound including hydroxyl and amino groups contiguous together on the benzene ring, which are suitable chemically reactive, amphoteric, and alleviating agents in nature. Amino phenols are appropriate precursors for synthesizing oxazoles and oxazines. However, since the toxicity of aniline and phenol can harm human and herbal organs, it is essential to improve a reliable technique for the determination of even a trace amount of amino phenols, as well as elimination or (bio)degradation/photodegradation of it to protect both the environment and people's health. For this purpose, various analytical methods have been suggested up till now, including spectrophotometry, liquid chromatography, spectrofluorometric and capillary electrophoresis, etc. However, some drawbacks such as the requirement of complex instruments, high costs, not being portable, slow response time, low sensitivity, etc. prevent them to be employed in a wide range and swift in-situ applications. In this regard, besides the efforts such as (bio)degradation/photodegradation or removal of 4-AP pollutants from real samples, electroanalytical techniques have become a promising alternative for monitoring them with high sensitivity. In this review, it was aimed to emphasize and summarize the recent advances, challenges, and opportunities for removal, degradation, and electrochemical sensing 4-AP in real samples. Electroanalytical monitoring of amino phenols was reviewed in detail and explored the various types of electrochemical sensors applied for detecting and monitoring in real samples. Furthermore, the various technique of removal and degradation of 4-AP in industrial and urban wastes were also deliberated. Moreover, deep criticism of multifunctional nanomaterials to be utilized as a catalyst, adsorbent/biosorbent, and electroactive material for the fabrication of electrochemical sensors was covered along with their unique properties. Future perspectives and conclusions were also criticized to pave the way for further studies in the field of application of up-and-coming nanostructures in environmental applications.
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Contaminantes Ambientales , Nanoestructuras , Humanos , Aminofenoles/análisis , Contaminantes Ambientales/análisis , Fenoles/análisis , Nanoestructuras/químicaRESUMEN
The first ultrasonic synthesis of [Cu(L)4(SCN)2] (L = 1-methylimidazole) nanocomplex was carried out under ultrasonic irradiation, and its photocatalytic performance for the degradation of remdesivir (RS) under sunlight irradiation was comprehensively investigated for the first time in this study. The physicochemical properties of the synthesized photocatalyst were examined by Fourier-transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), diffuse reflectance spectroscopy (DRS), and thermogravimetric analysis (TGA) techniques. The band gap of the synthesized [Cu(L)4(SCN)2] nanocomplex was determined to be 2.60 eV by the diffuse reflectance spectroscopy method using Kubelka-Munk formula. The photocatalytic performance of nanocomplex was examined for the removal of remdesivir under sunlight from water for which the results indicated that an amount of 0.5 gL-1 of the [Cu(L)4(SCN)2] nanocomplex was sufficient to remove more than 96% remdesivir from its 2 mg L-1 concentration within 20 min, at pH = 6. The kinetic data showed that the photodegradation onto the [Cu(L)4(SCN)2] nanocomplex has a high correlation (0.98) with the pseudo-second-order kinetic model. The decrease in chemical oxygen demand (COD) (from 70.5 mg L-1 to 36.4 mg L-1) under optimal conditions clearly confirmed the mineralization of the RS drug. The values of ΔS° (-0.131 kJ mol-1 K-1) and ΔH° (-49.750 kJ mol-1) were negative, indicating that the adsorption process was spontaneous and more favorable in lower temperatures. Moreover, the RS structure in the open shell state and the high HOMO and LUMO gaps based on the M06/6-31 + G (d) level of theory may be a confirmation of this fact. In addition, the Hirshfeld surface analysis (HSA) of the crystal packing of the prepared complex was discussed in detail to evaluate the interactions between the crystal packings. The results of this study confirm that the [Cu(L)4(SCN)2] nanocomplex can be successfully used for the photodegradation of pharmaceutical contaminants.
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Profármacos , Nucleótidos , Espectroscopía Infrarroja por Transformada de Fourier , Termodinámica , CatálisisRESUMEN
Co3O4 NPs in N-doped porous carbon (Co3O4 NPs@N-PC) materials were prepared by one-pot pyrolysis of a ZIF-67 powder under N2 atmosphere and followed by oxidation under air atmosphere (200 °C) toward promotion catalytic activity and activation of peroxymonosulfate (PMS) to degradation sulfamethoxazole (SMZ). 2-methylimidazole was used as a nitrogen source and a competitive ligand for the synthesis of Co3O4 NPs@N-PC, which in addition to affecting nucleation and growth of the crystal, promotes the production of active Co-N sites. Co3O4 NPs@N-PC nano-architecture has high specific surface areas (250 m2 g-1) and is a non-toxic, effective and stable PMS activator. The effect of operating parameters including SMZ concentration, catalyst dosage, temperature and pH in the presence of Co3O4 NPs@N-PC was investigated. The Co3O4 NPs@N-PC composite showed superior performance in activating PMS over a wide range of pH (2-10) and different temperatures so that complete degradation of SMZ (50 µM, 100 mL) was achieved within 15 min. The role of Co2+/Co3+ redox system in the mechanism before and after PMS activation was determined using XPS analysis. Surface-generated radicals led to the degradation of SMZ, in which the SMZ degradation rate attained 0.21 min-1 with the mineralization of 36.8%. The feasible degradation mechanism of SMZ was studied in the presence of different scavengers and it was revealed that the degradation reaction proceeds from the radical/non-radical pathway and in this process most of the SO4- and OH radicals are dominant. The recoverability and reuse of Co3O4 NPs@N-PC were evaluated to confirm its stability and potential for SMZ degradation and it was observed that the catalyst maintains its catalytic power for at least 5 cycles.
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Carbono , Nanocompuestos , Carbono/química , Sulfametoxazol , Aguas Residuales , Porosidad , Antibacterianos , Peróxidos/química , Nanocompuestos/química , Oxidación-Reducción , Estrés OxidativoRESUMEN
Two Cu(II) (C1) and Ni(II) (C2) complexes were designed through the one-pot reaction of pyridine-2,6-dicarboxylic acid and 2-aminobenzimidazole respectively with copper(II) nitrate hexahydrate and nickel(II) nitrate hexahydrate. Both complexes were characterized by single-crystal X-ray diffraction and the distorted octahedral geometry was recognized for them. The MTT assay indicated that the complexes have a significant antiproliferative effect on BEL-7404 cells. IC50 values confirmed that C1 (IC50 = 0.56 µM) is several times more potent than C2 (IC50 = 5.13 µM). The similar cellular uptake of the complexes in mentioned cells led to this proposal that the production of ROS with different values can be the main reason for different cytotoxicity of the complexes. In this study, C1 and C2 caused BEL-7404 cells arrest at the G2/M and S phases, respectively. The expression of p53, Bax up-regulation, and Bcl-2 down-regulation and also activation of procaspase-9, and 3 indicated that apoptosis through a caspase-dependent mitochondrion pathway is a remarkable pathway in BEL-7404 cells treated by C1 while mechanistic studies proved that C2 induce death of BEL-7404 cells through the activation of RAGE/PI3KC3/Beclin 1 autophagic cell signaling pathway, more specifically. The cytostatic effect of the complexes in the BEL-7404 3D spheroid model was depicted.
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Antineoplásicos , Níquel , Compuestos de Organocobre , Piridinas , Antineoplásicos/farmacología , Antineoplásicos/química , Apoptosis , Ligandos , Piridinas/química , Piridinas/farmacología , Níquel/química , Níquel/farmacología , Línea Celular Tumoral , Humanos , Compuestos de Organocobre/química , Compuestos de Organocobre/farmacologíaRESUMEN
Herein, we have presented a new insight for the synthesis of a hybrid heterogeneous catalyst. For this purpose, phosphonic acid tagged carbon quantum dots of CQDs-N(CH2PO3H2)2 encapsulated and assembled in channels of SBA-15 using a post-modification strategy. The mesoporous catalyst of functionalized carbon quantum dots (CQDs) was characterized by several techniques. CQDs-N(CH2PO3H2)2/SBA-15 as an excellent catalyst was applied for the preparation of novel pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine derivatives by using pyrazole, barbituric acid and indole moieties at 100 °C under the solvent-free condition. The present work shows that a significant increase in the catalytic activity can be achieved by a rational design of mesoporous SBA-15 modified with CQDs for the synthesis of biological active candidates. The synthesized compounds did not convert to their corresponding pyridines via an anomeric-based oxidation mechanism.
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Puntos Cuánticos , Carbono , IndolesRESUMEN
Here, we prepare an Au NP decorated dithiocarbamate functionalized boehmite (γ-AlO(OH)@C-NHCS2H·AuNPs). This stepwise synthetic method gives an efficient, cost-effective, and green heterogenous Au-based nanocatalyst for the A3-coupling preparation of the biologically essential propargylamines. Different characterization methods, including FT-IR, XRD, SEM, TEM, EDX spectra, and elemental SEM-mapping, were employed to investigate the structure of the manufactured γ-AlO(OH)@C-NHCS2H·AuNPs. Then we used the prepared composite as a heterogeneous gold-based nanocatalyst for the one-pot A3-coupling preparation of propargyl amines by reacting a variety of aldehydes, amines, and phenylacetylene which exhibited promising results.