RESUMEN
PURPOSE: The recommended duration of pulmonary tuberculosis therapy is 6 months. For extrapulmonary tuberculosis, treatment duration depends on tuberculosis involvement and HIV status. The objective of this study was to describe the main characteristics of a cohort of extrapulmonary tuberculosis patients, to compare patients with a 6-month treatment to those with more than a 6-month treatment, and to analyze the compliance of medical centres with recommended duration of treatment. METHODS: A retrospective cohort study of 210 patients with extrapulmonary tuberculosis was carried from January 1999 to December 2006 in two hospitals in the north-east of Paris. These patients were treated with quadruple therapy during two months, followed by dual therapy during 4 months (n=77) or more (n=66). The characteristics of each group were compared by uni- and multivariate analysis. The primary endpoint was the rate of relapse or treatment failure at 24-month follow-up after treatment completion. RESULTS: No relapse was observed after 24 months of follow-up after the end of treatment in the two groups. In univariate analysis, patients with lymph node tuberculosis were more often treated for 6 months than at other sites of tuberculosis (respectively 61% versus 40.9%; P=0.02); the decision of treatment duration was related to medical practices (79.2% treated 6 months in one hospital versus 20.7% in the other, P<0.001); patients living in private residence were more often treated during 6 months than patients living in residence (24.2% versus 10.3%, P=0.042). In multivariate analysis, only hospital (P=0.046), sex (P=0.007) and private residence were significantly different in each group. CONCLUSION: A period of 6 months seems to be sufficient to treat extrapulmonary tuberculosis (except for neuromeningeal localization).
Asunto(s)
Antituberculosos/uso terapéutico , Tuberculosis/tratamiento farmacológico , Infecciones Oportunistas Relacionadas con el SIDA/tratamiento farmacológico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Algoritmos , Estudios de Cohortes , Continuidad de la Atención al Paciente/estadística & datos numéricos , Interpretación Estadística de Datos , Bases de Datos Factuales/estadística & datos numéricos , Esquema de Medicación , Femenino , Infecciones por VIH/complicaciones , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Paris/epidemiología , Cooperación del Paciente/estadística & datos numéricos , Estudios Retrospectivos , Factores de Tiempo , Tuberculosis/complicaciones , Tuberculosis/epidemiología , Adulto JovenRESUMEN
OBJECTIVES: Muckle-Wells syndrome (MWS) and familial cold autoinflammatory syndrome (FCAS) are rare periodic fevers associated with CIAS1 mutations. A third entity, the chronic infantile neurological, cutaneous, articular (CINCA) syndrome was also recently associated with mutation in the same gene. A phenotypic and genotypic continuum seems to exist from the most benign (FCAS) to the most severe forms (CINCA). Although a CIAS1 mutation can be associated with two different phenotypes. METHODS: We report a family of three patients exhibiting the MWS and FCAS phenotypes. These phenotypes were associated with a novel missense mutation in CIAS1. RESULTS: Anakinra controlled inflammatory flares in the three patients. CONCLUSIONS: FCAS, MWS and CINCA could be different phenotype expressions of the same disease.
Asunto(s)
Enfermedades Autoinmunes/tratamiento farmacológico , Enfermedades Autoinmunes/genética , Proteínas Portadoras/genética , Predisposición Genética a la Enfermedad , Proteína Antagonista del Receptor de Interleucina 1/uso terapéutico , Mutación Missense , Adolescente , Adulto , Artralgia/genética , Artralgia/inmunología , Enfermedades Autoinmunes/fisiopatología , Enfermedad Crónica , Frío , Conjuntivitis/genética , Conjuntivitis/inmunología , Análisis Mutacional de ADN , Femenino , Fiebre/genética , Fiebre/inmunología , Estudios de Seguimiento , Heterocigoto , Humanos , Masculino , Persona de Mediana Edad , Proteína con Dominio Pirina 3 de la Familia NLR , Linaje , Fenotipo , Medición de Riesgo , Índice de Severidad de la Enfermedad , Síndrome , Resultado del Tratamiento , Urticaria/genética , Urticaria/inmunologíaRESUMEN
OBJECTIVE: The hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS) was originally defined by the presence of a high serum level of immunoglobulin D associated with recurrent fever. Since the discovery of the mevalonate kinase gene (MVK) gene encoding the mevalonate kinase enzyme, most patients with a clinical diagnostic of HIDS are now found to have a mevalonate kinase deficiency based on metabolic and genetic data. We aimed to asses the value of a high IgD serum level for the diagnosis of HIDS in a cohort of patients with a phenotype of recurrent fever, and to characterize patients with a high IgD serum level without mevalonate kinase mutation. METHODS: Main clinical and biological data of 50 patients who presented with clinical signs compatible with HIDS have been prospectively registered on a standard form. Clinical data have been analysed according the IgD serum level and the presence of MVK mutation. RESULTS: The metabolic and genetic data establishing the diagnosis of HIDS correlated in all cases. In this series of 50 patients, the sensitivity of a high IgD value for the diagnosis of HIDS is 0.79. In five patients with MVK mutation, IgD levels were found to be in the normal range. Likelihood ratios indicate that IgD measurement is not relevant for the diagnostic of HIDS. Most patients with a high serum IgD level and no MVK mutation have no definite diagnosis. CONCLUSION: The clinical relevance of the IgD measurement for the diagnosis of MKD in our population appears as poor, as reflected by likelihood ratios which are both close to 1.
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Fiebre Mediterránea Familiar/diagnóstico , Inmunoglobulina D/sangre , Deficiencia de Mevalonato Quinasa/diagnóstico , Biomarcadores/sangre , Niño , Preescolar , Fiebre Mediterránea Familiar/genética , Femenino , Humanos , Masculino , Deficiencia de Mevalonato Quinasa/genética , Mutación , Fosfotransferasas (Aceptor de Grupo Alcohol)/deficiencia , Fosfotransferasas (Aceptor de Grupo Alcohol)/genética , Estudios Prospectivos , Sensibilidad y EspecificidadRESUMEN
Splenic ruptures secondary to infection are rare, life threatening and difficult to diagnose. The main management is surgery, however non-operative management in the stable patient is possible. We report the case of a 60-yr-woman with spontaneous splenic rupture during CMV primary infection. Non-operative treatment failed and splenectomy was done.
Asunto(s)
Infecciones por Citomegalovirus/complicaciones , Mononucleosis Infecciosa/complicaciones , Rotura del Bazo/etiología , Síndrome CREST/complicaciones , Femenino , Humanos , Hipotensión/etiología , Mononucleosis Infecciosa/virología , Persona de Mediana Edad , Rotura Espontánea , Esplenectomía , Rotura del Bazo/diagnóstico por imagen , Rotura del Bazo/cirugía , UltrasonografíaRESUMEN
OBJECTIVE: Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) has been associated with several mutations in the TNF receptor super family 1A (TNFRSF1A), including most cysteine substitutions. However, the nature of two substitutions, P46L and R92Q, remains a topic of discussion. The aim of this study was to assess the actual role of these two sequence variations in a series of patients with TRAPS. METHODS: The main clinical data of 89 patients with TRAPS have been prospectively registered on a standard form. 84 patients or members of families with recurrent episodes of inflammatory symptoms spanning a period of more than 6 months and harbouring a TNFRSF1A mutation were studied. Clinical data have been analysed according to the nature of the mutation-P46L, R92Q or others. RESULTS: P46L is often seen in patients from Maghreb and is associated with a mild phenotype. P46L appears as a polymorphism with a non-specific role in inflammation. R92Q is associated with a variable phenotype and presents as a low-penetrance mutation. Interpreting these results will require a comparison with clinical signs and genetic background.