RESUMEN
Se presenta un caso de litiasis renal en el contexto de una hiperoxaluria primaria. Analizamos proceso diagnóstico y actitudes terapéuticas (AU)
Asunto(s)
Masculino , Niño , Humanos , Cálculos Renales/complicaciones , Cálculos Renales , Hiperoxaluria Primaria/complicaciones , Hiperoxaluria Primaria , Urografía , Hiperoxaluria Primaria/cirugía , Cálculos Renales/cirugíaRESUMEN
Nefrocalcinosis es un término que significa depósito de calcio, oxalato y fosfatos en el interior del túbulo renal y en el intersticio. Múltiples patologias son causantes potenciales de este, proceso aunque a festos prdcticos pocas de ellos la produzcan (AU)
Asunto(s)
Adulto , Femenino , Humanos , Nefrocalcinosis/fisiopatología , Cálculos Urinarios/terapia , Pielonefritis Xantogranulomatosa/diagnóstico , Insuficiencia Renal/diagnóstico , Acidosis Tubular Renal/diagnóstico , Acidosis Tubular Renal/clasificación , Embolización Terapéutica , Síndrome de Bartter/diagnósticoRESUMEN
A partir de tres casos de litiasis coraliforme que se trataron mediante realización de nefrolitotomía bivalva, presentamos la descripción de la técnica quirúrgica y nuestros resultados de 1989 a 1994, en que se realizaron 19 casos (AU)
Asunto(s)
Femenino , Masculino , Persona de Mediana Edad , Humanos , Cálculos Urinarios/cirugía , Cálculos Urinarios/diagnóstico , Cálculos Urinarios , Dolor de Espalda/complicaciones , Dolor de Espalda/diagnóstico , Dolor de Espalda/etiología , Infecciones Urinarias/complicaciones , Infecciones Urinarias/diagnóstico , Infecciones Urinarias/etiología , Recurrencia , Riñón/cirugía , Riñón/patología , Riñón , Nefrostomía Percutánea/métodos , Nefrostomía Percutánea , Isquemia/complicaciones , Isquemia/diagnóstico , Isquemia/etiología , Papaverina/uso terapéuticoRESUMEN
La monoterapia con ESWL del cálculo coraliforme constituye un punto de controversia habitual en la bibliografía y en la práctica clínica. Este trabajo presenta la clasificación actual del cálculo coraliforme, así como un protocolo de tratamiento (AU)
Asunto(s)
Humanos , Cálculos Urinarios/cirugía , Cálculos Urinarios/diagnóstico , Cálculos Urinarios/etiología , Litotricia/métodos , Cálculos Renales/diagnóstico , Cálculos Renales/química , Cálculos Renales/terapia , Cálculos/diagnóstico , Cálculos/terapia , Protocolos Clínicos , Cálculos Urinarios/epidemiología , Cálculos Urinarios/fisiopatología , Nefrectomía/métodos , Hidronefrosis/complicacionesRESUMEN
Un enfoque terapéutico adecuado e individualizado es la base fundamental para prevenir la recidiva litiásica en la cistnuria. Al ser un tratamiento de por vida existe una elevada falta de adherencia al mismo, por lo que se requiere de un seguimiento periódico por parte del médico. A pesar de todas las medidas terapéuticas y normas de conducta empleadas, en algunos casos la recidiva litiásica puede persistir (AU)
Asunto(s)
Adulto , Masculino , Humanos , Cistina/administración & dosificación , Cistina/uso terapéutico , Cálculos Renales/diagnóstico , Cálculos Renales/etiología , Cálculos Renales/terapia , Recurrencia , Cistinuria/diagnóstico , Cistinuria/cirugía , Cistinuria , Cálculos Renales/diagnóstico , Cálculos Renales/cirugía , Cálculos Renales/etiología , Cálculos Urinarios/complicaciones , Cálculos Urinarios/diagnóstico , Cálculos Urinarios/cirugía , Enfermedades Renales/cirugía , Enfermedades Renales/complicaciones , Enfermedades Renales/diagnósticoRESUMEN
En la formación de los cálculos de cistina es fundamental la presencia de una concentración elevada de cistina en orina deforma permanente; la acidez urinaria participa deforma importante en la cristalización urinaria de la cistina. La variabilidad fenotípica que presentan los pacientes afectos presupone que otros factores influyen en la formación del cálculo de cistina. A los factores etiopatogénicos ya conocidos que influyen en la génesis de la enfermedad litiásica en general se suman: otro/s aún por descubrir. La condición de enfermedad poligénica no parece influir en el fenotipo clínico de los pacientes. (AU)
Asunto(s)
Humanos , Cistinuria/complicaciones , Litiasis/etiología , Enfermedades Renales/etiología , Cistinuria/genética , Litiasis/genética , Enfermedades Renales/genética , Biología MolecularRESUMEN
OBJECTIVE: To assess baseline variables able to predict neuropsychiatric side effects (NPSEs) associated with the initiation of an efavirenz (EFV)-containing regimen in HIV-1-infected patients. DESIGN: Open-label, prospective, observational study. METHODS: Consecutive HIV-1-infected outpatients in whom EFV was prescribed underwent a psychiatric interview. At baseline and at 2, 4, and 12 weeks, patients completed the Symptoms Check List-90-Revised (SCL-90-R), the Medical Outcome Study for HIV-positive patients (MOS-HIV), and a standardized questionnaire concerning potential NPSEs. RESULTS: Preliminary data showed that discontinuation of EFV because of NPSEs occurred in 4 of 31 patients (13%). Patients who completed the follow-up showed a decrease in SCL-90-R total score (p =.004) and in several subscales such as Interpersonal Sensitivity (p =.009), Depression (p =.001), and Anxiety (p =.040), whereas no changes in MOS-HIV were observed. Having fewer years of education (p =.006), having fewer baseline central nervous symptoms (p =.000), reporting better baseline physical status (p =.013), and having higher baseline scores in the Heath Transition subscale of the MOS-HIV (p =.000) and in the Somatization subscale of the SCL-90-R (p =.002) were associated with more NPSEs. CONCLUSION: Patients maintained on EFV showed a decrease in psychologic distress related to self-image, depression, and anxiety, without any effect on quality of life. Patients with a lower level of education, those who feel physically and psychologically better at baseline than in the past, and those who suffer from more distress as a result of physical complaints may be at greater risk of reporting more NPSEs after EFV initiation.
Asunto(s)
Fármacos Anti-VIH/efectos adversos , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/psicología , Oxazinas/efectos adversos , Inhibidores de la Transcriptasa Inversa/efectos adversos , Adulto , Alquinos , Benzoxazinas , Ciclopropanos , Escolaridad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Pacientes Desistentes del Tratamiento , Estudios ProspectivosRESUMEN
El objetivo de la terapéutica médica aplicada a la enfermedad litiásica es retrasar la recidiva litiásica. La indicación, farmacológica estará circunscrita a aquellas alteraciones metabólicas susceptibles de ser tratadas. A la terapéutica farmacológica debe preceder la aplicación de unas normas generales relacionadas con la ingesta hídrica y la dieta. (AU)
Asunto(s)
Humanos , Litiasis/tratamiento farmacológico , Enfermedades Renales/tratamiento farmacológico , Litiasis/prevención & control , Litiasis/etiología , Litiasis/dietoterapia , Enfermedades Renales/prevención & control , Enfermedades Renales/dietoterapia , Cistinuria/etiología , Calcio de la Dieta , Dieta con Restricción de ProteínasRESUMEN
OBJECTIVE: Cystine renal stone is the only clinical consequence of cystinuria, an autosomal recessive hereditary disease that affects an average of 1 out of 7,000 newborns, and whose geographical distribution varies significantly. The diagnosis and treatment of this condition is reviewed in the light of the advances in genetics and molecular biology. METHODS: The evolution of current knowledge about this disease is reviewed. RESULTS/CONCLUSIONS: The advances over the last 8 years have led to the characterization, at the present time, of two genes responsible for this disease, which demonstrates its polygenic origin. By phenotype, cystinuria can be classified into two types: type 1 and non-type 1. Both types show genetic and biochemical, but not clinical differences. From the therapeutic viewpoint, the main objective is to eliminate existing calculi and, above all, prevent recurrence by acting on the pathophysiologic mechanisms of renal cystine. Experience shows that despite the correct use of our current therapeutic armamentarium and the application of the general guidelines discussed in this paper, some cystinuric patients still maintain an important stone-forming activity. Patient clinical evaluation and a genetic study of both patient and family will be decisive for phenotyping.
Asunto(s)
Cálculos Renales/diagnóstico , Cálculos Renales/terapia , Cistina , Asesoramiento Genético , Humanos , Cálculos Renales/genética , Cálculos Renales/orina , LinajeRESUMEN
Cystinuria is an amino acid disease due to a defect of intestinal and renal tubular transport of cystine and various basic amino acids (lysine, arginine and ornithine). The disease is transmitted horizontally according to an autosomal recessive pattern. The overall prevalence is one per 7,000 live births. It is the commonest hereditary disease affecting amino acid transport (MIM 220100). This disease is characterized by excessive urinary excretion of cystine and basic amino acids. From a clinical point of view, almost 50% of homozygotes will develop cystine renal stones with urinary tract infection, renal colic, partial or total obstruction of the urinary tract and possibly loss of renal function.
Asunto(s)
Cistinuria/genética , Aminoácidos/orina , Cólico/etiología , Cistinuria/orina , Genes Recesivos/genética , Homocigoto , Humanos , Cálculos Renales/etiología , Enfermedades Renales/etiología , Prevalencia , Infecciones Urinarias/etiologíaRESUMEN
From 1989 to 1993, 11,535 extracorporeal shock wave lithotripsy (ESWL) sessions were performed in 6,066 patients in our centre. In contrast, simple or extended pyelolithotomy was the treatment of choice in a small group of patients. The object of this paper is to review the results and complications of this type of operation. A total of 57 pyelolithotomies was performed, including 33 extended pyelolithotomies, in 55 patients (26 men and 29 women). The mean age of the series was 50 years (range: 5-77). The operated kidney was the left kidney in 34 cases and the right kidney in 23 cases. The mean interval between the diagnosis and the operation was 31 months. 64% of the patients had history of stone disease (33 ipsilateral and 2 bilateral). Thirteen patients had already been treated by ESWL (10 patients), percutaneous nephrolithotomy (PNL) (2 cases) and one case had previously undergone pyelolithotomy. A urinary tract infection was observed in 26 patients (47%). The incision consisted of lumbotomy in 40 patients (71%), or a subcostal incision in 12 cases. The mean operating time was 161 minutes (range: 90-245) and the mean intraoperative bleeding was 500 ml. Thirteen patients were transfused (23%). The renal artery had to be clamped in 9 cases (for an average of 19 minutes). After a mean follow-up of 20 month, 50.8% of patients were stone-free. 49% of patients presented residual caliceal fragments on the immediate postoperative X-ray. One patient had to be treated by percutaneous nephrolithotomy and ESWL. 12 cases (41% of patients with residual fragments) required subsequent treatment by ESWL and the remaining patients with residual fragments were asymptomatic and did not receive any further treatment. The immediate postoperative complication rate was 17% and 10% of patients developed late postoperative complications. Simple or extended pyelolithotomy remains an effective treatment for stones of the renal pelvis, either on its own or associated with ESWL. However, the possibility of serious complications demands meticulous patient selection.
Asunto(s)
Cálculos Renales/cirugía , Pelvis Renal/cirugía , Litotricia , Adolescente , Adulto , Anciano , Pérdida de Sangre Quirúrgica , Transfusión Sanguínea , Niño , Preescolar , Constricción , Femenino , Estudios de Seguimiento , Humanos , Cálculos Renales/terapia , Litotricia/efectos adversos , Litotricia/métodos , Masculino , Persona de Mediana Edad , Nefrostomía Percutánea/efectos adversos , Nefrostomía Percutánea/métodos , Complicaciones Posoperatorias , Recurrencia , Arteria Renal/cirugía , Factores de Tiempo , Infecciones Urinarias/etiologíaRESUMEN
Presentation of three cases of 2,8 dihydroxyadenine calculi. This is an infrequent but potentially serious form of lithiasis, of purinic origin, caused by a genetic abnormality (deficit of adenine phosphoribosyltransferase, APRT) affecting both sexes. Frequent confusion of this form with uric lithiasis forces to try the use of IR spectrum or X-ray diffraction. Long-term follow-up of these patients and treatment with allopurinol, avoiding alkalinizating agents, is essential.
Asunto(s)
Adenina/análogos & derivados , Cálculos Urinarios/química , Adenina/análisis , Adulto , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Purinas/metabolismo , Cálculos Urinarios/diagnóstico , Cálculos Urinarios/etiología , Cálculos Urinarios/genética , Cálculos Urinarios/metabolismo , Cálculos Urinarios/terapiaRESUMEN
The Puigvert Urology Centre in Barcelona reports the detailed results of five cases of ureteric stones all treated by first-line shock wave lithotripsy. Only one case obtained a positive result (after 4 sessions). In the other four cases, shock wave therapy had to be completed by ureteroscopy (1 case) or by open surgery (3 cases) to achieve cure.
Asunto(s)
Endoscopía , Litotricia , Cálculos Ureterales/cirugía , Cálculos Ureterales/terapia , Adulto , Anciano , Terapia Combinada , Femenino , Humanos , Cálculos Renales/cirugía , Cálculos Renales/terapia , Masculino , Persona de Mediana Edad , Nefrostomía Percutánea , Cateterismo Urinario/instrumentaciónRESUMEN
In an attempt to document the efficacy of potassium citrate in stone formation, 57 patients with active lithiasis (2 or more stones during the preceding 2 years) and hypocitraturia were randomly allocated into 2 groups, with 1 group taking 30 to 60 mEq. potassium citrate daily in wax matrix tablet formation and the other group receiving placebo. In 18 patients receiving potassium citrate for 3 years stone formation significantly declined after treatment from 1.2 +/- 0.6 to 0.1 +/- 0.2 per patient year (p < 0.0001), in 13 patients (72%) the disease was in remission and all patients showed a reduced stone formation rate individually. In contrast, 20 patients taking placebo medication for 3 years showed no significant change in stone formation rate (1.1 +/- 0.4 to 1.1 +/- 0.3 per patient year) and in only 4 patients (20%) was the disease in remission. The stone formation rate during potassium citrate treatment was significantly lower than during the placebo treatment (0.1 +/- 0.2 versus 1.1 +/- 0.3 per patient year, p < 0.001). Potassium citrate therapy caused a significant increase in urinary citrate, pH and potassium, whereas placebo did not. Adverse reactions to potassium citrate were mild causing only 2 patients in the potassium citrate group and 1 in the placebo group to withdraw from the study. In summary, our randomized trial showed the efficacy of potassium citrate in preventing new stone formation in idiopathic hypocitraturic calcium nephrolithiasis.
Asunto(s)
Citratos/uso terapéutico , Citratos/orina , Cálculos Renales/prevención & control , Adulto , Oxalato de Calcio/análisis , Fosfatos de Calcio/análisis , Ácido Cítrico , Método Doble Ciego , Femenino , Estudios de Seguimiento , Humanos , Cálculos Renales/química , Cálculos Renales/epidemiología , Masculino , Factores de TiempoRESUMEN
During the study of chronic anemia in a 38-year-old woman, a nonfunctioning left kidney due to multiple asymptomatic ureteral calculi was found on excretory urography. She had self-limited episodes of left flank pain 10 years previously. Antegrade pyelography through the nephrostomy tube and computerized tomography showed a pyonephrotic renogastric fistula on that side.
Asunto(s)
Fístula Gástrica/diagnóstico por imagen , Pelvis Renal , Fístula Urinaria/diagnóstico por imagen , Adulto , Femenino , Humanos , Enfermedades Renales/diagnóstico por imagen , RadiografíaRESUMEN
Report on one patient presenting pyelo-duodenal fistula secondary to pyonephrosis by an obstructive calculus in lumbar ureter, treated conservatively with percutaneous nephrostomy.
Asunto(s)
Enfermedades Duodenales/etiología , Fístula Intestinal/etiología , Pelvis Renal , Pielonefritis/complicaciones , Cálculos Ureterales/complicaciones , Fístula Urinaria/etiología , Anciano , Femenino , Humanos , Enfermedades Renales/etiología , Pielonefritis/etiologíaRESUMEN
We report on 10 pregnant women with renal calculi who presented with fever and recurrent renal colic. They were treated with analgesics and fluids. Antibiotics were administered to those with fever and/or positive urine culture. Seven were submitted to endoscopic maneuvers. A flute tipped (Couvelaire) catheter was placed in 4 and a double-J in 3 patients.