Validated, Quantitative, Machine Learning-Generated Neurologic Assessment of Multiple Sclerosis Using a Mobile Application.

BACKGROUND: The BeCare MS Link mobile app collects data as users complete different in-app assessments. It was specifically developed to evaluate the symptomatology and neurologic function of patients with multiple sclerosis (MS) and to become a digital equivalent of the Expanded Disability Status Scale (EDSS) and other standard clinical metrics of MS progression. METHODS: Our research compared EDSS scores derived from the BeCare MS link app to EDSS scores derived from neurologist assessment for the same cohort of 35 patients diagnosed with MS. App-derived data were supplied to 4 different machine learning algorithms (MLAs) with an independent EDSS score prediction generated from each. These scores were compared with the clinically derived EDSS score to assess the similarity of the scores and to determine an accuracy estimate for each. RESULTS: Of the 4 MLAs employed, the most accurate MLA produced 19 EDSS score predictions that exactly matched the clinically derived scores, 21 score predictions within 0.5 EDSS points, and 32 score predictions within 1 EDSS point. The remaining MLAs also provided a relatively high level of accuracy in predicting EDSS scores when compared with clinically derived EDSS, with over 80% of scores predicted within 1 point and a mean squared error with a range of 1.05 to 1.37. CONCLUSIONS: The BeCare MS Link app can replicate the clinically derived EDSS assessment of a patient with MS. The app may also offer a more complete evaluation of disability in patients with MS.

Modified motor unit properties in residual muscle following transtibial amputation.

Objective.Neural signals in residual muscles of amputated limbs are frequently decoded to control powered prostheses. Yet myoelectric controllers assume muscle activities of residual muscles are similar to that of intact muscles. This study sought to understand potential changes to motor unit (MU) properties after limb amputation.Approach.Six people with unilateral transtibial amputation were recruited. Surface electromyogram (EMG) of residual and intacttibialis anterior(TA) andgastrocnemius(GA) muscles were recorded while subjects traced profiles targeting up to 20% and 35% of maximum activation for each muscle (isometric for intact limbs). EMG was decomposed into groups of MU spike trains. MU recruitment thresholds, action potential amplitudes (MU size), and firing rates were correlated to model Henneman's size principle, the onion-skin phenomenon, and rate-size associations. Organization (correlation) and modulation (rates of change) of relations were compared between intact and residual muscles.Main results.The residual TA exhibited significantly lower correlation and flatter slopes in the size principle and onion-skin, and each outcome covaried between the MU relations. The residual GA was unaffected for most subjects. Subjects trained prior with myoelectric prostheses had minimally affected slopes in the TA. Rate-size association correlations were preserved, but both residual muscles exhibited flatter decay rates.Significance.We showed peripheral neuromuscular damage also leads to spinal-level functional reorganizations. Our findings suggest models of MU recruitment and discharge patterns for residual muscle EMG generation need reparameterization to account for disturbances observed. In the future, tracking MU pool adaptations may also provide a biomarker of neuromuscular control to aid training with myoelectric prostheses.

Ankle Torque Estimation With Motor Unit Discharges in Residual Muscles Following Lower-Limb Amputation.

There has been increased interest in using residual muscle activity for neural control of powered lower-limb prostheses. However, only surface electromyography (EMG)-based decoders have been investigated. This study aims to investigate the potential of using motor unit (MU)-based decoding methods as an alternative to EMG-based intent recognition for ankle torque estimation. Eight people without amputation (NON) and seven people with amputation (AMP) participated in the experiments. Subjects conducted isometric dorsi- and plantarflexion with their intact limb by tracing desired muscle activity of the tibialis anterior (TA) and gastrocnemius (GA) while ankle torque was recorded. To match phantom limb and intact limb activity, AMP mirrored muscle activation with their residual TA and GA. We compared neuromuscular decoders (linear regression) for ankle joint torque estimation based on 1) EMG amplitude (aEMG), 2) MU firing frequencies representing neural drive (ND), and 3) MU firings convolved with modeled twitch forces (MUDrive). In addition, sensitivity analysis and dimensionality reduction of optimization were performed on the MUDrive method to further improve its practical value. Our results suggest MUDrive significantly outperforms (lower root-mean-square error) EMG and ND methods in muscles of NON, as well as both intact and residual muscles of AMP. Reducing the number of optimized MUDrive parameters degraded performance. Even so, optimization computational time was reduced and MUDrive still outperformed aEMG. Our outcomes indicate integrating MU discharges with modeled biomechanical outputs may provide a more accurate torque control signal than direct EMG control of assistive, lower-limb devices, such as exoskeletons and powered prostheses.

Evaluation and characterization of imaging polarimetry through metasurface polarization gratings.

Metasurfaces are a new class of diffractive optical elements with subwavelength elements whose behavior can be lithographically tailored. By leveraging form birefringence, metasurfaces can serve as multifunctional freespace polarization optics. Metasurface gratings are novel, to the best of our knowledge, polarimetric components that integrate multiple polarization analyzers into a single optical element enabling the realization of compact imaging polarimeters. The promise of metasurfaces as a new polarization building block is contingent on the calibration of metagrating-based optical systems. A prototype metasurface full Stokes imaging polarimeter is compared to a benchtop reference instrument using an established linear Stokes test for 670, 532, and 460 nm gratings. We propose a complementary full Stokes accuracy test and demonstrate it using the 532 nm grating. This work presents methods and practical considerations involved in producing accurate polarization data from a metasurface-based Stokes imaging polarimeter and informs their use in polarimetric systems more generally.

Nonseparable Polarization Wavefront Transformation.

In this Letter, we investigate a new class of polarization wave front transformations which exhibit nonconventional far field interference behavior. We show that these can be realized by double-layer metasurfaces, which overcome the intrinsic limitations of single-layer metasurfaces. Holograms that encode four or more distinct patterns in nonorthogonal polarization states are theoretically demonstrated. This Letter clarifies and expands the possibilities enabled by a broad range of technologies which can spatially modulate light's polarization state and, for metasurfaces specifically, rigorously establishes when double-layer metasurfaces are-and are not-required.

Imaging polarimetry through metasurface polarization gratings.

Metasurfaces-subwavelength arrays of phase-shifting elements-present new possibilities for polarization optics and polarimetry. In particular, a periodic, polarization-sensitive metasurface diffraction grating can enable full-Stokes imaging polarimetry with a single polarization-sensitive component. In this work, we show that a suitably-designed metasurface grating can serve as a polarimetric "attachment" to an existing intensity-only imaging system, converting it into one capable of full-Stokes imaging polarimetry. Design rules and tradeoffs governing this adaptation are described and demonstrated using a machine vision imaging system as an example.

Finger Force Estimation Using Motor Unit Discharges Across Forearm Postures.

BACKGROUND: Myoelectric- based decoding has gained popularity in upper- limb neural-machine interfaces. Motor unit (MU) firings decomposed from surface electromyographic (EMG) signals can represent motor intent, but EMG properties at different arm configurations can change due to electrode shift and differing neuromuscular states. This study investigated whether isometric fingertip force estimation using MU firings is robust to forearm rotations from a neutral to either a fully pronated or supinated posture. METHODS: We extracted MU information from high- density EMG of the extensor digitorum communis in two ways: (1) Decomposed EMG in all three postures (MU-AllPost); and (2) Decomposed EMG in neutral posture (MU-Neu), and extracted MUs (separation matrix) were applied to other postures. Populational MU firing frequency estimated forces scaled to subjects' maximum voluntary contraction (MVC) using a regression analysis. The results were compared with the conventional EMG-amplitude method. RESULTS: We found largely similar root-mean-square errors (RMSE) for the two MU-methods, indicating that MU decomposition was robust to postural differences. MU-methods demonstrated lower RMSE in the ring (EMG = 6.23, MU-AllPost = 5.72, MU-Neu = 5.64% MVC) and pinky (EMG = 6.12, MU-AllPost = 4.95, MU-Neu = 5.36% MVC) fingers, with mixed results in the middle finger (EMG = 5.47, MU-AllPost = 5.52, MU-Neu = 6.19% MVC). CONCLUSION: Our results suggest that MU firings can be extracted reliably with little influence from forearm posture, highlighting its potential as an alternative decoding scheme for robust and continuous control of assistive devices.

Common Neural Input within and across Lower Limb Muscles: A Preliminary Study.

Motor units (MUs) are the basic unit of motor control. MU synchronization has been evaluated to identify common inputs in neural circuitry during motor coordination. Recent studies have compared common inputs between muscles in the lower limb, but further investigation is needed to compare common inputs to MUs both within a muscle and between MUs of different muscle pairs. The goal of this preliminary study was to characterize levels of common inputs to MUs in three muscle groups: MUs within a muscle, between bilateral homologous pairs, and between agonist/antagonist muscle pairs. To achieve this, surface electromyography (EMG) was recorded during bilateral ankle dorsiflexion and plantarflexion on the right and left tibiales anterior (RTA, LTA) and gastrocnemii (RGA, LGA) muscles. After decomposing EMG into active MU firings, we conducted coherence analyses of composite MU spike trains (CSTs) in each muscle group in both the beta (13-30 Hz) and gamma (30-60 Hz) frequency bands. Our results indicate MUs within a muscle have the greatest levels of common input, with decreasing levels of common input to bilateral and agonist/antagonist muscle pairs, respectively. Additionally, each muscle group exhibited similar levels of common input between the beta and gamma bands. This work may provide a way to unveil mechanisms of functional coordination in the lower limb across motor tasks.

Generalized polarization transformations with metasurfaces.

Metasurfaces are arrays of sub-wavelength spaced nanostructures, which can be designed to control the many degrees-of-freedom of light on an unprecedented scale. In this work, we design meta-gratings where the diffraction orders can perform general, arbitrarily specified, polarization transformation without any reliance on conventional polarization components, such as waveplates and polarizers. We use matrix Fourier optics to design our devices and introduce a novel approach for their optimization. We implement the designs using form-birefringent metasurfaces and quantify their behavior - retardance and diattenuation. Our work is of importance in applications, such as polarization abberation correction in imaging systems, and in experiments requiring novel and compact polarization detection and control.

Structuring total angular momentum of light along the propagation direction with polarization-controlled meta-optics.

Recent advances in wavefront shaping have enabled complex classes of Structured Light which carry spin and orbital angular momentum, offering new tools for light-matter interaction, communications, and imaging. Controlling both components of angular momentum along the propagation direction can potentially extend such applications to 3D. However, beams of this kind have previously been realized using bench-top setups, requiring multiple interaction with light of a fixed input polarization, thus impeding their widespread applications. Here, we introduce two classes of metasurfaces that lift these constraints, namely: i) polarization-switchable plates that couple any pair of orthogonal polarizations to two vortices in which the magnitude and/or sense of vorticity vary locally with propagation, and ii) versatile plates that can structure both components of angular momentum, spin and orbital, independently, along the optical path while operating on incident light of any polarization. Compact and integrated devices of this type can advance light-matter interaction and imaging and may enable applications that are not accessible via other wavefront shaping tools.

Jones matrix holography with metasurfaces.

We propose a new class of computer-generated holograms whose far-fields have designer-specified polarization response. We dub these Jones matrix holograms. We provide a simple procedure for their implementation using form-birefringent metasurfaces. Jones matrix holography generalizes a wide body of past work with a consistent mathematical framework, particularly in the field of metasurfaces, and suggests previously unrealized devices, examples of which are demonstrated here. In particular, we demonstrate holograms whose far-fields implement parallel polarization analysis and custom waveplate-like behavior.

Polariton nanophotonics using phase-change materials.

Polaritons formed by the coupling of light and material excitations enable light-matter interactions at the nanoscale beyond what is currently possible with conventional optics. However, novel techniques are required to control the propagation of polaritons at the nanoscale and to implement the first practical devices. Here we report the experimental realization of polariton refractive and meta-optics in the mid-infrared by exploiting the properties of low-loss phonon polaritons in isotopically pure hexagonal boron nitride interacting with the surrounding dielectric environment comprising the low-loss phase change material Ge3Sb2Te6. We demonstrate rewritable waveguides, refractive optical elements such as lenses, prisms, and metalenses, which allow for polariton wavefront engineering and sub-wavelength focusing. This method will enable the realization of programmable miniaturized integrated optoelectronic devices and on-demand biosensors based on high quality phonon resonators.

Matrix Fourier optics enables a compact full-Stokes polarization camera.

Recent developments have enabled the practical realization of optical elements in which the polarization of light may vary spatially. We present an extension of Fourier optics-matrix Fourier optics-for understanding these devices and apply it to the design and realization of metasurface gratings implementing arbitrary, parallel polarization analysis. We show how these gratings enable a compact, full-Stokes polarization camera without standard polarization optics. Our single-shot polarization camera requires no moving parts, specially patterned pixels, or conventional polarization optics and may enable the widespread adoption of polarization imaging in machine vision, remote sensing, and other areas.

Radio frequency transmitter based on a laser frequency comb.

Since the days of Hertz, radio transmitters have evolved from rudimentary circuits emitting around 50 MHz to modern ubiquitous Wi-Fi devices operating at gigahertz radio bands. As wireless data traffic continues to increase, there is a need for new communication technologies capable of high-frequency operation for high-speed data transfer. Here, we give a proof of concept of a compact radio frequency transmitter based on a semiconductor laser frequency comb. In this laser, the beating among the coherent modes oscillating inside the cavity generates a radio frequency current, which couples to the electrodes of the device. We show that redesigning the top contact of the laser allows one to exploit the internal oscillatory current to drive a dipole antenna, which radiates into free space. In addition, direct modulation of the laser current permits encoding a signal in the radiated radio frequency carrier. Working in the opposite direction, the antenna can receive an external radio frequency signal, couple it to the active region, and injection lock the laser. These results pave the way for applications and functionality in optical frequency combs, such as wireless radio communication and wireless synchronization to a reference source.

Versatile total angular momentum generation using cascaded J-plates.

Optical elements coupling the spin and orbital angular momentum (SAM/OAM) of light have found a range of applications in classical and quantum optics. The J-plate, with J referring to the photon's total angular momentum (TAM), is a metasurface device that imparts two arbitrary OAM states on an arbitrary orthogonal basis of spin states. We demonstrate that when these J-plates are cascaded in series, they can generate several single quantum number beams and versatile superpositions thereof. Moreover, in contrast to previous spin-orbit-converters, the output polarization states of cascaded J-plates are not constrained to be the conjugate of the input states. Cascaded J-plates are also demonstrated to produce vector vortex beams and complex structured light, providing new ways to control TAM states of light.

Identification of epsilon toxin-producing Clostridium perfringens strains in American retail food.

Food samples (n = 216) from New York city were tested for the presence of C. perfringens via PCR for specific toxin genes. Thirty-four (16%) samples were positive for C. perfringens. Of these 34, 31 (91.2%) were type A or E, one (2.9%) was type B, and two (5.9%) were type D.

Polarization state generation and measurement with a single metasurface.

The constituent elements of metasurfaces may be designed with explicit polarization dependence, making metasurfaces a fascinating platform for new polarization optics. In this work we show that a metasurface grating can be designed to produce arbitrarily specified polarization states on a set of defined diffraction orders given that the polarization of the incident beam is known. We also demonstrate that, when used in a reverse configuration, the same grating may be used as a parallel snapshot polarimeter, requiring a minimum of bulk polarization optics. We demonstrate its use in measuring partially polarized light, and show that it performs favorably in comparison to a commercial polarimeter. This work is of consequence in any application requiring lightweight, compact, and low-cost polarization optics, polarimetry, or polarization imaging.

High-efficiency chiral meta-lens.

We present here a compact metasurface lens element that enables simultaneous and spatially separated imaging of light of opposite circular polarization states. The design overcomes a limitation of previous chiral lenses reliant on the traditional geometric phase approach by allowing for independent focusing of both circular polarizations without a 50% efficiency trade-off. We demonstrate circular polarization-dependent imaging at visible wavelengths with polarization contrast greater than 20dB and efficiencies as high as 70%.

The harmonic state of quantum cascade lasers: origin, control, and prospective applications [Invited].

The recently discovered ability of the quantum cascade laser to produce a harmonic frequency comb has attracted new interest in these devices for both applications and fundamental laser physics. In this review we present an extensive experimental phenomenology of the harmonic state, including its appearance in mid-infrared and terahertz quantum cascade lasers, studies of its destabilization induced by delayed optical feedback, and the assessment of its frequency comb nature. A theoretical model explaining its origin as due to the mutual interaction of population gratings and population pulsations inside the laser cavity will be described. We explore different approaches to control the spacing of the harmonic state, such as optical injection seeding and variation of the device temperature. Prospective applications of the harmonic state include microwave and terahertz generation, picosecond pulse generation in the mid-infrared, and broadband spectroscopy.

Arbitrary spin-to-orbital angular momentum conversion of light.

Optical elements that convert the spin angular momentum (SAM) of light into vortex beams have found applications in classical and quantum optics. These elements-SAM-to-orbital angular momentum (OAM) converters-are based on the geometric phase and only permit the conversion of left- and right-circular polarizations (spin states) into states with opposite OAM. We present a method for converting arbitrary SAM states into total angular momentum states characterized by a superposition of independent OAM. We designed a metasurface that converts left- and right-circular polarizations into states with independent values of OAM and designed another device that performs this operation for elliptically polarized states. These results illustrate a general material-mediated connection between SAM and OAM of light and may find applications in producing complex structured light and in optical communication.