Varón de 38 años infectado por VIH con focalidad neurológica durante el tratamiento de hepatitis C / A 38-year old HIV infected male with neurological focality during treatment of hepatitis

Varón de 38 años infectado por el virus de la inmunodeficiencia humana (VIH) (con buen control inmunológico y virológico) y virus de la hepatitis C (VHC), que tras iniciar tratamiento con interferón, comienza con pérdida de fuerza en hemicuerpo izquierdo y parestesias en 4.° y 5.° dedos de la mano izquierda con inestabilidad de la marcha. Se solicitan pruebas de imagen y microbiológicas, requiriendo biopsia cerebral para llegar al diagnóstico(AU)

A 38-year old HIV infected male (with adequate immunologic and virologic control) and HCV who, after starting treatment with interferon, experienced loss of strength in the left hemisphere and parenthesis in 4th and 5th fingers of the left hand along with walking instability. Imaging and microbiological tests were performed, brain biopsy finally being necessary for the diagnosis(AU)

[A 38-year old HIV infected male with neurological focality during treatment of hepatitis]. / Varón de 38 años infectado por VIH con focalidad neurológica durante el tratamiento de hepatitis C.

A 38-year old HIV infected male (with adequate immunologic and virologic control) and HCV who, after starting treatment with interferon, experienced loss of strength in the left hemisphere and parenthesis in 4th and 5th fingers of the left hand along with walking instability. Imaging and microbiological tests were performed, brain biopsy finally being necessary for the diagnosis.

Fiebre Q: 54 nuevos casos de un hospital terciario de Madrid / Q fever: 54 new cases from a tertiary hospital in Madrid

Objetivos. Describir las características epidemiológicas y clínicas de la fiebre Q en una zona urbana de la Comunidad de Madrid. Material y métodos. Estudio observacional retrospectivo de cohorte de los casos diagnosticados de fiebre Q en un único centro desde enero de 2001 hasta diciembre de 2008. El diagnóstico de fiebre Q aguda se realizó mediante la detección de anticuerpos frente a antígenos fase II por técnica de enzyme-linked immunosorbent assay (ELISA) e inmunofluorescencia indirecta (IFI), en base a un título aislado ≥ 1/80 o cuando se demostró seroconversión o serorrefuerzo. El de fiebre Q crónica se realizó mediante anticuerpos frente antígenos fase I positivo si IgG >= 1/800. Resultados. Se diagnosticaron 54 casos de fiebre Q en adultos. Cincuenta y un pacientes con fiebre Q aguda y 3 con fiebre Q crónica. Predominaron los varones de más de 50 años de edad y residentes en medio urbano. La clínica más frecuente fue la neumonía, la insuficiencia renal (33%), la hepatitis y el síndrome febril sin focalidad (25% ambas), con infección concomitante en el 37% de los casos. El seguimiento clínico y serológico en la mayoría de los pacientes fue inadecuado. La doxiciclina fue el tratamiento de mayor respuesta en enfermedad aguda, aunque en 10% con duración inadecuada(AU)

Objectives. To describe the epidemiological and clinical characteristics of Q fever in an urban zone of the Community of Madrid (Spain). Material and methods. An observational, retrospective study was performed of a cohort of cases diagnosed of Q fever within a single center in Madrid from January 2001 to December 2008. The diagnosis of acute Q fever was made by detection of antibodies against phase II antigen by Enzyme-Linked Immunosorbent Assay (ELISA) and indirect immunofluorescence (IFA), based on isolated titer ≥ 1/80 or when they showed seroconversion or seroreinforcement. Chronic Q fever was diagnosed using antibodies against phase I with a positive value if IgG >= 1/800. Results. A total of 54 cases of Q fever in adults were diagnosed; 51 patients had acute Q fever and only 3 chronic. There was a predominance of men over > 50years and from urban areas. The most frequent manifestation was pneumonia (54%), followed by renal failure (33%), hepatitis and fever without focality (25% in both), with concomitant infection in 37% of the cases. The clinical and serological monitoring in most of the patients were inadequate. The best response to treatment was with doxycycline in acute illness, although duration was inadequate in 10%(AU)

[Q fever: 54 new cases from a tertiary hospital in Madrid]. / Fiebre Q: 54 nuevos casos de un hospital terciario de Madrid.

OBJECTIVES: To describe the epidemiological and clinical characteristics of Q fever in an urban zone of the Community of Madrid (Spain). MATERIAL AND METHODS: An observational, retrospective study was performed of a cohort of cases diagnosed of Q fever within a single center in Madrid from January 2001 to December 2008. The diagnosis of acute Q fever was made by detection of antibodies against phase II antigen by Enzyme-Linked Immunosorbent Assay (ELISA) and indirect immunofluorescence (IFA), based on isolated titer ≥ 1/80 or when they showed seroconversion or seroreinforcement. Chronic Q fever was diagnosed using antibodies against phase I with a positive value if IgG ≥ 1/800. RESULTS: A total of 54 cases of Q fever in adults were diagnosed; 51 patients had acute Q fever and only 3 chronic. There was a predominance of men over > 50 years and from urban areas. The most frequent manifestation was pneumonia (54%), followed by renal failure (33%), hepatitis and fever without focality (25% in both), with concomitant infection in 37% of the cases. The clinical and serological monitoring in most of the patients were inadequate. The best response to treatment was with doxycycline in acute illness, although duration was inadequate in 10%.