RESUMEN
The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions. The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity. The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells.
Asunto(s)
Citotoxicidad Inmunológica , Linfocitos/inmunología , Proteínas/inmunología , Proteínas de Secreción de la Vesícula Seminal , Vesículas Seminales/metabolismo , Animales , Epitelio/metabolismo , Humanos , Masculino , Proteínas/metabolismo , Ratas , Células Tumorales CultivadasRESUMEN
The authors report on the presence of anti-HCV antibodies in a uremic chronic (UC) patient population after 6 months and 1 year with regard to certain selective preventive measures. The nonincreased number of HCV-positive subjects among the UC population could lead to the conclusion that the risk of environmental spreading of HCV is less than the risk of HBV diffusion.