Asunto(s)
Cosméticos/administración & dosificación , Hidroxiácidos/administración & dosificación , Retinoides/administración & dosificación , Envejecimiento de la Piel/efectos de los fármacos , Administración Tópica , Cosméticos/análisis , Femenino , Humanos , Hidroxiácidos/efectos adversos , Hidroxiácidos/análisis , Masculino , Rejuvenecimiento/fisiología , Retinoides/efectos adversos , Retinoides/análisis , Sensibilidad y Especificidad , Envejecimiento de la Piel/fisiologíaRESUMEN
The authors report a case of culture-proven disseminated American muco-cutaneous leishmaniasis caused by Leishmania braziliensis braziliensis in an HIV positive patient. Lesions began in the oropharynx and nasal mucosa eventually spreading to much of the skin surface. The response to a short course of glucantime therapy was good.
Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Leishmania braziliensis/aislamiento & purificación , Leishmaniasis Mucocutánea/complicaciones , Adulto , Animales , Candidiasis Bucal/complicaciones , Criptococosis/complicaciones , Infecciones por Escherichia coli/complicaciones , Resultado Fatal , Humanos , Huésped Inmunocomprometido , Leishmaniasis Mucocutánea/tratamiento farmacológico , Leishmaniasis Mucocutánea/parasitología , Masculino , Meglumina/uso terapéutico , Antimoniato de Meglumina , Compuestos Organometálicos/uso terapéutico , Sepsis/complicacionesRESUMEN
The lymphocyte responsiveness to leishmanial antigens and its influence on the course of cutaneous leishmaniasis was studied in a patient with AIDS-associated American cutaneous leishmaniasis caused by Leishmania braziliensis. The patient had cutaneous disseminated erythematous papules or nodules and mucosal lesions as well as moniliasis and weight loss. The patient had a poor delayed-type hypersensitivity to leishmanial antigens, showing 3 mm of induration. The cellular immune responses were studied in vitro by lymphocyte proliferative assays induced by leishmanial antigens and concanavalin A. The T cell phenotypes were analysed by flow cytometry. The peripheral blood mononuclear cells before proliferation showed an inversion of the CD4/CD8 ratio (0.28:1). The lymphoproliferative responses to antigen and mitogen were very low (indices < 2.5). The blast-like cell phenotypes after antigen stimulation in culture were: CD3+ 44.8%, CD4+ 7.53% and CD8+ 17.45%. In AIDS patients the decrease in the pool of CD4+ cells, and consequent diminution of the CD4/CD8 ratio, produced by HIV infection provokes a generalized immune depression. The patient's disseminated clinical picture was probably related to the inability of his T cell-mediated immune responses to control the spread of Leishmania infection.
Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/inmunología , Antígenos de Protozoos/inmunología , Leishmania braziliensis/inmunología , Leishmaniasis Cutánea/inmunología , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Adulto , Animales , Relación CD4-CD8 , Técnica del Anticuerpo Fluorescente , Humanos , Inmunidad Celular , Leishmaniasis Cutánea/complicaciones , Leucocitos Mononucleares/inmunología , MasculinoRESUMEN
E feita a revisao geral do assunto, comparando-se os resultados universalmente conhecidos com aqueles obtidos em 197 pacientes do Hospital dos Servidores do Estado - RJ. Assim, foi constatada a maior incidencia nos individuos leucodermicos, bem como, proporcionalmente, durante a puberdade. Acreditam os autores que o zoster seja menos frequente do que se pensa nas regioes tropicais, isoladamente ou associado a neoplasias