RESUMEN
Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.
Asunto(s)
Mapeo Encefálico/métodos , Corteza Cerebral/fisiología , Interpretación de Imagen Asistida por Computador/instrumentación , Microscopía por Video/instrumentación , Tomografía de Coherencia Óptica/instrumentación , Animales , Diseño de Equipo , Análisis de Falla de Equipo , Interpretación de Imagen Asistida por Computador/métodos , Microscopía por Video/métodos , Ratas , Tomografía de Coherencia Óptica/métodosRESUMEN
Gentamicin- and methicillin-resistant strains of Staphylococcus aureus have been isolated from Spring 1979 to the present from many hospitals in New York City. A large proportion of the strains were resistant to the majority of antistaphylococcal antibiotics. The ratio of multiply resistant strains was highest among tetracycline-resistant strains. There were significant differences in phage susceptibility patterns and the resistance spectrum of strains isolated at different hospitals, whereas strains isolated at the same hospital often showed a marked degree of similarity. This suggests multiple origins of gentamicin- and methicillin-resistant strains isolated in New York City.