RESUMEN
The review considers features of efferent therapy employing extracorporeal systems, the devices known as "artificial liver" and "bioartificial liver" in the treatment of liver insufficiency. Analysis of literature data shows the need for further development of these biomedical studies and the search for optimal solutions in the selection of the source of hepatocytes, the development of bioreactors and biomaterials forming the basis of devices like "bioartificial liver". Taking into consideration certain advantages and disadvantages typical for various methods of extracorporeal support of the functional state of the liver one can evaluate prior experience in the treatment of liver diseases and approaches to the development of new, more effective medical technologies.
Asunto(s)
Técnicas de Cultivo de Célula/métodos , Hepatocitos/fisiología , Hepatopatías/terapia , Hígado Artificial , Materiales Biocompatibles/química , Materiales Biocompatibles/metabolismo , Reactores Biológicos , Técnicas de Cocultivo , Diseño de Equipo , Fibroblastos/citología , Fibroblastos/metabolismo , Hepatocitos/citología , Humanos , Hepatopatías/metabolismo , Hepatopatías/fisiopatología , Fotoféresis/instrumentación , Fotoféresis/métodos , Diálisis Renal/instrumentación , Diálisis Renal/métodosRESUMEN
Daily (for 3 days) 1-hour immobilizations were followed by an increase in protein oxidative modification and leukocyte infiltration in the liver, and a decrease in monoamine oxidase B activity. Receptor antagonist of glucocorticoids RU38486 limited the stress-induced increase in protein carbonylation and decrease in monoamine oxidase B activity in the organ and enhanced leukocyte infiltration of the liver.
Asunto(s)
Antagonistas de Hormonas/farmacología , Hígado/metabolismo , Mifepristona/farmacología , Carbonilación Proteica/efectos de los fármacos , Estrés Psicológico/metabolismo , Animales , Animales no Consanguíneos , Femenino , Glucocorticoides/antagonistas & inhibidores , Hígado/efectos de los fármacos , Hígado/inmunología , Masculino , Monoaminooxidasa/metabolismo , Ratas , Restricción Física , Estrés Psicológico/inmunologíaRESUMEN
An inverse relationship between erythropoiesis intensity and microsomal oxidation level has been detected during the early postnatal period in rats with high resistance to hypoxia.
Asunto(s)
Hemo/biosíntesis , Microsomas/metabolismo , Porfirinas/metabolismo , Anilina Hidroxilasa/metabolismo , Animales , Animales Recién Nacidos , Sistema Enzimático del Citocromo P-450/metabolismo , Hexobarbital/farmacología , Oxidación-Reducción , Ratas , Sueño/efectos de los fármacos , Sueño/fisiologíaRESUMEN
The therapeutic efficiency of bioactive preparations of the liver and spleen in the treatment of experimental toxic cirrhosis of the liver is shown. Evaluation of the nucleolar organizer activity showed the highest efficiency of treatment with human fetal liver extract.
