Seasonal influenza in children: complications, treatment, prevention (subject publication review).

OBJECTIVE: Aim: To study the specificity of seasonal flu in children, in particular, in young children, as well as treatment, prevention and complications of seasonal flu. PATIENTS AND METHODS: Materials and Methods: For the methodological justification of the article, we used the pool of research technologies. Methods of theoretical analysis, system-analytical, comparative methods provided us with the opportunity to characterize the features of influenza incidence in children. CONCLUSION: Conclusions: A distinctive feature of influenza is the high lability of the genes of the infectious agent. In this regard, it is extremely important to timely update information about new strains of the pathogen, creation of new types of vaccines and antiviral drugs, as well as changes in the course of the disease. Our literature review is intended to improve the medical community.

EBV-ENCEPHALITIS IN CHILDREN: DIAGNOSTIC CRITERIA.

OBJECTIVE: The aim: To investigate the clinical characteristics of EBV infection in the pediatric nervous system using laboratory methods and brain MRI data. PATIENTS AND METHODS: Materials and methods: We observed 41 children with EBV encephalitis ranging from 8 months to 17 years old. The diagnosis of EBV-encephalitis was established on the basis of clinical and medical history, laboratory and instrumental (brain MRI) data. The main thing in the diagnosis was clinical symptoms, combining general infection, cerebral syndromes and focal neurological symptoms. The etiology of Epstein-Barr virus was determined using ELISA and PCR. RESULTS: Results: EBV-encephalitis can be as a manifestation of reactivation of persistent EBV infection (85%), much less often - acute primary EBV infection (15%). By nature, the duration of EBV encephalitis has distinguished two forms of its course: acute (63%) and chronioc (37%). The criteria of differential diagnosis of acute and chronic forms of EBV-encephalitis are proposed, which include the most common anamnesis data, clinical manifestations and changes in brain MRI. CONCLUSION: Conclusions: The proposed criteria specifically for acute and chronic forms of EBV-encephalitis can contribute to the timely and more accurate diagnosis of this disease in children.

CLINICAL AND EPIDEMIOLOGICAL FEATURES OF COVID-19 IN CHILDREN FOR THE PERIOD 2020-2022.

OBJECTIVE: The aim: To investigate the epidemiological and clinical characteristics of COVID-19 in children for the period 2020-2022. PATIENTS AND METHODS: Materials and methods: A retrospective analysis of 1144 case histories of children who were hospitalized at the St. Zinaida Children's Clinical Hospital (Sumy, Ukraine) for coronavirus disease for 2020-2022 was carried out. The observed patients were divided into 3 groups corresponding to the 3 waves of the pandemic: group 1 - 120 children, group 2 - 311 children, and group 3 - 713. The diagnosis of COVID-19 was established based on clinical, medical histories, laboratory and instrumental data. The etiology of coronavirus disease was determined based on the detection of antigens of the SARS-CoV-2 virus using PCR reverse transcription of a nasopharyngeal swab. RESULTS: Results: An analysis of the clinical and epidemiological indicators of children who were treated for COVID-19 during 2020-2022 was conducted, depending on the outbreak of the pandemic. The frequency of lesions in children of different age groups was determined, and the main clinical symptoms and the frequency of complications in the form of pneumonia during different waves of COVID-19 were determined. CONCLUSION: Conclusions: The incidence of coronavirus infection was mainly observed in children of the younger group (0-5 years). A more severe course of the disease and a higher frequency of complications in the form of pneumonia in children were determined during the 3rd wave of the COVID-19 pandemic.