Carcinosarcoma of the gallbladder diagnosed in a cholecystectomy specimen.

We report the case of a patient with an incidental diagnosis of gallbladder adenocarcinoma with chondrosarcomatoid areas in a cholecystectomy specimen. Since it is associated with a worse prognosis when compared to usual carcinoma, we need to understand this entity to offer our patients a better treatment.

Primary Ewing's sarcoma of the small intestine.

17 year old female teenager with abdominal pain secondary to pelvic mass of 12 x 10 cm, which seems to depend on ovary. Surgery is scheduled for removal of the tumor, during which it is observed that the lesion originates in the ileum. The histopathological study shows a neoplasm of small round cells with nucleoli and scant cytoplasm. The tumor cells are immunoreactive to CD99 and ERG, being negative for cytokeratins, FLI1, WT1, DOG1 and lymphoid markers. By means of FISH, a rearrangement of the EWSR1 gene was demonstrated. By integrating these molecular and immunohistochemical findings with the morphology, it was diagnosed as Ewing's sarcoma. This aggressive and infrequent tumor originates from neuroectodermal cells and usually develops in the long bones of pediatric and young adult patients, although exceptionally it can occur in other locations. At the intestinal level, it mainly affects the ileum, with a non-specific pain and fatigue clinic. The treatment of choice is surgery for resection of the affected loop, followed by chemotherapy.

Tratamiento neoayuvante en el cáncer de mama gestacional / Neoadjuvant therapy in gestational breast cancer

El cáncer de mama gestacional, o el cáncer de mama asociado al embarazo se define como aquel que se diagnostica durante el embarazo, el primer año postparto o en cualquier momento durante la lactancia, su incidencia está entre el 0,2% y el 2,6%, pero esta cifra va en aumento en la medida en que la mujer retrasa la maternidad. Predominantemente son tumores pobremente diferenciados y se diagnostican en estadíos avanzados, particularmente cuando esto ocurre durante la lactancia. El tratamiento debe de tener intención curativa, y no debe retrasarse con motivo de la gestación. Los estudios sugieren que es seguro administrar algunos agentes quimioterápicos, sobre todo cuando se inician después del primer trimestre de la gestación, y que en la mayoría de las ocasiones los embarazos acaban con un recién nacido vivo con bajas tasas de morbilidad y mortalidad (1). Estudios recientes han evaluado específicamente los resultados en mujeres diagnosticadas de cáncer de mama durante la gestación y han demostrado que esta no tiene un impacto negativo en la supervivencia (2,3) (AU)

Gestational or pregnancy-associated breast cancer is defined as breast cancer that is diagnosed during pregnancy, in the first postpartum year, or any time during lantation. The incidence of pregnancy-associated breast cancer is between 0.2% and 2.6% and is currently increasing due to delayed childbearing. It´s predominantly poorly differenciated and diagnosed at an advanced stage, particlarly those diagnosed in lactating women. The treatmen should be approached with curative intent, and it should not be unnecessarily delayed because of pregnancy. The data suggest it is safe to administer many agents used in the treatmen of breast cancer during pregnancy when initiated after the first trimester, and that the majority of pregnancies result in live births with low related morbidity in the newborns (1). Contemporrary studies that specifically evaluated the outcomes of women diagnosed with breast cancer during pregnancy have consistently shown that there is no negative impact on survival (2,3) (AU)

Tumor fibroso solitario primario en tiroides: comunicación de un caso y revisión de la literatura / Primary solitary fibrous tumour of the thyroid: a case report and review of the literature

El tumor fibroso solitario es una neoplasia mesenquimal de localización tiroidea muy poco usual. Comunicamos el caso de un varón de 42 años con resección del lóbulo tiroideo derecho tras un diagnóstico citológico de proliferación folicular. Macroscópicamente la lesión correspondía a un nódulo encapsulado de 2,5 cm de diámetro máximo. Histológicamente la lesión estaba constituida por una proliferación de células fusiformes que engloban y atrapan a los folículos tiroideos, positivas para vimentina, CD34 y BCL2. El estudio ultraestructural confirmó la naturaleza miofibroblástica de las células neoplásicas (AU)

The thyroid gland is an unusual location for solitary fibrous tumours. We report a case of a 42 year old male with a cytological diagnosis of follicular proliferation. Macroscopically the lesion corresponded to an encapsulated nodule of 2.5 cm. Histologically, it showed a proliferation of spindle cells encompassing thyroid follicles, positive for vimentin, CD34 and BCL2. The ultrastructural study confirmed the myofibroblastic nature of the proliferative cells (AU)

[Multilocular cystic nephroma: diagnosis by imaging tests]. / Nefroma quístico multilocular: diagnóstico mediante técnicas de imagen.

OBJECTIVES: To describe the presenting signs of multilocular cystic nephroma (MCN) in various imaging tests. METHODS: We report a new case of MCN and describe the radiological characteristics of this neoplasia on intravenous urography (IVU), pyelography , CT scan and MRI. RESULTS: CT scan and MRI findings are highly suggestive of multilocular cystic nephroma. CONCLUSIONS: Various radiological tests may allow us to establish a working diagnosis for this kind of neoplasia, but CT scan and MRI are the main ones.