RESUMEN
We report pilomotor seizures in two patients who presented with piloerection or gooseflesh spreading in a pattern similar to the 'Jacksonian march'. Gooseflesh was confined to the ipsilateral side in most of the episodes. Occasionally it spread to the contralateral side. It was also associated with other autonomic symptoms and complex partial features of temporal lobe origin. Simple partial status that progressed to complex partial status occurred in the second patient. Very rarely secondary generalization occurred. The cause was left sphenoid meningioma and temporal tip contusion in the first case. It was idiopathic in the second case, although a positive family history of complex partial seizures was obtained in this patient. Interictal electroencephalogram (EEG) showed left temporal focus in the first and bitemporal foci with right fronto-temporal dominance in the second. Parenteral phenytoin controlled the partial complex status in the second and carbamazepine controlled the episodes in both cases. To our knowledge all reported cases were symptomatic and our case of idiopathic aetiology is the first to be recorded. We endorse that pilomotor seizures are autonomic in nature and constitute a subtype of simple partial seizures. These autonomic simple partial seizures may progress to, or be a component of, complex partial seizures of temporal lobe origin. Based on their dominance in such a symptom complex and careful interpretation of the ictal history, it can be logically concluded that pilomotor seizures may be underestimated by both patients and physicians.
Asunto(s)
Epilepsia/fisiopatología , Adulto , Carbamazepina/uso terapéutico , Electroencefalografía , Epilepsia/diagnóstico , Epilepsia/tratamiento farmacológico , Femenino , Lóbulo Frontal/diagnóstico por imagen , Lóbulo Frontal/fisiopatología , Humanos , Masculino , Índice de Severidad de la Enfermedad , Enfermedades de la Piel/diagnóstico , Lóbulo Temporal/fisiopatología , Tomografía Computarizada por Rayos XRESUMEN
PURPOSE: The primary aim was to provide experience with a functional evaluation instrument (modified Barthel index MBI) that assures the quality of work and identify its deficiencies, familiarize our staff with the feasibility of its application on our local inpatients and educate our personnel in the field of stroke rehabilitation. The secondary aim was to collect data that are measurable and reproducible, identify specific local factors that adversely affect outcomes and serve as a feedback system to our national organizations. METHODS: In this prospective/retrospective study we evaluated 80 hemiplegic patients with completed stroke, admitted to hospital during the year 1989 1990. They were assessed by a neurologist, physiatrist and physiotherapist on admission and discharge using the MBI. All patients received comprehensive inpatient rehabilitation. The study was interrupted at the beginning of the Gulf crisis. However, the data were revived and retrospectively studied in the year 1994-1995. RESULTS: The MBI proved to be fully acceptable and easily applicable in our community. The rehabilitation staff became rapidly familiarized with its application and the reproduction of its data. The goals of rehabilitation were achieved through the reduction in the number of individuals in the more severe MBI scores and the increase in the number of individuals in the less severe ones. Significant improvements occurred in dressing of the upper and lower body, washing, grooming, care of perineum, transfer chair, toilet and walking on a level of 50 yards (p < or = 0.0005). CONCLUSIONS: We conclude that MBI is simple, convenient, efficient, gives exact and accurate information about daily activities and ambulation and could be used in inpatient follow up sittings, in the Arab and culturally similar Middle East countries.
Asunto(s)
Actividades Cotidianas/clasificación , Perfil de Impacto de Enfermedad , Rehabilitación de Accidente Cerebrovascular , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Evaluación de la Discapacidad , Femenino , Humanos , Jordania , Masculino , Persona de Mediana Edad , Terapia Ocupacional/métodos , Modalidades de Fisioterapia/métodos , Probabilidad , Pronóstico , Estudios Prospectivos , Recuperación de la Función , Centros de Rehabilitación , Estudios Retrospectivos , Sensibilidad y Especificidad , Accidente Cerebrovascular/diagnósticoRESUMEN
Two cases of optic neuropathy associated with cimetidine therapy are reported. Recovery occurred in both after drug withdrawal. Rechallenge with the same agent totally reproduced the condition in the first case. Cimetidine exerts an unequivocal toxicity on the central and peripheral nervous systems. Since its introduction in 1976, it has been used in over 100 million patients, but only 3 cases of optic neuropathy have been reported as far as we know. Although the mechanism of toxicity is still unclear, cimetidine is a well-recognized zinc chelator, and zinc deficiency has been implicated in causing optic neuropathy. Hence, it can be concluded that cimetidine produced this toxicity through its mechanism of zinc chelation. However, close ophthalmic follow-up of such patients is unnecessary, but an unexplained visual deterioration should prompt immediate drug withdrawal.
Asunto(s)
Antiulcerosos/efectos adversos , Cimetidina/efectos adversos , Úlcera Duodenal/tratamiento farmacológico , Enfermedades del Nervio Óptico/inducido químicamente , Nervio Óptico/efectos de los fármacos , Adulto , Femenino , Antagonistas de los Receptores H2 de la Histamina/efectos adversos , Humanos , Masculino , Nervio Óptico/fisiopatología , Enfermedades del Nervio Óptico/fisiopatologíaRESUMEN
A previously healthy and immuno-competent 22-year-old man presented in confusional psychosis. Cryptococcal meningitis was later found to be the underlying cause as proven by culturing Cryptococcus neoformans serotype A from the cerebrospinal fluid. Combined antifungal therapy with amphotericin B and 5-fluorocytosine resulted in sustained improvement of all mental and physical functions. Cryptococcosis has rarely been reported from the Middle East. This represents the second case from Kuwait.
Asunto(s)
Confusión/etiología , Meningitis Criptocócica/complicaciones , Trastornos Neurocognitivos/etiología , Adulto , Anfotericina B/uso terapéutico , Confusión/tratamiento farmacológico , Flucitosina/uso terapéutico , Humanos , Masculino , Meningitis Criptocócica/tratamiento farmacológico , Trastornos Neurocognitivos/tratamiento farmacológicoRESUMEN
A 39-year-old previously healthy patient with combined pulmonary and neural cryptococcosis was successfully managed by pulmonary resection and antifungal chemotherapy. The pulmonary mass was removed under cover of miconazole and 5-fluorocytosine even though the patient had concomitant active meningitis. He recovered dramatically after the surgical procedure and remained well 2 years later. We suggest that, as in our patient, early removal of a pulmonary cryptococcal mass under antifungal cover may in other similar patients obviate the need for protracted antifungal therapy and lead to an excellent response of the neural cryptococcosis.