Percutaneous balloon valvuloplasty of a stenosed mitral bioprosthesis.

A 62-year-old woman with disabling mitral prosthetic stenosis underwent percutaneous balloon valvuloplasty. The transvalvular gradient preoperatively was 22 mm Hg and was reduced to 6 mm Hg after the valvuloplasty. the valve area was increased from an initial value of 0.77 cm2 to 1.53 cm2. No complications occurred related to the Further studies are necessary to ascertain the indications and long-term results of percutaneous valvuloplasty on bioprosthesis in the mitral position.

Incidence of coronary artery by-pass graft following percutaneous transluminal coronary angioplasty.

Two hundred fifty eight patients had percutaneous transluminal coronary angioplasty. Of those, 48 cases underwent surgical revascularization for unsuccessful angioplasty. Sex was not a risk factor. Timely surgical revascularization reversed acute ischemia and/or myocardial infarction or limited the size of the infarction in 32 of the 48 patients or 67%. Revascularization procedures were performed in six out of forty-eight patients who had previous aortocoronary by-pass surgery and attempted PTCA, none had any complications. Death occurred in one out of forty-eight patients, or 2%. Femoral-femoral by-pass devices, in addition to intra-aortic balloon devices, should be available in the cardiac catheterization laboratory. Patients with multi-vessel disease are at greater risk of angioplasty and surgery. Sixteen out of 23 patients (70%) who had emergency revascularization procedures had multi-vessel disease. In one patient with borderline renal function, emergency surgery after PTCA with a large amount of renograffin dye injected caused renal failure and led to permanent dialysis.

Fresh frozen plasma: a solution to heparin resistance during cardiopulmonary bypass.

The reasons for the highly variable response of patients to heparin remain incompletely understood. Empirical maintenance of the activated clotting time (ACT) at levels of 400 to 480 seconds appears to be safe for cardiopulmonary bypass (CPB). For patients with ACT responses lower than predicted for initial heparin doses, titration with additional heparin has been customary. In 44 patients undergoing cardiopulmonary bypass, 20 patients were identified as having initial ACTs of 300 seconds or less after receiving 300 units per kilogram of heparin. In 11 of them, ACTs were titrated to 400 to 480 seconds with additional heparin. Nine were given 2 units of fresh frozen plasma shortly after institution of CPB. In this group, there was significant augmentation of the ACT immediately after infusion of plasma. No differences in total heparin dosages given during CPB were found between 24 control patients with initially acceptable ACTs and the group receiving fresh frozen plasma. In contrast, more heparin was necessary in the patients with a low ACT titrated with heparin alone. Data also indicated that protamine sulfate requirements were substantially lower after administration of plasma than were those in either the control or the heparin-titrated, low ACT group. Fresh frozen plasma appears to "normalize" the heparin-ACT dose-response curve in heparin-resistant patients and to lessen total heparin requirements during CPB.

Acute dissection of the ascending aorta. Initial presentation as acute lower GI bleeding.

We present the unusual case of a 56-year-old man with acute dissection of the ascending aorta (DeBakey type I) whose presenting symptoms were those of lower gastrointestinal (GI) bleeding. Surgical repair was successfully accomplished with resection of the aorta with a Dacron tubular graft combined with aortic valvular replacement after obtaining bowel viability.

Fontan operation: modification of the valve position in conduit with brief review of the literature.

A Fontan operation was performed on a 10-year-old child for correction of tricuspid atresia. A xenograft, valved conduit was used to establish continuity between the right atrium and the small right ventricle. Atrial and ventricular septal defects were repaired with Dacron patches. Two hours postoperatively, the patient suffered a cardiac arrest secondary to hypoxia and was successfully resuscitated. Partial recurrence of a right-to-left shunt at the atrial level necessitated the patient's return to surgery. The insufficient conduit was replaced and the leaking patches were resutured. The conduit was shortened to one-third its length, and the conduit valve was repositioned directly at the proximal end, over the right atriotomy. Ten months postoperatively, the patient remains in stable condition.

Severe blood transfusion reaction from leukoagglutinin antibody with successful treatment by membrane oxygenation.

In the intensive care unit immediately after a triple aortocoronary bypass procedure, a 62-year-old man presented with copious amounts of frothy secretions in the endotracheal tube, became severely hypotensive, and remained hypoxic in the presence of maximum respiratory support. Chest roentgenograms showed pronounced pulmonary edema. Prior to leaving the operating room, the patient had received 1 unit of whole blood. A leukoagglutinin reaction to this blood transfusion was determined to be the cause of the pulmonary edema. When the patient continued to deteriorate after administration of diuretics, vasopressors, corticosteroids, albumin, and maximum respiratory support, the Sci-Med membrane oxygenator was inserted by the right femoral vein-artery. Bypass was continued for approximately 8 hours, until the PaO2 increased and the patient's condition stabilized. We think this is the first reported case of membrane oxygenation for treatment of noncardiogenic pulmonary edema due to leukoagglutinin reaction. It indicates the need for early diagnosis and utilization of the membrane oxygenator when other methods of treatment fail.