Asunto(s)
Ácido Ascórbico/análisis , Ácido Ascórbico/sangre , Análisis Químico de la Sangre/métodos , Deficiencia de Ácido Ascórbico/sangre , Deficiencia de Ácido Ascórbico/diagnóstico , Deficiencia de Ácido Ascórbico/etiología , Análisis Químico de la Sangre/instrumentación , Cromatografía Líquida de Alta Presión/instrumentación , Cromatografía Líquida de Alta Presión/métodos , Humanos , Evaluación Nutricional , Diálisis Renal/efectos adversos , Factores de Tiempo , Rayos Ultravioleta , Estudios de Validación como AsuntoRESUMEN
We report here a fatal intoxication case involving ammonium vanadate. A 24-year-old woman was admitted to the Emergency Department for abdominal pain, nausea, vomiting, multiple daily diarrheas, hypoglycaemia (0.2g/L) and severe acute renal failure with glomerular filtration rate estimated at 21 ml/min. This patient had taken an undetermined amount of ammonium vanadate 12h after ingesting. She died next morning in the context of respiratory distress despite intensive care and oxygen therapy. The autopsy revealed widespread asphyxia syndrome and erosive gastritis. Determination of vanadium concentration in blood was carried out by means of mass spectrometer (ICP-MS) using rhodium ((103)Rh) as the internal standard. The vanadium concentration was 6.22 mg/L, corresponding to 6000 times higher than normal concentration in the general population. The latency and the brutality of clinical picture degradation seem to be in consideration of systemic poisoning by vanadium leading to inhibition of the cellular respiratory process.
Asunto(s)
Oligoelementos/envenenamiento , Vanadio/envenenamiento , Lesión Renal Aguda/inducido químicamente , Adulto , Diarrea/inducido químicamente , Femenino , Toxicología Forense , Gastritis/inducido químicamente , Humanos , Hipoglucemia/inducido químicamente , Espectrometría de Masas , Síndrome de Dificultad Respiratoria/inducido químicamente , Oligoelementos/sangre , Vanadio/sangre , Adulto JovenAsunto(s)
Antipsicóticos/envenenamiento , Sulpirida/análogos & derivados , Adulto , Amisulprida , Antipsicóticos/uso terapéutico , Cardiomiopatías/inducido químicamente , Cardiomiopatías/patología , Femenino , Humanos , Concentración de Iones de Hidrógeno , Isquemia Miocárdica/inducido químicamente , Isquemia Miocárdica/fisiopatología , Necrosis , Esquizofrenia/tratamiento farmacológico , Sulpirida/envenenamiento , Sulpirida/uso terapéuticoAsunto(s)
Antidepresivos Tricíclicos/envenenamiento , Depresores del Sistema Nervioso Central/envenenamiento , Dotiepina/envenenamiento , Doxilamina/envenenamiento , Etanol/envenenamiento , Hipnóticos y Sedantes/envenenamiento , Psicosis Inducidas por Sustancias/psicología , Síndrome de la Serotonina/psicología , Femenino , Humanos , Persona de Mediana Edad , Intento de SuicidioRESUMEN
Methcathinone, a methyl derivative of cathinone, is an illicit drug also known as ephedrone. It is a stimulant found in the "khat" plant, Catha edulis, which can easily be synthesized from pseudoephedrine. Its intoxication is difficult to diagnose and cure properly for two reasons: (i) target consumers are usually "well-educated people" aware of the risks and precautionary measures and (ii) intoxication by cathinone derivatives of synthetic or natural (derived from the khat) origin induce misleading symptoms. As a result, documented reports of methcathinone intoxication that are based on reliable analyses are rare. This paper describes a case of reiterated coma due to an overdose of methcathinone dissolved in alcohol that was taken with bromazepam. A 29-year-old woman was admitted to an emergency department for a coma of toxic origin. Medical files showed that it was her second such episode to occur that month. Moreover, the family indicated signs of depression, incoherent behaviour and intake of "amphetamine-like" drugs. Clinical examination revealed a Glasgow coma score of 9, symmetrical reactive pupils with mydriasis and no convulsions. The patient presented with rapid respirations and her blood pressure was 93/53 mmHg. The ionogram and the blood gas analyses were normal, while the blood alcohol level was 0.167 g/dL. Urinalysis revealed the presence of benzodiazepines and a high concentration of amphetamines (methcathinone: 17.24 mg/L, ephedrine: 11.60 mg/L and methylephedrine: 11.10 mg/L). In addition, serum analysis revealed bromazepam (8.89 mg/L), methcathinone (0.50 mg/L) and methylephedrine (0.19 mg/L). This case showed that the consumption of bromazepam and alcohol altered the typical clinical symptoms of cathinone derivative intoxication, namely hypertension and convulsions. Methylephedrine, an impurity resulting from the alkylation of a primary amine, can be considered a chemical tag indicating fraudulent synthetic origin of the drug. This case describes a documented example of new addictive behaviour of "well-educated" people involving the intake of methcathinone, a postindustrial psychostimulant intentionally combined with an anticonvulsant benzodiazepine. However, this specific case suggests that in spite of a very high bromazepam concentration in presence of the potentiator alcohol, the vital respiratory function would be probably maintained, thanks to the association with methcathinone.