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Clin Exp Pharmacol Physiol ; 46(12): 1111-1123, 2019 12.
Artículo en Inglés | MEDLINE | ID: mdl-31398260

RESUMEN

This study investigates the effect of chronic consumption of a high-fat diet rich in corn oil (CO-HFD) on atrial cells ultrastructure, antioxidant levels and markers of intrinsic cell death of both control and type 1 diabetes mellitus (T1DM)-induced rats. Adult male rats (10 rats/group) were divided into four groups: control fed standard diet (STD) (3.82 kcal/g, 9.4% fat), CO-HFD (5.4 kcal/g, 40% fat), T1DM fed STD, and T1DM + CO-HFD. CO-HFD and T1DM alone or in combination impaired systolic and diastolic functions of rats and significantly reduced levels of GSH and the activity of SOD, enhanced lipid peroxidation, increased protein levels of P53, Bax, cleaved caspase-3, and ANF and decreased levels of Bcl-2 in their atria. Concomitantly, atrial cells exhibited fragmentation of the myofibrils, disorganized mitochondria, decreased number of atrionatriuretic factor (ANF) granules, and loss of gap junctions accompanied by changes in capillary walls. Among all treatments, the severity of all these findings was more severe in T1DM and most profound in the atria of T1DM + CO-HFD. In conclusion, chronic consumption of CO-HFD by T1DM-induced rats elicits significant biochemical and ultrastructural damage to rat atrial cells accompanied by elevated oxidative stress and mitochondria-mediated cell death.


Asunto(s)
Muerte Celular/efectos de los fármacos , Aceite de Maíz/efectos adversos , Diabetes Mellitus Tipo 1/patología , Dieta Alta en Grasa/efectos adversos , Grasas de la Dieta/farmacología , Atrios Cardíacos/efectos de los fármacos , Atrios Cardíacos/ultraestructura , Animales , Antioxidantes/metabolismo , Aceite de Maíz/administración & dosificación , Diabetes Mellitus Experimental/complicaciones , Diabetes Mellitus Experimental/patología , Diabetes Mellitus Experimental/fisiopatología , Diabetes Mellitus Tipo 1/complicaciones , Diabetes Mellitus Tipo 1/fisiopatología , Angiopatías Diabéticas/etiología , Angiopatías Diabéticas/patología , Angiopatías Diabéticas/fisiopatología , Conducta Alimentaria/fisiología , Atrios Cardíacos/metabolismo , Atrios Cardíacos/patología , Hemodinámica/efectos de los fármacos , Peroxidación de Lípido/efectos de los fármacos , Masculino , Estrés Oxidativo/efectos de los fármacos , Ratas , Ratas Wistar , Transducción de Señal/efectos de los fármacos
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