[Minoxidil-induced ophthalmic hypertension (case report)]. / Indutsirovannaya minoksidilom oftal'mogipertenziya (klinicheskoe nablyudenie).

This article presents a case of a 31-year-old male patient who presented to the outpatient department of the Krasnov Research Institute of Eye Diseases with complaints of diplopia and increased intraocular pressure (IOP) up to 30 mm Hg. The patient had been using minoxidil topically for androgenic alopecia for 8 years. On examination, mild swelling of the bulbar conjunctiva in the upper fornix was revealed; optical coherence tomography showed thinning of the ganglion cell layer, most likely due to moderate myopia. The patient responded well to discontinuation of minoxidil and topical therapy with prostaglandin analogues. After 4 months, an attempt was made to replace topical hypotensive therapy with carbonic anhydrase inhibitors, but the previous hypotensive regimen had to be resumed due to an increase in IOP. During 10 months of observation, no signs of progression were detected according to optical coherence tomography and static perimetry.

[On refraction shift after trabeculectomy]. / K voprosu ob izmeneniyakh refraktsii posle trabekulektomii.

PURPOSE: To determine the factors affecting the shift of refraction after trabeculectomy. MATERIAL AND METHODS: The study included 42 patients who were examined prior to trabeculectomy and at the following timepoints: 1 week, 1 month and 3 months after surgery. Examination included tonometry with assessment of corneal biomechanical properties, keratorefractometry with vector analysis, and biometry. The obtained data was processed for regression analysis and to find the possible correlations. RESULTS: All significant correlations between the measured parameters only occur on week 1. Postoperative spherical component of refraction (sphere) correlates negatively both with preoperative axial length (AL) and anterior chamber depth (ACD) (r=-0.699 and r=-0.458, p<0.05) and postoperative AL and ACD (r= -0.767 and r= -0.415, p<0.011). Dependence of sphere on AL is also expressed as a regression model. The magnitude of AL change depends on the magnitude of intraocular pressure (IOP) change (r=0.729, p<0.0001) and correlates negatively with postoperative IOP (r=-0.454, p=0.009) and baseline corneal hysteresis (CH; r= -0.482, p=0.009). Dependence of AL on IOP is also expressed as a regression model. The magnitudes of sphere and cylinder shifts correlate negatively with each other (r=-0.416, p=0.038). Keratometry reveals that the overall cylinder value correlates with the corneal cylinder, and so do the magnitudes of their shifts (r=0.589 and r=0.574, p<0.0001). Dependence of corneal hysteresis on IOP is expressed as a regression model; however, neither tonometric nor biomechanical corneal properties correlate with refraction. CONCLUSIONS: Sphere correlates negatively with AL and ACD. In turn, AL is related to the reduction in IOP. This dependence is likely the most important one for the refraction shift after trabeculectomy. No correlations were found for the change of astigmatism.