Enfermedad de Forestier como causa de compresión cervicomedular. Reporte de un caso y revisión bibliográfica / Forestier's disease as the cause of cervicomedullary compression. Case report and literature review

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¿Cuál es su diagnóstico?: Mucocele fronto-etmoidal gigante con extensión intracraneal y orbitaria / What would your diagnosis be?: Mucocele fronto-etmoidal gigante con extensión intracraneal y orbitaria

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Mucocele fronto-etmoidal gigante con extensión intracraneal y orbitaria / Giant frontoethmoidal mucocele with intracranial and orbital extension

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Abordaje subfrontal para el tratamiento de un estesioneuroblastoma / Sub-frontal approach in the treatment of esthesioneuroblastoma

El estesioneuroblastoma es un tumor maligno de la mucosa olfatoria localizado en el tracto nasosinusal con un manejo controvertido debido a su baja incidencia y a su origen desconocido. La resección craneofacial, empleando un abordaje subfrontal, es uno de los abordajes de elección para el tratamiento de esta compleja entidad. Describimos un caso tratado en nuestra institución que fue resuelto favorablemente con este procedimiento, así como una revisión exhaustiva de la bibliografía con respecto a este tipo de tumor y a las ventajas de este abordaje (AU)

Esthesioneuroblastoma is a rare malignant tumor of the olfactory mucosa located in the sinonasal tract with a controversial management due to its low incidence and unknown origin. Craniofacial resection using a subfrontal approach is one of the techniques of choice for treating this complex entity. We describe a case treated in our institution that responded favorably to this procedure, as well as a thorough review of the literature regarding this type of tumor and the advantages of the approach (AU)

[Matrix metaloproteinases in neurological brain lesions: a new therapeutic target?]. / Metaloproteinasas de matriz en las lesiones neurológicas: ¿una nueva diana terapéutica?

INTRODUCTION: Matrix metalloproteinases (MMP) are a family of proteolytic enzymes that degrade the extracellular matrix and are found in a large amount of human tissues. Their main functions are to maintain the integrity of the extracellular matrix, to modulate the interaction of the cells during development, to contribute to tissue remodeling, to directly participate in angiogenesis and to facilitate cellular migration. Due to the importance of its maintaining extracellular matrix function, MMP expression is tightly regulated at transcriptional level, through proform activation and with the binding to tissular inhibitors. Despite this complex regulation system, MMP regulation can be altered, producing an overexpression of these proteolytic proteins that alter the tissular structure, possibly destroying the tissue, as observed in some neurologic pathologies such as multiple sclerosis, aneurism formation and cerebral ischemia. The role that MMP have in traumatic brain lesions is almost unknown and is derived mainly from in vivo and in vitro experimental studies, and only from three papers performed in humans. There are some experimental studies that relate the brain alterations produced after traumatic brain injury with an increase in the concentration of various MMP. AIM: To review the role of these proteases in human brain lesions, emphasizing on the function of these proteases in traumatic brain injury lesions and their possible therapeutic target. DEVELOPMENT: A bibliographic search was performed on Medline database. CONCLUSIONS: Some MMP could be related to blood-brain barrier alteration and postraumatic edema formation, turning them into promising therapeutic targets.